Overview
Background
Professor Andrew Barbour is an academic general surgeon who specialises in upper gastrointestinal, pancreatic, melanoma and sarcoma surgery.
On completion of his training, Dr Barbour worked at the Bristol Royal Infirmary as an Upper Gastrointestinal and Hepatobiliary Surgery Fellow and then as a Surgical Oncology Fellow at the Memorial Sloan-Kettering Cancer Centre, New York.
Professor Andrew Barbour specializes in the treatment of oesophageal, gastric, and pancreatic diseases, as well as melanoma and soft tissue tumours. He has expertise in minimally invasive treatments these conditions, including robotic surgery, minimally invasive oesophagectomy, laparoscopic anti-reflux surgery (fundoplication), laparoscopic gastrectomy, and laparoscopic pancreatectomy.
Professor Barbour’s research interests are in the treatment of cancer. His academic interests have encompassed the areas of 1) clinical research, including randomised controlled clinical trials, 2) laboratory based research, including molecular biology pertinent to upper gastrointestinal disease, pancreatic cancer and melanoma, 3) translational research integrating the laboratory and clinical domains, and 4) health-related quality of life and patient reported outcomes research.
As a clinical researcher, Prof Barbour has been active in the conduct of clinical trials at Phase I, II and III levels. He was the Principal Investigator for investigator initiated, multicentre phase II trials in oesophageal (DOCTOR trial) and pancreatic cancer (GAP Trial), funded by the NH&MRC and sponsored by the Australasian Gastrointestinal Trials Group (AGITG). Both of these national trials include biological substudies with tumour tissue and blood banking and subsequent molecular analyses aimed at answering specific questions, including the identification of biomarkers of response to therapy. These studies are aimed at developing personalized, precision therapy for cancer. The DOCTOR trial was the first trial to use PET scans to “tailor” or “personalize” therapy for patients with oesophageal cancer. The GAP trial has shown that pre-operative chemotherapy is a safe strategy for patients with pancreatic cancer. Building on the GAP trial, the AGITG has undertaken the MRFF funded MASTERPLAN clinical trial for pancreatic cancer exploring th e role of stereotactic radiation in pancreatic cancer. Professor Barbour is the Chair of the AGITG Upper GI working party and a member of the AGITG Board.
Prof Barbour is a translational researcher at the School of Medicine, The University of Queensland. He is the head of Surgical Oncology Lab at the School of Medicine. His research has focused on using genomic, epigenomic, mRNA expression and next generation sequencing data to classify oesophageal adenocarcinoma (OAC), pancreatic cancer and melanoma and to identify biomarkers of outcome. His lab team was the first to identify genomic catastrophes as potential drivers for oesophageal adenocarcinoma. In addition, his lab is seeking to identify genetic markers in melanoma that will identify patients at high risk for recurrence following surgery and to identify patients who will benefit from the current exciting advances in treatment for advanced melanoma. His work in melanoma is supported by a Queensland Advancing Clinical Research Fellowship. He was also a member of the Australian Pancreatic Cancer Genome Initiative (APGI) that has published several key studies that have improved our understanding of pancreatic cancer. His lab is currently undertaking studies using next generation sequencing of tumour and circulating tumour DNA. Professor Barbour is the Chief Investigator for the Cancer Evolution Biobank based at the Translational Research Institute. This biobank contains tumour tissue and blood from patients with melanoma, oesophageal or gastric cancer linked to clinical outcomes and supports several research projects.
Availability
- Professor Andrew Barbour is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
- Faculty of Anaesthetists of the Royal Australasian College of Surgeons, Faculty of Anaesthetists of the Royal Australasian College of Surgeons
Works
Search Professor Andrew Barbour’s works on UQ eSpace
2017
Journal Article
Primary cutaneous melanoma of the scalp: Patterns of recurrence
Sparks, David S., Read, Tavis, Lonne, Michael, Barbour, Andrew P., Wagels, Michael, Bayley, Gerard J. and Smithers, B. Mark (2017). Primary cutaneous melanoma of the scalp: Patterns of recurrence. Journal of Surgical Oncology, 115 (4), 449-454. doi: 10.1002/jso.24535
2017
Journal Article
Whole-genome landscape of pancreatic neuroendocrine tumours
Scarpa, Aldo, Chang, David K., Nones, Katia, Corbo, Vincenzo, Patch, Ann-Marie, Bailey, Peter, Lawlor, Rita T., Johns, Amber L., Miller, David K., Mafficini, Andrea, Rusev, Borislav, Scardoni, Maria, Antonello, Davide, Barbi, Stefano, Sikora, Katarzyna O., Cingarlini, Sara, Vicentini, Caterina, McKay, Skye, Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, McLean, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wilson, Peter J., Anderson, Matthew J., Fink, J. Lynn ... Grimmond, Sean M. (2017). Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543 (7643), 65-71. doi: 10.1038/nature21063
2017
Journal Article
Corrigendum: Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Secrier, Maria, Li, Xiaodun, de Silva, Nadeera, Eldridge, Matthew D., Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Núria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P., Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A W, Lynch, Andy G., Tavaré, Simon and Fitzgerald, Rebecca C. (2017). Corrigendum: Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance. Nature Genetics, 49 (2), 317-317. doi: 10.1038/ng0217-317a
2017
Journal Article
Hypermutation in pancreatic cancer
Humphris, Jeremy L., Patch, Ann-Marie, Nones, Katia, Bailey, Peter J., Johns, Amber L., McKay, Skye, Chang, David K., Miller, David K., Pajic, Marina, Kassahn, Karin S., Quinn, Michael C. J., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Stone, Andrew, Wilson, Peter J., Anderson, Matthew, Fink, J. Lynn, Holmes, Oliver, Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Mead, Ronald S. ... Biankin, Andrew V. (2017). Hypermutation in pancreatic cancer. Gastroenterology, 152 (1), 68-74.e2. doi: 10.1053/j.gastro.2016.09.060
2017
Conference Publication
Long-term health-related quality of life following esophagectomy: A nonrandomized comparison of thoracoscopically assisted and open surgery
Barbour, Andrew P., McCormack, Orla M. , Baker, Peter J., Hirst, Jodi, Krause, Lutz, Brosda, Sandra, Thomas, Janine M., Blazeby, Jane M., Thomson, Iain G., Gotley, David C. and Smithers, Bernard M. (2017). Long-term health-related quality of life following esophagectomy: A nonrandomized comparison of thoracoscopically assisted and open surgery. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/SLA.0000000000001899
2016
Journal Article
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
Krause, Lutz, Nones, Katia , Loffler, Kelly A., Nancarrow, Derek, Oey, Harald , Tang, Yue Hang, Wayte, Nicola J., Patch, Ann Marie, Patel, Kalpana , Brosda, Sandra, Manning, Suzanne, Lampe, Guy, Clouston, Andrew, Thomas, Janine, Stoye, Jens, Hussey, Damian J., Watson, David I., Lord, Reginald V., Phillips, Wayne A., Gotley, David, Smithers, B. Mark, Whiteman, David C., Hayward, Nicholas K., Grimmond, Sean M., Waddell, Nicola and Barbour, Andrew P. (2016). Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma. Carcinogenesis, 37 (4), 356-365. doi: 10.1093/carcin/bgw018
2016
Journal Article
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Secrier, Maria, Li, Xiaodun, De Silva, Nadeera, Eldridge, Matthew D., Contino, Gianmarco, Bornschein, Jan, Macrae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Núria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P., Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A. W., Lynch, Andy G., Tavare, Simon, Fitzgerald, Rebecca C., Noorani, Ayesha, Elliott, Rachael Fels, Weaver, Jamie ... Grimmond, Sean M. (2016). Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance. Nature Genetics, 48 (10), 1131-1141. doi: 10.1038/ng.3659
2016
Journal Article
Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma
Rowe, Casey J., Tang, Fiona, Hughes, Maria Celia B., Rodero, Mathieu P., Malt, Maryrose, Lambie, Duncan, Barbour, Andrew, Hayward, Nicholas K., Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2016). Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma. International Journal of Cancer, 139 (3), 664-672. doi: 10.1002/ijc.30085
2016
Journal Article
Refining the care of patients with pancreatic cancer: the AGITG pancreatic cancer workshop consensus
Gandy, Robert C., Barbour, Andrew P., Samra, Jaswinder, Nikfarjam, Mehrdad, Haghighi, Koroush, Kench, James G., Saxena, Payal and Goldstein, David (2016). Refining the care of patients with pancreatic cancer: the AGITG pancreatic cancer workshop consensus. Medical Journal of Australia, 204 (11), 419-422. doi: 10.5694/mja16.00061
2016
Journal Article
Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett's esophagus and esophageal adenocarcinoma individuals
Shah, Alok K., Le Cao, Kim-Anh, Choi, Eunju, Chen, David, Gautier, Benoit, Nancarrow, Derek, Whiteman, David C., Baker, Peter R., Clauser, Karl R., Chalkley, Robert J., Saunders, Nicholas A., Barbour, Andrew P., Joshi, Virendra and Hill, Michelle M. (2016). Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett's esophagus and esophageal adenocarcinoma individuals. Data in Brief, 7, 1058-1062. doi: 10.1016/j.dib.2016.03.081
2016
Journal Article
Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma
Theodore, Jane E., Frankel, Adam J., Thomas, Janine M., Barbour, Andrew P., Bayley, Gerard J., Allan, Christopher P., Wagels, Michael and Smithers, B. Mark (2016). Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma. ANZ journal of surgery, 87 (1-2), 44-48. doi: 10.1111/ans.13526
2016
Journal Article
Australian multicenter study of isolated limb infusion for melanoma
Kroon, Hidde M., Coventry, Brendon J., Giles, Mitchell H., Henderson, Michael A., Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Coventry, Alexander G. J., Sullivan, Thomas, Smithers, Bernard Mark and Thompson, John F. (2016). Australian multicenter study of isolated limb infusion for melanoma. Annals of Surgical Oncology, 23 (4), 1096-1103. doi: 10.1245/s10434-015-4969-2
2016
Journal Article
Genomic analyses identify molecular subtypes of pancreatic cancer
Baile, Peter, Chang, David K., Nones, Katia, Johns, Amber L., Patch, Ann-Marie, Gingras, Marie-Claude, Miller, David K., Christ, Angelika N., Bruxner, Tim J. C., Quinn, Michael C., Nourse, Craig, Murtaugh, L. Charles, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourbakhsh, Ehsan, Wani, Shivangi, Fink, Lynn, Holmes, Oliver, Chin, Vencssa, Anderson, Matthew J., Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Xu, Qinying, Wilson, Peter J., Cloonan, Nicole ... Grimmond, Sean M. (2016). Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531 (7592), 47-52. doi: 10.1038/nature16965
2016
Journal Article
Pancreatic cancer: is the surgeon still relevant?
Butler, Nick, Samra, Jaswinder, Nikfarjam, Mehrdad and Barbour, Andrew P. (2016). Pancreatic cancer: is the surgeon still relevant?. Cancer Forum, 40 (1), 39-42.
2016
Journal Article
Genomics of pancreatic tumours - what we now know
Patch, Ann-Marie, Barbour, Andrew and Waddell, Nicola (2016). Genomics of pancreatic tumours - what we now know. Cancer Forum, 40 (1), 6-10.
2016
Conference Publication
An AGITG trial - A randomised phase II study of pre-operative cisplatin, fluorouracil and DOCetaxel plus /-radio Therapy based on poOR early response to cisplatin and fluorouracil for resectable esophageal adenocarcinoma
Barbour, A., Walpole, E., Mai, G. T., Chan, H., Barnes, E., Watson, D., Ackland, S., Wills, V., Martin, J., Burge, M., Karapetis, C., Shannon, J., Nott, L., Gebski, V., Wilson, K., Thomas, J., Lampe, G., Zalcberg, J., Simes, J. and Smithers, M. (2016). An AGITG trial - A randomised phase II study of pre-operative cisplatin, fluorouracil and DOCetaxel plus /-radio Therapy based on poOR early response to cisplatin and fluorouracil for resectable esophageal adenocarcinoma. 41st Congress of the European-Society-for-Medical-Oncology (ESMO), Copenhagen, Denmark, 7-11 October 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdw371.02
2016
Conference Publication
Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma
Rowe, C., Tang, F., Hughes, M. C., Rodero, M., Malt, M., Lambie, D., Barbour, A., Hayward, N., Smithers, B. M., Green, A. and Khosrotehrani, K. (2016). Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, Australia, 14–17 May, 2016. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480
2015
Journal Article
Sentinel node biopsy in patients with intermediate and thick melanomas - A balanced view
Saw, Robyn, Allan, Christopher, Barbour, Andrew, Ch'ng, Sydney, Coventry, Brendon J., Gyorki, David, Henderson, Michael, Howle, Julie, Hughes, T. Michael, Lee, Kenneth, Neuhaus, Susan, Saunders, Christobel, Shannon, Kerwin, Smithers, Mark, Speakman, David, Spillane, John and Stretch, Jonathan (2015). Sentinel node biopsy in patients with intermediate and thick melanomas - A balanced view. Australian Family Physician, 44 (12), 876-876.
2015
Journal Article
Meta-analysis of radical resection rates and margin assessment in pancreatic cancer
Chandrasegaram, M. D., Goldstein, D., Simes, J., Gebski, V., Kench, J. G., Gill, A. J., Samra, J. S., Merrett, N. D., Richardson, A. J. and Barbour, A. P. (2015). Meta-analysis of radical resection rates and margin assessment in pancreatic cancer. British Journal of Surgery, 102 (12), 1459-1472. doi: 10.1002/bjs.9892
2015
Journal Article
Serum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarker candidates for esophageal adenocarcinoma
Shah, Alok K., Le Cao, Kim-Anh, Choi, Eunju, Chen, David, Gautier, Benoit, Nancarrow, Derek, Whiteman, David C., Saunders, Nicholas A., Barbour, Andrew P., Joshi, Virendra and Hill, Michelle M. (2015). Serum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarker candidates for esophageal adenocarcinoma. Molecular and Cellular Proteomics, 14 (11), 3023-3039. doi: 10.1074/mcp.M115.050922
Funding
Current funding
Past funding
Supervision
Availability
- Professor Andrew Barbour is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Haressing tumour immune responses in oesophageal cancer: towards better personalised therapeutic strategies
Principal Advisor
Other advisors: Dr Sandra Brosda
-
Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Associate Advisor
-
Doctor Philosophy
Immune regulation through bi-directional interactions between subsets of Natural Killer cells and Dendritic cells.
Associate Advisor
Other advisors: Dr Arutha Kulasinghe, Dr Camille Guillerey, Dr Gustavo Rodrigues Rossi, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Deep spatial phenotyping analysis to characterize cancer evolution
Associate Advisor
Other advisors: Dr Sandra Brosda
Completed supervision
-
2020
Doctor Philosophy
Spatial and temporal tumour evolution and genetic biomarker discovery for personalised treatment in oesophageal adenocarcinoma
Principal Advisor
-
2013
Doctor Philosophy
Genomic investigations in oesophageal adenocarcinoma: towards biomarkers of prognosis
Principal Advisor
-
2019
Doctor Philosophy
Human dendritic cell immunoprofiling in advanced melanoma patients and responses to immunotherapy
Associate Advisor
Other advisors: Honorary Professor Kristen Radford
-
2019
Doctor Philosophy
Lipid Metabolism in Barrett's Esophagus and Esophageal Adenocarcinoma
Associate Advisor
-
2016
Doctor Philosophy
In vitro and in vivo evaluation of alginate-based microparticles for oral delivery of active entities to sites of inflammation in the colon
Associate Advisor
Other advisors: Professor Peter Cabot
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2015
Doctor Philosophy
Serum diagnostic glycoprotein biomarkers for Barrett's esophagus and esophageal adenocarcinoma
Associate Advisor
Media
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