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Honorary Professor Katharina Ronacher
Honorary Professor

Katharina Ronacher

Email: 
Phone: 
+61 7 344 37633

Overview

Background

Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.

She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.

Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision
Media expert

Research interests

  • Bacterial and Viral Respiratory Infections

Research impacts

Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.

Works

Search Professor Katharina Ronacher’s works on UQ eSpace

79 works between 2004 and 2024

41 - 60 of 79 works

2017

Journal Article

Host blood RNA signatures predict the outcome of tuberculosis treatment

Thompson, Ethan G., Du, Ying, Malherbe, Stephanus T., Shankar, Smitha, Braun, Jackie, Valvo, Joe, Ronacher, Katharina, Tromp, Gerard, Tabb, David L. , Alland, David , Shenai, Shubhada, Via, Laura E., Warwick, James, Aderem, Alan, Scriba, Thomas J., Winter, Jill, Walzl, Gerhard, Zak, Daniel E. and Catalysis TB-Biomarker Consortium (2017). Host blood RNA signatures predict the outcome of tuberculosis treatment. Tuberculosis, 107, 45-58. doi: 10.1016/j.tube.2017.08.004

Host blood RNA signatures predict the outcome of tuberculosis treatment

2017

Journal Article

Predicting tuberculosis treatment outcome using metabolomics

Luies, Laneke, Reenen, Mari van, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2017). Predicting tuberculosis treatment outcome using metabolomics. Biomarkers in Medicine, 11 (12), 1057-1067. doi: 10.2217/bmm-2017-0133

Predicting tuberculosis treatment outcome using metabolomics

2017

Journal Article

Urinary metabolite markers characterising tuberculosis treatment failure

Luies, Laneke, Mienie, Japie, Motshwane, Christinah, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit  (2017). Urinary metabolite markers characterising tuberculosis treatment failure. Metabolomics, 13 (10) 124. doi: 10.1007/s11306-017-1261-4

Urinary metabolite markers characterising tuberculosis treatment failure

2017

Journal Article

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management

Critchley, Julia A., Restrepo, Blanca I., Ronacher, Katharina, Kapur, Anil, Bremer, Andrew A., Schlesinger, Larry S., Basaraba, Randall, Kornfeld, Hardy and van Crevel, Reinout (2017). Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management. Chest, 152 (1), 165-173. doi: 10.1016/j.chest.2017.04.155

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management

2017

Journal Article

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: underlying biological mechanisms

Ronacher, Katharina, van Crevel, Reinout, Critchley, Julia, Bremer, Andrew A., Schlesinger, Larry S., Kapur, Anil, Basaraba, Randall, Kornfeld, Hardy and Restrepo, Blanca I. (2017). Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: underlying biological mechanisms. Chest, 152 (1), 174-180. doi: 10.1016/j.chest.2017.02.032

Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: underlying biological mechanisms

2017

Journal Article

Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes

Kleynhans, Leanie, Ruzive, Sheena, Ehlers, Lizaan, Thiart, Lani, Chegou, Novel N., Conradie, Magda, Kriel, Magdalena, Stanley, Kim, van der Spuy, Gian D., Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2017). Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes. Frontiers in Immunology, 8 (JUN) 690, 690. doi: 10.3389/fimmu.2017.00690

Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes

2017

Journal Article

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Malherbe, Stephanus T, Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G, Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y, Warwick, James, Via, Laura E, Song, Taeksun, Lee, Myungsun, Schoolnik, Gary, Tromp, Gerard, Alland, David, Barry, Clifton E, Winter, Jill, Walzl, Gerhard and Catalysis TB–Biomarker Consortium (2017). Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nature Medicine, 23 (4), 526-526. doi: 10.1038/nm0417-526a

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

2017

Journal Article

High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections

Mendes, Kimberly R., Malone, Marie Lynne, Ndungu, John Maina, Suponitsky-Kroyter, Irena, Cavett, Valerie J., McEnaney, Patrick J., MacConnell, Andrew B., Doran, Todd M., Ronacher, Katharina, Stanley, Kim, Utset, Ofelia, Walzl, Gerhard, Paegel, Brian M. and Kodadek, Thomas (2017). High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections. ACS Chemical Biology, 12 (1), 234-243. doi: 10.1021/acschembio.6b00855

High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections

2016

Journal Article

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Malherbe, Stephanus T., Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G., Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y., Warwick, James, Via, Laura E., Song, Taeksun, Lee, Myungsun, Schoolnik, Gary, Tromp, Gerard, Alland, David, Barry, Clifton E, Winter, Jill, Walzl, Gerhard, Catalysis TB–Biomarker Consortium, Lucas, L., Spuy, G.V.D., Stanley, K., Theart, L., Smith, B., Burger, N., Beltran, C.G.G., Maasdorp, E., Ellmann, A., Choi, H. ... Griffith-Richards, S. (2016). Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nature Medicine, 22 (10), 1094-1100. doi: 10.1038/nm.4177

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

2016

Journal Article

Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA

van Rensburg, Ilana C., Wagman, Chandre, Stanley, Kim, Beltran, Caroline, Ronacher, Katharina, Walzl, Gerhard and Loxton, Andre G. (2016). Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA. Oncotarget, 8 (2), 2037-2043. doi: 10.18632/oncotarget.12184

Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA

2016

Journal Article

Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and biological cure in pulmonary TB

Shenai, Shubhada, Ronacher, Katharina, Malherbe, Stefanus, Stanley, Kim, Kriel, Magdalena, Winter, Jill, Peppard, Thomas, Barry, Charles E., Wang, Jing, Dodd, Lori E., Via, Laura E., Barry, Clifton E. 3rd, Walzl, Gerhard and Alland, David (2016). Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and biological cure in pulmonary TB. PLoS One, 11 (8) e0160062, e0160062.1-e0160062.13. doi: 10.1371/journal.pone.0160062

Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and biological cure in pulmonary TB

2016

Journal Article

The functional response of B cells to antigenic stimulation: a preliminary report of latent tuberculosis

Du Plessis, Willem J., Kleynhans, Léanie, Du Plessis, Nelita, Stanley, Kim, Malherbe, Stephanus T., Maasdorp, Elizna, Ronacher, Katharina , Chegou, Novel N., Walzl, Gerhard and Loxton, Andre G. (2016). The functional response of B cells to antigenic stimulation: a preliminary report of latent tuberculosis. PLoS One, 11 (4) e0152710, e0152710.1-e0152710.16. doi: 10.1371/journal.pone.0152710

The functional response of B cells to antigenic stimulation: a preliminary report of latent tuberculosis

2016

Journal Article

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Honeyborne, Isobella, McHugh, Timothy D., Kuittinen, Iitu, Cichonska, Anna, Evangelopoulos, Dimitrios, Ronacher, Katharina, van Helden, Paul D., Gillespie, Stephen H., Fernandez-Reyes, Delmiro, Walzl, Gerhard, Rousu, Juho, Butcher, Philip D. and Waddell, Simon J. (2016). Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy. BMC Medicine, 14 (1) 68, 68.1-68.13. doi: 10.1186/s12916-016-0609-3

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

2016

Journal Article

Excessive cytolytic responses predict tuberculosis relapse after apparently successful treatment

Cliff, Jacqueline M., Cho, Jang-Eun, Lee, Ji-Sook, Ronacher, Katharina, King, Elizabeth C., van Helden, Paul, Walzl, Gerhard and Dockrell, Hazel M. (2016). Excessive cytolytic responses predict tuberculosis relapse after apparently successful treatment. Journal of Infectious Diseases, 213 (3), 485-495. doi: 10.1093/infdis/jiv447

Excessive cytolytic responses predict tuberculosis relapse after apparently successful treatment

2015

Journal Article

Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells

Masson, Lindi, Salkinder, Amy L. , Olivier, Abraham Jacobus, Mckinnon, Lyle R. , Gamieldien, Hoyam, Mlisana, Koleka, Scriba, Thomas J. , Lewis, David A. , Little, Francesca, Jaspan, Heather B. , Ronacher, Katharina, Denny, Lynette, Abdool Karim, Salim S. and Passmore, Jo-Ann S. (2015). Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells. Immunology, 146 (4), 557-567. doi: 10.1111/imm.12527

Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells

2015

Journal Article

Genital Inflammation and the Risk of HIV Acquisition in Women

Masson L., Passmore J.-A.S., Liebenberg L.J., Werner L., Baxter C., Arnold K.B., Williamson C., Little F., Mansoor L.E., Naranbhai V., Lauffenburger D.A., Ronacher K., Walzl G., Garrett N.J., Williams B.L., Couto-Rodriguez M., Hornig M., Lipkin W.I., Grobler A., Abdool Karim Q. and Abdool Karim S.S. (2015). Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases, 61 (2), 260-269. doi: 10.1093/cid/civ298

Genital Inflammation and the Risk of HIV Acquisition in Women

2015

Journal Article

Clinical immunology and multiplex biomarkers of human tuberculosis

Walzl, Gerhard, Haks, Mariëlle C., Joosten, Simone A., Kleynhans, Léanie, Ronacher, Katharina and Ottenhoff, Tom H. M. (2015). Clinical immunology and multiplex biomarkers of human tuberculosis. Cold Spring Harbor Perspectives in Medicine, 5 (4) a018515. doi: 10.1101/cshperspect.a018515

Clinical immunology and multiplex biomarkers of human tuberculosis

2015

Journal Article

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus

Ronacher, Katharina, Joosten, Simone A., van Crevel, Reinout, Dockrell, Hazel M., Walzl, Gerhard and Ottenhoff, Tom H. M. (2015). Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus. Immunological Reviews, 264 (1), 121-137. doi: 10.1111/imr.12257

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus

2015

Journal Article

Host immune response to tuberculous meningitis

Visser, Douwe H., Solomons, Regan S., Ronacher, Katharina, Van Well, Gijs T., Heymans, Martijn W., Walzl, Gerhard, Chegou, Novel N., Schoeman, Johan F. and Van Furth, Anne M. (2015). Host immune response to tuberculous meningitis. Clinical Infectious Diseases, 60 (2), 177-187. doi: 10.1093/cid/ciu781

Host immune response to tuberculous meningitis

2014

Journal Article

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study

Masson, Lindi, Mlisana, Koleka, Little, Francesca, Werner, Lise, Mkhize, Nonhlanhla N., Ronacher, Katharina, Gamieldien, Hoyam, Williamson, Carolyn, McKinnon, Lyle R., Walzl, Gerhard, Karim, Quarraisha A., Karim, Salim S.A. and Passmore, Jo-Ann S. (2014). Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study. Sexually Transmitted Infections, 90 (8), 580-587. doi: 10.1136/sextrans-2014-051601

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study

Funding

Current funding

  • 2023 - 2026
    Oxidised Cholesterols as Key Regulators of Host Immunity to Tuberculosis
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2024
    Oxidised cholesterols as key mediators of fibrotic lung disease (TPCH grant led by Metro North)
    Prince Charles Hospital Foundation
    Open grant
  • 2022
    Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
    Diabetes Australia Research Program
    Open grant
  • 2020
    Pre-clinical validation of a novel target for host-directed therapy for the treatment of Tuberculosis
    Australian Respiratory Council
    Open grant
  • 2017 - 2022
    Altered immune-endocrine axis during type 2 diabetes and tuberculosis risk (NIH grant administered by Stellenbosch University)
    Stellenbosch University, South Africa
    Open grant

Supervision

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision

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Available projects

  • Host-directed therapies for the treatment of intracellular pathogens

    Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.

    Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.

    We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au

  • Harnessing oxidised cholesterols to improve viral respiratory infection outcomes

    Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.

    To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:

    katharina.ronacher@mater.uq.edu.au

Supervision history

Current supervision

  • Doctor Philosophy

    The role of a fatty acid receptor in the lung during respiratory infections and asthma

    Principal Advisor

    Other advisors: Professor Kirsty Short

  • Doctor Philosophy

    The Role of Oxidised Cholesterols in Chronic and Infectious Diseases: Potential for Novel Therapeutic Interventions

    Principal Advisor

    Other advisors: Dr Katharine Irvine, Professor Kirsty Short

  • Doctor Philosophy

    The role of cholesterol and its derivatives in the lung during infection and inflammation

    Principal Advisor

  • Master Philosophy

    The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung

    Principal Advisor

Completed supervision

Media

Enquiries

Contact Honorary Professor Katharina Ronacher directly for media enquiries about:

  • cholesterol
  • diabetes
  • host-directed therapies
  • infectious diseases
  • metabolic diseases
  • respiratory infections
  • SARS-CoV-2
  • tuberculosis

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au