Skip to menu Skip to content Skip to footer
Dr Melissa Reichelt
Dr

Melissa Reichelt

Email: 
Phone: 
+61 7 336 52957

Overview

Background

Dr Reichelt is a tenured teaching and research academic in The University of Queensland’s School of Biomedical Sciences. She completed her PhD in cardiovascular Physiology at Griffith University, and held postdoctoral positions at The Victor Chang Cardiac Research Institute (VCCRI) in Sydney, the University of California, San Diego (USA) and was a NHMRC Peter Doherty Postdoctoral Fellow at the University of Melbourne. Dr Reichelt is currently funded by two Australian Research Council Discovery Project Grants and lead a 2019 Major Equipment Infrastructure Grant for a preclinical ultrasound machine (Vevo 3100) which measures cardiac function in animals as small as embryos in utero.

Dr Reichelt investigated the most important receptors governing cardiac function (adenosinergic, adrenergic, angiotensin, growth factor, mineralocorticoid, SGLT2), and the influence of ageing, diabetes, hypertension, exercise, influenza and sepsis on cardiovascular physiology. This work has been published in leading cardiovascular journals including Circulation Research, Basic Research in Cardiology, Cardiovascular Research, Hypertension and broader or other specialist journals such as Autophagy, Antioxidant and Redox Signalling, Journal of Infectious Disease and Scientific Reports. Dr Reichelt’s research has most recently been augmented by in-house design and production of viruses that control the expression of receptors and their ligands. She remains fascinated by what the heart can accomplish; filling with and ejecting blood every second (or so) of every day and night, year after year, while retaining the capacity to more than treble cardiac output during exercise. It’s an incredible feat of engineering and only gets more and more interesting the more I learn about it.

Availability

Dr Melissa Reichelt is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Griffith University

Research impacts

Dr Reichelt heads the Cardiac Disease and Therapy group, focused on optimising heart function in clinically relevant models of cardiovascular disease including chronic high blood pressure, heart ischemia (lack of flow), diabetes, ageing and cardiotoxicity associated with cancer therapy. Her research spans studies of single cell populations (cell culture), isolated heart function, and function of the intact heart. This approach is integrated with advanced techniques for gene editing to target specific cell subtypes in the heart to modify receptor expression and function. This ability to intervene in a time- and cell-subtype-specific manner with gene therapy has many applciations the heart, which are currently being pursued by the Cardiac Disease and Therapy group.

Works

Search Professor Melissa Reichelt’s works on UQ eSpace

48 works between 2000 and 2024

21 - 40 of 48 works

2017

Journal Article

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice

Bienvenu, Laura A., Morgan, James, Reichelt, Melissa E., Delbridge, Lea M. D. and Young, Morag J. (2017). Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice. Journal of Molecular and Cellular Cardiology, 112, 8-15. doi: 10.1016/j.yjmcc.2017.08.012

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice

2017

Journal Article

Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection

Reichelt, Melissa E., O'Brien, Shannon, Thomas, Walter G. and Headrick, John P. (2017). Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection. International Journal of Biochemistry and Cell Biology, 83, 97-110. doi: 10.1016/j.biocel.2016.12.014

Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection

2016

Journal Article

Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion

Kassan, Adam, Pham, Uyen, Quynhmy Nguyen, Reichelt, Melissa E., Cho, Eunbyul, Patel, Piyush M., Roth, David M., Head, Brian P. and Patel, Hemal H. (2016). Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. American Journal of Physiology - Cell Physiology, 311 (6), C854-C865. doi: 10.1152/ajpcell.00147.2016

Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion

2016

Journal Article

Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium

Ashton, Kevin J., Reichelt, Melissa E., Mustafa, S. Jamal, Teng, Bunyen, Ledent, Catherine, Delbridge, Lea M. D., Hofmann, Polly A., Morrison, R. Ray and Headrick, John P. (2016). Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. Purinergic Signalling, 13 (1), 1-23. doi: 10.1007/s11302-016-9536-1

Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium

2015

Journal Article

Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult

Bienvenu, Laura A., Reichelt, Melissa E., Morgan, James, Fletcher, Elizabeth K., Bell, James R., Rickard, Amanda J., Delbridge, Lea M. and Young, Morag J. (2015). Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult. Hypertension, 66 (5), 970-977. doi: 10.1161/HYPERTENSIONAHA.115.05981

Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult

2015

Journal Article

Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

Bell, James R., Raaijmakers, Antonia J. A., Curl, Claire L., Reichelt, Melissa E., Harding, TristanW., Bei, Aier, Ng, Dominic C. H., Erickson, Jeffrey R., Petroff, Martin Vila, Harrap, Stephen B. and Delbridge, Lea M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

2014

Journal Article

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility

Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C., Iismaa, Siiri E., Xiao, Xiao-Hui, Kesteven, Scott H., Reichelt, Melissa E., Mohl, Marion C., Smith, Nicola J., Fatkin, Diane, Allen, David, Head, Stewart I., Graham, Robert M. and Feneley, Michael P. (2014). RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility. PLoS ONE, 9 (6) e99024, e99024. doi: 10.1371/journal.pone.0099024

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility

2014

Journal Article

Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

Peart, Jason N., Pepe, Salvatore, Reichelt, Melissa E., Beckett, Nikkie, Hoe, Louise See, Ozberk, Victoria, Niesman, Ingrid R., Patel, Hemal H. and Headrick, John P. (2014). Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium. Experimental Gerontology, 50 (1), 72-81. doi: 10.1016/j.exger.2013.11.015

Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

2013

Journal Article

Myocardial glycophagy - a specific glycogen handling response to metabolic stress is accentuated in the female heart

Reichelt, M. E., Mellor, K. M., Curl, C. L., Stapleton, D. and Delbridge, L. M. D. (2013). Myocardial glycophagy - a specific glycogen handling response to metabolic stress is accentuated in the female heart. Journal of Molecular and Cellular Cardiology, 65, 67-75. doi: 10.1016/j.yjmcc.2013.09.014

Myocardial glycophagy - a specific glycogen handling response to metabolic stress is accentuated in the female heart

2013

Journal Article

Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte

Bienvenu, Laura A., Reichelt, Melissa E., Delbridge, Lea M. D. and Young, Morag J. (2013). Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte. Clinical Science, 125 (9), 409-421. doi: 10.1042/CS20130050

Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte

2013

Journal Article

Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus

Reichelt, Melissa E., Mellor, Kimberley M., Bell, James R., Chandramouli, Chanchal, Headrick, John P. and Delbridge, Lea M. D. (2013). Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus. American Journal of Physiology. Heart and Circulatory Physiology, 305 (6), H779-H792. doi: 10.1152/ajpheart.00141.2013

Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus

2013

Journal Article

The adenosine A2A receptor - myocardial protectant and coronary target in endotoxemia

Reichelt, Melissa E., Ashton, Kevin J., Tan, Xing Lin, Mustafa, S. Jamal, Ledent, Catherine, Delbridge, Lea M. D., Hofmann, Polly A., Headrick, John P. and Morrison, R. Ray (2013). The adenosine A2A receptor - myocardial protectant and coronary target in endotoxemia. International Journal of Cardiology, 166 (3), 672-680. doi: 10.1016/j.ijcard.2011.11.075

The adenosine A2A receptor - myocardial protectant and coronary target in endotoxemia

2013

Journal Article

Autophagic predisposition in the insulin resistant diabetic heart

Mellor, Kimberley M., Reichelt, Melissa E. and Delbridge, Lea M. D. (2013). Autophagic predisposition in the insulin resistant diabetic heart. Life Sciences, 92 (11), 616-620. doi: 10.1016/j.lfs.2012.03.042

Autophagic predisposition in the insulin resistant diabetic heart

2012

Journal Article

Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis

Rickard, Amanda J., Morgan, James, Bienvenu, Laura A., Fletcher, Elizabeth K., Cranston, Greg A., Shen, Jimmy Z., Reichelt, Melissa E., Delbridge, Lea M. and Young, Morag J. (2012). Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis. Hypertension, 60 (6), 1443-1450. doi: 10.1161/HYPERTENSIONAHA.112.203158

Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis

2012

Journal Article

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

Prele, Cecilia M., Reichelt, Melissa E., Mutsaers, Steven E., Davies, Marilyn, Delbridge, Lea M., Headrick, John P., Rosenthal, Nadia, Bogoyevitch, Marie A. and Grounds, Miranda D. (2012). Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia. Cardiovascular Pathology, 21 (1), 17-27. doi: 10.1016/j.carpath.2010.11.008

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

2011

Journal Article

Aromatase deficiency confers paradoxical postischemic cardioprotection

Bell, James R., Mellor, Kimberley M., Wollermann, Amanda C., Ip, Wendy T. K., Reichelt, Melissa E., Meachem, Sarah J., Simpson, Evan R. and Delbridge, Lea M. D. (2011). Aromatase deficiency confers paradoxical postischemic cardioprotection. Endocrinology, 152 (12), 4937-4947. doi: 10.1210/en.2011-1212

Aromatase deficiency confers paradoxical postischemic cardioprotection

2011

Journal Article

Autophagy anomalies in the diabetic myocardium

Mellor, Kimberley M., Reichelt, Melissa E. and Delbridge, Lea M. D. (2011). Autophagy anomalies in the diabetic myocardium. Autophagy, 7 (10), 1263-1267. doi: 10.4161/auto.7.10.17148

Autophagy anomalies in the diabetic myocardium

2011

Journal Article

Adenosine and its receptors in the heart: regulation, retaliation and adaptation

Headrick, John P., Peart, Jason N., Reichelt, Melissa E. and Haseler, Luke J. (2011). Adenosine and its receptors in the heart: regulation, retaliation and adaptation. Biochimica et Biophysica Acta. Biomembranes, 1808 (5), 1413-1428. doi: 10.1016/j.bbamem.2010.11.016

Adenosine and its receptors in the heart: regulation, retaliation and adaptation

2009

Journal Article

Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts

Reichelt, Melissa E., Shanu, Anu, Willems, Laura, Witting, Paul K., Ellis, Natasha A., Blackburn, Michael R. and Headrick, John P. (2009). Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts. Antioxidants and Redox Signaling, 11 (11), 2641-2650. doi: 10.1089/ars.2009.2644

Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts

2009

Journal Article

Cardiac and coronary function in the Langendorff-perfused mouse heart model

Reichelt, Melissa E., Willems, Laura, Hack, Benjamin A., Peart, Jason N. and Headrick, John P. (2009). Cardiac and coronary function in the Langendorff-perfused mouse heart model. Experimental Physiology, 94 (1), 54-70. doi: 10.1113/expphysiol.2008.043554

Cardiac and coronary function in the Langendorff-perfused mouse heart model

Funding

Current funding

  • 2023 - 2025
    Studying the basis of and developing new therapies to treat heart disease
    IPF Healthy - Medical Research
    Open grant
  • 2023 - 2025
    Protecting hearts from trastuzumab-induced cardiomyopathy
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2024
    Targeting cavin-1 via gene therapy in a model of metabolic/low-level chronic stress
    Diabetes Australia Research Program
    Open grant
  • 2020 - 2023
    Understanding how an old heart gets stiff
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Eph receptor blockade to prevent and repair endothelial damage in systemic inflammation
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    How tissues generate the peptide hormone angiotensin II
    ARC Discovery Projects
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Melissa Reichelt is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Understanding how growth factor receptors regulate heart enlargement

    Cardiac enlargement is essential for normal maturation, and adaptation to exercise. It also occurs in pathological settings such as chronic hypertension. We are interested in the role that two receptors play in this response; ErbB1 also known as the Epidermal Growth Factor Receptor (EGFR) and it’s sibling ErbB4. We use adeno-associated viruses (AAV) in animals with floxed animals to delete our receptors of interest in a time and cell subtype specific manner and examine the impact on heart enlargement.

    Multiple research projects are available for this large project which would involve some small animal work, immunohistochemistry, qPCR, western blot, isolated heart experiments (langendorff), cell culture and in vivo assessment of heat function (echocardiography) depending on student preferences.

  • Understanding the mechanisms underlying diastolic dysfunction in hearts

    The ability of the ventricle relax and expand to fill with blood in diastole is essential to normal heart function. Diastolic dysfunction, where cardiac filling is impaired, occurs in a number of clinical pathologies including heart failure with preserved ejection fraction (HFpEF) and diabetes. We recently published the first evidence that a membrane protein essential to sensing stretch, called cavin is essential to normal diastolic tone. Hearts from Cavin knockout animals are stiff and unable to detect stretch, and we were able to demonstrate that this was due to elevation of nitric oxide. We are now looking to translate this finding in animals into human heart tissues, through a collaboration with the Prince Charles Hospital. We are also intested in seeing if stiffness is also present mice lacking another membrane protein, Caveolin, and what heart cell-subtypes are the most important.

    This project could involve work at Prince Chales Hospital on fresh human heart tissue (tranbeculae that are removed as a part of some surgical procedures), or could involve isolated heart experiments in Caveolin 1 and 3 knockout mice. Both projects would also involve real time PCR of RNA isolated from tissues, western blot, immunohistochemistry and nitric oxide and nitrosylation assays.

Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng

  • Doctor Philosophy

    Understanding the role of HER2 in cardiac function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Professor Fiona Simpson

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Principal Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Principal Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    Understanding the role of mitophagy in cardiac aging and responses to pathophysiological stressors

    Principal Advisor

    Other advisors: Dr Julia Pagan

  • Doctor Philosophy

    Epidermal growth factor receptors in cardiac function and disease

    Associate Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    The role of neuregulin in cardiac function and failure

    Associate Advisor

    Other advisors: Professor Wally Thomas

Completed supervision

Media

Enquiries

For media enquiries about Dr Melissa Reichelt's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au