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Honorary Professor Katharina Ronacher
Honorary Professor

Katharina Ronacher

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+61 7 344 37633

Overview

Background

Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.

She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.

Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision
Media expert

Research interests

  • Bacterial and Viral Respiratory Infections

Research impacts

Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.

Works

Search Professor Katharina Ronacher’s works on UQ eSpace

82 works between 2004 and 2024

81 - 82 of 82 works

2005

Journal Article

Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes

Hapgood, J. P., Sadie, H., van Biljon, W. and Ronacher, K. (2005). Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. Journal of Neuroendocrinology, 17 (10), 619-638. doi: 10.1111/j.1365-2826.2005.01353.x

Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes

2004

Journal Article

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization

Ronacher, Katharina, Matsiliza, Nosisa, Nkwanyana, Nonhlanhla, Pawson, Adam J. , Adam, Tasneem, Flanagan, Colleen A. , Millar, Robert P. and Katz, Arieh A. (2004). Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization. Endocrinology, 145 (10), 4480-4488. doi: 10.1210/en.2004-0075

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2026
    Oxidised Cholesterols as Key Regulators of Host Immunity to Tuberculosis
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2024
    Oxidised cholesterols as key mediators of fibrotic lung disease (TPCH grant led by Metro North)
    Prince Charles Hospital Foundation
    Open grant
  • 2022
    Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
    Diabetes Australia Research Program
    Open grant
  • 2020
    Pre-clinical validation of a novel target for host-directed therapy for the treatment of Tuberculosis
    Australian Respiratory Council
    Open grant
  • 2017 - 2022
    Altered immune-endocrine axis during type 2 diabetes and tuberculosis risk (NIH grant administered by Stellenbosch University)
    Stellenbosch University, South Africa
    Open grant

Supervision

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Host-directed therapies for the treatment of intracellular pathogens

    Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.

    Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.

    We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au

  • Harnessing oxidised cholesterols to improve viral respiratory infection outcomes

    Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.

    To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:

    katharina.ronacher@mater.uq.edu.au

Supervision history

Current supervision

  • Doctor Philosophy

    The Role of Oxidised Cholesterols in Chronic and Infectious Diseases: Potential for Novel Therapeutic Interventions

    Principal Advisor

    Other advisors: Dr Katharine Irvine, Professor Kirsty Short

  • Doctor Philosophy

    The role of cholesterol and its derivatives in the lung during infection and inflammation

    Principal Advisor

  • Doctor Philosophy

    The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions

    Principal Advisor

    Other advisors: Dr Katharine Irvine, Professor Kirsty Short

  • Master Philosophy

    The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung

    Principal Advisor

  • Doctor Philosophy

    The role of a fatty acid receptor in the lung during respiratory infections and asthma

    Principal Advisor

    Other advisors: Professor Kirsty Short

Completed supervision

Media

Enquiries

Contact Honorary Professor Katharina Ronacher directly for media enquiries about:

  • cholesterol
  • diabetes
  • host-directed therapies
  • infectious diseases
  • metabolic diseases
  • respiratory infections
  • SARS-CoV-2
  • tuberculosis

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