Skip to menu Skip to content Skip to footer
Dr Melissa Reichelt
Dr

Melissa Reichelt

Email: 
Phone: 
+61 7 336 52957

Overview

Background

Dr Reichelt is a tenured teaching and research academic in The University of Queensland’s School of Biomedical Sciences. She completed her PhD in cardiovascular Physiology at Griffith University, and held postdoctoral positions at The Victor Chang Cardiac Research Institute (VCCRI) in Sydney, the University of California, San Diego (USA) and was a NHMRC Peter Doherty Postdoctoral Fellow at the University of Melbourne. Dr Reichelt is currently funded by two Australian Research Council Discovery Project Grants and lead a 2019 Major Equipment Infrastructure Grant for a preclinical ultrasound machine (Vevo 3100) which measures cardiac function in animals as small as embryos in utero.

Dr Reichelt investigated the most important receptors governing cardiac function (adenosinergic, adrenergic, angiotensin, growth factor, mineralocorticoid, SGLT2), and the influence of ageing, diabetes, hypertension, exercise, influenza and sepsis on cardiovascular physiology. This work has been published in leading cardiovascular journals including Circulation Research, Basic Research in Cardiology, Cardiovascular Research, Hypertension and broader or other specialist journals such as Autophagy, Antioxidant and Redox Signalling, Journal of Infectious Disease and Scientific Reports. Dr Reichelt’s research has most recently been augmented by in-house design and production of viruses that control the expression of receptors and their ligands. She remains fascinated by what the heart can accomplish; filling with and ejecting blood every second (or so) of every day and night, year after year, while retaining the capacity to more than treble cardiac output during exercise. It’s an incredible feat of engineering and only gets more and more interesting the more I learn about it.

Availability

Dr Melissa Reichelt is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Griffith University

Research impacts

Dr Reichelt heads the Cardiac Disease and Therapy group, focused on optimising heart function in clinically relevant models of cardiovascular disease including chronic high blood pressure, heart ischemia (lack of flow), diabetes, ageing and cardiotoxicity associated with cancer therapy. Her research spans studies of single cell populations (cell culture), isolated heart function, and function of the intact heart. This approach is integrated with advanced techniques for gene editing to target specific cell subtypes in the heart to modify receptor expression and function. This ability to intervene in a time- and cell-subtype-specific manner with gene therapy has many applciations the heart, which are currently being pursued by the Cardiac Disease and Therapy group.

Works

Search Professor Melissa Reichelt’s works on UQ eSpace

48 works between 2000 and 2024

41 - 48 of 48 works

2008

Journal Article

Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts

Peart, Jason N., Gross, Eric R., Reichelt, Melissa E., Hsu, Anna, Headrick, John P. and Gross, Garrett J. (2008). Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. Basic Research in Cardiology, 103 (5), 454-463. doi: 10.1007/s00395-008-0726-z

Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts

2008

Journal Article

Cardiac α1-adrenergic drive in pathological remodelling

Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E. and Graham, Robert M. (2008). Cardiac α1-adrenergic drive in pathological remodelling. Cardiovascular Research, 77 (3), 452-462. doi: 10.1093/cvr/cvm078

Cardiac α1-adrenergic drive in pathological remodelling

2007

Journal Article

Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine

Reichelt, Melissa E., Willems, Laura, Peart, Jason N., Ashton, Kevin J., Matherne, G. Paul, Blackburn, Michael R. and Headrick, John P. (2007). Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine. Experimental Physiology, 92 (1), 175-185. doi: 10.1113/expphysiol.2006.035568

Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine

2006

Journal Article

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Willems, Laura, Reichelt, Melissa E., Molina, Jose G., Sun, Chun-Xiao, Chunn, Janci L., Ashton, Kevin J., Schnermann, Jurgen, Blackburn, Michael R. and Headrick, John P. (2006). Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovascular Research, 71 (1), 79-87. doi: 10.1016/j.cardiores.2006.03.006

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

2005

Journal Article

Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance

Reichelt, ME, Willems, L, Molina, JG, Sun, CX, Noble, JC, Ashton, KJ, Schnermann, J, Blackburn, MR and Headrick, JP (2005). Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance. Circulation Research, 96 (3), 363-367. doi: 10.1161/01.RES.0000156075.00127.C3

Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance

2003

Journal Article

Vascular endothelial growth factor-B and retinal vascular development in the mouse

Reichelt, M., Shi, S. N., Hayes, M., Kay, G., Batch, J., Gole, G. A. and Browning, J. (2003). Vascular endothelial growth factor-B and retinal vascular development in the mouse. Clinical And Experimental Ophthalmology, 31 (1), 61-65. doi: 10.1046/j.1442-9071.2003.00602.x

Vascular endothelial growth factor-B and retinal vascular development in the mouse

2000

Conference Publication

Vascular changes in the proximal hyaloid in oxygen-induced retinopathy.

Browning, J, Reichelt, M, Naug, H and Gole, G (2000). Vascular changes in the proximal hyaloid in oxygen-induced retinopathy..

Vascular changes in the proximal hyaloid in oxygen-induced retinopathy.

2000

Journal Article

Vascular change in the proximal hyaloid in oxygen induced retinopathy

Browning, J., Reichelt, M., Naug, H. L. and Gole, G. (2000). Vascular change in the proximal hyaloid in oxygen induced retinopathy. Investigative Ophthalmology and Visual Science, 41 (4), 5336.

Vascular change in the proximal hyaloid in oxygen induced retinopathy

Funding

Current funding

  • 2023 - 2025
    Studying the basis of and developing new therapies to treat heart disease
    IPF Healthy - Medical Research
    Open grant
  • 2023 - 2025
    Protecting hearts from trastuzumab-induced cardiomyopathy
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2024
    Targeting cavin-1 via gene therapy in a model of metabolic/low-level chronic stress
    Diabetes Australia Research Program
    Open grant
  • 2020 - 2023
    Understanding how an old heart gets stiff
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Eph receptor blockade to prevent and repair endothelial damage in systemic inflammation
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    How tissues generate the peptide hormone angiotensin II
    ARC Discovery Projects
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Melissa Reichelt is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Understanding how growth factor receptors regulate heart enlargement

    Cardiac enlargement is essential for normal maturation, and adaptation to exercise. It also occurs in pathological settings such as chronic hypertension. We are interested in the role that two receptors play in this response; ErbB1 also known as the Epidermal Growth Factor Receptor (EGFR) and it’s sibling ErbB4. We use adeno-associated viruses (AAV) in animals with floxed animals to delete our receptors of interest in a time and cell subtype specific manner and examine the impact on heart enlargement.

    Multiple research projects are available for this large project which would involve some small animal work, immunohistochemistry, qPCR, western blot, isolated heart experiments (langendorff), cell culture and in vivo assessment of heat function (echocardiography) depending on student preferences.

  • Understanding the mechanisms underlying diastolic dysfunction in hearts

    The ability of the ventricle relax and expand to fill with blood in diastole is essential to normal heart function. Diastolic dysfunction, where cardiac filling is impaired, occurs in a number of clinical pathologies including heart failure with preserved ejection fraction (HFpEF) and diabetes. We recently published the first evidence that a membrane protein essential to sensing stretch, called cavin is essential to normal diastolic tone. Hearts from Cavin knockout animals are stiff and unable to detect stretch, and we were able to demonstrate that this was due to elevation of nitric oxide. We are now looking to translate this finding in animals into human heart tissues, through a collaboration with the Prince Charles Hospital. We are also intested in seeing if stiffness is also present mice lacking another membrane protein, Caveolin, and what heart cell-subtypes are the most important.

    This project could involve work at Prince Chales Hospital on fresh human heart tissue (tranbeculae that are removed as a part of some surgical procedures), or could involve isolated heart experiments in Caveolin 1 and 3 knockout mice. Both projects would also involve real time PCR of RNA isolated from tissues, western blot, immunohistochemistry and nitric oxide and nitrosylation assays.

Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the role of mitophagy in cardiac aging and responses to pathophysiological stressors

    Principal Advisor

    Other advisors: Dr Julia Pagan

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Associate Professor Dominic Ng

  • Doctor Philosophy

    Understanding the role of HER2 in cardiac function.

    Principal Advisor

    Other advisors: Professor Wally Thomas, Professor Fiona Simpson

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Principal Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Principal Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    The role of neuregulin in cardiac function and failure

    Associate Advisor

    Other advisors: Professor Wally Thomas

  • Doctor Philosophy

    Epidermal growth factor receptors in cardiac function and disease

    Associate Advisor

    Other advisors: Professor Wally Thomas

Completed supervision

Media

Enquiries

For media enquiries about Dr Melissa Reichelt's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au