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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2025 Journal Article The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune responseSenent, Yaiza, Remírez, Ana, Repáraz, David, Llopiz, Diana, Celias, Daiana P., Sainz, Cristina, Entrialgo-Cadierno, Rodrigo, Suarez, Lucia, Rouzaut, Ana, Alignani, Diego, Tavira, Beatriz, Lambris, John D., Woodruff, Trent M., de Andrea, Carlos E., Ruffell, Brian, Sarobe, Pablo, Ajona, Daniel and Pio, Ruben (2025). The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response. Cancer Immunology Research, 13 (3), 384-399. doi: 10.1158/2326-6066.cir-24-0250 |
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2024 Journal Article Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitmentSnelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2 |
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2024 Journal Article The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathologyStables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743. doi: 10.1016/j.nbd.2024.106743 |
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2024 Conference Publication Deciphering complement-dependent macrophage phenotypes in human rheumatoid arthritis using combined computationalexperimental single-cell omicsVargas, Juan, Mantel, Ian, Inamo, Jun, Banda, Nirmal, Jonsson, Anna Helena, Wei, Kevin, Rao, Deepak, Goodman, Susan, Deane, Kevin, Seifert, Jennifer, Anolik, Jennifer, Brenner, Michael, Raychaudhuri, Soumya, Woodruff, Trent, Holers, Michael, Donlin, Laura and Zhang, Fan (2024). Deciphering complement-dependent macrophage phenotypes in human rheumatoid arthritis using combined computationalexperimental single-cell omics. ACR Convergence 2024, Washington, DC, United States, 15-19 November 2024. Hoboken, NJ 07030 United States: John Wiley & Sons. doi: 10.1002/art.42992 |
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2024 Conference Publication Colon-targeted complement C5aR1 inhibition using pH-sensitive nanoparticles ameliorates experimental colitisCui, Cedric, Lee, John and Woodruff, Trent (2024). Colon-targeted complement C5aR1 inhibition using pH-sensitive nanoparticles ameliorates experimental colitis. 19th European Meeting on Complement in Human Diseases, Lübeck, Germany, 2-6 September 2024. Weinheim, Germany: Wiley-VCH. |
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2024 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2024). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 134 (16), 16. doi: 10.1172/jci185067 |
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2024 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Gorman, Declan, Li, Xaria, Dent, Joshua, Cui, Cedric, Lee, Han Siean, Fung, Jenny, Lee, John, Rosengren, K. Johan and Woodruff, Trent (2024). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Conference Publication Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2024). Temporal characterisation of renal immunophenotype with mitochondrial kinetic profile in a preclinical model of diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14360 |
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2024 Conference Publication Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney diseaseTan, Sih Min, Trambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Woodruff, Trent and Coughlan, Melinda (2024). Dual inhibition of complement C5a receptor 1 and 2 in diabetic kidney disease. 59th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Adelaide, SA, Australia, 31 August–4 September 2024. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14361 |
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2024 Journal Article Sex differences in Huntington's disease from a neuroinflammation perspectiveRisby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480 |
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2024 Journal Article Complement(ing) long-COVID thromboinflammation and pathogenesisLee, John D. and Woodruff, Trent M. (2024). Complement(ing) long-COVID thromboinflammation and pathogenesis. Trends in Immunology, 45 (6), 397-399. doi: 10.1016/j.it.2024.04.001 |
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2024 Conference Publication C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environmentAhmari, Niousha, Perrino, Melissa, Pundavela, Jay, Szabo, Sara, Woodruff, Trent, Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment. ASPET 2024 Annual Meeting, Arlington, VA United States, 16-19 May 2024. Rockville, MD United States: American Society for Pharmacology and Experimental Therapeutics. doi: 10.1124/jpet.249.988670 |
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2024 Conference Publication Dysregulation of T cell intrinsic C5aR2 activation causes uncontrolled inflammatory Th responses and autoinflammatory syndromeWest, Erin, Merle, Nicolas, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Morgensen, Trine Hyrup, Woodruff, Trent, Monk, Peter, Christiansen, Mette and Kemper, Claudia (2024). Dysregulation of T cell intrinsic C5aR2 activation causes uncontrolled inflammatory Th responses and autoinflammatory syndrome. Annual Meeting of the American Association of Immunologists (IMMUNOLOGY), Chicago, IL, United States, 3-7 May 2024. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.212.supp.0526.5407 |
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2024 Conference Publication Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironmentsBeach, Callum, MacLean, David, Majorova, Dominika, Valbuena, Gabriel N., Damavandi, Mahnaz Darvish, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Moon, Eui Jung, Guglietta, Silvia, Krieg, Carsten, Woodruff, Trent M., Maughan, Tim, Buczacki, Simon J.A., Leedham, Simon J., Giaccia, Amato J., Clark, Heather and Olcina, Monica M. (2024). Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments. ESTRO meets Asia 2024, Kuala Lumpur, Malaysia, 23-25 August 2024. Shannon, Ireland: Elsevier. doi: 10.1016/s0167-8140(24)01225-8 |
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2024 Journal Article Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposureChen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306 |
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2024 Journal Article C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisPerrino, Melissa R., Ahmari, Niousha, Hall, Ashley, Jackson, Mark, Na, Youjin, Pundavela, Jay, Szabo, Sara, Woodruff, Trent M., Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance, 7 (5) e202302229, 1-16. doi: 10.26508/lsa.202302229 |
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2024 Journal Article A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosisVassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 61 (8), 5901-5915. doi: 10.1007/s12035-023-03857-z |
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2024 Book Chapter The role of the complement system in cancer etiology and managementSonderegger, Stefan E., Manzanero, Silvia, Woodruff, Trent M., Farouqa, Jad, Nabizadeh, Jamileh, Panagides, Nadya and Rolfe, Barbara E. (2024). The role of the complement system in cancer etiology and management. Clinical immuno-oncology. (pp. 41-60.e10) edited by John E. Niederhuber. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-87763-3.00012-5 |
