Overview
Background
Professor Andrew Barbour is an academic general surgeon who specialises in upper gastrointestinal, pancreatic, melanoma and sarcoma surgery.
On completion of his training, Dr Barbour worked at the Bristol Royal Infirmary as an Upper Gastrointestinal and Hepatobiliary Surgery Fellow and then as a Surgical Oncology Fellow at the Memorial Sloan-Kettering Cancer Centre, New York.
Professor Andrew Barbour specializes in the treatment of oesophageal, gastric, and pancreatic diseases, as well as melanoma and soft tissue tumours. He has expertise in minimally invasive treatments these conditions, including robotic surgery, minimally invasive oesophagectomy, laparoscopic anti-reflux surgery (fundoplication), laparoscopic gastrectomy, and laparoscopic pancreatectomy.
Professor Barbour’s research interests are in the treatment of cancer. His academic interests have encompassed the areas of 1) clinical research, including randomised controlled clinical trials, 2) laboratory based research, including molecular biology pertinent to upper gastrointestinal disease, pancreatic cancer and melanoma, 3) translational research integrating the laboratory and clinical domains, and 4) health-related quality of life and patient reported outcomes research.
As a clinical researcher, Prof Barbour has been active in the conduct of clinical trials at Phase I, II and III levels. He was the Principal Investigator for investigator initiated, multicentre phase II trials in oesophageal (DOCTOR trial) and pancreatic cancer (GAP Trial), funded by the NH&MRC and sponsored by the Australasian Gastrointestinal Trials Group (AGITG). Both of these national trials include biological substudies with tumour tissue and blood banking and subsequent molecular analyses aimed at answering specific questions, including the identification of biomarkers of response to therapy. These studies are aimed at developing personalized, precision therapy for cancer. The DOCTOR trial was the first trial to use PET scans to “tailor” or “personalize” therapy for patients with oesophageal cancer. The GAP trial has shown that pre-operative chemotherapy is a safe strategy for patients with pancreatic cancer. Building on the GAP trial, the AGITG has undertaken the MRFF funded MASTERPLAN clinical trial for pancreatic cancer exploring th e role of stereotactic radiation in pancreatic cancer. Professor Barbour is the Chair of the AGITG Upper GI working party and a member of the AGITG Board.
Prof Barbour is a translational researcher at the School of Medicine, The University of Queensland. He is the head of Surgical Oncology Lab at the School of Medicine. His research has focused on using genomic, epigenomic, mRNA expression and next generation sequencing data to classify oesophageal adenocarcinoma (OAC), pancreatic cancer and melanoma and to identify biomarkers of outcome. His lab team was the first to identify genomic catastrophes as potential drivers for oesophageal adenocarcinoma. In addition, his lab is seeking to identify genetic markers in melanoma that will identify patients at high risk for recurrence following surgery and to identify patients who will benefit from the current exciting advances in treatment for advanced melanoma. His work in melanoma is supported by a Queensland Advancing Clinical Research Fellowship. He was also a member of the Australian Pancreatic Cancer Genome Initiative (APGI) that has published several key studies that have improved our understanding of pancreatic cancer. His lab is currently undertaking studies using next generation sequencing of tumour and circulating tumour DNA. Professor Barbour is the Chief Investigator for the Cancer Evolution Biobank based at the Translational Research Institute. This biobank contains tumour tissue and blood from patients with melanoma, oesophageal or gastric cancer linked to clinical outcomes and supports several research projects.
Availability
- Professor Andrew Barbour is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
- Faculty of Anaesthetists of the Royal Australasian College of Surgeons, Faculty of Anaesthetists of the Royal Australasian College of Surgeons
Works
Search Professor Andrew Barbour’s works on UQ eSpace
2015
Journal Article
Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia
Smithers, B.Mark, Hughes, Maria Celia B., Beesley, Vanessa L., Barbour, Andrew P., Malt, Maryrose K., Weedon, David, Zonta, Mark J., Wood, Dominic J., Triscott, Joseph A., Bayley, Gerard J., Brown, Lee J., Allan, Christopher P., D'Arcy, Justin, Williamson, Richard, Khosrotehrani, Kiarash and Green, Adele C. (2015). Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia. Journal of Surgical Oncology, 112 (4), 359-365. doi: 10.1002/jso.24013
2015
Journal Article
Two cases of NSAID-induced gastropathy and enteropathy of the ileum
Auld, Michael C., Dodd, Benjamin R., Barbour, Andrew P. and Smithers, Mark (2015). Two cases of NSAID-induced gastropathy and enteropathy of the ileum. ANZ Journal of Surgery, 85 (7-8), 584-585. doi: 10.1111/ans.12462
2015
Journal Article
MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis
Tembe, Varsha, Schramm, Sarah-Jane, Stark, Mitchell, Patrick, Ellis, Jayaswal, Vivek, Tang, Yue Hang, Barbour, Andrew, Hayward, Nicholas K., Thompson, John F., Scolyer, Richard A., Yang, Yee Hwa and Mann, Graham J. (2015). MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis. Pigment Cell and Melanoma Research, 28 (3), 254-266. doi: 10.1111/pcmr.12343
2015
Journal Article
The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis
Stark, Mitchell S., Klein, Kerenaftali, Weide, Benjamin, Haydu, Lauren E., Pflugfelder, Annette, Tang, Yue Hang, Palmer, Jane M., Whiteman, David C., Scolyer, Richard A., Mann, Graham J., Thompson, John F., Long, Georgina V., Barbour, Andrew P., Soyer, H. Peter, Garbe, Claus, Herington, Adrian, Pollock, Pamela M. and Hayward, Nicholas K. (2015). The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis. EBioMedicine, 2 (7), 671-680. doi: 10.1016/j.ebiom.2015.05.011
2015
Journal Article
Whole genomes redefine the mutational landscape of pancreatic cancer
Waddell, Nicola, Pajic, Marina, Patch, Anne-Marie, Chang, David K, Kassahn, Karin S, Bailey, Peter, Johns, Amber L, Miller, David, Nones, Katia, Quek, Kelly, Quinn, Michael C. J, Robertson, Alan J, Fadlullah, Muhammad Z.H, Bruxner, Tim J.C, Christ, Angelika N, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Wilson, Peter J, Markham, Emma, Cloonan, Nicole, Anderson, Matthew J, Fink, J. Lynn, Holmes, Oliver, Kazakoff, Stephen H, Leonard, Conrad ... Grimmond, Sean M (2015). Whole genomes redefine the mutational landscape of pancreatic cancer. Nature, 518 (7540), 495-501. doi: 10.1038/nature14169
2015
Journal Article
Patterns of recurrence in patients with stage IIIB/C cutaneous melanoma of the head and neck following surgery with and without adjuvant radiation therapy: is isolated regional recurrence salvageable?
Barbour, Samantha, Smithers, B. Mark, Allan, Chris, Bayley, Gerard, Thomas, Janine, Foote, Matthew, Burmeister, Bryan and Barbour, Andrew P. (2015). Patterns of recurrence in patients with stage IIIB/C cutaneous melanoma of the head and neck following surgery with and without adjuvant radiation therapy: is isolated regional recurrence salvageable?. Annals of Surgical Oncology, 22 (12), 4052-4059. doi: 10.1245/s10434-014-4356-4
2014
Journal Article
Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia
Beesley, Vanessa L., Smithers, B. Mark, Khosrotehrani, Kiarash, Khatun, Modsina, O'Rourke, Peter, Hughes, Maria Celia B., Malt, Maryrose K., Zonta, Mark J., Bayley, Gerard J., Barbour, Andrew P., Brown, Lee J., D'Arcy, Justin, Allan, Christopher and Green, Adèle C. (2014). Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia. Psycho-Oncology, 24 (7), 763-770. doi: 10.1002/pon.3718
2014
Journal Article
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Nones, Katia, Waddell, Nicola, Wayte, Nicci, Patch, Ann-Marie, Bailey, Peter, Newell, Felicity, Holmes, Oliver, Fink, J. Lynn, Quinn, Michael C. J., Tang, Yue Hang, Lampe, Guy, Quek, Kelly, Loffler, Kelly A., Manning, Suzanne, Idrisoglu, Senel, Miller, David, Xu, Qinying, Waddell, Nick, Wilson, Peter J., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Nourse, Craig, Nourbakhsh, Ehsan, Anderson, Matthew, Kazakoff, Stephen, Leonard, Conrad, Wood, Scott, Simpson, Peter T. ... Barbour, Andrew P. (2014). Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nature Communications, 5 (1) 6224, 5224.1-5224.9. doi: 10.1038/ncomms6224
2014
Journal Article
BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy
Barbour, Andrew P., Tang, Yue Hang, Armour, Nicola, Dutton-Regester, Ken, Krause, Lutz, Loffler, Kelly A., Lambie, Duncan, Burmeister, Bryan, Thomas, Janine, Smithers, B. Mark and Hayward, Nicholas K. (2014). BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy. European Journal of Cancer, 50 (15), 2668-2676. doi: 10.1016/j.ejca.2014.06.009
2014
Journal Article
Controversies in the management of gastrointestinal stromal tumors
Yip, Desmond, Zalcberg, John, Ackland, Stephen, Barbour, Andrew P., Desai, Jayesh, Fox, Stephen, Kotasek, Dusan, McArthur, Grant and Smithers, B. Mark (2014). Controversies in the management of gastrointestinal stromal tumors. Asia-Pacific Journal of Clinical Oncology, 10 (3), 216-227. doi: 10.1111/ajco.12187
2014
Journal Article
Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma
Coventry, Brendon J., Kroon, Hidde M., Giles, Mitchell H., Henderson, Michael, Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Coventry, Alexander G.J., Sullivan, Thomas and Smithers, B. Mark (2014). Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma. Journal of Surgical Oncology, 109 (8), 780-785. doi: 10.1002/jso.23590
2014
Journal Article
Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy
Khosrotehrani, Kiarash, van der Ploeg, Augustinus P.T., Siskind,Victor, Hughes, Maria Celia, Wright, Annaliesa, Thomas, Janine, Barbour, Andrew, Allan, Christopher, Bayley, Gerard, Eggermont, Alexander, Verhoef, Cornelis, Smithers, B. Mark and Green, Adele C. (2014). Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy. European Journal of Cancer, 50 (7), 1301-1309. doi: 10.1016/j.ejca.2014.02.010
2014
Journal Article
Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis
Frankel, Adam, Armour, Nicola, Nancarrow, Derek, Krause, Lutz, Hayward, Nicholas, Lampe, Guy, Smithers, B. Mark and Barbour, Andrew (2014). Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis. Genes Chromosomes and Cancer, 53 (4), 324-338. doi: 10.1002/gcc.22143
2014
Conference Publication
Oesophageal adenocarcinoma genomics
Barbour, Andrew (2014). Oesophageal adenocarcinoma genomics. Sydney Cancer Conference, The University of Sydney, Australia, 26 November 2014. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12282
2014
Conference Publication
Discovery and validation of novel serum glycoprotein biomarkers for Barrett's esophagus and esophageal adenocarcinoma
Shah, Alok K., Chen, David, Le Cao, Kim-Anh, Choi, Eunju, Nancarrow, Derek, Whiteman, David, Saunders, Nicholas A., Barbour, Andrew P. and Hill, Michelle M. (2014). Discovery and validation of novel serum glycoprotein biomarkers for Barrett's esophagus and esophageal adenocarcinoma. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-2492
2014
Journal Article
Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes
Thomson I.G., Gotley D.C., Barbour A.P., Martin I., Jayasuria N., Thomas J. and Smithers B.M. (2014). Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes. Gastric Cancer, 17 (1), 152-160. doi: 10.1007/s10120-013-0240-3
2014
Journal Article
A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia
Liyanage, Surabhi S., Segelov, Eva, Malik, Aisha, Garland, Suzanne M., Tabrizi, Sepehr N., Cummins, Eleanor, Seale, Holly, Rahman, Bayzidur, Moa, Aye, Barbour, Andrew P., Crowe, Philip J. and Macintyre, C. Raina (2014). A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia. Journal of Oncology, 2014 (Article No. 236482) 236482, 236482-7. doi: 10.1155/2014/236482
2013
Journal Article
Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome
Hughes, Maria Celia, Wright, Annaliesa, Barbour, Andrew, Thomas, Janine, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2013). Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome. International Journal of Cancer, 133 (12), 3000-3007. doi: 10.1002/ijc.28318
2013
Journal Article
Early diagnostic biomarkers for esophageal adenocarcinoma: the current state of play
Shah, Alok Kishorkumar, Saunders, Nicholas A., Barbour, Andrew P. and Hill, Michelle M. (2013). Early diagnostic biomarkers for esophageal adenocarcinoma: the current state of play. Cancer Epidemiology: Biomarkers and Prevention, 22 (7), 1185-1209. doi: 10.1158/1055-9965.EPI-12-1415
2013
Journal Article
Role of human papillomaviruses in esophageal squamous cell carcinoma
Liyanage, Surabhi S., Segelov, Eva, Garland, Suzanne M., Tabrizi, Sepehr N., Seale, Holly, Crowe, Philip J., Dwyer, Dominic E., Barbour, Andrew, Newall, Anthony T., Malik, Aisha and Macintyre, C. Raina (2013). Role of human papillomaviruses in esophageal squamous cell carcinoma. Asia-Pacific Journal of Clinical Oncology, 9 (1), 12-28. doi: 10.1111/j.1743-7563.2012.01555.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Andrew Barbour is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Haressing tumour immune responses in oesophageal cancer: towards better personalised therapeutic strategies
Principal Advisor
Other advisors: Dr Sandra Brosda
-
Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Associate Advisor
-
Doctor Philosophy
Deep spatial phenotyping analysis to characterize cancer evolution
Associate Advisor
Other advisors: Dr Sandra Brosda
-
Doctor Philosophy
Immune regulation through bi-directional interactions between subsets of Natural Killer cells and Dendritic cells.
Associate Advisor
Other advisors: Dr Arutha Kulasinghe, Dr Camille Guillerey, Dr Gustavo Rodrigues Rossi, Associate Professor Fernando Guimaraes
Completed supervision
-
2020
Doctor Philosophy
Spatial and temporal tumour evolution and genetic biomarker discovery for personalised treatment in oesophageal adenocarcinoma
Principal Advisor
-
2013
Doctor Philosophy
Genomic investigations in oesophageal adenocarcinoma: towards biomarkers of prognosis
Principal Advisor
-
2019
Doctor Philosophy
Human dendritic cell immunoprofiling in advanced melanoma patients and responses to immunotherapy
Associate Advisor
Other advisors: Honorary Professor Kristen Radford
-
2019
Doctor Philosophy
Lipid Metabolism in Barrett's Esophagus and Esophageal Adenocarcinoma
Associate Advisor
-
2016
Doctor Philosophy
In vitro and in vivo evaluation of alginate-based microparticles for oral delivery of active entities to sites of inflammation in the colon
Associate Advisor
Other advisors: Professor Peter Cabot
-
2015
Doctor Philosophy
Serum diagnostic glycoprotein biomarkers for Barrett's esophagus and esophageal adenocarcinoma
Associate Advisor
Media
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