Overview
Background
Dr Lauren Aoude is a research leader at the University of Queensland (UQ) Frazer Institute. Her research program explores barriers to precision oncology, and establishes more accurate prognostics to enhance therapeutic options for oesophageal adenocarcinoma (OAC) and melanoma patients. Her research integrates genomic sequencing data with clinical, pathological and imaging information. Recent work includes the establishment of patient-derived organoid models to enable a personalised medicine approach.
During her PhD (completed Nov 2014, QIMR Berghofer) she was a key member of international collaborations that significantly enhanced the understanding of melanoma susceptibility in at-risk families. Dr Aoude joined UQ as an NHMRC Early Career Fellow (2016-2021), where she led projects exploring precision medicine for metastatic melanoma and oesophageal cancer. In 2021, she was awarded a UQ Amplify fellowship to pursue research while expanding teaching and mentoring opportunities, including an on-going course co-ordinator role in the Master of Medicine Skin Cancer Program.
In 2025, she was awarded an NHMRC (EL2) Emerging Leader Fellowship. Her program vision is to better inform treatment decisions and improve health outcomes for patients through the integration of genomics into the clinic.
Availability
- Dr Lauren Aoude is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Arts, The University of Queensland
- Bachelor of Engineering, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Lauren Aoude’s works on UQ eSpace
Featured
2022
Journal Article
ctDNA as a biomarker of progression in oesophageal adenocarcinoma
Bonazzi, V. F., Aoude, L. G., Brosda, S., Lonie, J. M., Patel, K., Bradford, J. J., Koufariotis, L. T., Wood, S., Smithers, B. Mark, Waddell, N. and Barbour, A. P. (2022). ctDNA as a biomarker of progression in oesophageal adenocarcinoma. ESMO Open, 7 (3) 100452, 100452. doi: 10.1016/j.esmoop.2022.100452
Featured
2021
Journal Article
Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients
Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038
Featured
2020
Journal Article
Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients
Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola and Barbour, Andrew P. (2020). Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients. Scientific Reports, 10 (1) 17687, 17687. doi: 10.1038/s41598-020-74956-3
Featured
2015
Journal Article
A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma
Wadt, K. A. W., Aoude, L. G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M. T., Kiilgaard, J. F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J. F., Mccarthy, S. W., Goodwin, A., Tsao, H., Jonsson, G., Busam, K., Gupta, R., Trent, J. M., Gerdes, A. -M., Brown, K. M., Scolyer, R. A. and Hayward, N. K. (2015). A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clinical Genetics, 88 (3), 267-272. doi: 10.1111/cge.12501
Featured
2015
Journal Article
POLE mutations in families predisposed to cutaneous melanoma
Aoude, Lauren G., Heitzer, Ellen, Johansson, Peter, Gartside, Michael, Wadt, Karin, Pritchard, Antonia L., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Montgomery, Grant W., Martin, Nicholas G., Tomlinson, Ian, Kearsey, Stephen and Hayward, Nicholas K. (2015). POLE mutations in families predisposed to cutaneous melanoma. Familial Cancer, 14 (4), 621-628. doi: 10.1007/s10689-015-9826-8
Featured
2014
Journal Article
Assessment of PALB2 as a candidate melanoma susceptibility gene
Aoude, Lauren G., Xu, Mai, Zhao, Zhen Zhen, Kovacs, Michael, Palmer, Jane M., Johansson, Peter, Symmons, Judith, Trent, Jeffrey M., Martin, Nicholas G., Montgomery, Grant W., Brown, Kevin M. and Hayward, Nicholas K. (2014). Assessment of PALB2 as a candidate melanoma susceptibility gene. PLoS One, 9 (6) e100683, e100683.1-e100683.7. doi: 10.1371/journal.pone.0100683
Featured
2013
Journal Article
A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers
Aoude, Lauren G., Wadt, Karin, Bojesen, Anders, Cruger, Dorthe, Borg, Ake, Trent, Jeffrey M., Brown, Kevin M., Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2013). A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers. PloS One, 8 (8) e72144, e72144. doi: 10.1371/journal.pone.0072144
2024
Journal Article
Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy
Brosda, Sandra, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lonie, James M., Belle, Clemence J., Newell, Felicity, Koufariotis, Lambros T., Addala, Venkateswar, Naeini, Marjan M., Simes, John, Walpole, Euan T., Mai, Gang T., Watson, David I., Karapetis, Chris S., Gebski, Val, Barnes, Elizabeth H., Oostendorp, Martijn, Wilson, Kate, Ackland, Stephen P., Shannon, Jenny, Marx, Gavin, Burge, Matthew, Finch, Robert, Thomas, Janine, Varma, Suresh, Nott, Louise, Pearson, John V., Krause, Lutz ... Barbour, Andrew P. (2024). Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy. Genome Medicine, 16 (1) 90. doi: 10.1186/s13073-024-01362-z
2024
Conference Publication
Unsupervised clustering of PET/CT imaging features in stage III/IV melanoma
Vashistha, Rajat, Moradi, Hamed, Brosda, Sandra, Aoude, Lauren, Vegh, Viktor and Barbour, Andrew (2024). Unsupervised clustering of PET/CT imaging features in stage III/IV melanoma. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), Toronto, ON, Canada, 8-11 June 2024. Reston, VA, United States: Society of Nuclear Medicine.
2024
Journal Article
POT1 and multiple primary melanomas: the dermatological phenotype
Maas, Ellie J., DeBortoli, Emily, Nathan, Vaishnavi, Freeman, Ned P., Mothershaw, Adam, Smit, Darren J., Betz-Stablein, Brigid, Aoude, Lauren G., Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen M. (2024). POT1 and multiple primary melanomas: the dermatological phenotype. Journal of Medical Genetics, 61 (9) jmg-2023-109637, 1-4. doi: 10.1136/jmg-2023-109637
2024
Journal Article
The role of artificial intelligence and convolutional neural networks in the management of melanoma: a clinical, pathological, and radiological perspective
Yee, Joshua, Rosendahl, Cliff and Aoude, Lauren G. (2024). The role of artificial intelligence and convolutional neural networks in the management of melanoma: a clinical, pathological, and radiological perspective. Melanoma Research, 34 (2), 96-104. doi: 10.1097/cmr.0000000000000951
2023
Journal Article
The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy – results from the AGITG DOCTOR trial and the cancer evolution biobank
Lonie, James M., Brosda, Sandra, Bonazzi, Vanessa F., Aoude, Lauren G., Patel, Kalpana, Brown, Ian, Sharma, Sowmya, Lampe, Guy, Addala, Venkateswar, Koufariotis, Lambros T., Wood, Scott, Waddell, Nicola, Dolcetti, Riccardo and Barbour, Andrew P. (2023). The oesophageal adenocarcinoma tumour immune microenvironment dictates outcomes with different modalities of neoadjuvant therapy – results from the AGITG DOCTOR trial and the cancer evolution biobank. Frontiers in Immunology, 14 1220129, 1-15. doi: 10.3389/fimmu.2023.1220129
2023
Journal Article
ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients
Aoude, Lauren G., Brosda, Sandra, Ng, Jessica, Lonie, James M., Belle, Clemence J., Patel, Kalpana, Koufariotis, Lambros T., Wood, Scott, Atkinson, Victoria, Smithers, B. Mark, Pearson, John V., Waddell, Nicola, Barbour, Andrew P. and Bonazzi, Vanessa F. (2023). ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients. Journal of Molecular Diagnostics, 25 (10), 771-781. doi: 10.1016/j.jmoldx.2023.06.014
2023
Journal Article
GOLM1: expanding our understanding of melanoma susceptibility
Maas, Ellie J., Wallingford, Courtney K., DeBortoli, Emily, Smit, Darren J., Betz-Stablein, Brigid, Aoude, Lauren G., Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen M. (2023). GOLM1: expanding our understanding of melanoma susceptibility. Journal of Medical Genetics, 60 (9) jmg-2023-109348, 1-3. doi: 10.1136/jmg-2023-109348
2023
Journal Article
C‐reactive protein is a prognostic biomarker in pancreatic ductal adenocarcinoma patients
Bonazzi, Vanessa F., Aoude, Lauren G., Brosda, Sandra, Bradford, Julia J., Lonie, James M., Loffler, Kelly A., Gartside, Michael G., Patel, Kalpana, Mukhopadhyay, Pamela, Keane, Colm, Gebski, Val, Kench, James G., Goldstein, David, Waddell, Nicola, Barbour, Andrew P. and the Australasian Gastro‐Intestinal Trials Group (AGITG) GAP investigators (2023). C‐reactive protein is a prognostic biomarker in pancreatic ductal adenocarcinoma patients. Asia-Pacific Journal of Clinical Oncology, 21 (1), 77-86. doi: 10.1111/ajco.13993
2023
Journal Article
Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy
M. Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lampe, Guy, Koufariotis, Lambros T., Lakis, Vanessa, Addala, Venkateswar, Kondrashova, Olga, Johnston, Rebecca L., Sharma, Sowmya, Brosda, Sandra, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Thomas, Janine, Walpole, Euan, Tao Mai, G., Ackland, Stephen P., Martin, Jarad, Burge, Matthew, Finch, Robert, Karapetis, Christos S., Shannon, Jenny, Nott, Louise, Bohmer, Robert, Wilson, Kate ... Waddell, Nicola (2023). Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy. Nature Communications, 14 (1) 3155, 3155. doi: 10.1038/s41467-023-38891-x
2023
Conference Publication
Unusual suspects in hereditary melanoma: POT1, POLE and BAP1
Maas, Ellie, Betz-Stablein, Brigid, Aoude, Lauren, Soyer, Hans Peter and McInerney-Leo, Aideen (2023). Unusual suspects in hereditary melanoma: POT1, POLE and BAP1. 55th European Society of Human Genetics (ESHG) Conference, Vienna, Austria, 11-14 June 2022. London, United Kingdom: Nature Publishing Group.
2022
Journal Article
Unusual suspects in hereditary melanoma: POT1, POLE, BAP1
Maas, Ellie J., Betz-Stablein, Brigid, Aoude, Lauren G., Soyer, H. Peter and McInerney-Leo, Aideen M. (2022). Unusual suspects in hereditary melanoma: POT1, POLE, BAP1. Trends in Genetics, 38 (12), 1204-1207. doi: 10.1016/j.tig.2022.06.007
2022
Conference Publication
Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma
Aoude, L.G., Bonazzi, V.F., Brosda, S., Wong, B., Moradi, H., Lonie, J., Bradford, J., Bloxham, C., Atkinson, V.G., Law, P., Lampe, G., Smithers, M., Waddell, N., Vegh, V., Miles, K. and Barbour, A.P. (2022). Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma. ESMO Congress 2022, Singapore, 9 - 13 September 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2022.07.1357
2022
Journal Article
Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels
Ramarao-Milne, P, Kondrashova, O, Patch, A-M, Nones, K, Koufariotis, L T, Newell, F, Addala, V, Lakis, V, Holmes, O, Leonard, C, Wood, S, Xu, Q, Mukhopadhyay, P, Naeini, M M, Steinfort, D, Williamson, J P, Bint, M, Pahoff, C, Nguyen, P T, Twaddell, S, Arnold, D, Grainge, C, Basirzadeh, F, Fielding, D, Dalley, A J, Chittoory, H, Simpson, P T, Aoude, L G, Bonazzi, V F ... Waddell, N (2022). Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels. ESMO Open, 7 (4) 100540, 1-11. doi: 10.1016/j.esmoop.2022.100540
Funding
Current funding
Past funding
Supervision
Availability
- Dr Lauren Aoude is:
- Available for supervision
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Available projects
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Identifying genetic drivers of oesophageal cancer
Identify variants/pathways associated with genetic risk and survival in patients with oesophageal cancer.
Media
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