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2025 Conference Publication Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1Cao, Yuzhihan, Pietrogrande, Giovanni, Pars, Selin, Clark, Richard, Wolvetang, Ernst, Woodruff, Trent and Albornoz, Eduardo (2025). Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153008 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Conference Publication The complement C3a receptor regulates the tumour microenvironmentRolfe, Barbara, Sonderegger, Stefan, Panagides, Nadya, McGirr, Crystal, Nabizadeh, Jamileh, Li, Xaria and Woodruff, Trent (2025). The complement C3a receptor regulates the tumour microenvironment. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153021 |
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2025 Conference Publication Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membraneSun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969 |
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2025 Conference Publication Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington's diseaseLerskiatiphanich, Titaya, McDonald, Tanya, Cui, Cedric, Fung, Jenny, Woodruff, Trent and Lee, John (2025). Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington's disease. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153064 |
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2025 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Dent, Joshua, Gorman, Declan, Li, Xaria, Wu, Xiaosa, Cui, Cedric, Fung, Jenny, Lee, John, Rosengren, Johan and Woodruff, Trent (2025). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153001 |
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2025 Conference Publication Investigating the role of neuronally-expressed C5aR1 in motor neuron diseaseRisby-Jones, Grace, Woodruff, Trent M., Fung, Jenny N. and Lee, John D. (2025). Investigating the role of neuronally-expressed C5aR1 in motor neuron disease. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153079 |
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2025 Conference Publication The enigmatic role of C5aR2 in diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Gan, Poh Yi, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2025). The enigmatic role of C5aR2 in diabetic kidney disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153007 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Journal Article The Complement System: Biology, Pathology and Therapeutic InterventionsLi, Xaria X. and Woodruff, Trent M. (2025). The Complement System: Biology, Pathology and Therapeutic Interventions. Pharmacological Reviews, 77 (5) 100079, 100079. doi: 10.1016/j.pharmr.2025.100079 |
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2025 Journal Article Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALIChen, Dawei, Liang, Huaqin, Xu, Xiuzhang, Xia, Wenjie, Ye, Xin, Luo, Yalin, He, Jiansen, Xu, Yaori, Liu, Jing, Ren, Hui, Luo, Shengxue, Woodruff, Trent M., Zelek, Wioleta M., Morgan, Bryan Paul, Kapur, Rick, Santoso, Sentot and Fu, Yongshui (2025). Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI. Blood Journal, 146 (6) 2024028012, 1-16. doi: 10.1182/blood.2024028012 |
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2025 Journal Article The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune responseSenent, Yaiza, Remírez, Ana, Repáraz, David, Llopiz, Diana, Celias, Daiana P., Sainz, Cristina, Entrialgo-Cadierno, Rodrigo, Suarez, Lucia, Rouzaut, Ana, Alignani, Diego, Tavira, Beatriz, Lambris, John D., Woodruff, Trent M., de Andrea, Carlos E., Ruffell, Brian, Sarobe, Pablo, Ajona, Daniel and Pio, Ruben (2025). The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response. Cancer Immunology Research, 13 (3), 384-399. doi: 10.1158/2326-6066.cir-24-0250 |
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2024 Journal Article Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitmentSnelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2 |
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2024 Journal Article The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathologyStables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743 |
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2024 Conference Publication Deciphering complement-dependent macrophage phenotypes in human rheumatoid arthritis using combined computationalexperimental single-cell omicsVargas, Juan, Mantel, Ian, Inamo, Jun, Banda, Nirmal, Jonsson, Anna Helena, Wei, Kevin, Rao, Deepak, Goodman, Susan, Deane, Kevin, Seifert, Jennifer, Anolik, Jennifer, Brenner, Michael, Raychaudhuri, Soumya, Woodruff, Trent, Holers, Michael, Donlin, Laura and Zhang, Fan (2024). Deciphering complement-dependent macrophage phenotypes in human rheumatoid arthritis using combined computationalexperimental single-cell omics. ACR Convergence 2024, Washington, DC, United States, 15-19 November 2024. Hoboken, NJ 07030 United States: John Wiley & Sons. doi: 10.1002/art.42992 |
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2024 Conference Publication Colon-targeted complement C5aR1 inhibition using pH-sensitive nanoparticles ameliorates experimental colitisCui, Cedric, Lee, John and Woodruff, Trent (2024). Colon-targeted complement C5aR1 inhibition using pH-sensitive nanoparticles ameliorates experimental colitis. 19th European Meeting on Complement in Human Diseases, Lübeck, Germany, 2-6 September 2024. Weinheim, Germany: Wiley-VCH. |
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2024 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2024). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 134 (16), 16. doi: 10.1172/jci185067 |
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2024 Conference Publication Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2024). Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14360 |
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2024 Conference Publication Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney diseaseTan, Sih Min, Trambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent and Coughlan, Melinda (2024). Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14361 |
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2024 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Gorman, Declan, Li, Xaria, Dent, Joshua, Cui, Cedric, Lee, Han Siean, Fung, Jenny, Lee, John, Rosengren, K. Johan and Woodruff, Trent (2024). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
