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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2025 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A, Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H R, Cowin, Gary, Cui, Cedric S, Butler, Mark S, Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C, Schroder, Kate, Halai, Reena, MacLeod, Angus M, Matthews, Kim, Robertson, Avril A B, Cooper, Matthew A and Woodruff, Trent M (2025). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain awaf372. doi: 10.1093/brain/awaf372 |
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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Conference Publication A conserved molecular mechanism orchestrates diverse ligand recognition at the complement anaphylatoxin receptor C3aRMishra, Sudha, Dalal, Annu, Yadav, Manish Kumar, Yadav, Ravi, Ganguly, Manisankar, Lee, John, Banerjee, Ramanuj, Woodruff, Trent, Gati, Cornelius and Shukla, Arun Kumar (2025). A conserved molecular mechanism orchestrates diverse ligand recognition at the complement anaphylatoxin receptor C3aR. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152978 |
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2025 Conference Publication Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytesJulianisya, Alana R., Fung, Jenny N.T., Lerskiatiphanich, Titaya, Woodruff, Trent M. and Lee, John D. (2025). Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytes. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153081 |
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2025 Conference Publication A detrimental role for complement C5aR1 activation in Huntington’s diseaseMarallag, Jianina, Fung, Jenny, Lee, John and Woodruff, Trent (2025). A detrimental role for complement C5aR1 activation in Huntington’s disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153080 |
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2025 Conference Publication Complement C5aR1 modulates excitatory synaptic transmission in cortical pyramidal neurons via a calcium-independent mechanismParker, Sandra, Bellingham, Mark and Woodruff, Trent (2025). Complement C5aR1 modulates excitatory synaptic transmission in cortical pyramidal neurons via a calcium-independent mechanism. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153054 |
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2025 Conference Publication Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1Cao, Yuzhihan, Pietrogrande, Giovanni, Pars, Selin, Clark, Richard, Wolvetang, Ernst, Woodruff, Trent and Albornoz, Eduardo (2025). Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153008 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Conference Publication The complement C3a receptor regulates the tumour microenvironmentRolfe, Barbara, Sonderegger, Stefan, Panagides, Nadya, McGirr, Crystal, Nabizadeh, Jamileh, Li, Xaria and Woodruff, Trent (2025). The complement C3a receptor regulates the tumour microenvironment. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153021 |
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2025 Conference Publication Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membraneSun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969 |
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2025 Conference Publication Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington's diseaseLerskiatiphanich, Titaya, McDonald, Tanya, Cui, Cedric, Fung, Jenny, Woodruff, Trent and Lee, John (2025). Investigating complement receptor C3aR1 signalling in metabolic dysfunction in the R6/1 mouse model of Huntington's disease. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153064 |
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2025 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Dent, Joshua, Gorman, Declan, Li, Xaria, Wu, Xiaosa, Cui, Cedric, Fung, Jenny, Lee, John, Rosengren, Johan and Woodruff, Trent (2025). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153001 |
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2025 Conference Publication Investigating the role of neuronally-expressed C5aR1 in motor neuron diseaseRisby-Jones, Grace, Woodruff, Trent M., Fung, Jenny N. and Lee, John D. (2025). Investigating the role of neuronally-expressed C5aR1 in motor neuron disease. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153079 |
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2025 Conference Publication The enigmatic role of C5aR2 in diabetic kidney diseaseTrambas, Inez, Laskowski, Adrienne, Khayyira, Amalia, Sharma, Arpeeta, Gan, Poh Yi, Woodruff, Trent, Coughlan, Melinda and Tan, Sih Min (2025). The enigmatic role of C5aR2 in diabetic kidney disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153007 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Conference Publication Role of complement components 3A (C3A) and 5A (C5A) in the acute-to-chronic pain transition in a mouse model of neuropathic painVygonskaya, Marina, Smith, Maree, Woodruff, Trent and Han, Felicity (2025). Role of complement components 3A (C3A) and 5A (C5A) in the acute-to-chronic pain transition in a mouse model of neuropathic pain. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152963 |
