
Overview
Background
Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.
She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.
Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Bacterial and Viral Respiratory Infections
Research impacts
Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.
Works
Search Professor Katharina Ronacher’s works on UQ eSpace
2017
Journal Article
Host blood RNA signatures predict the outcome of tuberculosis treatment
Thompson, Ethan G., Du, Ying, Malherbe, Stephanus T., Shankar, Smitha, Braun, Jackie, Valvo, Joe, Ronacher, Katharina, Tromp, Gerard, Tabb, David L. , Alland, David , Shenai, Shubhada, Via, Laura E., Warwick, James, Aderem, Alan, Scriba, Thomas J., Winter, Jill, Walzl, Gerhard, Zak, Daniel E. and Catalysis TB-Biomarker Consortium (2017). Host blood RNA signatures predict the outcome of tuberculosis treatment. Tuberculosis, 107, 45-58. doi: 10.1016/j.tube.2017.08.004
2017
Journal Article
Predicting tuberculosis treatment outcome using metabolomics
Luies, Laneke, Reenen, Mari van, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2017). Predicting tuberculosis treatment outcome using metabolomics. Biomarkers in Medicine, 11 (12), 1057-1067. doi: 10.2217/bmm-2017-0133
2017
Journal Article
Urinary metabolite markers characterising tuberculosis treatment failure
Luies, Laneke, Mienie, Japie, Motshwane, Christinah, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2017). Urinary metabolite markers characterising tuberculosis treatment failure. Metabolomics, 13 (10) 124. doi: 10.1007/s11306-017-1261-4
2017
Journal Article
Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management
Critchley, Julia A., Restrepo, Blanca I., Ronacher, Katharina, Kapur, Anil, Bremer, Andrew A., Schlesinger, Larry S., Basaraba, Randall, Kornfeld, Hardy and van Crevel, Reinout (2017). Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management. Chest, 152 (1), 165-173. doi: 10.1016/j.chest.2017.04.155
2017
Journal Article
Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: underlying biological mechanisms
Ronacher, Katharina, van Crevel, Reinout, Critchley, Julia, Bremer, Andrew A., Schlesinger, Larry S., Kapur, Anil, Basaraba, Randall, Kornfeld, Hardy and Restrepo, Blanca I. (2017). Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: underlying biological mechanisms. Chest, 152 (1), 174-180. doi: 10.1016/j.chest.2017.02.032
2017
Journal Article
Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes
Kleynhans, Leanie, Ruzive, Sheena, Ehlers, Lizaan, Thiart, Lani, Chegou, Novel N., Conradie, Magda, Kriel, Magdalena, Stanley, Kim, van der Spuy, Gian D., Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2017). Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes. Frontiers in Immunology, 8 (JUN) 690, 690. doi: 10.3389/fimmu.2017.00690
2017
Journal Article
Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
Malherbe, Stephanus T, Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G, Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y, Warwick, James, Via, Laura E, Song, Taeksun, Lee, Myungsun, Schoolnik, Gary, Tromp, Gerard, Alland, David, Barry, Clifton E, Winter, Jill, Walzl, Gerhard and Catalysis TB–Biomarker Consortium (2017). Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nature Medicine, 23 (4), 526-526. doi: 10.1038/nm0417-526a
2017
Journal Article
High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections
Mendes, Kimberly R., Malone, Marie Lynne, Ndungu, John Maina, Suponitsky-Kroyter, Irena, Cavett, Valerie J., McEnaney, Patrick J., MacConnell, Andrew B., Doran, Todd M., Ronacher, Katharina, Stanley, Kim, Utset, Ofelia, Walzl, Gerhard, Paegel, Brian M. and Kodadek, Thomas (2017). High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections. ACS Chemical Biology, 12 (1), 234-243. doi: 10.1021/acschembio.6b00855
2016
Journal Article
Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
Malherbe, Stephanus T., Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G., Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y., Warwick, James, Via, Laura E., Song, Taeksun, Lee, Myungsun, Schoolnik, Gary, Tromp, Gerard, Alland, David, Barry, Clifton E, Winter, Jill, Walzl, Gerhard, Catalysis TB–Biomarker Consortium, Lucas, L., Spuy, G.V.D., Stanley, K., Theart, L., Smith, B., Burger, N., Beltran, C.G.G., Maasdorp, E., Ellmann, A., Choi, H. ... Griffith-Richards, S. (2016). Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nature Medicine, 22 (10), 1094-1100. doi: 10.1038/nm.4177
2016
Journal Article
Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA
van Rensburg, Ilana C., Wagman, Chandre, Stanley, Kim, Beltran, Caroline, Ronacher, Katharina, Walzl, Gerhard and Loxton, Andre G. (2016). Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA. Oncotarget, 8 (2), 2037-2043. doi: 10.18632/oncotarget.12184
2016
Journal Article
Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and biological cure in pulmonary TB
Shenai, Shubhada, Ronacher, Katharina, Malherbe, Stefanus, Stanley, Kim, Kriel, Magdalena, Winter, Jill, Peppard, Thomas, Barry, Charles E., Wang, Jing, Dodd, Lori E., Via, Laura E., Barry, Clifton E. 3rd, Walzl, Gerhard and Alland, David (2016). Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and biological cure in pulmonary TB. PLoS One, 11 (8) e0160062, e0160062.1-e0160062.13. doi: 10.1371/journal.pone.0160062
2016
Journal Article
The functional response of B cells to antigenic stimulation: a preliminary report of latent tuberculosis
Du Plessis, Willem J., Kleynhans, Léanie, Du Plessis, Nelita, Stanley, Kim, Malherbe, Stephanus T., Maasdorp, Elizna, Ronacher, Katharina , Chegou, Novel N., Walzl, Gerhard and Loxton, Andre G. (2016). The functional response of B cells to antigenic stimulation: a preliminary report of latent tuberculosis. PLoS One, 11 (4) e0152710, e0152710.1-e0152710.16. doi: 10.1371/journal.pone.0152710
2016
Journal Article
Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy
Honeyborne, Isobella, McHugh, Timothy D., Kuittinen, Iitu, Cichonska, Anna, Evangelopoulos, Dimitrios, Ronacher, Katharina, van Helden, Paul D., Gillespie, Stephen H., Fernandez-Reyes, Delmiro, Walzl, Gerhard, Rousu, Juho, Butcher, Philip D. and Waddell, Simon J. (2016). Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy. BMC Medicine, 14 (1) 68, 68.1-68.13. doi: 10.1186/s12916-016-0609-3
2016
Journal Article
Excessive cytolytic responses predict tuberculosis relapse after apparently successful treatment
Cliff, Jacqueline M., Cho, Jang-Eun, Lee, Ji-Sook, Ronacher, Katharina, King, Elizabeth C., van Helden, Paul, Walzl, Gerhard and Dockrell, Hazel M. (2016). Excessive cytolytic responses predict tuberculosis relapse after apparently successful treatment. Journal of Infectious Diseases, 213 (3), 485-495. doi: 10.1093/infdis/jiv447
2015
Journal Article
Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells
Masson, Lindi, Salkinder, Amy L. , Olivier, Abraham Jacobus, Mckinnon, Lyle R. , Gamieldien, Hoyam, Mlisana, Koleka, Scriba, Thomas J. , Lewis, David A. , Little, Francesca, Jaspan, Heather B. , Ronacher, Katharina, Denny, Lynette, Abdool Karim, Salim S. and Passmore, Jo-Ann S. (2015). Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells. Immunology, 146 (4), 557-567. doi: 10.1111/imm.12527
2015
Journal Article
Genital Inflammation and the Risk of HIV Acquisition in Women
Masson L., Passmore J.-A.S., Liebenberg L.J., Werner L., Baxter C., Arnold K.B., Williamson C., Little F., Mansoor L.E., Naranbhai V., Lauffenburger D.A., Ronacher K., Walzl G., Garrett N.J., Williams B.L., Couto-Rodriguez M., Hornig M., Lipkin W.I., Grobler A., Abdool Karim Q. and Abdool Karim S.S. (2015). Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases, 61 (2), 260-269. doi: 10.1093/cid/civ298
2015
Journal Article
Clinical immunology and multiplex biomarkers of human tuberculosis
Walzl, Gerhard, Haks, Mariëlle C., Joosten, Simone A., Kleynhans, Léanie, Ronacher, Katharina and Ottenhoff, Tom H. M. (2015). Clinical immunology and multiplex biomarkers of human tuberculosis. Cold Spring Harbor Perspectives in Medicine, 5 (4) a018515. doi: 10.1101/cshperspect.a018515
2015
Journal Article
Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus
Ronacher, Katharina, Joosten, Simone A., van Crevel, Reinout, Dockrell, Hazel M., Walzl, Gerhard and Ottenhoff, Tom H. M. (2015). Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus. Immunological Reviews, 264 (1), 121-137. doi: 10.1111/imr.12257
2015
Journal Article
Host immune response to tuberculous meningitis
Visser, Douwe H., Solomons, Regan S., Ronacher, Katharina, Van Well, Gijs T., Heymans, Martijn W., Walzl, Gerhard, Chegou, Novel N., Schoeman, Johan F. and Van Furth, Anne M. (2015). Host immune response to tuberculous meningitis. Clinical Infectious Diseases, 60 (2), 177-187. doi: 10.1093/cid/ciu781
2014
Journal Article
Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study
Masson, Lindi, Mlisana, Koleka, Little, Francesca, Werner, Lise, Mkhize, Nonhlanhla N., Ronacher, Katharina, Gamieldien, Hoyam, Williamson, Carolyn, McKinnon, Lyle R., Walzl, Gerhard, Karim, Quarraisha A., Karim, Salim S.A. and Passmore, Jo-Ann S. (2014). Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study. Sexually Transmitted Infections, 90 (8), 580-587. doi: 10.1136/sextrans-2014-051601
Funding
Current funding
Past funding
Supervision
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Host-directed therapies for the treatment of intracellular pathogens
Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.
Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.
We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au
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Harnessing oxidised cholesterols to improve viral respiratory infection outcomes
Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.
To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:
katharina.ronacher@mater.uq.edu.au
Supervision history
Current supervision
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Doctor Philosophy
The role of a fatty acid receptor in the lung during respiratory infections and asthma
Principal Advisor
Other advisors: Professor Kirsty Short
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Doctor Philosophy
The Role of Oxidised Cholesterols in Chronic and Infectious Diseases: Potential for Novel Therapeutic Interventions
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Kirsty Short
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Doctor Philosophy
The role of cholesterol and its derivatives in the lung during infection and inflammation
Principal Advisor
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Master Philosophy
The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung
Principal Advisor
Completed supervision
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2024
Doctor Philosophy
Characterisation of a Pathogen-Exploited and Host-Defense G Protein-Coupled Receptor During Viral Infections
Principal Advisor
Other advisors: Professor Matt Sweet, Professor Kirsty Short
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2022
Doctor Philosophy
Investigation of the Underlying Mechanisms of Diabetes-induced Susceptibility to Tuberculosis
Principal Advisor
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2022
Doctor Philosophy
The Role of Host Co-morbidities in Influenza Severity
Associate Advisor
Other advisors: Professor Kirsty Short
Media
Enquiries
Contact Honorary Professor Katharina Ronacher directly for media enquiries about:
- cholesterol
- diabetes
- host-directed therapies
- infectious diseases
- metabolic diseases
- respiratory infections
- SARS-CoV-2
- tuberculosis
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