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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2026 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A., Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H. R., Cowin, Gary, Cui, Cedric S., Butler, Mark S., Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C., Schroder, Kate, Halai, Reena, MacLeod, Angus M., Matthews, Kim, Robertson, Avril A. B., Cooper, Matthew A. and Woodruff, Trent M. (2026). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain, 149 (4) awaf372, 1289-1301. doi: 10.1093/brain/awaf372 |
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2026 Journal Article Complement dysregulation in multiple sclerosis: emerging mechanisms and translational therapeutic opportunitiesKhan, Nemat, Zakriya, Zikra M., McCombe, Pamela and Woodruff, Trent M. (2026). Complement dysregulation in multiple sclerosis: emerging mechanisms and translational therapeutic opportunities. Trends in Pharmacological Sciences, 47 (4), 355-368. doi: 10.1016/j.tips.2026.02.006 |
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2026 Conference Publication Preface to the special issue for the 30th International Complement Workshop Brisbane 2025Rolfe, Barbara E., Lee, John D. and Woodruff, Trent M. (2026). Preface to the special issue for the 30th International Complement Workshop Brisbane 2025. 30th International Complement Workshop, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153149 |
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2026 Journal Article C5aR1 inhibition alleviates cranial radiation-induced cognitive declineKrattli, Robert P., Do, An H., El-Khatib, Sanad M., Alikhani, Leila, Markarian, Mineh, Vagadia, Arya R., Usmani, Manal T., Madan, Shreya, Baulch, Janet E., Clark, Richard J., Woodruff, Trent M., Tenner, Andrea J. and Acharya, Munjal M. (2026). C5aR1 inhibition alleviates cranial radiation-induced cognitive decline. Cancer Research, 86 (1), OF1-OF18. doi: 10.1158/0008-5472.can-24-4869 |
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2026 Journal Article Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxinsGabrili, Joel J. M., Megale, Ângela A. A., Pidde, Giselle, Woodruff, Trent M. and Tambourgi, Denise V. (2026). Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins. Frontiers in Immunology, 16 1706235, 16. doi: 10.3389/fimmu.2025.1706235 |
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2025 Journal Article The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activationGrunenwald, Anne, Boudhabhay, Idris, Revel, Margot, Poillerat, Victoria, Voilin, Elodie, Majdi, Amine, Chaibi, Khalil, Gaudry, Stephane, Woodruff, Trent M., Crambert, Gilles, Guihaire, Julien, Zaidan, Mohamad, Oniszczuk, Julie, Frimat, Marie, Gnemmi, Viviane, Aletti, Marc, Nielly, Hubert, Gilardin, Laurent and Roumenina, Lubka T. (2025). The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activation. Communications Biology, 9 (1) 171, 1-13. doi: 10.1038/s42003-025-09449-y |
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2025 Journal Article The concise guide to PHARMACOLOGY 2025/26: G protein‐coupled receptorsAlexander, Stephen P. H., Davenport, Anthony P., Kelly, Eamonn, Gibb, Alasdair J., Mathie, Alistair A., Peach, Chloe J., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George R., Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bennett, Kirstie A., Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria A. ... Zaidman, Nathan (2025). The concise guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors. British Journal of Pharmacology, 182 (S1), S24-S151. doi: 10.1111/bph.70230 |
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2025 Conference Publication Perturbations in the T cell-intrinsic complement C5 program cause uncontrolled inflammatory Th responses and autoinflammatory syndromeWest, Erin E., Merle, Nicolas S, Singh, Parul, Case, Ayden, Bibby, Jack, Rahman, Jubayer, Woodruff, Trent M., Christiansen, Mette, Mogensen, Trine and Kemper, Claudia (2025). Perturbations in the T cell-intrinsic complement C5 program cause uncontrolled inflammatory Th responses and autoinflammatory syndrome. Immunology 2025™ Meeting, Honolulu, HI United States, 3-7 May 2025. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/jimmun/vkaf283.622 |
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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Journal Article Complement peptide receptors in GtoPdb v.2025.3Cianciulli, Antonia, Shukla, Arun K., Panaro, Maria A., Monk, Peter, Mitolo, Vincenzo, Li, Xaria X., Lee, John D., Hawksworth, Owen, Coulthard, Liam and Woodruff, Trent M. (2025). Complement peptide receptors in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f5/2025.3 |
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2025 Conference Publication Targeting NLRP3 inflammasome with MCC950 restores neurometabolic and structural integrity in an EAE model of progressive multiple sclerosisKhan, Nemat, Althobity, Abdullah, Kumar, Vinod, Cowin, Gary, Brereton, Ian, Kurniawan, Nyoman and Woodruff, Trent (2025). Targeting NLRP3 inflammasome with MCC950 restores neurometabolic and structural integrity in an EAE model of progressive multiple sclerosis. 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Barcelona, Spain, 24-26 September 2025. London, United Kingdom: Sage Publications. |
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2025 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Dent, Joshua, Gorman, Declan, Li, Xaria, Wu, Xiaosa, Cui, Cedric, Fung, Jenny, Lee, John, Rosengren, Johan and Woodruff, Trent (2025). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153001 |
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2025 Conference Publication Investigating the role of neuronally-expressed C5aR1 in motor neuron diseaseRisby-Jones, Grace, Woodruff, Trent M., Fung, Jenny N. and Lee, John D. (2025). Investigating the role of neuronally-expressed C5aR1 in motor neuron disease. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153079 |
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2025 Conference Publication The enigmatic role of C5aR2 in diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Gan, Poh Yi, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2025). The enigmatic role of C5aR2 in diabetic kidney disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153007 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Conference Publication Role of complement components 3A (C3A) and 5A (C5A) in the acute-to-chronic pain transition in a mouse model of neuropathic painVygonskaya, Marina, Smith, Maree, Woodruff, Trent and Han, Felicity (2025). Role of complement components 3A (C3A) and 5A (C5A) in the acute-to-chronic pain transition in a mouse model of neuropathic pain. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152963 |
