
Overview
Background
Dr Reichelt is a tenured teaching and research academic in The University of Queensland’s School of Biomedical Sciences. She completed her PhD in cardiovascular Physiology at Griffith University, and held postdoctoral positions at The Victor Chang Cardiac Research Institute (VCCRI) in Sydney, the University of California, San Diego (USA) and was a NHMRC Peter Doherty Postdoctoral Fellow at the University of Melbourne. Dr Reichelt is currently funded by two Australian Research Council Discovery Project Grants and lead a 2019 Major Equipment Infrastructure Grant for a preclinical ultrasound machine (Vevo 3100) which measures cardiac function in animals as small as embryos in utero.
Dr Reichelt investigated the most important receptors governing cardiac function (adenosinergic, adrenergic, angiotensin, growth factor, mineralocorticoid, SGLT2), and the influence of ageing, diabetes, hypertension, exercise, influenza and sepsis on cardiovascular physiology. This work has been published in leading cardiovascular journals including Circulation Research, Basic Research in Cardiology, Cardiovascular Research, Hypertension and broader or other specialist journals such as Autophagy, Antioxidant and Redox Signalling, Journal of Infectious Disease and Scientific Reports. Dr Reichelt’s research has most recently been augmented by in-house design and production of viruses that control the expression of receptors and their ligands. She remains fascinated by what the heart can accomplish; filling with and ejecting blood every second (or so) of every day and night, year after year, while retaining the capacity to more than treble cardiac output during exercise. It’s an incredible feat of engineering and only gets more and more interesting the more I learn about it.
Availability
- Dr Melissa Reichelt is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Griffith University
Research impacts
Dr Reichelt heads the Cardiac Disease and Therapy group, focused on optimising heart function in clinically relevant models of cardiovascular disease including chronic high blood pressure, heart ischemia (lack of flow), diabetes, ageing and cardiotoxicity associated with cancer therapy. Her research spans studies of single cell populations (cell culture), isolated heart function, and function of the intact heart. This approach is integrated with advanced techniques for gene editing to target specific cell subtypes in the heart to modify receptor expression and function. This ability to intervene in a time- and cell-subtype-specific manner with gene therapy has many applciations the heart, which are currently being pursued by the Cardiac Disease and Therapy group.
Works
Search Professor Melissa Reichelt’s works on UQ eSpace
2017
Journal Article
Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice
Bienvenu, Laura A., Morgan, James, Reichelt, Melissa E., Delbridge, Lea M. D. and Young, Morag J. (2017). Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice. Journal of Molecular and Cellular Cardiology, 112, 8-15. doi: 10.1016/j.yjmcc.2017.08.012
2017
Journal Article
Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection
Reichelt, Melissa E., O'Brien, Shannon, Thomas, Walter G. and Headrick, John P. (2017). Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection. International Journal of Biochemistry and Cell Biology, 83, 97-110. doi: 10.1016/j.biocel.2016.12.014
2016
Journal Article
Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion
Kassan, Adam, Pham, Uyen, Quynhmy Nguyen, Reichelt, Melissa E., Cho, Eunbyul, Patel, Piyush M., Roth, David M., Head, Brian P. and Patel, Hemal H. (2016). Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. American Journal of Physiology - Cell Physiology, 311 (6), C854-C865. doi: 10.1152/ajpcell.00147.2016
2016
Journal Article
Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium
Ashton, Kevin J., Reichelt, Melissa E., Mustafa, S. Jamal, Teng, Bunyen, Ledent, Catherine, Delbridge, Lea M. D., Hofmann, Polly A., Morrison, R. Ray and Headrick, John P. (2016). Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. Purinergic Signalling, 13 (1), 1-23. doi: 10.1007/s11302-016-9536-1
2015
Journal Article
Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult
Bienvenu, Laura A., Reichelt, Melissa E., Morgan, James, Fletcher, Elizabeth K., Bell, James R., Rickard, Amanda J., Delbridge, Lea M. and Young, Morag J. (2015). Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult. Hypertension, 66 (5), 970-977. doi: 10.1161/HYPERTENSIONAHA.115.05981
2015
Journal Article
Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart
Bell, James R., Raaijmakers, Antonia J. A., Curl, Claire L., Reichelt, Melissa E., Harding, TristanW., Bei, Aier, Ng, Dominic C. H., Erickson, Jeffrey R., Petroff, Martin Vila, Harrap, Stephen B. and Delbridge, Lea M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159
2014
Journal Article
RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility
Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C., Iismaa, Siiri E., Xiao, Xiao-Hui, Kesteven, Scott H., Reichelt, Melissa E., Mohl, Marion C., Smith, Nicola J., Fatkin, Diane, Allen, David, Head, Stewart I., Graham, Robert M. and Feneley, Michael P. (2014). RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility. PLoS ONE, 9 (6) e99024, e99024. doi: 10.1371/journal.pone.0099024
2014
Journal Article
Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium
Peart, Jason N., Pepe, Salvatore, Reichelt, Melissa E., Beckett, Nikkie, Hoe, Louise See, Ozberk, Victoria, Niesman, Ingrid R., Patel, Hemal H. and Headrick, John P. (2014). Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium. Experimental Gerontology, 50 (1), 72-81. doi: 10.1016/j.exger.2013.11.015
2013
Journal Article
Myocardial glycophagy - a specific glycogen handling response to metabolic stress is accentuated in the female heart
Reichelt, M. E., Mellor, K. M., Curl, C. L., Stapleton, D. and Delbridge, L. M. D. (2013). Myocardial glycophagy - a specific glycogen handling response to metabolic stress is accentuated in the female heart. Journal of Molecular and Cellular Cardiology, 65, 67-75. doi: 10.1016/j.yjmcc.2013.09.014
2013
Journal Article
Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte
Bienvenu, Laura A., Reichelt, Melissa E., Delbridge, Lea M. D. and Young, Morag J. (2013). Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte. Clinical Science, 125 (9), 409-421. doi: 10.1042/CS20130050
2013
Journal Article
Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus
Reichelt, Melissa E., Mellor, Kimberley M., Bell, James R., Chandramouli, Chanchal, Headrick, John P. and Delbridge, Lea M. D. (2013). Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus. American Journal of Physiology. Heart and Circulatory Physiology, 305 (6), H779-H792. doi: 10.1152/ajpheart.00141.2013
2013
Journal Article
The adenosine A2A receptor - myocardial protectant and coronary target in endotoxemia
Reichelt, Melissa E., Ashton, Kevin J., Tan, Xing Lin, Mustafa, S. Jamal, Ledent, Catherine, Delbridge, Lea M. D., Hofmann, Polly A., Headrick, John P. and Morrison, R. Ray (2013). The adenosine A2A receptor - myocardial protectant and coronary target in endotoxemia. International Journal of Cardiology, 166 (3), 672-680. doi: 10.1016/j.ijcard.2011.11.075
2013
Journal Article
Autophagic predisposition in the insulin resistant diabetic heart
Mellor, Kimberley M., Reichelt, Melissa E. and Delbridge, Lea M. D. (2013). Autophagic predisposition in the insulin resistant diabetic heart. Life Sciences, 92 (11), 616-620. doi: 10.1016/j.lfs.2012.03.042
2012
Journal Article
Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis
Rickard, Amanda J., Morgan, James, Bienvenu, Laura A., Fletcher, Elizabeth K., Cranston, Greg A., Shen, Jimmy Z., Reichelt, Melissa E., Delbridge, Lea M. and Young, Morag J. (2012). Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis. Hypertension, 60 (6), 1443-1450. doi: 10.1161/HYPERTENSIONAHA.112.203158
2012
Journal Article
Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia
Prele, Cecilia M., Reichelt, Melissa E., Mutsaers, Steven E., Davies, Marilyn, Delbridge, Lea M., Headrick, John P., Rosenthal, Nadia, Bogoyevitch, Marie A. and Grounds, Miranda D. (2012). Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia. Cardiovascular Pathology, 21 (1), 17-27. doi: 10.1016/j.carpath.2010.11.008
2011
Journal Article
Aromatase deficiency confers paradoxical postischemic cardioprotection
Bell, James R., Mellor, Kimberley M., Wollermann, Amanda C., Ip, Wendy T. K., Reichelt, Melissa E., Meachem, Sarah J., Simpson, Evan R. and Delbridge, Lea M. D. (2011). Aromatase deficiency confers paradoxical postischemic cardioprotection. Endocrinology, 152 (12), 4937-4947. doi: 10.1210/en.2011-1212
2011
Journal Article
Autophagy anomalies in the diabetic myocardium
Mellor, Kimberley M., Reichelt, Melissa E. and Delbridge, Lea M. D. (2011). Autophagy anomalies in the diabetic myocardium. Autophagy, 7 (10), 1263-1267. doi: 10.4161/auto.7.10.17148
2011
Journal Article
Adenosine and its receptors in the heart: regulation, retaliation and adaptation
Headrick, John P., Peart, Jason N., Reichelt, Melissa E. and Haseler, Luke J. (2011). Adenosine and its receptors in the heart: regulation, retaliation and adaptation. Biochimica et Biophysica Acta. Biomembranes, 1808 (5), 1413-1428. doi: 10.1016/j.bbamem.2010.11.016
2009
Journal Article
Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts
Reichelt, Melissa E., Shanu, Anu, Willems, Laura, Witting, Paul K., Ellis, Natasha A., Blackburn, Michael R. and Headrick, John P. (2009). Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts. Antioxidants and Redox Signaling, 11 (11), 2641-2650. doi: 10.1089/ars.2009.2644
2009
Journal Article
Cardiac and coronary function in the Langendorff-perfused mouse heart model
Reichelt, Melissa E., Willems, Laura, Hack, Benjamin A., Peart, Jason N. and Headrick, John P. (2009). Cardiac and coronary function in the Langendorff-perfused mouse heart model. Experimental Physiology, 94 (1), 54-70. doi: 10.1113/expphysiol.2008.043554
Funding
Current funding
Past funding
Supervision
Availability
- Dr Melissa Reichelt is:
- Available for supervision
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Available projects
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Understanding how growth factor receptors regulate heart enlargement
Cardiac enlargement is essential for normal maturation, and adaptation to exercise. It also occurs in pathological settings such as chronic hypertension. We are interested in the role that two receptors play in this response; ErbB1 also known as the Epidermal Growth Factor Receptor (EGFR) and it’s sibling ErbB4. We use adeno-associated viruses (AAV) in animals with floxed animals to delete our receptors of interest in a time and cell subtype specific manner and examine the impact on heart enlargement.
Multiple research projects are available for this large project which would involve some small animal work, immunohistochemistry, qPCR, western blot, isolated heart experiments (langendorff), cell culture and in vivo assessment of heat function (echocardiography) depending on student preferences.
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Understanding the mechanisms underlying diastolic dysfunction in hearts
The ability of the ventricle relax and expand to fill with blood in diastole is essential to normal heart function. Diastolic dysfunction, where cardiac filling is impaired, occurs in a number of clinical pathologies including heart failure with preserved ejection fraction (HFpEF) and diabetes. We recently published the first evidence that a membrane protein essential to sensing stretch, called cavin is essential to normal diastolic tone. Hearts from Cavin knockout animals are stiff and unable to detect stretch, and we were able to demonstrate that this was due to elevation of nitric oxide. We are now looking to translate this finding in animals into human heart tissues, through a collaboration with the Prince Charles Hospital. We are also intested in seeing if stiffness is also present mice lacking another membrane protein, Caveolin, and what heart cell-subtypes are the most important.
This project could involve work at Prince Chales Hospital on fresh human heart tissue (tranbeculae that are removed as a part of some surgical procedures), or could involve isolated heart experiments in Caveolin 1 and 3 knockout mice. Both projects would also involve real time PCR of RNA isolated from tissues, western blot, immunohistochemistry and nitric oxide and nitrosylation assays.
Supervision history
Current supervision
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Doctor Philosophy
Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.
Principal Advisor
Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng
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Doctor Philosophy
Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.
Principal Advisor
Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng
-
Doctor Philosophy
Understanding the role of HER2 in cardiac function.
Principal Advisor
Other advisors: Professor Wally Thomas, Professor Fiona Simpson
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Doctor Philosophy
Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function
Principal Advisor
Other advisors: Professor Wally Thomas
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Doctor Philosophy
Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function
Principal Advisor
Other advisors: Professor Wally Thomas
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Doctor Philosophy
Understanding the role of mitophagy in cardiac aging and responses to pathophysiological stressors
Principal Advisor
Other advisors: Dr Julia Pagan
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Doctor Philosophy
Epidermal growth factor receptors in cardiac function and disease
Associate Advisor
Other advisors: Professor Wally Thomas
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Doctor Philosophy
The role of neuregulin in cardiac function and failure
Associate Advisor
Other advisors: Professor Wally Thomas
Completed supervision
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2024
Doctor Philosophy
Understanding the role and regulation of the FBXL4-BNIP3/NIX pathway in mitophagy
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Mathew Jones, Dr Julia Pagan
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2024
Doctor Philosophy
Local regulation of cardiac pathophysiology
Associate Advisor
Other advisors: Professor Wally Thomas
Media
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