
Overview
Background
Dr Reichelt is a tenured teaching and research academic in The University of Queensland’s School of Biomedical Sciences. She completed her PhD in cardiovascular Physiology at Griffith University, and held postdoctoral positions at The Victor Chang Cardiac Research Institute (VCCRI) in Sydney, the University of California, San Diego (USA) and was a NHMRC Peter Doherty Postdoctoral Fellow at the University of Melbourne. Dr Reichelt is currently funded by two Australian Research Council Discovery Project Grants and lead a 2019 Major Equipment Infrastructure Grant for a preclinical ultrasound machine (Vevo 3100) which measures cardiac function in animals as small as embryos in utero.
Dr Reichelt investigated the most important receptors governing cardiac function (adenosinergic, adrenergic, angiotensin, growth factor, mineralocorticoid, SGLT2), and the influence of ageing, diabetes, hypertension, exercise, influenza and sepsis on cardiovascular physiology. This work has been published in leading cardiovascular journals including Circulation Research, Basic Research in Cardiology, Cardiovascular Research, Hypertension and broader or other specialist journals such as Autophagy, Antioxidant and Redox Signalling, Journal of Infectious Disease and Scientific Reports. Dr Reichelt’s research has most recently been augmented by in-house design and production of viruses that control the expression of receptors and their ligands. She remains fascinated by what the heart can accomplish; filling with and ejecting blood every second (or so) of every day and night, year after year, while retaining the capacity to more than treble cardiac output during exercise. It’s an incredible feat of engineering and only gets more and more interesting the more I learn about it.
Availability
- Dr Melissa Reichelt is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Griffith University
Research impacts
Dr Reichelt heads the Cardiac Disease and Therapy group, focused on optimising heart function in clinically relevant models of cardiovascular disease including chronic high blood pressure, heart ischemia (lack of flow), diabetes, ageing and cardiotoxicity associated with cancer therapy. Her research spans studies of single cell populations (cell culture), isolated heart function, and function of the intact heart. This approach is integrated with advanced techniques for gene editing to target specific cell subtypes in the heart to modify receptor expression and function. This ability to intervene in a time- and cell-subtype-specific manner with gene therapy has many applciations the heart, which are currently being pursued by the Cardiac Disease and Therapy group.
Works
Search Professor Melissa Reichelt’s works on UQ eSpace
2008
Journal Article
Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts
Peart, Jason N., Gross, Eric R., Reichelt, Melissa E., Hsu, Anna, Headrick, John P. and Gross, Garrett J. (2008). Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. Basic Research in Cardiology, 103 (5), 454-463. doi: 10.1007/s00395-008-0726-z
2008
Journal Article
Cardiac α1-adrenergic drive in pathological remodelling
Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E. and Graham, Robert M. (2008). Cardiac α1-adrenergic drive in pathological remodelling. Cardiovascular Research, 77 (3), 452-462. doi: 10.1093/cvr/cvm078
2007
Journal Article
Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine
Reichelt, Melissa E., Willems, Laura, Peart, Jason N., Ashton, Kevin J., Matherne, G. Paul, Blackburn, Michael R. and Headrick, John P. (2007). Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine. Experimental Physiology, 92 (1), 175-185. doi: 10.1113/expphysiol.2006.035568
2006
Journal Article
Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts
Willems, Laura, Reichelt, Melissa E., Molina, Jose G., Sun, Chun-Xiao, Chunn, Janci L., Ashton, Kevin J., Schnermann, Jurgen, Blackburn, Michael R. and Headrick, John P. (2006). Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovascular Research, 71 (1), 79-87. doi: 10.1016/j.cardiores.2006.03.006
2005
Journal Article
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance
Reichelt, ME, Willems, L, Molina, JG, Sun, CX, Noble, JC, Ashton, KJ, Schnermann, J, Blackburn, MR and Headrick, JP (2005). Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance. Circulation Research, 96 (3), 363-367. doi: 10.1161/01.RES.0000156075.00127.C3
2003
Journal Article
Vascular endothelial growth factor-B and retinal vascular development in the mouse
Reichelt, M., Shi, S. N., Hayes, M., Kay, G., Batch, J., Gole, G. A. and Browning, J. (2003). Vascular endothelial growth factor-B and retinal vascular development in the mouse. Clinical And Experimental Ophthalmology, 31 (1), 61-65. doi: 10.1046/j.1442-9071.2003.00602.x
2000
Conference Publication
Vascular changes in the proximal hyaloid in oxygen-induced retinopathy.
Browning, J, Reichelt, M, Naug, H and Gole, G (2000). Vascular changes in the proximal hyaloid in oxygen-induced retinopathy..
2000
Journal Article
Vascular change in the proximal hyaloid in oxygen induced retinopathy
Browning, J., Reichelt, M., Naug, H. L. and Gole, G. (2000). Vascular change in the proximal hyaloid in oxygen induced retinopathy. Investigative Ophthalmology and Visual Science, 41 (4), 5336.
Funding
Current funding
Past funding
Supervision
Availability
- Dr Melissa Reichelt is:
- Available for supervision
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Available projects
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Understanding how growth factor receptors regulate heart enlargement
Cardiac enlargement is essential for normal maturation, and adaptation to exercise. It also occurs in pathological settings such as chronic hypertension. We are interested in the role that two receptors play in this response; ErbB1 also known as the Epidermal Growth Factor Receptor (EGFR) and it’s sibling ErbB4. We use adeno-associated viruses (AAV) in animals with floxed animals to delete our receptors of interest in a time and cell subtype specific manner and examine the impact on heart enlargement.
Multiple research projects are available for this large project which would involve some small animal work, immunohistochemistry, qPCR, western blot, isolated heart experiments (langendorff), cell culture and in vivo assessment of heat function (echocardiography) depending on student preferences.
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Understanding the mechanisms underlying diastolic dysfunction in hearts
The ability of the ventricle relax and expand to fill with blood in diastole is essential to normal heart function. Diastolic dysfunction, where cardiac filling is impaired, occurs in a number of clinical pathologies including heart failure with preserved ejection fraction (HFpEF) and diabetes. We recently published the first evidence that a membrane protein essential to sensing stretch, called cavin is essential to normal diastolic tone. Hearts from Cavin knockout animals are stiff and unable to detect stretch, and we were able to demonstrate that this was due to elevation of nitric oxide. We are now looking to translate this finding in animals into human heart tissues, through a collaboration with the Prince Charles Hospital. We are also intested in seeing if stiffness is also present mice lacking another membrane protein, Caveolin, and what heart cell-subtypes are the most important.
This project could involve work at Prince Chales Hospital on fresh human heart tissue (tranbeculae that are removed as a part of some surgical procedures), or could involve isolated heart experiments in Caveolin 1 and 3 knockout mice. Both projects would also involve real time PCR of RNA isolated from tissues, western blot, immunohistochemistry and nitric oxide and nitrosylation assays.
Supervision history
Current supervision
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Doctor Philosophy
Understanding the role of mitophagy in cardiac aging and responses to pathophysiological stressors
Principal Advisor
Other advisors: Dr Julia Pagan
-
Doctor Philosophy
Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.
Principal Advisor
Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng
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Doctor Philosophy
Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.
Principal Advisor
Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng
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Doctor Philosophy
Understanding the role of HER2 in cardiac function.
Principal Advisor
Other advisors: Professor Wally Thomas, Professor Fiona Simpson
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Doctor Philosophy
Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function
Principal Advisor
Other advisors: Professor Wally Thomas
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Doctor Philosophy
Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function
Principal Advisor
Other advisors: Professor Wally Thomas
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Doctor Philosophy
The role of neuregulin in cardiac function and failure
Associate Advisor
Other advisors: Professor Wally Thomas
-
Doctor Philosophy
Epidermal growth factor receptors in cardiac function and disease
Associate Advisor
Other advisors: Professor Wally Thomas
Completed supervision
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2024
Doctor Philosophy
Understanding the role and regulation of the FBXL4-BNIP3/NIX pathway in mitophagy
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Mathew Jones, Dr Julia Pagan
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2024
Doctor Philosophy
Local regulation of cardiac pathophysiology
Associate Advisor
Other advisors: Professor Wally Thomas
Media
Enquiries
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