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Honorary Professor Katharina Ronacher
Honorary Professor

Katharina Ronacher

Email: 
Phone: 
+61 7 344 37633

Overview

Background

Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.

She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.

Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision
Media expert

Research interests

  • Bacterial and Viral Respiratory Infections

Research impacts

Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.

Works

Search Professor Katharina Ronacher’s works on UQ eSpace

80 works between 2004 and 2024

21 - 40 of 80 works

2020

Journal Article

GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity

Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., Christensen, Liv von Voss, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020). GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity. Frontiers in Immunology, 11 601534, 601534. doi: 10.3389/fimmu.2020.601534

GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity

2020

Journal Article

Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa

Alisjahbana, Bachti, McAllister, Susan M, Ugarte-Gil, Cesar, Panduru, Nicolae Mircea, Ronacher, Katharina, Koesoemadinata, Raspati C, Zubiate, Carlos, Riza, Anca Lelia, Malherbe, Stephanus T, Kleynhans, Leanie, Lopez, Sonia, Dockrell, Hazel M, Ruslami, Rovina, Ioana, Mihai, Walzl, Gerhard, Pearson, Fiona, Critchley, Julia A, Moore, David A J, van Crevel, Reinout and Hill, Philip C (2020). Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115 (6), 1-10. doi: 10.1093/trstmh/traa100

Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa

2020

Journal Article

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

2020

Journal Article

Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis

Eckold, Clare, Kumar, Vinod, Weiner Rd, January, Alisjahbana, Bachti, Riza, Anca-Lelia, Ronacher, Katharina, Coronel, Jorge, Kerry-Barnard, Sarah, Malherbe, Stephanus T., Kleynhans, Leanie, Stanley, Kim, Ruslami, Rovina, Ioana, Mihai, Ugarte-Gil, Cesar, Walzl, Gerhard, van Crevel, Reinout, Wijmenga, Cisca, Critchley, Julia A., Dockrell, Hazel M., Cliff, Jacqueline M. and for the TANDEM consortium (2020). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, 72 (1), 69-78. doi: 10.1093/cid/ciaa751

Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis

2020

Journal Article

Glycemic variability in diabetes increases the severity of influenza

Marshall, Rebecca J., Armart, Pornthida, Hulme, Katina D., Chew, Keng Yih, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A. and Short, Kirsty R. (2020). Glycemic variability in diabetes increases the severity of influenza. mBio, 11 (2) e02841-19. doi: 10.1128/mbio.02841-19

Glycemic variability in diabetes increases the severity of influenza

2020

Journal Article

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

Malherbe, Stephanus T., Chen, Ray Y., Dupont, Patrick, Kant, Ilse, Kriel, Magdalena, Loxton, André G., Smith, Bronwyn, Beltran, Caroline G. G., van Zyl, Susan, McAnda, Shirely, Abrahams, Charmaine, Maasdorp, Elizna, Doruyter, Alex, Via, Laura E., Barry, Clifton E., Alland, David, Griffith-Richards, Stephanie , Ellman, Annare, Peppard, Thomas, Belisle, John, Tromp, Gerard, Ronacher, Katharina, Warwick, James M., Winter, Jill and Walzl, Gerhard (2020). Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response. EJNMMI Research, 10 (1) 8, 8. doi: 10.1186/s13550-020-0591-9

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

2020

Conference Publication

A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection

Gemiarto, Adrian T., Sinha, Roma, Sajiir, Haressh, Hailu, Semira, Bartlett, Stacey, Ngo, Minh Dao, Foo, Cheng Xiang, Kleynhans, Leanie, Tshivhula, Happy, Bielefeldt-Ohmann, Helle, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette M., Mandrup-Poulsen, T and Ronacher, Katharina (2020). A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection. Keystone Symposia: Tuberculosis Immunity and Immune Evasion, Santa Fe, New Mexico, United States, 16-21 January 2020.

A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection

2019

Journal Article

Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study

Combrink, Monique, du Preez, Ilse, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2019). Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study. OMICS: A Journal of Integrative Biology, 23 (11) omi.2019.0140, 560-572. doi: 10.1089/omi.2019.0140

Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study

2019

Journal Article

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

Ronacher, Katharina, Chegou, Novel N., Kleynhans, Léanie, Djoba Siawaya, Joel F., du Plessis, Nelita, Loxton, André G., Maasdorp, Elizna, Tromp, Gerard, Kidd, Martin, Stanley, Kim, Kriel, Magdalena, Menezes, Angela, Gutschmidt, Andrea, van der Spuy, Gian D., Warren, Robin M., Dietze, Reynaldo, Okwera, Alphonse, Thiel, Bonnie, Belisle, John T., Cliff, Jacqueline M., Boom, W. Henry, Johnson, John L., van Helden, Paul D., Dockrell, Hazel M. and Walzl, Gerhard (2019). Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis, 118 101859, 101859. doi: 10.1016/j.tube.2019.101859

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

2019

Journal Article

Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study

Ugarte-Gil, Cesar, Alisjahbana, Bachti, Ronacher, Katharina, Riza, Anca Lelia, Koesoemadinata, Raspati C., Malherbe, Stephanus T., Cioboata, Ramona, Llontop, Juan Carlos, Kleynhans, Leanie, Lopez, Sonia, Santoso, Prayudi, Marius, Ciontea, Villaizan, Katerine, Ruslami, Rovina, Walzl, Gerhard, Panduru, Nicolae Mircea, Dockrell, Hazel M., Hill, Philip C., Mc Allister, Susan, Pearson, Fiona, Moore, David A. J, Critchley, Julia A., van Crevel, Reinout and TANDEM Consortium (2019). Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study. Clinical Infectious Diseases, 70 (5), 780-788. doi: 10.1093/cid/ciz284

Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study

2019

Journal Article

Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries

Huangfu, P., Laurence, Y. V., Alisjahbana, B., Ugarte-Gil, C., Riza, A-L., Walzl, G., Ruslami, R., Moore, D. A. J., Ioana, M.., McAllister, S., Ronacher, K., Koesoemadinata, R. C., Grint, D., Kerry, S., Coronel, J., Malherbe, S. T., Griffiths, U., Dockrell, H. M., Hill, P. C., van Crevel, R., Pearson, F. and Critchley, J. A. (2019). Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries. International Journal of Tuberculosis and Lung Disease, 23 (3), 283-292. doi: 10.5588/ijtld.18.0359

Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries

2018

Journal Article

Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x)

Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qianting, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x). Nature, 564 (7734), E5-E5. doi: 10.1038/s41586-018-0635-8

Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x)

2018

Journal Article

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

Restrepo, Blanca I., Kleynhans, Léanie, Salinas, Alejandra B., Abdelbary, Bassent, Tshivhula, Happy, Aguillón-Durán, Genesis P., Kunsevi-Kilola, Carine, Salinas, Gloria, Stanley, Kim, Malherbe, Stephanus T., Maasdorp, Elizna, Garcia-Viveros, Moncerrato, Louw, Ilze, Garcia-Oropesa, Esperanza M., Lopez-Alvarenga, Juan Carlos, Prins, John B., Walzl, Gerhard, Schlesinger, Larry S. and Ronacher, Katharina (2018). Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups. Tuberculosis, 113, 10-18. doi: 10.1016/j.tube.2018.08.007

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

2018

Journal Article

Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response

Warsinske, Hayley C., Rao, Aditya M., Moreira, Flora M. F., Cesar, Paulo, Liu, Andrew B., Scott, Madeleine, Malherbe, Stephaus T., Ronacher, Katharina, Walzl, Gerhard, Winter, Jill , Sweeney, Timothy E. , Croda, Julio , Andrews, Jason R. and Khatri, Purvesh (2018). Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response. JAMA Network Open, 1 (6), e183779. doi: 10.1001/jamanetworkopen.2018.3779

Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response

2018

Journal Article

IL-22: an underestimated player in natural resistance to tuberculosis?

Ronacher, Katharina, Sinha, Roma and Cestari, Michelle (2018). IL-22: an underestimated player in natural resistance to tuberculosis?. Frontiers in Immunology, 9 (SEP) 2209. doi: 10.3389/fimmu.2018.02209

IL-22: an underestimated player in natural resistance to tuberculosis?

2018

Journal Article

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

Grint, Daniel, Alisjhabana, Bachti, Ugarte-Gil, Cesar, Riza, Anca-Leila, Walzl, Gerhard, Pearson, Fiona, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, McAllister, Susan, Ronacher, Katharina, Koeseomadinata, Raspati C., Kerry-Barnard, Sarah R., Coronel, Jorge, Malherbe, Stephanus T., Dockrell, Hazel M., Hill, Philip C., Van Crevel, Reinout and Critchley, Julia A. (2018). Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa. Bulletin of the World Health Organization, 96 (11), 738-749. doi: 10.2471/blt.17.206227

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

2018

Journal Article

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qiantian, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature, 560 (7720), 644-648. doi: 10.1038/s41586-018-0439-x

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

2018

Journal Article

Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa

Soetedjo, Nanny N. M., McAllister, Susan M., Ugarte-Gil, Cesar, Firanescu, Adela G., Ronacher, Katharina, Alisjahbana, Bachti, Costache, Anca L., Zubiate, Carlos, Malherbe, Stephanus T., Koesoemadinata, Raspati C., Laurence, Yoko V., Pearson, Fiona, Kerry-Barnard, Sarah, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, Kleynhans, Leanie, Pernama, Hikmat, Hill, Philip C., Mota, Maria, Walzl, Gerhard, Dockrell, Hazel M., Critchley, Julia A. and van Crevel, Reinout (2018). Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa. Tropical Medicine and International Health, 23 (10), 1118-1128. doi: 10.1111/tmi.13137

Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa

2018

Journal Article

A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images

Malherbe, Stephanus T., Dupont, Patrick, Kant, Ilse, Ahlers, Petri, Kriel, Magdalena, Loxton, Andre G., Chen, Ray Y., Via, Laura E., Thienemann, Friedrich, Wilkinson, Robert J., Barry, Clifton E., Griffith-Richards, Stephanie, Ellman, Annare, Ronacher, Katharina, Winter, Jill, Walzl, Gerhard and Warwick, James M. (2018). A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images. EJNMMI Research, 8 (1) 55, 55-14. doi: 10.1186/s13550-018-0411-7

A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images

2018

Journal Article

Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile

Vrieling, Frank, Ronacher, Katharina, Kleynhans, Léanie, van den Akker, Erik, Walzl, Gerhard, Ottenhoff, Tom H. M. and Joosten, Simone A. (2018). Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32, 192-200. doi: 10.1016/j.ebiom.2018.05.011

Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2024
    Oxidised cholesterols as key mediators of fibrotic lung disease (TPCH grant led by Metro North)
    Prince Charles Hospital Foundation
    Open grant
  • 2023 - 2026
    Oxidised Cholesterols as Key Regulators of Host Immunity to Tuberculosis
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022
    Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
    Diabetes Australia Research Program
    Open grant
  • 2020
    Pre-clinical validation of a novel target for host-directed therapy for the treatment of Tuberculosis
    Australian Respiratory Council
    Open grant
  • 2017 - 2022
    Altered immune-endocrine axis during type 2 diabetes and tuberculosis risk (NIH grant administered by Stellenbosch University)
    Stellenbosch University, South Africa
    Open grant

Supervision

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Host-directed therapies for the treatment of intracellular pathogens

    Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.

    Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.

    We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au

  • Harnessing oxidised cholesterols to improve viral respiratory infection outcomes

    Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.

    To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:

    katharina.ronacher@mater.uq.edu.au

Supervision history

Current supervision

  • Doctor Philosophy

    The role of cholesterol and its derivatives in the lung during infection and inflammation

    Principal Advisor

    Other advisors: Honorary Professor Vicki Clifton

  • Doctor Philosophy

    The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions

    Principal Advisor

    Other advisors: Dr Katharine Irvine, Associate Professor Kirsty Short

  • Master Philosophy

    The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung

    Principal Advisor

  • Doctor Philosophy

    The role of a fatty acid receptor in the lung during respiratory infections and asthma

    Principal Advisor

    Other advisors: Associate Professor Kirsty Short

Completed supervision

Media

Enquiries

Contact Honorary Professor Katharina Ronacher directly for media enquiries about:

  • cholesterol
  • diabetes
  • host-directed therapies
  • infectious diseases
  • metabolic diseases
  • respiratory infections
  • SARS-CoV-2
  • tuberculosis

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