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Dr Natasha Hungerford
Dr

Natasha Hungerford

Email: 
Phone: 
+61 7 344 32473

Overview

Background

Dr Natasha Hungerford is an organic chemist and has extensive experience in natural products chemistry. She is a Senior Research Fellow in the Natural Toxin group within the Centre for Animal Science, Queensland Alliance for Agricultural and Food Innovation (QAAFI) and is based at the Health and Food Sciences Precinct (Cooper's Plains). She joined QAAFI in 2016 and is utilising analytical techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify, evaluate and minimise risks associated with natural toxins found in certain plants. This research focuses on minimising risks to Australian livestock production and to the consumer of certain food products.

Work on honey analysing for toxic pyrrolizidine alkaloids, pesticides, herbicides and PAHs, and mineral and trace elements has been conducted in collaboration with Queensland Health.Work on stingless bee (Meliponini) honey has extended to the analyses of beneficial components in this honey, including novel sugars, leading to projects funded by AgriFutures Australia and Queensland Health, as well as collaborations with Malaysian researchers.

Poisoning of cattle in pastures by Pimelea plant species is a problem in semi-arid regions of Australia and research work funded by Meat and Livestock Australia (MLA) has focussed on minimising the impacts of the Pimelea toxin on Australian cattle production. MLA now fund a collaborative UQ-DAF project that applies novel technologies to progress the industry ambition of a carbon neutral beef industry by 2030.

Dr. Hungerford achieved her PhD in 1998, through the UQ School of Chemistry and Molecular Biosciences, and subsequently conducted postdoctoral research in natural products chemistry and in synthetic organic chemistry, at the University of Oxford, Australian National University, The University of Sydney, Griffith University and Memorial Sloan-Kettering Cancer Center.

Availability

Dr Natasha Hungerford is:
Available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Natural toxins analysis

    Dr Natasha Hungerford's research interests focus on the identification and analysis of natural toxins present in specific plants, with the aim of minimising risks to Australian livestock and to the consumer of certain food products. In particular, the source and identity of pyrrolizidine alkaloid contamination has been assessed by the extraction and identification of pyrrolizidine alkaloids from various plants. Work to mitigate the Pimelea toxin, simplexin, which causes often fatal cattle poisoning in animals grazing inland areas of Australia, is being undertaken. The level of simplexin is being analysed in in vitro rumen trials to monitor and assess the effects of various strategies to breakdown or remove the toxin in the rumen, including microbial degradation, use of adsorbents or biopolymers.

  • Atypical sugars in novel foods

    The presence of significant quantities of the sugar trehalulose in stingless bee honey has prompted a study, funded by Queensland Health, into the levels of atypical sugars in other novel and emerging foods. Public health implications of atypical sugars identified will be examined.

  • Slowed delivery of bioactive compounds that reduce enteric methane

    This project involves an interdisciplinary team of researchers from UQ and DAF with the aim of reducing methane emissions from beef cattle. The developed technology will be assessed for the controlled release of active-agents to provide a sustained reduction in enteric methane, applicable to extensive cattle grazing systems.

  • Bioactives in stingless bee honey

    A recent focus has been the analysis of the properties of stingless bee honey, particularly the unique sugar content of these honeys, with this work culminating in grants from AgriFutures Australia and the Malaysian Government International Collaborative Fund (led by Universiti Putra Malaysia). LCMS technologies, ion chromatography, and stable isotope MS techniques have been used in collaboration with Queensland Health with the aims of optimising stingless bee honey bioactive content. This work provided the first report of the atypical disaccharide trehalulose as a major component of the honey of stingless bees (Meliponini) from Australia (2 species), Malaysia (2 species) and Brazil (1 species). Our research has shown that the low GI sugar trehalulose, which is not found significantly in regular honey or as a major component in any other food, is produced by the bees themselves from nectar sucrose. Further studies seek to understand the mechanism of this bee catalysed isomerisation of sucrose to trehalulose.

Works

Search Professor Natasha Hungerford’s works on UQ eSpace

109 works between 1995 and 2024

101 - 109 of 109 works

1999

Journal Article

Efficient palladium(II)-mediated construction of functionalized plakortone cores

Paddon-Jones, G. C., Hungerford, N. L., Hayes, P. and Kitching, W. (1999). Efficient palladium(II)-mediated construction of functionalized plakortone cores. Organic Letters, 1 (12), 1905-1907. doi: 10.1021/ol991055c

Efficient palladium(II)-mediated construction of functionalized plakortone cores

1999

Conference Publication

Synthesis of oxygen-heterocycles from a bug and a sponge

Moore, C. J., Possner, S., Hayes, P., Paddon-Jones, G. C., Hungerford, N. L. and Kitching, W. (1999). Synthesis of oxygen-heterocycles from a bug and a sponge. 1st Asia-Pacific Conference on Chemical Ecology, Shanghai, China, 1 -4 November 1999. Shanghai, China: Chinese Academy of Science.

Synthesis of oxygen-heterocycles from a bug and a sponge

1998

Journal Article

Titanium(II)-based Z-reduction of alkynes. Syntheses of deuterium labelled linolenic and oleic acids and (3E,8Z,11Z)-tetradeca-3,8,11-trienyl acetate, the sex pheromone of a tomato pest, Scrobipalpuloides absoluta

Hungerford, N. L. and Kitching, W. (1998). Titanium(II)-based Z-reduction of alkynes. Syntheses of deuterium labelled linolenic and oleic acids and (3E,8Z,11Z)-tetradeca-3,8,11-trienyl acetate, the sex pheromone of a tomato pest, Scrobipalpuloides absoluta. Journal of the Chemical Society - Perkin Transactions 1, 29 (11), 1839-1858. doi: 10.1039/a800674a

Titanium(II)-based Z-reduction of alkynes. Syntheses of deuterium labelled linolenic and oleic acids and (3E,8Z,11Z)-tetradeca-3,8,11-trienyl acetate, the sex pheromone of a tomato pest, Scrobipalpuloides absoluta

1998

Journal Article

Biogenesis of sex pheromones in the female olive fruit-fly

Hungerford, Natasha L., Mazomenos, Basilis E., Konstantopoulou, Maria A., Krokos, Fragoulis D., Haniotakis, George E., Hubener, Achim, Fletcher, Mary T., Moore, Christopher J., DeVoss, James J. and Kitching, William (1998). Biogenesis of sex pheromones in the female olive fruit-fly. Chemical Communications, 29 (8), 863-864. doi: 10.1039/a800691a

Biogenesis of sex pheromones in the female olive fruit-fly

1998

Journal Article

Isolation and structure of some constituents of the Australian medicinal plant Tinospora smilacina ('snakevine')

Hungerford, NL, Sands, DPA and Kitching, W (1998). Isolation and structure of some constituents of the Australian medicinal plant Tinospora smilacina ('snakevine'). Australian Journal of Chemistry, 51 (12), 1103-1111. doi: 10.1071/C98034

Isolation and structure of some constituents of the Australian medicinal plant Tinospora smilacina ('snakevine')

1997

Journal Article

Conformational analysis of the cis- and trans-1,2-bis(trimethylsilyl)cyclohexanes (BTMSC): Molecular mechanics calculations and nuclear magnetic resonance spectroscopy. A preferred diaxial conformation for the trans-isomer

Nunez, R, Unwalla, RJ, Cartledge, FK, Cho, SG, Riches, BH, Glenn, MP, Hungerford, NL, Lambert, LK, Brecknell, DJ and Kitching, W (1997). Conformational analysis of the cis- and trans-1,2-bis(trimethylsilyl)cyclohexanes (BTMSC): Molecular mechanics calculations and nuclear magnetic resonance spectroscopy. A preferred diaxial conformation for the trans-isomer. Journal of the Chemical Society-Perkin Transactions 2, 1997 (7), 1365-1368. doi: 10.1039/a607563k

Conformational analysis of the cis- and trans-1,2-bis(trimethylsilyl)cyclohexanes (BTMSC): Molecular mechanics calculations and nuclear magnetic resonance spectroscopy. A preferred diaxial conformation for the trans-isomer

1997

Other Outputs

Natural products chemistry : structure, synthesis and biosynthesis

Hungerford, Natasha Lynn (1997). Natural products chemistry : structure, synthesis and biosynthesis. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/365846

Natural products chemistry : structure, synthesis and biosynthesis

1996

Journal Article

Titanium(II)-based Z-reduction of alkynes: Stereo- and regio-specific Z-dideuteriation of conjugated and methylene-skipped ynes

Hungerford, Natasha L. and Kitching, William (1996). Titanium(II)-based Z-reduction of alkynes: Stereo- and regio-specific Z-dideuteriation of conjugated and methylene-skipped ynes. Chemical Communications (14), 1697-1698. doi: 10.1039/CC9960001697

Titanium(II)-based Z-reduction of alkynes: Stereo- and regio-specific Z-dideuteriation of conjugated and methylene-skipped ynes

1995

Conference Publication

Titanium (II) Based Cis-Reduction of Alkynes: Stereo- and Regiospecific Cis-Deuteriation of Methylene-Skipped Ynes

Hungerford, N. and Kitching, W. (1995). Titanium (II) Based Cis-Reduction of Alkynes: Stereo- and Regiospecific Cis-Deuteriation of Methylene-Skipped Ynes. RACI 9th Brisbane Organic Chemistry Symposium, The University of Queensland, Brisbane, Queensland, Australia, November 1995.

Titanium (II) Based Cis-Reduction of Alkynes: Stereo- and Regiospecific Cis-Deuteriation of Methylene-Skipped Ynes

Funding

Current funding

  • 2023 - 2025
    Harnessing the synbio potential of Australia's stingless bees, the first step
    Sugar Research Australia Limited
    Open grant
  • 2022 - 2025
    Developing cutting-edge capability for atypical saccharides in emerging and novel foods
    Queensland Health Forensic and Scientific Services
    Open grant

Past funding

  • 2021
    Rapid and Non-destructive Identification of Mycotoxins in Animal Feed Ingredients
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2020 - 2021
    Optimising bioactive content of Australian stingless bee honey
    Agrifutures Australia
    Open grant
  • 2017 - 2018
    Analysis of environmental contaminants in Australian/Queensland honey
    Queensland Health Forensic and Scientific Services
    Open grant

Supervision

Availability

Dr Natasha Hungerford is:
Available for supervision

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Available projects

  • Slow-release rumen inserts to deliver bioactive compounds that reduce enteric methane

    Methane emissions could be substantially cut through a $7.5-million project to develop slow-release rumen insert technology for cattle containing a gas-reducing bioactive.

    The University of Queensland and Department of Agriculture and Fisheries (DAF) collaboration is being funded by Meat & Livestock Australia (MLA) and the MLA Donor Company Limited, to help producers meet the CN30 target to make the meat industry carbon neutral by 2030. The ability to ensure each animal receives a sustained dose of a methane-reducing active agent over an extended timeframe would be a fantastic win for the beef cattle industry, helping it achieve its goal to reduce methane emissions – particularly in cattle grazing extensive pastures.

    This is a large multdisciplinary project and there is opportunity for PhD candidates with either an animal science or analytical chemistry background to be part of this biotechnology project.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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