Overview
Background
Professor Elizabeth Krenske leads a computational chemistry laboratory that specialises in understanding molecular behaviour. Her laboratory has a particular focus on the study of chemical reaction mechanisms, including the computational prediction of reaction outcomes. Prof. Krenske obtained her PhD in synthetic main-group chemistry at The Australian National University's Research School of Chemistry, where she worked with Professor Bruce Wild. After two years of postdoctoral research at the ANU she was awarded a Fulbright Postdoctoral Scholarship and spent two years at the University of California, Los Angeles, working in the field of theoretical and computational chemistry with Professor Kendall Houk. She returned to Australia in 2009 as an ARC Australian Postdoctoral Fellow at the University of Melbourne, and moved to The University of Queensland in 2012 as an ARC Future Fellow. She is currently a Professor in the UQ School of Chemistry and Molecular Biosciences.
Prof. Krenske is a Fellow of the Royal Australian Chemical Institute, Fellow of the Royal Society of Chemistry, Fellow of the Higher Education Academy and former Associate Editor of the RSC journal Organic & Biomolecular Chemistry.
Availability
- Professor Elizabeth Krenske is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, Australian National University
Works
Search Professor Elizabeth Krenske’s works on UQ eSpace
Featured
2024
Journal Article
Diastereo‐ and Enantioselective Construction of Stereochemical Arrays Exploiting Non‐Classical Hydrogen Bonding in Enolborates
Li, Matthew Tin-lok, Scheeff, Stephan, Chen, Jiahua, Johnston, Ryne C., Rizzo, Antonio, Krenske, Elizabeth H. and Chiu, Pauline (2024). Diastereo‐ and Enantioselective Construction of Stereochemical Arrays Exploiting Non‐Classical Hydrogen Bonding in Enolborates. Chemistry – A European Journal, 30 (46) e202401485, e202401485. doi: 10.1002/chem.202401485
Featured
2024
Journal Article
Data-efficient, chemistry-aware machine learning predictions of Diels-Alder reaction outcomes
Keto, Angus, Guo, Taicheng, Underdue, Morgan, Stuyver, Thijs, Coley, Connor W, Zhang, Xiangliang, Krenske, Elizabeth H. and Wiest, Olaf (2024). Data-efficient, chemistry-aware machine learning predictions of Diels-Alder reaction outcomes. Journal of the American Chemical Society, 146 (23), 16052-16061. doi: 10.1021/jacs.4c03131
Featured
2023
Journal Article
Mechanistic aspects of thiol additions to Michael acceptors: insights from computations
Roseli, Ras Baizureen, Keto, Angus B. and Krenske, Elizabeth H. (2023). Mechanistic aspects of thiol additions to Michael acceptors: insights from computations. WIREs Computational Molecular Science, 13 (2) e1636, 1-16. doi: 10.1002/wcms.1636
Featured
2022
Journal Article
Chemoselective and diastereoselective intramolecular (3+2) cycloadditions of epoxy and aziridinyl enolsilanes
Chen, Yueyao, Ling, Jesse, Keto, Angus B., He, Yun, Low, Kam‐Hung, Krenske, Elizabeth H. and Chiu, Pauline (2022). Chemoselective and diastereoselective intramolecular (3+2) cycloadditions of epoxy and aziridinyl enolsilanes. Angewandte Chemie International Edition, 61 (21) e202116099, 1-7. doi: 10.1002/anie.202116099
2024
Journal Article
Structure‐based clustering and mutagenesis of bacterial tannases reveals the importance and diversity of active site‐capping domains
Coleman, Tom, Viknander, Sandra, Kirk, Alicia M., Sandberg, David, Caron, Elise, Zelezniak, Aleksej, Krenske, Elizabeth and Larsbrink, Johan (2024). Structure‐based clustering and mutagenesis of bacterial tannases reveals the importance and diversity of active site‐capping domains. Protein Science, 33 (12). doi: 10.1002/pro.5202
2024
Journal Article
A New Organic Laser Material Design Toward Ultra‐Low Amplified Spontaneous Red Emission and Ultra‐Bright Electroluminescence
Wallwork, Nicholle R., Shukla, Atul, Roseli, Ras Baizureen, Allison, Ilene, McGregor, Sarah K. M., Coles, Max, Gale, Innes, Rahane, Vijay P., Entoma, Volter, Moore, Evan G., Krenske, Elizabeth H., Namdas, Ebinazar B. and Lo, Shih‐Chun (2024). A New Organic Laser Material Design Toward Ultra‐Low Amplified Spontaneous Red Emission and Ultra‐Bright Electroluminescence. Small, e2406817. doi: 10.1002/smll.202406817
2024
Journal Article
Steric activation in the Nazarov cyclization of fully substituted divinyl ketones
Flynn, Bernard Luke, Chen, Shuqi, Keto, Angus B., El-Hawli, Ahmad, Gahan, Lawrence R., White, Jonathan M. and Krenske, Elizabeth H. (2024). Steric activation in the Nazarov cyclization of fully substituted divinyl ketones. Chemistry: A European Journal. doi: 10.1002/chem.202402779
2024
Journal Article
Conformational sampling in computational studies of natural products: why is it important?
Zhou, Yuchen, Limbu, Ingso, Garson, Mary J. and Krenske, Elizabeth H. (2024). Conformational sampling in computational studies of natural products: why is it important?. Journal of Natural Products, 87 (10), 2543-2549. doi: 10.1021/acs.jnatprod.4c00852
2024
Journal Article
Origins of temperature‐dependent anomeric selectivity in glycosylations with an L‐idose thioglycoside
See, Nicholas W., Roseli, Ras Baizureen, Wimmer, Norbert, Le, Tri T., Krenske, Elizabeth H. and Ferro, Vito (2024). Origins of temperature‐dependent anomeric selectivity in glycosylations with an L‐idose thioglycoside. Chemistry – A European Journal, 30 (52) e202400331, e202400331. doi: 10.1002/chem.202400331
2024
Journal Article
Dearomative intramolecular (4+3) cycloadditions of thiophenes
Zheng, Yufen, Chen, Yueyao, He, Yuxuan, Rizzo, Antonio, Zhou, Yuchen, Low, Kam-Hung, Krenske, Elizabeth H. and Chiu, Pauline (2024). Dearomative intramolecular (4+3) cycloadditions of thiophenes. Angewandte Chemie (International Edition), 63 (33) e202407059, e202407059. doi: 10.1002/anie.202407059
2024
Journal Article
Highly Stable Red Emissive Organic Semiconductor Materials with Low Amplified Spontaneous Emission Thresholds
Rahane, Vijay P., Roseli, Ras Baizureen, Ireland, Alexander R., Gale, Innes, Shukla, Atul, Moore, Evan G., Krenske, Elizabeth H., Namdas, Ebinazar B., Jain, Nidhi and Lo, Shih‐Chun (2024). Highly Stable Red Emissive Organic Semiconductor Materials with Low Amplified Spontaneous Emission Thresholds. Advanced Optical Materials, 12 (25) 2400892. doi: 10.1002/adom.202400892
2024
Journal Article
Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450blt
Coe, Laura J., Zhao, Yongwei, Padva, Leo, Keto, Angus, Schittenhelm, Ralf, Tailhades, Julien, Pierens, Greg, Krenske, Elizabeth H., Crüsemann, Max, De Voss, James and Cryle, Max J. (2024). Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450blt. Chemistry: A European Journal, 30 (38) e202400988. doi: 10.1002/chem.202400988
2024
Journal Article
Cytochrome P450<sub>Blt</sub> Enables Versatile Peptide Cyclisation to Generate Histidine and Tyrosine Containing Crosslinked Tripeptide Building Blocks (vol 61, e202204957, 2022)
Coe, L. J., Zhao, Y., Padva, L., Keto, A., Schittenhelm, R., Tailhades, J., Pierens, G., Krenske, E. H., Crusemann, M., De Voss, J. and Cryle, M. J. (2024). Cytochrome P450Blt Enables Versatile Peptide Cyclisation to Generate Histidine and Tyrosine Containing Crosslinked Tripeptide Building Blocks (vol 61, e202204957, 2022). Angewandte Chemie-International Edition, 63 (26) ARTN e202408719. doi: 10.1002/anie.202408719
2024
Journal Article
Low amplified spontaneous emission threshold from solution processable excited‐state intramolecular proton transfer chromophores
Rahane, Vijay P., Shukla, Atul, Roseli, Ras Baizureen, Ireland, Alexander R., Gale, Innes, Krenske, Elizabeth H., Moore, Evan G., Namdas, Ebinazar B., Jain, Nidhi and Lo, Shih‐Chun (2024). Low amplified spontaneous emission threshold from solution processable excited‐state intramolecular proton transfer chromophores. Advanced Optical Materials, 12 (24). doi: 10.1002/adom.202400840
2024
Journal Article
Binding of the plant-derived toxin simplexin to bovine protein kinase C: insights from molecular dynamics
Zhou, Yuchen, Roseli, Ras Baizureen, Hungerford, Natasha L., Fletcher, Mary T., Ouwerkerk, Diane, Gilbert, Rosalind A. and Krenske, Elizabeth H. (2024). Binding of the plant-derived toxin simplexin to bovine protein kinase C: insights from molecular dynamics. Organic and Biomolecular Chemistry, 22 (14), 2863-2876. doi: 10.1039/d4ob00065j
2024
Journal Article
Revisiting Staudinger and Ruzicka’s altered pyrethrolone: the cyclopentadienone dimers derived from pyrethrin I, cinerin I and jasmolin I
Hutt, Oliver E., Freemont, Jamie A., Kyi, Stella, Littler, Stuart W., McGeary, Ross P., Duggan, Peter J., Tsanaktsidis, John, Cole, Helen F., Kerr, Maurice G., Krenske, Elizabeth H. and Ryan, John H. (2024). Revisiting Staudinger and Ruzicka’s altered pyrethrolone: the cyclopentadienone dimers derived from pyrethrin I, cinerin I and jasmolin I. Australian Journal of Chemistry, 77 (3) CH23197. doi: 10.1071/ch23197
2024
Journal Article
Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesis
Hansen, Mathias H., Keto, Angus, Treisman, Maxine, Sasi, Vishnu Mini, Coe, Laura, Zhao, Yongwei, Padva, Leo, Hess, Caroline, Leichthammer, Victor, Machell, Daniel L., Schittenhelm, Ralf B., Jackson, Colin J., Tailhades, Julien, Crüsemann, Max, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesis. ACS Catalysis, 14 (2), 812-826. doi: 10.1021/acscatal.3c05417
2024
Journal Article
Co(<scp>iii</scp>) complexes of the pentadentate NHC ligand PY4Im: carbene-induced <i>trans</i> influences and the non-disappearing <sup>13</sup>C NMR peak
Ismael, Fouad, Fleming, Cassandra L., Christopher, Timothy D., Söhnel, Tilo, Zhou, Yuchen, Krenske, Elizabeth H., Gahan, Lawrence R. and Blackman, Allan G. (2024). Co(iii) complexes of the pentadentate NHC ligand PY4Im: carbene-induced trans influences and the non-disappearing 13C NMR peak. Dalton Transactions, 53 (30), 12688-12697. doi: 10.1039/d4dt01579g
2024
Journal Article
Hyperstable alkenes: are they remarkably unreactive?
Summersgill, Matthew D., Gahan, Lawrence R., Chow, Sharon, Pierens, Gregory K., Bernhardt, Paul V., Krenske, Elizabeth H. and Williams, Craig M. (2024). Hyperstable alkenes: are they remarkably unreactive?. Chemical Science, 15 (46), 19299-19306. doi: 10.1039/d4sc06697a
2024
Journal Article
Loss of fluorine during crosslinking by the biarylitide P450<sub>Blt</sub> proceeds due to restricted peptide orientation
Zhao, Yongwei, Gullick, Jemma, Hansen, Mathias H., Coe, Laura, Treisman, Maxine, Schittenhelm, Ralf B., McKay, Alasdair, Murray, Lauren A. M., Tailhades, Julien, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Loss of fluorine during crosslinking by the biarylitide P450Blt proceeds due to restricted peptide orientation. Chemical Communications, 60 (94), 13951-13954. doi: 10.1039/d4cc04092a
Funding
Current funding
Past funding
Supervision
Availability
- Professor Elizabeth Krenske is:
- Available for supervision
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Available projects
-
Molecular modelling. Chemical Reactivity. Catalysis. Drug Design.
Supervision history
Current supervision
-
Doctor Philosophy
New technology for computational prediction of chemical reaction outcomes
Principal Advisor
Other advisors: Professor Debra Bernhardt
-
Doctor Philosophy
Development of new computational techniques for carbohydrate and agricultural chemistry
Principal Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Synthesis of L-sugars via radical chemistry
Associate Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Insight into Nonequilibrium Behaviour from Molecular Simulations
Associate Advisor
Other advisors: Professor Debra Bernhardt
-
Doctor Philosophy
Insight into Nonequilibrium Behaviour from Molecular Simulations
Associate Advisor
Other advisors: Professor Debra Bernhardt
Completed supervision
-
2024
Doctor Philosophy
Theoretical and experimental investigations into the mechanisms of Cytochromes P450
Principal Advisor
Other advisors: Professor James De Voss
-
2022
Doctor Philosophy
Application of Molecular Modelling Techniques to Guide the Design of New Molecules in Material Science and Drug Discovery
Principal Advisor
Other advisors: Associate Professor Shih-Chun Lo, Associate Professor Ebinazar Namdas
-
2021
Doctor Philosophy
Computational studies of asymmetric catalytic reactions
Principal Advisor
Other advisors: Professor Debra Bernhardt
-
2023
Doctor Philosophy
A Synergistic Approach to L-Hexose Synthesis
Associate Advisor
Other advisors: Professor Vito Ferro
-
2017
Doctor Philosophy
Cubane in Drug Discovery and Development
Associate Advisor
Other advisors: Professor Craig Williams
-
2017
Doctor Philosophy
Explorations in Novel Caged Hydrocarbon Chemistry
Associate Advisor
Other advisors: Professor Craig Williams
-
2017
Doctor Philosophy
Kinetic, mechanistic, structural and spectroscopic investigations of Bimetallic Metallohydrolases.
Associate Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Experimental and Computational Investigations into the Benzyl-Claisen Rearrangement
Associate Advisor
Media
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