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2023 Journal Article Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activationLi, Xaria X. and Woodruff, Trent M. (2023). Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation. STAR Protocols, 4 (4) 102758, 1-20. doi: 10.1016/j.xpro.2023.102758 |
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2023 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2023). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23) e168277, 1-19. doi: 10.1172/jci168277 |
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2023 Journal Article The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180 (S2), S23-S144. doi: 10.1111/bph.16177 |
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2023 Journal Article Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse ModelChen, Min, Edwards, Stephen R., Maskey, Dhiraj, Woodruff, Trent M., Tomlinson, Stephen and Reutens, David (2023). Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model. Neurotrauma Reports, 4 (1), 663-681. doi: 10.1089/neur.2023.0024 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Conference Publication T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunityMerle, Nicolas S., Freeley, Simon, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Kolev, Martin, Niyonzima, Nathalie, Morgensen, Trine Hyrup, Woodruff, Trent M., Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollness, Tom Eirik, Christiansen, Mette, West, Erin E. and Kemper, Claudia (2023). T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.64.15 |
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2023 Journal Article Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivoAlthobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964, e4964. doi: 10.1002/nbm.4964 |
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2023 Journal Article Complement peptide receptors in GtoPdb v.2023.1Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2023). Complement peptide receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f5/2023.1 |
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2023 Journal Article Neutrophil conversion to a tumor-killing phenotype underpins effective microbial therapyYam, Andrew O., Bailey, Jacqueline, Lin, Francis, Jakovija, Arnolda, Youlten, Scott E., Counoupas, Claudio, Gunzer, Matthias, Bald, Tobias, Woodruff, Trent M., Triccas, James A., Goldstein, Leonard D., Gallego-Ortega, David, Grey, Shane T. and Chtanova, Tatyana (2023). Neutrophil conversion to a tumor-killing phenotype underpins effective microbial therapy. Cancer Research, 83 (8), 1315-1328. doi: 10.1158/0008-5472.can-21-4025 |
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2023 Journal Article In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell modelGerogianni, Alexandra, Bal, Melissa, Mohlin, Camilla, Woodruff, Trent M., Lambris, John D., Mollnes, Tom E., Sjöström, Dick J. and Nilsson, Per H. (2023). In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model. Frontiers in Immunology, 14 1101387, 1101387. doi: 10.3389/fimmu.2023.1101387 |
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2023 Journal Article Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionSikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002 |
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2023 Journal Article TLQP-21 is a low potency partial C3aR activator on human primary macrophagesLi, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673 |
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2023 Conference Publication Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic miceSnelson, M., Tan, S. M., Kumar, V., Woodruff, T. and Coughlan, M. T. (2023). Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic mice. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA, Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001921 |
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2022 Journal Article Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptorsCoughlan, Melinda T., Ziemann, Mark, Laskowski, Adrienne, Woodruff, Trent M. and Tan, Sih Min (2022). Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors. Scientific Reports, 12 (1) 20278, 1-10. doi: 10.1038/s41598-022-24851-w |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022)Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y. (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030 |
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2022 Journal Article Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine releasede Boer, Eline, Sokolova, Marina, Quach, Huy Q., McAdam, Karin E., Götz, Maximilian P., Chaban, Viktoriia, Vaage, Jarle, Fageräng, Beatrice, Woodruff, Trent M., Garred, Peter, Nilsson, Per H., Mollnes, Tom E. and Pischke, Søren E. (2022). Synthetic oligodeoxynucleotide CpG motifs activate human complement through their backbone structure and induce complement-dependent cytokine release. The Journal of Immunology, 209 (9), 1760-1767. doi: 10.4049/jimmunol.2101191 |
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2022 Journal Article Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillarGabrili, Joel J. M., Villas-Boas, Isadora Maria, Pidde, Giselle, Squaiella-Baptistão, Carla Cristina, Woodruff, Trent M. and Tambourgi, Denise V. (2022). Complement system inhibition modulates the inflammation induced by the venom of Premolis semirufa, an Amazon rainforest moth caterpillar. International Journal of Molecular Sciences, 23 (21) 13333, 1-20. doi: 10.3390/ijms232113333 |
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2022 Journal Article Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disordersMcDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061 |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacyXu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
