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2024 Journal Article The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD modelsRaut, Sanket B., Joly, Fanny, Haass, Nikolas K., Eri, Rajaraman, Canales, Juan J., Benedek, David M., Ursano, Robert J. and Johnson, Luke R. (2024). The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models. Translational Psychiatry, 14 (1) 492. doi: 10.1038/s41398-024-03190-6 |
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2024 Journal Article Compression-dependent microtubule reinforcement enables cells to navigate confined environmentsJu, Robert J., Falconer, Alistair D., Schmidt, Christanny J., Martinez, Marco A. Enriquez, Dean, Kevin M., Fiolka, Reto P., Sester, David P., Nobis, Max, Timpson, Paul, Lomakin, Alexis J., Danuser, Gaudenz, White, Melanie D., Haass, Nikolas K., Oelz, Dietmar B. and Stehbens, Samantha J. (2024). Compression-dependent microtubule reinforcement enables cells to navigate confined environments. Nature Cell Biology, 26 (9), 1520-1534. doi: 10.1038/s41556-024-01476-x |
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2024 Journal Article VEGF/VEGFR axis and its signaling in melanoma: current knowledge toward therapeutic targeting agents and future perspectivesMalekan, Mohammad, Haass, Nikolas K., Rokni, Ghasem Rahmatpour, Gholizadeh, Nasim, Ebrahimzadeh, Mohammad Ali and Kazeminejad, Armaghan (2024). VEGF/VEGFR axis and its signaling in melanoma: current knowledge toward therapeutic targeting agents and future perspectives. Life Sciences, 345 122563, 122563. doi: 10.1016/j.lfs.2024.122563 |
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2024 Journal Article Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia miceKe, Yazi D., van Hummel, Annika, Au, Carol, Chan, Gabriella, Lee, Wei Siang, van der Hoven, Julia, Przybyla, Magdalena, Deng, Yuanyuan, Sabale, Miheer, Morey, Nicolle, Bertz, Josefine, Feiten, Astrid, Ippati, Stefania, Stevens, Claire H., Yang, Shu, Gladbach, Amadeus, Haass, Nikolas K., Kril, Jillian J., Blair, Ian P., Delerue, Fabien and Ittner, Lars M. (2024). Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice. Neuron, 112 (8), 1249-1264.e8. doi: 10.1016/j.neuron.2024.01.022 |
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2023 Journal Article Formation and growth of co-culture tumour spheroids: new compartment-based mathematical models and experimentsMurphy, Ryan J., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2023). Formation and growth of co-culture tumour spheroids: new compartment-based mathematical models and experiments. Bulletin of Mathematical Biology, 86 (1) 8, 1-434. doi: 10.1007/s11538-023-01229-1 |
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2023 Journal Article H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferaseMenon, Dinoop Ravindran, Hammerlindl, Heinz, Gimenez, Gregory, Hammerlindl, Sabrina, Zuegner, Elmar, Torrano, Joachim, Bordag, Natalie, Emran, Abdullah Al, Giam, Maybelline, Denil, Simon, Pavelka, Norman, Tan, Aik-Choon, Sturm, Richard A., Haass, Nikolas K., Rancati, Giulia, Herlyn, Meenhard, Magnes, Christoph, Eccles, Michael R., Fujita, Mayumi and Schaider, Helmut (2023). H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase. Drug Resistance Updates, 71 100993, 100993. doi: 10.1016/j.drup.2023.100993 |
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2023 Journal Article The MC1R r allele does not increase melanoma risk in MITF E318K carriersWallingford, Courtney K., Demeshko, Anastassia, Krishnakripa, Asha Krishnankutty, Smit, Darren J., Duffy, David L., Betz-Stablein, Brigid, Pflugfelder, Annette, Jagirdar, Kasturee, Holland, Elizabeth, Mann, Graham J., Primiero, Clare A., Yanes, Tatiane, Malvehy, Josep, Badenas, Cèlia, Carrera, Cristina, Aguilera, Paula, Olsen, Catherine M., Ward, Sarah V., Haass, Nikolas K., Sturm, Richard A., Puig, Susanna, Whiteman, David C., Law, Matthew H., Cust, Anne E., Potrony, Miriam, Soyer, H. Peter and McInerney-Leo, Aideen M. (2023). The MC1R r allele does not increase melanoma risk in MITF E318K carriers. British Journal of Dermatology, 188 (6), 770-776. doi: 10.1093/bjd/ljad041 |
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2023 Journal Article Head and neck cancer patient-derived tumouroid cultures: opportunities and challengesBasnayake, B. W. M. Thilini J., Leo, Paul, Rao, Sudha, Vasani, Sarju, Kenny, Lizbeth, Haass, Nikolas K. and Punyadeera, Chamindie (2023). Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges. British Journal of Cancer, 128 (10), 1807-1818. doi: 10.1038/s41416-023-02167-4 |
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2023 Journal Article Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availabilityMurphy, Ryan J., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2023). Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability. PLoS Computational Biology, 19 (1) e1010833, 1-29. doi: 10.1371/journal.pcbi.1010833 |
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2022 Journal Article Rapid Optical Clearing for Semi-High-Throughput Analysis of Tumor SpheroidsGunasingh, Gency, Browning, Alexander P. and Haass, Nikolas K. (2022). Rapid Optical Clearing for Semi-High-Throughput Analysis of Tumor Spheroids. Journal of Visualized Experiments, 2022 (186) e64103. doi: 10.3791/64103 |
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2022 Journal Article Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasionFane, Mitchell E., Chhabra, Yash, Spoerri, Loredana, Simmons, Jacinta L., Ludwig, Raquelle, Bonvin, Elise, Goding, Colin R., Sturm, Richard A., Boyle, Glen M., Haass, Nikolas K., Piper, Michael and Smith, Aaron G. (2022). Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion. Journal of Investigative Dermatology, 142 (7), 1845-1857. doi: 10.1016/j.jid.2020.12.039 |
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2022 Journal Article Persister state-directed transitioning and vulnerability in melanomaChauvistré, Heike, Shannan, Batool, Daignault-Mill, Sheena M., Ju, Robert J., Picard, Daniel, Egetemaier, Stefanie, Váraljai, Renáta, Gibhardt, Christine S., Sechi, Antonio, Kaschani, Farnusch, Keminer, Oliver, Stehbens, Samantha J., Liu, Qin, Yin, Xiangfan, Jeyakumar, Kirujan, Vogel, Felix C. E., Krepler, Clemens, Rebecca, Vito W., Kubat, Linda, Lueong, Smiths S., Forster, Jan, Horn, Susanne, Remke, Marc, Ehrmann, Michael, Paschen, Annette, Becker, Jürgen C., Helfrich, Iris, Rauh, Daniel, Kaiser, Markus ... Roesch, Alexander (2022). Persister state-directed transitioning and vulnerability in melanoma. Nature Communications, 13 (1) 3055, 3055. doi: 10.1038/s41467-022-30641-9 |
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2022 Journal Article A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labellingKlowss, Jonah J., Browning, Alexander P., Murphy, Ryan J., Carr, Elliot J., Plank, Michael J., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2022). A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling. Journal of the Royal Society. Interface, 19 (189) 20210903, 20210903. doi: 10.1098/rsif.2021.0903 |
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2022 Journal Article PTEN: a novel target for vitamin D in melanomaShariev, Artur, Painter, Nicole, Reeve, Vivienne E., Haass, Nikolas K., Rybchyn, Mark S., Ince, Furkan A., Mason, Rebecca S. and Dixon, Katie M. (2022). PTEN: a novel target for vitamin D in melanoma. The Journal of Steroid Biochemistry and Molecular Biology, 218 106059, 1-10. doi: 10.1016/j.jsbmb.2022.106059 |
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2022 Journal Article Designing and interpreting 4D tumour spheroid experimentsMurphy, Ryan J., Browning, Alexander P., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2022). Designing and interpreting 4D tumour spheroid experiments. Communications Biology, 5 (1) 91, 91. doi: 10.1038/s42003-022-03018-3 |
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2021 Journal Article Quantitative analysis of tumour spheroid structureBrowning, Alexander P., Sharp, Jesse A., Murphy, Ryan J., Gunasingh, Gency, Lawson, Brodie, Burrage, Kevin, Haass, Nikolas K. and Simpson, Matthew (2021). Quantitative analysis of tumour spheroid structure. eLife, 10 e73020. doi: 10.7554/elife.73020 |
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2021 Journal Article Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour RegressionProctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733 |
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2021 Journal Article GGCX mutations in a patient with PXE/CL-like overlapping phenotypeLi, D., Ryu, E., Saeidian, A. H., Youssefian, L., Oliphant, E., Terry, S. F., Tong, P. L., Uitto, J., Haass, N. K. and Li, Q. (2021). GGCX mutations in a patient with PXE/CL-like overlapping phenotype. British Journal of Dermatology, 184 (6) , 1170-1174. doi: 10.1111/bjd.19576 |
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2021 Journal Article Fluorescence-based quantitative and spatial analysis of tumour spheroids: a proposed tool to predict patient-specific therapy responseSpoerri, Loredana, Gunasingh, Gency and Haass, Nikolas K. (2021). Fluorescence-based quantitative and spatial analysis of tumour spheroids: a proposed tool to predict patient-specific therapy response. Frontiers in Digital Health, 3 668390, 1-19. doi: 10.3389/fdgth.2021.668390 |
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2021 Journal Article Synchronised oscillations in growing cell populations are explained by demographic noiseGavagnin, Enrico, Vittadello, Sean T., Gunasingh, Gency, Haass, Nikolas K., Simpson, Matthew J., Rogers, Tim and Yates, Christian A. (2021). Synchronised oscillations in growing cell populations are explained by demographic noise. Biophysical Journal, 120 (8), 1314-1322. doi: 10.1016/j.bpj.2021.02.017 |
