![Professor Elizabeth Coulson](/sites/default/files/profiles/1188.jpeg)
Elizabeth Coulson
- Email:
- e.coulson@uq.edu.au
- Phone:
- +61 7 336 52905
- Phone:
- +61 7 336 59022
Overview
Background
Professor Elizabeth (Lizzie) Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer’s disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institute with Professor Perry Bartlett before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute. She was appointed Professor in 2015, joining the School of Biomedical Sciences and becoming Deputy Head of School in 2016/7 and 2019 and Head of School in 2020. She maintains a 20% Queensland Brain Institutes appointment and is a member of the Clem Jones Centre for Ageing Dementia Research.
Her Lab webpage is: Coulson Lab - Neurotrophin - School of Biomedical Sciences ...
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Melbourne
- Doctor of Philosophy, University of Melbourne
Research interests
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Role of p75NTR in neurodegenerative disease.
The laboratory recently reported that p75NTR death signalling can be promoted by amyloid-ß peptide that characteristically accumulates in Alzheimer’s disease. We are investigating the regulation and activation of p75NTR death signalling in cholinergic neurons in this condition, and testing whether disrupting p75NTR function can prevent cholinergic degeneration, and cognitive decline, in animal models. As an extension of this work we are developing methods to assess cholinergic degeneration and amyloid plaque deposition in animal models of Alzheimer’s disease by magnetic resonance imaging (MRI).
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How neurotransmitter- and neurotrophin-mediated signals determine cell survival.
We are investigating the basic molecular mechanisms by which neurotransmitter receptor activation and receptor trafficking affect p75NTR activation and subsequent death signalling using molecular and biochemical techniques in in vitro and in vivo models. We are also investigating the role of p75NTR cleavage in promoting death signalling, using confocal microscopy techniques to image live cells and cell membranes in real time. This project will lead to a greater understanding of p75NTR biology, and will also provide knowledge of the kinetics of p75NTR-mediated death signals and the time frame within which they can be inhibited.
Works
Search Professor Elizabeth Coulson’s works on UQ eSpace
2003
Journal Article
Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons
Murray, SS, Bartlett, PF, Lopes, EC, Coulson, EJ, Greferath, U and Cheema, SS (2003). Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons. Clinical And Experimental Pharmacology And Physiology, 30 (4), 217-222. doi: 10.1046/j.1440-1681.2003.03827.x
2002
Journal Article
The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis
Jabbour, AM, Ekert, PG, Coulson, EJ, Knight, MJ, Ashley, DM and Hawkins, CJ (2002). The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death And Differentiation, 9 (12), 1311-1320. doi: 10.1038/sj.cdd.4401135
2001
Journal Article
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
Verhagen, A. M., Coulson, E. J. and Vaux, D. L. (2001). Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biology, 2 (7) 3009
2001
Journal Article
Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons
Lowry, KS, Murray, SS, Coulson, EJ, Epa, R, Bartlett, PF, Barrett, G and Cheema, SS (2001). Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons. Journal of Neuroscience Research, 64 (1), 11-17. doi: 10.1002/jnr.1048
2000
Journal Article
Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death
Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J. and Bartlett, P. F. (2000). Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. Journal of Biological Chemistry, 275 (39), 30537-30545. doi: 10.1074/jbc.M005214200
2000
Journal Article
What the evolution of the amyloid protein precursor supergene family tells us about its function
Coulson, EJ, Paliga, K, Beyreuther, K and Masters, CL (2000). What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochemistry International, 36 (3), 175-184. doi: 10.1016/S0197-0186(99)00125-4
2000
Journal Article
Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury
Coulson, E. J., Reid, K., Murray, S. S., Cheema, S. S. and Bartlett, P. F. (2000). Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clinical And Experimental Pharmacology And Physiology, 27 (7), 537-541. doi: 10.1046/j.1440-1681.2000.03295.x
1999
Journal Article
Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Coulson, E. J., Reid, K. and Bartlett, P. F. (1999). Signaling of neuronal cell death by the p75NTR neurotrophin receptor. Molecular Neurobiology, 20 (1), 29-44. doi: 10.1007/BF02741363
1999
Journal Article
p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L)
Coulson, E. J., Reid, K., Barrett, G. L. and Bartlett, P. F. (1999). p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L). Journal of Biological Chemistry, 274 (23), 16387-16391. doi: 10.1074/jbc.274.23.16387
1998
Journal Article
Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides
Epa, WR, Rong, P, Bartlett, PF, Coulson, EJ and Barrett, GL (1998). Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides. Antisense & Nucleic Acid Drug Development, 8 (6), 489-498. doi: 10.1089/oli.1.1998.8.489
1998
Journal Article
Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts
Uren, AG, Coulson, EJ and Vaux, DL (1998). Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. Trends In Biochemical Sciences, 23 (5), 159-162. doi: 10.1016/S0968-0004(98)01198-0
1997
Conference Publication
The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc
Whyte, S, Jones, L, Coulson, EJ, Moir, RD, Bush, AI, Beyreuther, K and Masters, CL (1997). The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc. 5th International Conference on Alzheimers Disease and Related Disorders, Osaka Japan, Jul 24-29, 1996. CHICHESTER: JOHN WILEY & SONS LTD.
1997
Journal Article
Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata
Coulson, EJ, Barrett, GL, Storey, E, Bartlett, PF, Beyreuther, K and Masters, CL (1997). Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata. Brain Research, 770 (1-2), 72-80. doi: 10.1016/S0006-8993(97)00757-9
1996
Conference Publication
The effect of oral zinc supplementation on the amyloid precursor protein of Alzheimer's disease in human plasma and rat brain
Whyte, S., Currie, J., Maruff, P., Malone, V., Coulson, E.J., Beyreuther, K. and Masters, C.L. (1996). The effect of oral zinc supplementation on the amyloid precursor protein of Alzheimer's disease in human plasma and rat brain. The Fifth International Conference on Alzheimer's Disease and Related Disorders, Osaka, Japan, 1996. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0197-4580(96)80326-5
Funding
Current funding
Past funding
Supervision
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Dissection of the Role of Active Dendritic Integration in Neuronal Computation
Principal Advisor
-
Doctor Philosophy
Detecting risk of dementia in people with sleep apnoea
Principal Advisor
Other advisors: Associate Professor Philip Terrill
-
Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Principal Advisor
Other advisors: Associate Professor Kai-Hsiang Chuang
-
Master Philosophy
Efficacy of Non-Invasive Ventilation for the treatment of sleep hypoventilation in Myotonic Dystrophy
Associate Advisor
Other advisors: Professor Kwun Fong
Completed supervision
-
2020
Doctor Philosophy
p75 neurotrophin receptor function in brain development
Principal Advisor
Other advisors: Professor Michael Piper
-
2017
Master Philosophy
An investigation of risk factors for Alzheimer's disease in obstructive sleep apnoea patients
Principal Advisor
-
2016
Doctor Philosophy
Role of p75 neurotrophin receptor in normal cholinergic basal forebrain function in adults
Principal Advisor
-
2016
Doctor Philosophy
Neurotrophin Regulation of Alzheimer's Disease Pathology
Principal Advisor
Other advisors: Professor Jürgen Götz
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2014
Master Philosophy
Efficacy of a novel neuronal death inhibitor in Alzheimer¿s disease models
Principal Advisor
-
2012
Doctor Philosophy
Characterisation of a novel p75 neurotrophin receptor death signalling pathway
Principal Advisor
Other advisors: Professor Pankaj Sah
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2008
Doctor Philosophy
Role of p75NTR in BDNF - Stimulated Neurogenesis in the Adult Hippocampus
Principal Advisor
Other advisors: Professor Helen Cooper
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2007
Doctor Philosophy
REGULATION OF P75 NEUROTROPHIN RECEPTOR-MEDIATED NEURONAL DEATH THROUGH POST-TRANSLATIONAL MODIFICATIONS
Principal Advisor
-
2006
Doctor Philosophy
CELL DEATH AND PROLIFERATION IN PSYCHIATRIC DISORDERS
Principal Advisor
-
2024
Doctor Philosophy
Stimulating the counter-regulatory renin-angiotensin system: a novel approach to prevent Alzheimer's disease
Associate Advisor
Other advisors: Dr Niwanthi Rajapakse
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2021
Master Philosophy
Cholinergic regulation of hippocampal neural precursor cell activity and neurogenesis
Associate Advisor
Other advisors: Dr Dhanisha Jhaveri
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2014
Doctor Philosophy
The regulation of membrane trafficking pathways at the presynaptic nerve terminal
Associate Advisor
Other advisors: Professor Frederic Meunier
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2012
Doctor Philosophy
Role of Munc18-1 in regulating neuroexocytosis
Associate Advisor
Other advisors: Professor Frederic Meunier, Professor Brett Collins
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2011
Doctor Philosophy
Post-synaptic scaffolding protein changes in Alzheimer's disease.
Associate Advisor
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2007
Master Philosophy
Neurogenesis in the adult hippocampus: quantification, identification of neural subtypes, andregulation by the immune system
Associate Advisor
Media
Enquiries
Contact Professor Elizabeth Coulson directly for media enquiries about:
- Alzheimer's disease
- Biochemistry
- Cell biology
- Disease - Alzheimer's
- Disease - Motor Neuron
- Molecular mechanisms
- Motor Neuron disease
- Research models
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