Overview
Background
Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.
She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.
Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Bacterial and Viral Respiratory Infections
Research impacts
Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.
Works
Search Professor Katharina Ronacher’s works on UQ eSpace
2020
Journal Article
GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity
Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., Christensen, Liv von Voss, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020). GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity. Frontiers in Immunology, 11 601534, 601534. doi: 10.3389/fimmu.2020.601534
2020
Journal Article
Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa
Alisjahbana, Bachti, McAllister, Susan M, Ugarte-Gil, Cesar, Panduru, Nicolae Mircea, Ronacher, Katharina, Koesoemadinata, Raspati C, Zubiate, Carlos, Riza, Anca Lelia, Malherbe, Stephanus T, Kleynhans, Leanie, Lopez, Sonia, Dockrell, Hazel M, Ruslami, Rovina, Ioana, Mihai, Walzl, Gerhard, Pearson, Fiona, Critchley, Julia A, Moore, David A J, van Crevel, Reinout and Hill, Philip C (2020). Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115 (6), 1-10. doi: 10.1093/trstmh/traa100
2020
Journal Article
High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier
Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907
2020
Journal Article
Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis
Eckold, Clare, Kumar, Vinod, Weiner Rd, January, Alisjahbana, Bachti, Riza, Anca-Lelia, Ronacher, Katharina, Coronel, Jorge, Kerry-Barnard, Sarah, Malherbe, Stephanus T., Kleynhans, Leanie, Stanley, Kim, Ruslami, Rovina, Ioana, Mihai, Ugarte-Gil, Cesar, Walzl, Gerhard, van Crevel, Reinout, Wijmenga, Cisca, Critchley, Julia A., Dockrell, Hazel M., Cliff, Jacqueline M. and for the TANDEM consortium (2020). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, 72 (1), 69-78. doi: 10.1093/cid/ciaa751
2020
Journal Article
Glycemic variability in diabetes increases the severity of influenza
Marshall, Rebecca J., Armart, Pornthida, Hulme, Katina D., Chew, Keng Yih, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A. and Short, Kirsty R. (2020). Glycemic variability in diabetes increases the severity of influenza. mBio, 11 (2) e02841-19. doi: 10.1128/mbio.02841-19
2020
Journal Article
Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response
Malherbe, Stephanus T., Chen, Ray Y., Dupont, Patrick, Kant, Ilse, Kriel, Magdalena, Loxton, André G., Smith, Bronwyn, Beltran, Caroline G. G., van Zyl, Susan, McAnda, Shirely, Abrahams, Charmaine, Maasdorp, Elizna, Doruyter, Alex, Via, Laura E., Barry, Clifton E., Alland, David, Griffith-Richards, Stephanie , Ellman, Annare, Peppard, Thomas, Belisle, John, Tromp, Gerard, Ronacher, Katharina, Warwick, James M., Winter, Jill and Walzl, Gerhard (2020). Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response. EJNMMI Research, 10 (1) 8, 8. doi: 10.1186/s13550-020-0591-9
2020
Conference Publication
A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection
Gemiarto, Adrian T., Sinha, Roma, Sajiir, Haressh, Hailu, Semira, Bartlett, Stacey, Ngo, Minh Dao, Foo, Cheng Xiang, Kleynhans, Leanie, Tshivhula, Happy, Bielefeldt-Ohmann, Helle, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette M., Mandrup-Poulsen, T and Ronacher, Katharina (2020). A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection. Keystone Symposia: Tuberculosis Immunity and Immune Evasion, Santa Fe, New Mexico, United States, 16-21 January 2020.
2019
Journal Article
Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study
Combrink, Monique, du Preez, Ilse, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2019). Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study. OMICS: A Journal of Integrative Biology, 23 (11) omi.2019.0140, 560-572. doi: 10.1089/omi.2019.0140
2019
Journal Article
Distinct serum biosignatures are associated with different tuberculosis treatment outcomes
Ronacher, Katharina, Chegou, Novel N., Kleynhans, Léanie, Djoba Siawaya, Joel F., du Plessis, Nelita, Loxton, André G., Maasdorp, Elizna, Tromp, Gerard, Kidd, Martin, Stanley, Kim, Kriel, Magdalena, Menezes, Angela, Gutschmidt, Andrea, van der Spuy, Gian D., Warren, Robin M., Dietze, Reynaldo, Okwera, Alphonse, Thiel, Bonnie, Belisle, John T., Cliff, Jacqueline M., Boom, W. Henry, Johnson, John L., van Helden, Paul D., Dockrell, Hazel M. and Walzl, Gerhard (2019). Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis, 118 101859, 101859. doi: 10.1016/j.tube.2019.101859
2019
Journal Article
Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study
Ugarte-Gil, Cesar, Alisjahbana, Bachti, Ronacher, Katharina, Riza, Anca Lelia, Koesoemadinata, Raspati C., Malherbe, Stephanus T., Cioboata, Ramona, Llontop, Juan Carlos, Kleynhans, Leanie, Lopez, Sonia, Santoso, Prayudi, Marius, Ciontea, Villaizan, Katerine, Ruslami, Rovina, Walzl, Gerhard, Panduru, Nicolae Mircea, Dockrell, Hazel M., Hill, Philip C., Mc Allister, Susan, Pearson, Fiona, Moore, David A. J, Critchley, Julia A., van Crevel, Reinout and TANDEM Consortium (2019). Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study. Clinical Infectious Diseases, 70 (5), 780-788. doi: 10.1093/cid/ciz284
2019
Journal Article
Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries
Huangfu, P., Laurence, Y. V., Alisjahbana, B., Ugarte-Gil, C., Riza, A-L., Walzl, G., Ruslami, R., Moore, D. A. J., Ioana, M.., McAllister, S., Ronacher, K., Koesoemadinata, R. C., Grint, D., Kerry, S., Coronel, J., Malherbe, S. T., Griffiths, U., Dockrell, H. M., Hill, P. C., van Crevel, R., Pearson, F. and Critchley, J. A. (2019). Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries. International Journal of Tuberculosis and Lung Disease, 23 (3), 283-292. doi: 10.5588/ijtld.18.0359
2018
Journal Article
Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x)
Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qianting, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x). Nature, 564 (7734), E5-E5. doi: 10.1038/s41586-018-0635-8
2018
Journal Article
Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups
Restrepo, Blanca I., Kleynhans, Léanie, Salinas, Alejandra B., Abdelbary, Bassent, Tshivhula, Happy, Aguillón-Durán, Genesis P., Kunsevi-Kilola, Carine, Salinas, Gloria, Stanley, Kim, Malherbe, Stephanus T., Maasdorp, Elizna, Garcia-Viveros, Moncerrato, Louw, Ilze, Garcia-Oropesa, Esperanza M., Lopez-Alvarenga, Juan Carlos, Prins, John B., Walzl, Gerhard, Schlesinger, Larry S. and Ronacher, Katharina (2018). Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups. Tuberculosis, 113, 10-18. doi: 10.1016/j.tube.2018.08.007
2018
Journal Article
Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response
Warsinske, Hayley C., Rao, Aditya M., Moreira, Flora M. F., Cesar, Paulo, Liu, Andrew B., Scott, Madeleine, Malherbe, Stephaus T., Ronacher, Katharina, Walzl, Gerhard, Winter, Jill , Sweeney, Timothy E. , Croda, Julio , Andrews, Jason R. and Khatri, Purvesh (2018). Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response. JAMA Network Open, 1 (6), e183779. doi: 10.1001/jamanetworkopen.2018.3779
2018
Journal Article
IL-22: an underestimated player in natural resistance to tuberculosis?
Ronacher, Katharina, Sinha, Roma and Cestari, Michelle (2018). IL-22: an underestimated player in natural resistance to tuberculosis?. Frontiers in Immunology, 9 (SEP) 2209. doi: 10.3389/fimmu.2018.02209
2018
Journal Article
Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa
Grint, Daniel, Alisjhabana, Bachti, Ugarte-Gil, Cesar, Riza, Anca-Leila, Walzl, Gerhard, Pearson, Fiona, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, McAllister, Susan, Ronacher, Katharina, Koeseomadinata, Raspati C., Kerry-Barnard, Sarah R., Coronel, Jorge, Malherbe, Stephanus T., Dockrell, Hazel M., Hill, Philip C., Van Crevel, Reinout and Critchley, Julia A. (2018). Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa. Bulletin of the World Health Organization, 96 (11), 738-749. doi: 10.2471/blt.17.206227
2018
Journal Article
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qiantian, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature, 560 (7720), 644-648. doi: 10.1038/s41586-018-0439-x
2018
Journal Article
Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa
Soetedjo, Nanny N. M., McAllister, Susan M., Ugarte-Gil, Cesar, Firanescu, Adela G., Ronacher, Katharina, Alisjahbana, Bachti, Costache, Anca L., Zubiate, Carlos, Malherbe, Stephanus T., Koesoemadinata, Raspati C., Laurence, Yoko V., Pearson, Fiona, Kerry-Barnard, Sarah, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, Kleynhans, Leanie, Pernama, Hikmat, Hill, Philip C., Mota, Maria, Walzl, Gerhard, Dockrell, Hazel M., Critchley, Julia A. and van Crevel, Reinout (2018). Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa. Tropical Medicine and International Health, 23 (10), 1118-1128. doi: 10.1111/tmi.13137
2018
Journal Article
A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images
Malherbe, Stephanus T., Dupont, Patrick, Kant, Ilse, Ahlers, Petri, Kriel, Magdalena, Loxton, Andre G., Chen, Ray Y., Via, Laura E., Thienemann, Friedrich, Wilkinson, Robert J., Barry, Clifton E., Griffith-Richards, Stephanie, Ellman, Annare, Ronacher, Katharina, Winter, Jill, Walzl, Gerhard and Warwick, James M. (2018). A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images. EJNMMI Research, 8 (1) 55, 55-14. doi: 10.1186/s13550-018-0411-7
2018
Journal Article
Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile
Vrieling, Frank, Ronacher, Katharina, Kleynhans, Léanie, van den Akker, Erik, Walzl, Gerhard, Ottenhoff, Tom H. M. and Joosten, Simone A. (2018). Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32, 192-200. doi: 10.1016/j.ebiom.2018.05.011
Funding
Current funding
Past funding
Supervision
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
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Available projects
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Host-directed therapies for the treatment of intracellular pathogens
Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.
Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.
We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au
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Harnessing oxidised cholesterols to improve viral respiratory infection outcomes
Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.
To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:
katharina.ronacher@mater.uq.edu.au
Supervision history
Current supervision
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Doctor Philosophy
The role of cholesterol and its derivatives in the lung during infection and inflammation
Principal Advisor
Other advisors: Honorary Professor Vicki Clifton
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Doctor Philosophy
The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions
Principal Advisor
Other advisors: Dr Katharine Irvine, Associate Professor Kirsty Short
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Master Philosophy
The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung
Principal Advisor
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Doctor Philosophy
The role of a fatty acid receptor in the lung during respiratory infections and asthma
Principal Advisor
Other advisors: Associate Professor Kirsty Short
Completed supervision
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2024
Doctor Philosophy
Characterisation of a Pathogen-Exploited and Host-Defense G Protein-Coupled Receptor During Viral Infections
Principal Advisor
Other advisors: Professor Matt Sweet, Associate Professor Kirsty Short
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2022
Doctor Philosophy
Investigation of the Underlying Mechanisms of Diabetes-induced Susceptibility to Tuberculosis
Principal Advisor
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2022
Doctor Philosophy
The Role of Host Co-morbidities in Influenza Severity
Associate Advisor
Other advisors: Dr Linda Gallo, Associate Professor Kirsty Short
Media
Enquiries
Contact Honorary Professor Katharina Ronacher directly for media enquiries about:
- cholesterol
- diabetes
- host-directed therapies
- infectious diseases
- metabolic diseases
- respiratory infections
- SARS-CoV-2
- tuberculosis
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