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Honorary Professor Katharina Ronacher
Honorary Professor

Katharina Ronacher

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Phone: 
+61 7 344 37633

Overview

Background

Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.

She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.

Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision
Media expert

Research interests

  • Bacterial and Viral Respiratory Infections

Research impacts

Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.

Works

Search Professor Katharina Ronacher’s works on UQ eSpace

80 works between 2004 and 2024

61 - 80 of 80 works

2014

Journal Article

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study

Masson, Lindi, Mlisana, Koleka, Little, Francesca, Werner, Lise, Mkhize, Nonhlanhla N., Ronacher, Katharina, Gamieldien, Hoyam, Williamson, Carolyn, McKinnon, Lyle R., Walzl, Gerhard, Karim, Quarraisha A., Karim, Salim S.A. and Passmore, Jo-Ann S. (2014). Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study. Sexually Transmitted Infections, 90 (8), 580-587. doi: 10.1136/sextrans-2014-051601

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study

2014

Journal Article

TANDEM: understanding diabetes and tuberculosis

van Crevel, Reinout, Dockrell, Hazel M., TANDEM Consortium and Ronacher, Katharina (2014). TANDEM: understanding diabetes and tuberculosis. Lancet Diabetes & Endocrinology, 2 (4), 270-272. doi: 10.1016/S2213-8587(14)70011-7

TANDEM: understanding diabetes and tuberculosis

2014

Journal Article

Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation

Olivier, Abraham J., Masson, Linda, Ronacher, Katharina, Walzl, Gerhard, Coetzee, David, Lewis, David A., Williamson, Anna-Lise., Passmore, Jo-Ann S. and Burgers, Wendy A. (2014). Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation. Journal of Infectious Diseases, 209 (8), 1174-1184. doi: 10.1093/infdis/jit649

Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation

2013

Journal Article

Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the geneXpert MTB/RIF assay

Shenai, Shubhada, Amisano, Danielle, Ronacher, Katharina, Kriel, Magdalena, Banada, Padmapriya P., Song, Taeksun, Lee, Myungsun, Joh, Joon Sung, Winter, Jill, Thayer, Rich, Via, Laura E., Kim, Soyeon, Barry III, Clifton E., Walzl, Gerhard and Alland, David (2013). Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the geneXpert MTB/RIF assay. Journal of Clinical Microbiology, 51 (12), 4161-4166. doi: 10.1128/JCM.01743-13

Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the geneXpert MTB/RIF assay

2013

Journal Article

The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis

Kleynhans, Leanie, Du Plessis, Nelita, Allie, Nasiema, Jacobs, Muazzam, Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2013). The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis. Infection and Immunity, 81 (4), 1234-1244. doi: 10.1128/IAI.01189-12

The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis

2013

Journal Article

Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response

Cliff, Jacqueline M., Lee, Ji-Sook, Constantinou, Nicholas, Cho, Jang-Eun, Clark, Taane G., Ronacher, Katharina, King, Elizabeth C., Lukey, Pauline T., Duncan, Ken, Van Helden, Paul D., Walzl, Gerhard and Dockrell, Hazel M. (2013). Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. Journal of Infectious Diseases, 207 (1), 18-29. doi: 10.1093/infdis/jis499

Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response

2012

Journal Article

Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa

Mlisana, Koleka, Naicker, Nivashnee, Werner, Lise, Roberts, Lindi, Van Loggerenberg, Francois, Baxter, Cheryl, Passmore, Jo-Ann S., Grobler, Anneke C., Sturm, A.Willem, Williamson, Carolyn, Ronacher, Katharina, Walzl, Gerhard and Abdool Karim, Salim S. (2012). Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa. Journal of Infectious Diseases, 206 (1), 6-14. doi: 10.1093/infdis/jis298

Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa

2012

Journal Article

Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis

Riou, Catherine, Perez Peixoto, Blas, Roberts, Lindi, Ronacher, Katharina, Walzl, Gerhard, Manca, Claudia, Rustomjee, Roxana, Mthiyane, Thuli, Fallows, Dorothy, Gray, Clive M. and Kaplan, Gilla (2012). Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis. PLoS One, 7 (5) e36886, 123-137. doi: 10.1371/journal.pone.0036886

Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis

2011

Journal Article

Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment

Honeyborne, Isobella, McHugh, Timothy D., Phillips, Patrick P.J., Bannoo, Selina, Bateson, Anna, Carroll, Nora, Perrin, Felicity M., Ronacher, Katharina, Wright, Laura, Van Helden, Paul D., Walzl, Gerhard and Gillespie, Stephen H. (2011). Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment. Journal of Clinical Microbiology, 49 (11), 3905-3911. doi: 10.1128/JCM.00547-11

Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment

2011

Journal Article

Medroxyprogesterone acetate alters mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users

Kleynhans, Le´anie, du Plessis, Nelita, Black, Gillian F., Loxton, Andre G., Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2011). Medroxyprogesterone acetate alters mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users. Plos One, 6 (9) e24639, e24639. doi: 10.1371/journal.pone.0024639

Medroxyprogesterone acetate alters mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users

2011

Journal Article

Immunological biomarkers of tuberculosis

Walzl, Gerhard, Ronacher, Katharina, Hanekom, Willem, Scriba, Thomas J. and Zumla, Alimuddin (2011). Immunological biomarkers of tuberculosis. Nature Reviews Immunology, 11 (5), 343-354. doi: 10.1038/nri2960

Immunological biomarkers of tuberculosis

2011

Book Chapter

Cytokines in pulmonary tuberculosis

Ronacher, Katharina, Djoba-Siawaya, Joel Fleury and Walzl, Gerhard (2011). Cytokines in pulmonary tuberculosis. Cytokines. (pp. 123-137) edited by Victor R. Preedy and Ross Hunter. Boca Raton, Florida, United States: CRC Press.

Cytokines in pulmonary tuberculosis

2010

Journal Article

Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity

Avenant, Chanel, Ronacher, Katharina, Stubsrud, Elisabeth, Louw, Ann and Hapgood, Janet P. (2010). Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity. Molecular and Cellular Endocrinology, 327 (1-2), 72-88. doi: 10.1016/j.mce.2010.06.007

Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity

2009

Journal Article

Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction

Ronacher, Katharina, Hadley, Katie, Avenant, Chanel, Stubsrud, Elisabeth, Simons Jr., S. Stoney, Louw, Ann and Hapgood, Janet P. (2009). Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction. Molecular and Cellular Endocrinology, 299 (2), 219-231. doi: 10.1016/j.mce.2008.10.008

Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction

2008

Journal Article

Biomarkers for TB treatment response: Challenges and future strategies

Walzl, Gerhard, Ronacher, Katharina , Djoba Siawaya, Joel Fleury and Dockrell, Hazel M. (2008). Biomarkers for TB treatment response: Challenges and future strategies. Journal of Infection, 57 (2), 103-109. doi: 10.1016/j.jinf.2008.06.007

Biomarkers for TB treatment response: Challenges and future strategies

2008

Journal Article

Differential expression of interleukin-4 (IL-4) and IL-4δ2 mRNA, but not transforming growth factor beta (TGF-β), TGF-βRII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis treatment

Siawaya, Joel Fleury Djoba, Bapela, Nchinya Bennedict, Ronacher, Katharina, Beyers, Nulda, Van Helden, Paul and Walzl, Gerhard (2008). Differential expression of interleukin-4 (IL-4) and IL-4δ2 mRNA, but not transforming growth factor beta (TGF-β), TGF-βRII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis treatment. Clinical and Vaccine Immunology, 15 (8), 1165-1170. doi: 10.1128/CVI.00084-08

Differential expression of interleukin-4 (IL-4) and IL-4δ2 mRNA, but not transforming growth factor beta (TGF-β), TGF-βRII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis treatment

2008

Journal Article

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

Djoba Siawaya, Joel Fleury, Bapela, Nchinya Bennedict, Ronacher, Katharina, Veenstra, Hanne, Kidd, Martin, Gie, Robert, Beyers, Nulda, van Helden, Paul and Walzl, Gerhard (2008). Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. Journal of Infection, 56 (5), 340-347. doi: 10.1016/j.jinf.2008.02.007

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

2005

Journal Article

Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes

Hapgood, J. P., Sadie, H., van Biljon, W. and Ronacher, K. (2005). Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. Journal of Neuroendocrinology, 17 (10), 619-638. doi: 10.1111/j.1365-2826.2005.01353.x

Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes

2005

Journal Article

Synthetic progestins used in HRT have different glucocorticoid agonist properties

Koubovec, Dominique, Ronacher, Katharina, Stubsrud, Elisabeth, Louw, Ann and Hapgood, Janet P. (2005). Synthetic progestins used in HRT have different glucocorticoid agonist properties. Molecular and Cellular Endocrinology, 242 (1-2), 23-32. doi: 10.1016/j.mce.2005.07.001

Synthetic progestins used in HRT have different glucocorticoid agonist properties

2004

Journal Article

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization

Ronacher, Katharina, Matsiliza, Nosisa, Nkwanyana, Nonhlanhla, Pawson, Adam J. , Adam, Tasneem, Flanagan, Colleen A. , Millar, Robert P. and Katz, Arieh A. (2004). Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization. Endocrinology, 145 (10), 4480-4488. doi: 10.1210/en.2004-0075

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2024
    Oxidised cholesterols as key mediators of fibrotic lung disease (TPCH grant led by Metro North)
    Prince Charles Hospital Foundation
    Open grant
  • 2023 - 2026
    Oxidised Cholesterols as Key Regulators of Host Immunity to Tuberculosis
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022
    Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
    Diabetes Australia Research Program
    Open grant
  • 2020
    Pre-clinical validation of a novel target for host-directed therapy for the treatment of Tuberculosis
    Australian Respiratory Council
    Open grant
  • 2017 - 2022
    Altered immune-endocrine axis during type 2 diabetes and tuberculosis risk (NIH grant administered by Stellenbosch University)
    Stellenbosch University, South Africa
    Open grant

Supervision

Availability

Honorary Professor Katharina Ronacher is:
Available for supervision

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Available projects

  • Host-directed therapies for the treatment of intracellular pathogens

    Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.

    Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.

    We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au

  • Harnessing oxidised cholesterols to improve viral respiratory infection outcomes

    Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.

    To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:

    katharina.ronacher@mater.uq.edu.au

Supervision history

Current supervision

  • Doctor Philosophy

    The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions

    Principal Advisor

    Other advisors: Dr Katharine Irvine, Associate Professor Kirsty Short

  • Master Philosophy

    The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung

    Principal Advisor

  • Doctor Philosophy

    The role of a fatty acid receptor in the lung during respiratory infections and asthma

    Principal Advisor

    Other advisors: Associate Professor Kirsty Short

  • Doctor Philosophy

    The role of cholesterol and its derivatives in the lung during infection and inflammation

    Principal Advisor

    Other advisors: Honorary Professor Vicki Clifton

Completed supervision

Media

Enquiries

Contact Honorary Professor Katharina Ronacher directly for media enquiries about:

  • cholesterol
  • diabetes
  • host-directed therapies
  • infectious diseases
  • metabolic diseases
  • respiratory infections
  • SARS-CoV-2
  • tuberculosis

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