Overview
Background
Dr Lauren Aoude was awarded a PhD in melanoma genetics from the University of Queensland in 2014. Her research focused on large scale genetic sequencing projects that described novel melanoma predisposition genes. In 2016, Dr Aoude was awarded an NHMRC Early Career Fellowship to investigate precision medicine for the treatment of metastatic melanoma.
Currently, Dr Aoude is a UQ Amplify Fellow in the Surgical Oncology Group at the University of Queensland Diamantina Institute. Her research primarily focuses on ways to better predict treatment responses and outcomes for patients with cancer, particularly melanoma and oesophageal adenocarcinoma. Her research integrates genomic sequencing data from both tumours and circulating tumour DNA with clinical, pathological and imaging information. The results of her research will inform treatment decisions and improve health outcomes for patients through the integration of genomics into the clinic.
Availability
- Dr Lauren Aoude is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Arts, The University of Queensland
- Bachelor of Engineering, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Lauren Aoude’s works on UQ eSpace
2021
Journal Article
Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
2020
Journal Article
EZH2 cooperates with DNA methylation to downregulate key tumour suppressors and interferon gene signatures in melanoma
Tiffen, Jessamy, Gallagher, Stuart, Filipp, Fabian, Gunatilake, Dilini, Al Emran, Abdullah, Cullinane, Carleen, Dutton-Register, Ken, Aoude, Lauren, Hayward, Nick, Chatterjee, Aniruddha, Rodger, Euan J., Eccles, Michael R. and Hersey, Peter (2020). EZH2 cooperates with DNA methylation to downregulate key tumour suppressors and interferon gene signatures in melanoma. The Journal of Investigative Dermatology, 140 (12), 2442-2454.e5. doi: 10.1016/j.jid.2020.02.042
2020
Journal Article
Multiplex melanoma families are enriched for polygenic risk
Law, Matthew H., Aoude, Lauren G., Duffy, David L., Long, Georgina V., Johansson, Peter A., Pritchard, Antonia L., Khosrotehrani, Kiarash, Mann, Graham J., Montgomery, Grant W., Iles, Mark M., Cust, Anne E., Palmer, Jane M., Melanoma GWAS Consortium, Shannon, Kerwin F., Spillane, Andrew J., Stretch, Jonathan R., Thompson, John F., Saw, Robyn P. M., Scolyer, Richard A., Martin, Nicholas G., Hayward, Nicholas K. and MacGregor, Stuart (2020). Multiplex melanoma families are enriched for polygenic risk. Human Molecular Genetics, 29 (17), 2976-2985. doi: 10.1093/hmg/ddaa156
2019
Journal Article
Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples
Newell, Felicity, Patel, Kalpana, Gartside, Michael, Krause, Lutz, Brosda, Sandra, Aoude, Lauren G., Loffler, Kelly A., Bonazzi, Vanessa F., Patch, Ann-Marie, Kazakoff, Stephen H., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Lampe, Guy, Lord, Reginald V., Whiteman, David C., Pearson, John V., Nones, Katia, Waddell, Nicola and Barbour, Andrew P. (2019). Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples. BMC Medical Genomics, 12 (1) 31, 31. doi: 10.1186/s12920-019-0476-9
2017
Conference Publication
Novel high risk genes of melanoma
Hayward, N., Pritchard, A., Johansson, P., Aoude, L., Jonsson, G., Hoiom, V., Wadt, K. and Adams, D. (2017). Novel high risk genes of melanoma. 13th Congress of the European Association of Dermato‐Oncology (EADO), Athens, Greece, 3–6 May 2017. Hoboken, NJ United States: Wiley.
2017
Conference Publication
Novel germline variants in cutaneous and uveal melanoma families
Hayward, N., Pritchard, A., Johansson, P., Aoude, L., Jonsson, G., Hoiom, V. and Wadt, K. (2017). Novel germline variants in cutaneous and uveal melanoma families. 13th Congress of the European Association of Dermato‐Oncology (EADO), Athens, Greece, 3–6 May 2017. Hoboken, NJ United States: Wiley.
2016
Journal Article
Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4
Johansson, Peter, Aoude, Lauren G., Wadt, Karin, Glasson, William J., Warrier, Sunil K., Hewitt, Alex W., Kiilgaard, Jens Folke, Heegaard, Steffen, Isaacs, Tim, Franchina, Maria, Ingvar, Christian, Vermeulen, Tersia, Whitehead, Kevin J., Schmidt, Christopher W., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2016). Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget, 7 (4), 4624-4631. doi: 10.18632/oncotarget.6614
2016
Journal Article
Germline TERT promoter mutations are rare in familial melanoma
Harland, Mark, Petljak, Mia, Robles-Espinoza, Carla Daniela, Ding, Zhihao, Gruis, Nelleke A., van Doorn, Remco, Pooley, Karen A., Dunning, Alison M., Aoude, Lauren G., Wadt, Karin A. W., Gerdes, Anne-Marie, Brown, Kevin M., Hayward, Nicholas K., Newton-Bishop, Julia A., Adams, David J. and Bishop, D. Timothy (2016). Germline TERT promoter mutations are rare in familial melanoma. Familial Cancer, 15 (1), 139-144. doi: 10.1007/s10689-015-9841-9
2015
Journal Article
Germline RAD51B truncating mutation in a family with cutaneous melanoma
Wadt, Karin A. W., Aoude, Lauren G., Golmard, Lisa, Hansen, Thomas V. O., Sastre-Garau, Xavier, Hayward, Nicholas K. and Gerdes, Anne-Marie (2015). Germline RAD51B truncating mutation in a family with cutaneous melanoma. Familial Cancer, 14 (2), 337-340. doi: 10.1007/s10689-015-9781-4
2015
Journal Article
Prevalence of germline BAP1, CDKN2A, and CDK4 mutations in an australian population-based sample of cutaneous melanoma cases
Aoude, Lauren G., Gartside, Michael, Johansson, Peter, Palmer, Jane M., Symmons, Judith, Martin, Nicholas G., Montgomery, Grant W. and Hayward, Nicholas K. (2015). Prevalence of germline BAP1, CDKN2A, and CDK4 mutations in an australian population-based sample of cutaneous melanoma cases. Twin Research and Human Genetics, 18 (2), 126-133. doi: 10.1017/thg.2015.12
2015
Journal Article
Genetics of familial melanoma: 20 years after CDKN2A
Aoude, Lauren G, Wadt, A.W, Pritchard, Antonia L and Hayward, Nicholas K (2015). Genetics of familial melanoma: 20 years after CDKN2A. Pigment Cell and Melanoma Research, 28 (2), 148-160. doi: 10.1111/pcmr.12333
2015
Journal Article
Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition
Wadt, Karin A. W., Aoude, Lauren G., Krogh, Lotte, Sunde, Lone, Bojesen, Anders, Gronskov, Karen, Wartacz, Nine, Ek, Jakob, Tolstrup-Andersen, Morten, Klarskov-Andersen, Mette, Borg, Ake, Heegaard, Steffen, Kiilgaard, Jens F., Hansen, Thomas V. O., Klein, Kerenaftali, Jonsson, Goran, Drzewiecki, Krzysztof T., Duno, Morten, Hayward, Nicholas K. and Gerdes, Anne-Marie (2015). Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition. PLoS One, 10 (3) e0122662, e0122662.1-e0122662.16. doi: 10.1371/journal.pone.0122662
2015
Journal Article
Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma
Aoude, Lauren G., Pritchard, Antonia L., Robles-Espinoza, Carla Daniela, Wadt, Karin, Harland, Mark, Choi, Jiyeon, Gartside, Michael, Quesada, Victor, Johansson, Peter, Palmer, Jane M., Ramsay, Andrew J., Zhang, Xijun, Jones, Kristine, Symmons, Judith, Holland, Elizabeth A., Schmid, Helen, Bonazzi, Vanessa, Woods, Susan, Dutton-Regester, Ken, Stark, Mitchell S., Snowden, Helen, van Doom, Remco, Montgomery, Grant W., Martin, Nicholas G., Keane, Thomas M., Lopez-Otin, Carlos, Gerdes, Anne-Marie, Olsson, Hakan, Ingvar, Christian ... Hayward, Nicholas K. (2015). Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute, 107 (2) dju408, 1-7. doi: 10.1093/jnci/dju408
2014
Other Outputs
Dissecting the genetic architecture of familial melanoma
Aoude, Lauren Gabriel (2014). Dissecting the genetic architecture of familial melanoma. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2015.132
2014
Journal Article
POT1 loss-of-function variants predispose to familial melanoma
Robles-Espinoza, Carla Daniela, Harland, Mark, Ramsay, Andrew J, Aoude, Lauren G, Quesada, Víctor, Ding, Zhihao, Pooley, Karen A, Pritchard, Antonia L, Tiffen, Jessamy C, Petljak, Mia, Palmer, Jane M, Symmons, Judith, Johansson, Peter, Stark, Mitchell S., Gartside, Michael G, Snowden, Helen, Montgomery, Grant W, Martin, Nicholas G, Liu, Jimmy Z, Choi, Jiyeon, Makowski, Matthew, Brown, Kevin M, Dunning, Alison M, Keane, Thomas M, Lopez-Otin, Carlos, Gruis, Nelleke A, Hayward, Nicholas K, Bishop, D Timothy, Newton-Bishop, Julia A and Adams, David J (2014). POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46 (5), 478-481. doi: 10.1038/ng.2947
2013
Journal Article
Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma
Dutton-Regester, K., Kakavand, H., Aoude, L.G., Stark, M.S., Gartside, M.G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G.M., Haydu, L.E., Schmidt, C.W., Mann, G.J., Thompson, J.F., Scolyer, R.A. and Hayward, N.K. (2013). Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell and Melanoma Research, 26 (6), 852-860. doi: 10.1111/pcmr.12153
2013
Journal Article
SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis
Cronin, J.C., Watkins-Chow, D.E., Incao, A., Hasskamp, J.H., Schonewolf, N., Aoude, L.G., Hayward, N.K., Bastian, B.C., Dummer, R., Loftus, S.K. and Pavan, W.J. (2013). SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Research, 73 (18), 5709-5718. doi: 10.1158/0008-5472.CAN-12-4620
2013
Journal Article
Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases
Aoude, Lauren G., Vajdic, Claire M., Kricker, Anne, Armstrong, Bruce and Hayward, Nicholas K. (2013). Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases. Pigment Cell and Melanoma Research, 26 (2), 1-3. doi: 10.1111/pcmr.12046
2012
Journal Article
Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene
Dutton-Regester, Ken, Aoude, Lauren G., Nancarrow, Derek J., Stark, Mitchell S., O'Connor, Linda, Lanagan, Cathy, Pupo, Gulietta M., Tembe, Varsha, Carter, Candace D., O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012). Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes and Cancer, 51 (5), 452-461. doi: 10.1002/gcc.21932
2012
Journal Article
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012). Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 (2), 165-169. doi: 10.1038/ng.1041
Funding
Current funding
Past funding
Supervision
Availability
- Dr Lauren Aoude is:
- Available for supervision
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