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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2025 Journal Article Preface to the special issue for the 30th International Complement Workshop Brisbane 2025Rolfe, Barbara E., Lee, John D. and Woodruff, Trent M. (2025). Preface to the special issue for the 30th International Complement Workshop Brisbane 2025. Immunobiology 153149, 153149. doi: 10.1016/j.imbio.2025.153149 |
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2025 Journal Article The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptorsAlexander, Stephen P. H., Davenport, Anthony P., Kelly, Eamonn, Gibb, Alasdair J., Mathie, Alistair A., Peach, Chloe J., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George R., Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bennett, Kirstie A., Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria A. ... Zaidman, Nathan (2025). The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors. British Journal of Pharmacology, 182 (S1), S24-S151. doi: 10.1111/bph.70230 |
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2025 Journal Article Perturbations in the T cell-intrinsic complement C5 program cause uncontrolled inflammatory Th responses and autoinflammatory syndrome 2735West, Erin E., Merle, Nicolas S, Singh, Parul, Case, Ayden, Bibby, Jack, Rahman, Jubayer, Woodruff, Trent M., Christiansen, Mette, Mogensen, Trine and Kemper, Claudia (2025). Perturbations in the T cell-intrinsic complement C5 program cause uncontrolled inflammatory Th responses and autoinflammatory syndrome 2735. The Journal of Immunology, 214 (Supplement_1) vkaf283.622. doi: 10.1093/jimmun/vkaf283.622 |
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2025 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A., Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H. R., Cowin, Gary, Cui, Cedric S., Butler, Mark S., Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C., Schroder, Kate, Halai, Reena, MacLeod, Angus M., Matthews, Kim, Robertson, Avril A. B., Cooper, Matthew A. and Woodruff, Trent M. (2025). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain awaf372. doi: 10.1093/brain/awaf372 |
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2025 Journal Article C5aR1 inhibition alleviates cranial radiation-induced cognitive declineKrattli, Robert P., Do, An H., El-Khatib, Sanad M., Alikhani, Leila, Markarian, Mineh, Vagadia, Arya R., Usmani, Manal T., Madan, Shreya, Baulch, Janet E., Clark, Richard J., Woodruff, Trent M., Tenner, Andrea J. and Acharya, Munjal M. (2025). C5aR1 inhibition alleviates cranial radiation-induced cognitive decline. Cancer Research, 86 (1), OF1-OF18. doi: 10.1158/0008-5472.can-24-4869 |
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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Journal Article Complement peptide receptors in GtoPdb v.2025.3Cianciulli, Antonia, Shukla, Arun K., Panaro, Maria A., Monk, Peter, Mitolo, Vincenzo, Li, Xaria X., Lee, John D., Hawksworth, Owen, Coulthard, Liam and Woodruff, Trent M. (2025). Complement peptide receptors in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f5/2025.3 |
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2025 Conference Publication Targeting NLRP3 inflammasome with MCC950 restores neurometabolic and structural integrity in an EAE model of progressive multiple sclerosisKhan, Nemat, Althobity, Abdullah, Kumar, Vinod, Cowin, Gary, Brereton, Ian, Kurniawan, Nyoman and Woodruff, Trent (2025). Targeting NLRP3 inflammasome with MCC950 restores neurometabolic and structural integrity in an EAE model of progressive multiple sclerosis. 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Barcelona, Spain, 24-26 September 2025. London, United Kingdom: Sage Publications. |
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2025 Conference Publication A conserved molecular mechanism orchestrates diverse ligand recognition at the complement anaphylatoxin receptor C3aRMishra, Sudha, Dalal, Annu, Yadav, Manish Kumar, Yadav, Ravi, Ganguly, Manisankar, Lee, John, Banerjee, Ramanuj, Woodruff, Trent, Gati, Cornelius and Shukla, Arun Kumar (2025). A conserved molecular mechanism orchestrates diverse ligand recognition at the complement anaphylatoxin receptor C3aR. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152978 |
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2025 Conference Publication Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytesJulianisya, Alana R., Fung, Jenny N.T., Lerskiatiphanich, Titaya, Woodruff, Trent M. and Lee, John D. (2025). Complement C3a receptor signalling mitigates motor neuron degeneration by modulating neurotoxic astrocytes. 30th International Complement Workshop - ICW2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153081 |
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2025 Conference Publication A detrimental role for complement C5aR1 activation in Huntington’s diseaseMarallag, Jianina, Fung, Jenny, Lee, John and Woodruff, Trent (2025). A detrimental role for complement C5aR1 activation in Huntington’s disease. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153080 |
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2025 Conference Publication Complement C5aR1 modulates excitatory synaptic transmission in cortical pyramidal neurons via a calcium-independent mechanismParker, Sandra, Bellingham, Mark and Woodruff, Trent (2025). Complement C5aR1 modulates excitatory synaptic transmission in cortical pyramidal neurons via a calcium-independent mechanism. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153054 |
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2025 Conference Publication Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1Cao, Yuzhihan, Pietrogrande, Giovanni, Pars, Selin, Clark, Richard, Wolvetang, Ernst, Woodruff, Trent and Albornoz, Eduardo (2025). Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153008 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Conference Publication The complement C3a receptor regulates the tumour microenvironmentRolfe, Barbara, Sonderegger, Stefan, Panagides, Nadya, McGirr, Crystal, Nabizadeh, Jamileh, Li, Xaria and Woodruff, Trent (2025). The complement C3a receptor regulates the tumour microenvironment. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153021 |
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2025 Conference Publication Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membraneSun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969 |
