Overview
Background
I am a clinician scientist and academic leader with research in melanoma cell biology and experimental melanoma therapy. I received my degree in medicine from the University of Heidelberg, Germany (1990-1998). I graduated summa cum laude with a PhD in Cell Biology from the University of Heidelberg (1993-1999) and trained in clinical dermatology at the University of Hamburg, Germany (1999-2003). In 2003 I moved to Philadelphia, PA, to work as a post-doctoral fellow in Meenhard Herlyn’s lab at The Wistar Institute (2003-2007). From there I was recruited as an associate faculty member to the Centenary Institute/University of Sydney (2007-2013). In 2013 I commenced a position as Associate Professor for Cutaneous Oncology at University of Queensland Diamantina Institute (now Frazer Institute) and was promoted to full Professor in April 2016.
Availability
- Professor Nikolas Haass is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, Ruprecht Karls Universität Heidelberg
Research impacts
Using cutting-edge technology, including real-time cell cycle imaging in 3D culture and in vivo, my team studies the role of dynamic melanoma heterogeneity in melanomagenesis with the goal to develop novel therapeutic approaches by simultaneously targeting different tumor cell subpopulations. My laboratory and our team are in the unique position to combine sophisticated imaging and biosensor approaches with biochemical methods to provide unprecedented insight to the mechanisms of tumor heterogeneity, tumor-stroma interactions and cancer immunology.
My contribution to the field is best evidenced by 97 original papers and invited reviews in leading biomedical journals. Many of our papers have a large impact in the field (>7500 citations in total, and 19 papers cited >100 times each). The papers in Mol Cancer Ther (2006, cited >500x), Cancer Res (2007, cited 265x) and PNAS (2008, cited 1500x) were evaluated by Faculty 1000 Biology as recommended or exceptional, respectively.
Works
Search Professor Nikolas Haass’s works on UQ eSpace
2012
Conference Publication
Sequential digital dermoscopic imaging and total body photography aid detection of primary melanoma in individuals at high risk: a prospective 5-year follow-up study
Moloney, F., Guitera, P., Coates, E., Haass, N., Ho, K., Khoury, R., Mann, G. and Menzies, S. (2012). Sequential digital dermoscopic imaging and total body photography aid detection of primary melanoma in individuals at high risk: a prospective 5-year follow-up study. 92nd Annual Meeting of the British-Association-of-Dermatologists, Birmingham England, Jul 03-05, 2012. WILEY-BLACKWELL. doi: 10.1111/j.1365-2133.2012.10976.x
2012
Conference Publication
The use of multi-photon microscopy as a tool for studying elastin and elastin-related disorders in human skin
Tong, P. L., Qin, J., Roediger, B., Lowe, P. M., Leecy, T., Mrass, P., Weninger, W. and Haass, N. K. (2012). The use of multi-photon microscopy as a tool for studying elastin and elastin-related disorders in human skin. WILEY-BLACKWELL.
2012
Conference Publication
Effect of the BH3 mimetic ABT-737 on human melanoma cells to apoptosis induced by selective BRAF inhibitors.
Hersey, Peter, Wroblewski, David, Mijatov, Branka, Zhang, Xu Dong and Haass, Nikolas (2012). Effect of the BH3 mimetic ABT-737 on human melanoma cells to apoptosis induced by selective BRAF inhibitors.. 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 01-06, 2012. AMER SOC CLINICAL ONCOLOGY.
2012
Conference Publication
Melanoma detection in high risk patients: A case series
Coates, E., Moloney, F. J., Guitera, P., Haass, N., Ho, K., Khoury, R., Mann, G. and Menzies, S. W. (2012). Melanoma detection in high risk patients: A case series. WILEY-BLACKWELL.
2012
Conference Publication
MITF-driven subcompartment-specific distribution of differentially cycling tumor cells in melanoma
Haass, N. K., Anfosso, A., Beaumont, K. A., Hill, D. S., Mrass, P., Kinjyo, I., Kanagawa, O. and Weninger, W. (2012). MITF-driven subcompartment-specific distribution of differentially cycling tumor cells in melanoma. 75th Annual Meeting of the Society-for-Investigative-Dermatology, Raleigh Nc, May 09-12, 2012. NATURE PUBLISHING GROUP.
2012
Conference Publication
Observation of a five year high risk clinic for primary melanoma
Moloney, F. J., Guitera, P., Coates, E., Haass, N., Ho, K., Khoury, R., Mann, G. and Menzies, S. W. (2012). Observation of a five year high risk clinic for primary melanoma. WILEY-BLACKWELL.
2012
Conference Publication
The subcompartment-specific distribution of differentially cycling tumor cells in melanoma is regulated by MITF
Haass, N. K., Anfosso, A., Beaumont, K. A., Hill, D. S., Mrass, P., Kinjyo, I., Kanagawa, O. and Weninger, W. (2012). The subcompartment-specific distribution of differentially cycling tumor cells in melanoma is regulated by MITF. 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg Germany, Mar 01-03, 2012. WILEY-BLACKWELL.
2012
Conference Publication
Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells
Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R., Butler, T., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I., Weninger, W., Cripe, T. P. and Gunning, P. (2012). Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells. 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg Germany, Mar 01-03, 2012. WILEY-BLACKWELL.
2012
Conference Publication
The role(s) of the junction protein ZO-1 in malignant melanoma
Bohner, C., Pandjaitan, M. A., Haass, N. K., Zorn-Kruppa, M., Moll, I., von den Driesch, P., Schaider, H. and Brandner, J. M. (2012). The role(s) of the junction protein ZO-1 in malignant melanoma. 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg Germany, Mar 01-03, 2012. WILEY-BLACKWELL.
2012
Journal Article
Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737
Lucas, Keryn M., Mohana-Kumaran, Nethia, Lau, Diana, Zhang, Xu Dong, Hersey, Peter, Huang, David C., Weninger, Wolfgang, Haass, Nikolas K. and Allen, John D. (2012). Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737. Clinical Cancer Research, 18 (3), 783-795. doi: 10.1158/1078-0432.CCR-11-1166
2012
Conference Publication
Meeting report from the 2011 international melanoma congress, Tampa, Florida
Smalley, Keiran S. M., Aplin, Andrew E., Flaherty, Keith T., Hoeller, Christoph, Bosserhoff, Anja K., Haass, Nikolas K., Bosenberg, Marcus, Ribas, Antoni, Barnhill, Raymond, Kudchadkar, Ragini and Messina, Jane L. (2012). Meeting report from the 2011 international melanoma congress, Tampa, Florida. Malden, MA, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-148X.2011.00943.x
2011
Conference Publication
Real-time cell cycle imaging: Melanomas are composed of differentially cycling tumor cells in a subcompartment-specific distribution
Haass, N. K., Anfosso, A., Kinjyo, I., Kanagawa, O. and Weninger, W. (2011). Real-time cell cycle imaging: Melanomas are composed of differentially cycling tumor cells in a subcompartment-specific distribution. Annual Meeting of the Society-for-Investigative-Dermatology, Phoenix Az, May 04-07, 2011. NATURE PUBLISHING GROUP.
2011
Journal Article
Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010
Hersey, P., Smalley, K. S., Weeraratna, A., Bosenberg, M., Zhang, X. D., Haass, N. K., Paton, E., Mann, G., Scolyer, R. A. and Tüting, T. (2011). Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell and Melanoma Research, 24 (1), e1-e15. doi: 10.1111/j.1755-148X.2010.00811.x
2011
Conference Publication
Utilization of the auto fluorescent drug Rose Bengal as a novel approach for the investigation of drug effects within solid tumors in 3D culture and in vivo
Nascimento, P. R., Knuever, J., Weninger, W. and Haass, N. (2011). Utilization of the auto fluorescent drug Rose Bengal as a novel approach for the investigation of drug effects within solid tumors in 3D culture and in vivo. 38th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung, Tuebingen Germany, Feb 17-19, 2011. WILEY-BLACKWELL PUBLISHING, INC.
2011
Conference Publication
Differential expression of ZO-1 in melanoma and nevi and their tumor microenvironment - an indicator of malignancy
Bohner, C., Haass, N. K., Vidal-y-Sy, S., Moll, I., von den Driesch, P., Schaider, H. and Brandner, J. (2011). Differential expression of ZO-1 in melanoma and nevi and their tumor microenvironment - an indicator of malignancy. 38th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung, Tuebingen Germany, Feb 17-19, 2011. WILEY-BLACKWELL PUBLISHING, INC.
2011
Conference Publication
Real-time imaging of cell cycle progression in melanoma
Haass, N., Anfosso, A., Kinjyo, I., Kanagawa, O. and Weninger, W. (2011). Real-time imaging of cell cycle progression in melanoma. 38th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung, Tuebingen Germany, Feb 17-19, 2011. WILEY-BLACKWELL PUBLISHING, INC.
2011
Book Chapter
Egretta schistacea: Kuestenreiher
Haass, N. K. and Bauer, H.-G. (2011). Egretta schistacea: Kuestenreiher. Nicht-Singvögel: Rheidae (Nandus) - Phoenicopteridae (Flamingos). (pp. 266-268) edited by Jochen Hölzinger and Hans-Günther Bauer. Stuttgart, Germany: Ulmer Eugen Verlag.
2011
Conference Publication
Different ZO-1 Localization in Melanoma, Nevi and their Tumor-Microenvironment - An Indicator of Malignancy
Bohner, C., Haass, N. K., Moll, I, von den Driesch, P., Schaider, H. and Brandner, J. M. (2011). Different ZO-1 Localization in Melanoma, Nevi and their Tumor-Microenvironment - An Indicator of Malignancy. 46. Tagung der Deutschen Dermatologischen Gesellschaft Vereinigung Deutschsprachiger Dermatologen e. V., Dresden, Germany, 30 March - 2 April 2011. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/j.1610-0387.2011.07632.x
2011
Journal Article
Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: Pitfalls of the MTS assay
McGowan, Eileen M., Alling, Nikki, Jackson, Elise A., Yagoub, Daniel, Haass, Nikolas K., Allen, John D. and Martinello-Wilks, Rosetta (2011). Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: Pitfalls of the MTS assay. PLoS ONE, 6 (6) e20623, e20623.1-e20623.8. doi: 10.1371/journal.pone.0020623
2011
Book Chapter
Cell-cell and cell-matrix contacts in melanoma and the tumor microenvironment
Kuphal, Silke and Haass, Nikolas K. (2011). Cell-cell and cell-matrix contacts in melanoma and the tumor microenvironment. Melanoma Development: Molecular Biology, Genetics and Clinical Application. (pp. 181-215) edited by Anja Bosserhoff. Vienna, Austria: SpringerWienNewYork. doi: 10.1007/978-3-7091-0371-5
Funding
Supervision
Availability
- Professor Nikolas Haass is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Assessment of cell cycle phase-dependent immunogenicity of melanoma treated with the proteasome inhibitor bortezomib
Principal Advisor
Other advisors: Professor Brian Gabrielli
-
Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Modulating phenotypic melanoma heterogeneity and lymphocyte infiltration to improve both targeted and immune therapy
Principal Advisor
Other advisors: Professor Brian Gabrielli, Dr Janin Chandra
-
Doctor Philosophy
Understanding the interplay of MITF, TFEB and CDK4/6 on lysosome activity in melanoma
Principal Advisor
Other advisors: Associate Professor Jason Lee
-
Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Strategies to improve immunotherapy for patients with glioblastoma or breast cancer brain metastases
Associate Advisor
Other advisors: Dr Jodi Saunus, Professor Fiona Simpson
Completed supervision
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2023
Doctor Philosophy
Enhancing ER stress induced apoptosis and immunogenic cell death in melanoma
Principal Advisor
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2019
Doctor Philosophy
Investigation of Microphthalmia-Associated Transcription Factor (MITF)-driven tumour heterogeneity in a 3D melanoma spheroid model in vitro.
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
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2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Associate Advisor
Other advisors: Professor Paul Clarke
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2022
Doctor Philosophy
Regulation of Microtubules in 3D by CLASPs
Associate Advisor
Other advisors: Dr Samantha Stehbens
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2017
Doctor Philosophy
Mechanisms and markers of CHK1 inhibitors sensitivity in melanoma
Associate Advisor
Other advisors: Professor Brian Gabrielli
Media
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