Professor Nikolas Haass
Professor

Nikolas Haass

Email: 
Phone: 
+61 7 344 37087

Background

I am a clinician scientist and academic leader with research in melanoma cell biology and experimental melanoma therapy. I received my degree in medicine from the University of Heidelberg, Germany (1990-1998). I graduated summa cum laude with a PhD in Cell Biology from the University of Heidelberg (1993-1999) and trained in clinical dermatology at the University of Hamburg, Germany (1999-2003). In 2003 I moved to Philadelphia, PA, to work as a post-doctoral fellow in Meenhard Herlyn’s lab at The Wistar Institute (2003-2007). From there I was recruited as an associate faculty member to the Centenary Institute/University of Sydney (2007-2013). In 2013 I commenced a position as Associate Professor for Cutaneous Oncology at University of Queensland Diamantina Institute (now Frazer Institute) and was promoted to full Professor in April 2016.

Availability

Professor Nikolas Haass is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences

Qualifications

  • Doctoral Diploma, Ruprecht Karls Universität Heidelberg

Research impacts

Using cutting-edge technology, including real-time cell cycle imaging in 3D culture and in vivo, my team studies the role of dynamic melanoma heterogeneity in melanomagenesis with the goal to develop novel therapeutic approaches by simultaneously targeting different tumor cell subpopulations. My laboratory and our team are in the unique position to combine sophisticated imaging and biosensor approaches with biochemical methods to provide unprecedented insight to the mechanisms of tumor heterogeneity, tumor-stroma interactions and cancer immunology.

My contribution to the field is best evidenced by 97 original papers and invited reviews in leading biomedical journals. Many of our papers have a large impact in the field (>7500 citations in total, and 19 papers cited >100 times each). The papers in Mol Cancer Ther (2006, cited >500x), Cancer Res (2007, cited 265x) and PNAS (2008, cited 1500x) were evaluated by Faculty 1000 Biology as recommended or exceptional, respectively.

Search Professor Nikolas Haass’s works on UQ eSpace

218 works between 1996 and 2024
All (218) Journal Article (98) Book Chapter (14) Conference Publication (105) Other Outputs (1)

121 - 140 of 218 works

2014

Journal Article

Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy

Mohana-Kumaran, Nethia, Hill, David S., Allen, John D. and Haass, Nikolas K. (2014). Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy. Pigment Cell and Melanoma Research, 27 (4), 525-539. doi: 10.1111/pcmr.12242

Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy

2014

Conference Publication

Defining the mode of melanoma's proliferative heterogeneity by real-time cell cycle imaging

Haass, N. K., Beaumont, K., Anfosso, A., Hill, D., Jurek, R., Sharp, D., Mrass, P., Munoz, M., Kinjyo, I. and Weninger, W. (2014). Defining the mode of melanoma's proliferative heterogeneity by real-time cell cycle imaging. 41st Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Cologne, Germany, 13-15 March 2014. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/exd.12314

Defining the mode of melanoma's proliferative heterogeneity by real-time cell cycle imaging

2014

Book Chapter

The Grey-headed Albatross conundrum at the Australian east coast

Haass, Nikolas K. (2014). The Grey-headed Albatross conundrum at the Australian east coast. The Petrel: Annual Report for Southport The Brisbane Seabird Study Group SOSSA, Northern Sector. (pp. 96-107) edited by Paul Walbridge. Brisbane, QLD Australia: SOSSA.

The Grey-headed Albatross conundrum at the Australian east coast

2014

Conference Publication

Rose Bengal melanoma therapy: Phototoxicity versus intrinsic cytotoxicity

Nascimento, P. R. B. B., Baesler, K., Knuever, J., Douglas, G., Anfosso, A., Weninger, W. and Haass, N. K. (2014). Rose Bengal melanoma therapy: Phototoxicity versus intrinsic cytotoxicity. The Australasian College of Dermatologists 47th Annual Scientific Meeting, Melbourne, VIC Australia, 18-21 May 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12174

Rose Bengal melanoma therapy: Phototoxicity versus intrinsic cytotoxicity

2013

Journal Article

Modeling Melanoma In Vitro and In Vivo

Beaumont, Kimberley A., Mohana-Kumaran, Nethia and Haass, Nikolas K. (2013). Modeling Melanoma In Vitro and In Vivo. Healthcare, 2 (1), 27-46. doi: 10.3390/healthcare2010027

Modeling Melanoma In Vitro and In Vivo

2013

Journal Article

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

Pavey, Sandra, Spoerri, Loredana, Haass, Nikolas K. and Gabrielli, Brian (2013). DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.. Pigment Cell and Melanoma Research, 26 (6), 805-816. doi: 10.1111/pcmr.12136

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

2013

Journal Article

A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy

Tong, P. L., Qin, J., Cooper, C. L., Lowe, P. M., Murrell, D. F., Kossard, S., Ng, L. G., Roediger, B., Weninger, W. and Haass, N. K. (2013). A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy. British Journal of Dermatology, 169 (4), 869-879. doi: 10.1111/bjd.12430

A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy

2013

Journal Article

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, Justine R., Haass, Nikolas K., Bonello, Teresa, Desouza, Melissa, Kottyan, Gregg, Treutlein, Herbert, Zeng, Jun, Nascimento, Paula R. B. B., Sequeira, Vanessa B., Butler, Tanya L., Allanson, Munif, Fath, Thomas, Hill, Timothy A., McCluskey, Adam, Schevzov, Galina, Palmer, Stephen J., Hardeman, Edna C., Winlaw, David, Reeve, Vivienne E., Dixon, Ian, Weninger, Wolfgang, Cripe, Timothy P. and Gunning, Peter W. (2013). A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells. Cancer Research, 73 (16), 5169-5182. doi: 10.1158/0008-5472.CAN-12-4501

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

2013

Conference Publication

Loss of Noxa and Puma have inverse effects on melanomagenesis in a predisposed, genetically-defined mouse melanoma model

Mohana-Kumaran, N., Lucas, K. M., Roediger, B., Scolyer, R. A., Weninger, W., Allen, J. D. and Haass, N. K. (2013). Loss of Noxa and Puma have inverse effects on melanomagenesis in a predisposed, genetically-defined mouse melanoma model. International Investigative Dermatology Meeting, Edinburgh Scotland, May 08-11, 2013. NEW YORK: NATURE PUBLISHING GROUP.

Loss of Noxa and Puma have inverse effects on melanomagenesis in a predisposed, genetically-defined mouse melanoma model

2013

Conference Publication

MITF regulates the proliferative architecture of the melanoma microenvironment

Haass, N. K., Beaumont, K. A., Anfosso, A., Hill, D. S., Jurek, R. K., Mrass, P., Munoz, M., Kinjyo, I., Miyawaki, A. and Weninger, W. (2013). MITF regulates the proliferative architecture of the melanoma microenvironment. International Investigative Dermatology Meeting, Edinburgh Scotland, May 08-11, 2013. NEW YORK: NATURE PUBLISHING GROUP.

MITF regulates the proliferative architecture of the melanoma microenvironment

2013

Conference Publication

Cancer cells and galaxies - novel image analysis techniques identify subcompartment-specific cell cycle dynamics and motility in melanoma

Beaumont, K. A., Anfosso, A., Hill, D. S., Jurek, R. J., Mrass, P., Munoz, M. M., Kinjyo, I., Miyawaki, A., Weninger, W. and Haass, N. K. (2013). Cancer cells and galaxies - novel image analysis techniques identify subcompartment-specific cell cycle dynamics and motility in melanoma. 40th Annual Meeting of the Association-of-Dermatological-Research, Dessau Germany, Mar 14-16, 2013. HOBOKEN: WILEY-BLACKWELL.

Cancer cells and galaxies - novel image analysis techniques identify subcompartment-specific cell cycle dynamics and motility in melanoma

2013

Journal Article

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance

Wroblewski, David, Mijatov, Branka, Mohana- Kumaran, Nethia, Lai, Fritz, Gallagher, Stuart J., Haass, Nikolas K., Zhang, Xu Dong and Hersey, Peter (2013). The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance. Carcinogenesis, 34 (2), 237-247. doi: 10.1093/carcin/bgs330

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance

2013

Journal Article

Melanoma's connections to the tumour microenvironment

Brandner, Johanna M. and Haass, Nikolas K. (2013). Melanoma's connections to the tumour microenvironment. Pathology, 45 (5), 443-452. doi: 10.1097/PAT.0b013e328363b3bd

Melanoma's connections to the tumour microenvironment

2013

Conference Publication

Induction of Endoplasmic Reticulum Stress as a Strategy for Melanoma Therapy

Hill, D., Beaumont, K., Anfosso, A., Miyawaki, A., Weninger, W., Lovat, P. and Haass, N. (2013). Induction of Endoplasmic Reticulum Stress as a Strategy for Melanoma Therapy. 8th World Congress of Melanoma, 9th Congress of the European Association of Dermatology (EADO), 7th Interdisciplinary Melanoma/Skin Cancer Meeting, 3rd European Post-Chicago Melanoma Meeting 2013, Hamburg, German, 77 - 20 July 2013. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/ddg.12162

Induction of Endoplasmic Reticulum Stress as a Strategy for Melanoma Therapy

2013

Conference Publication

ZO-1 kontrolliert die Invasivität von Melanomzellen

Pandjaitan, M. A. T., Bohner, C., Zorn-Kruppa, M., Vidal-y-Sy, S., Haass, N. K., Moll, I and Brandner, J. M. (2013). ZO-1 kontrolliert die Invasivität von Melanomzellen. 23. Deutscher Hautkrebskongress 2013 und ADO-Jahrestagung, Essen, 26 - 28 September 2013. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/ddg.12189

ZO-1 kontrolliert die Invasivität von Melanomzellen

2013

Conference Publication

Rose Bengal - Phototoxicity versus Intrinsic Cytotoxicity

Nascimento, P., Baesler, K., Knuever, J., Douglas, G., Anfosso, A., Weninger, W. and Haass, N. (2013). Rose Bengal - Phototoxicity versus Intrinsic Cytotoxicity. 8th World Congress of Melanoma, 9th Congress of the European Association of Dermatology (EADO), 7th Interdisciplinary Melanoma/Skin Cancer Meeting, 3rd European Post-Chicago Melanoma Meeting 2013, Hamburg, Germany, 17 - 20 July 2013. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/ddg.12160

Rose Bengal - Phototoxicity versus Intrinsic Cytotoxicity

2013

Conference Publication

BRAF New World

Haass, N. (2013). BRAF New World. 46th Annual Scientific Meeting, Sydney, New South Wales, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051

BRAF New World

2013

Conference Publication

The Microphthalmia-Associated Transcription Factor (MITF) Regulates the Proliferative Architecture of the Melanoma Microenvironment

Haass, N., Beaumont, K., Anfosso, A., Hill, D., Jurek, R., Mrass, P., Munoz, M., Kinjyo, I., Miyawaki, A. and Weninger, W. (2013). The Microphthalmia-Associated Transcription Factor (MITF) Regulates the Proliferative Architecture of the Melanoma Microenvironment. 8th World Congress of Melanoma, 9th Congress of the European Association of Dermatology (EADO), 7th Interdisciplinary Melanoma/Skin Cancer Meeting, 3rd European Post-Chicago Melanoma Meeting 2013, Hamburg, Germany, 17 - 20 July 2013. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/ddg.12161

The Microphthalmia-Associated Transcription Factor (MITF) Regulates the Proliferative Architecture of the Melanoma Microenvironment

2012

Conference Publication

Optimization of Endoplasmic Reticulum (Er) Stress-Inducing Therapies for Melanoma Using Real-Time Cell Cycle Imaging

Hill, D. S., Anfosso, A., Kinjyo, I., Lovat, P. E., Kanagawa, O. and Haass, N. K. (2012). Optimization of Endoplasmic Reticulum (Er) Stress-Inducing Therapies for Melanoma Using Real-Time Cell Cycle Imaging. 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston Ma, Nov 02-06, 2007. JOHN WILEY & SONS INC.

Optimization of Endoplasmic Reticulum (Er) Stress-Inducing Therapies for Melanoma Using Real-Time Cell Cycle Imaging

2012

Conference Publication

Rab27A Regulates Melanoma Proliferation and Invasion

Beaumont, K. A., Weninger, W. and Haass, N. K. (2012). Rab27A Regulates Melanoma Proliferation and Invasion. WILEY-BLACKWELL.

Rab27A Regulates Melanoma Proliferation and Invasion

Past funding

  • 2023 - 2024
    Changing the melanoma tumour microenvironment to improve both targeted and immune therapy
    Australasian College of Dermatologists Scientific Research Fund
    Open grant
  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2020 - 2023
    Mathematical models of 4D multicellular spheroids (ARC Discovery Project administered by Queensland University of Technology)
    Queensland University of Technology
    Open grant
  • 2019
    Improving Immune Checkpoint Therapy of Melanoma
    Australasian College of Dermatologists Scientific Research Fund
    Open grant
  • 2019 - 2022
    Induction of endoplasmic reticulum stress to potentiate immunogenic cell death to improve melanoma therapy
    Cancer Council Queensland
    Open grant
  • 2018 - 2022
    Improving outcomes for patients with melanoma brain metastases using novel personalised and response-adapted treatment strategies (PARF Translation Research Innovation Award administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2017 - 2024
    ACRF Cancer Ultrastructure and Function Facility
    Australian Cancer Research Foundation
    Open grant
  • 2017 - 2019
    Melanoma environment and heterogeneity in therapy sensitivity and resistance - Haass
    Meehan Bequest
    Open grant
  • 2017 - 2018
    Personalized medicine for renal cell carcinoma patients: use of patient-derived tumors for 3-D cell culture and animal models
    UQ-Ochsner Seed Fund for Collaborative Research - MABS funds
    Open grant
  • 2016
    Epigenetic remodelling driving acquired permanent drug resistance in melanoma cells
    PA Research Foundation
    Open grant
  • 2015 - 2018
    Defining the role of Microphthalmia-associated Transcription Factor (MITF) in melanoma heterogeneity by real-time cell cycle imaging
    NHMRC Project Grant
    Open grant
  • 2015
    Next-generation cell analysis: Automated high-throughput 3D microscope and multimode microplate reader
    NHMRC Equipment Grant
    Open grant
  • 2014
    Purchase of low O2 incubator and Dissociator
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2014
    Real-time Imaging of cell cycle progression in melanoma
    NHMRC Project Grant
    Open grant

Availability

Professor Nikolas Haass is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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