
Overview
Background
Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.
She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.
Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Bacterial and Viral Respiratory Infections
Research impacts
Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.
Works
Search Professor Katharina Ronacher’s works on UQ eSpace
2005
Journal Article
Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes
Hapgood, J. P., Sadie, H., van Biljon, W. and Ronacher, K. (2005). Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. Journal of Neuroendocrinology, 17 (10), 619-638. doi: 10.1111/j.1365-2826.2005.01353.x
2004
Journal Article
Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization
Ronacher, Katharina, Matsiliza, Nosisa, Nkwanyana, Nonhlanhla, Pawson, Adam J. , Adam, Tasneem, Flanagan, Colleen A. , Millar, Robert P. and Katz, Arieh A. (2004). Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization. Endocrinology, 145 (10), 4480-4488. doi: 10.1210/en.2004-0075
Funding
Current funding
Past funding
Supervision
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
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Available projects
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Host-directed therapies for the treatment of intracellular pathogens
Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.
Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.
We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au
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Harnessing oxidised cholesterols to improve viral respiratory infection outcomes
Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.
To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:
katharina.ronacher@mater.uq.edu.au
Supervision history
Current supervision
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Doctor Philosophy
The Role of Oxidised Cholesterols in Chronic and Infectious Diseases: Potential for Novel Therapeutic Interventions
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Kirsty Short
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Doctor Philosophy
The role of cholesterol and its derivatives in the lung during infection and inflammation
Principal Advisor
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Doctor Philosophy
The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Kirsty Short
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Master Philosophy
The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung
Principal Advisor
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Doctor Philosophy
The role of a fatty acid receptor in the lung during respiratory infections and asthma
Principal Advisor
Other advisors: Professor Kirsty Short
Completed supervision
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2024
Doctor Philosophy
Characterisation of a Pathogen-Exploited and Host-Defense G Protein-Coupled Receptor During Viral Infections
Principal Advisor
Other advisors: Professor Matt Sweet, Professor Kirsty Short
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2022
Doctor Philosophy
Investigation of the Underlying Mechanisms of Diabetes-induced Susceptibility to Tuberculosis
Principal Advisor
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2022
Doctor Philosophy
The Role of Host Co-morbidities in Influenza Severity
Associate Advisor
Other advisors: Professor Kirsty Short
Media
Enquiries
Contact Honorary Professor Katharina Ronacher directly for media enquiries about:
- cholesterol
- diabetes
- host-directed therapies
- infectious diseases
- metabolic diseases
- respiratory infections
- SARS-CoV-2
- tuberculosis
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