Overview
Background
Prof Katharina Ronacher obtained an MSc degree in Medical Biochemistry from the University of Vienna (Austria). Thereafter, she was awarded a prestigious fellowship from the Austrian Ministry of Science and Technology to complete a PhD at the University of Cape Town (South Africa). She completed her post-doctoral fellowship at Stellenbosch University, where she was subsequently offered a faculty position. Prof Ronacher was Senior Scientist on several large clinical research trials funded by the Bill and Melinda Gates Foundation, the European Union and the US National Institutes of Health with focus on identification of biomarkers for tuberculosis (TB) treatment response. In parallel, she established her independent research group investigating how endocrine factors impact immune responses to TB, for which she received uninterrupted funding from national and international funding bodies since 2008. In 2015, she was awarded a NIH R01 grant for her ground-breaking research into the underlying immunological and metabolic mechanisms of increased susceptibility of diabetes patients to TB. With this grant she has lead the international ALERT Consortium with clinical field sites in South Africa and at the Texas/Mexico border.
She relocated to Brisbane in 2017, where she now heads the Infection, Immunity and Metabolism group at the Mater Research Institute – University of Queensland, but continues to collaborate with clinicians and researchers in South Africa, the USA and Europe and holds an affiliate appointment as Professor Extraordinary at Stellenbosch University.
Prof Ronacher's current research investigates the underlying immunological mechanisms contributing to more severe bacterial and viral respiratory infections in obesity and diabetes. Her research provides critical insights into the role of cholesterol and its derivatives in regulation of inflammation in the lung and how this knowledge can be exploided for novel therapeutic approaches to treat respiratory infections.
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Bacterial and Viral Respiratory Infections
Research impacts
Prof Ronacher has published in high-ranking journals including Nature, Nature Medicine, JAMA and Clinical and Infectious Diseases. Two of her articles have been cited by WHO policy documents, highlighting the impact of her research on clinical practice, and nine publications have been cited by 17 patent applications.
Works
Search Professor Katharina Ronacher’s works on UQ eSpace
2014
Journal Article
Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study
Masson, Lindi, Mlisana, Koleka, Little, Francesca, Werner, Lise, Mkhize, Nonhlanhla N., Ronacher, Katharina, Gamieldien, Hoyam, Williamson, Carolyn, McKinnon, Lyle R., Walzl, Gerhard, Karim, Quarraisha A., Karim, Salim S.A. and Passmore, Jo-Ann S. (2014). Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study. Sexually Transmitted Infections, 90 (8), 580-587. doi: 10.1136/sextrans-2014-051601
2014
Journal Article
TANDEM: understanding diabetes and tuberculosis
van Crevel, Reinout, Dockrell, Hazel M., TANDEM Consortium and Ronacher, Katharina (2014). TANDEM: understanding diabetes and tuberculosis. Lancet Diabetes & Endocrinology, 2 (4), 270-272. doi: 10.1016/S2213-8587(14)70011-7
2014
Journal Article
Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation
Olivier, Abraham J., Masson, Linda, Ronacher, Katharina, Walzl, Gerhard, Coetzee, David, Lewis, David A., Williamson, Anna-Lise., Passmore, Jo-Ann S. and Burgers, Wendy A. (2014). Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation. Journal of Infectious Diseases, 209 (8), 1174-1184. doi: 10.1093/infdis/jit649
2013
Journal Article
Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the geneXpert MTB/RIF assay
Shenai, Shubhada, Amisano, Danielle, Ronacher, Katharina, Kriel, Magdalena, Banada, Padmapriya P., Song, Taeksun, Lee, Myungsun, Joh, Joon Sung, Winter, Jill, Thayer, Rich, Via, Laura E., Kim, Soyeon, Barry III, Clifton E., Walzl, Gerhard and Alland, David (2013). Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the geneXpert MTB/RIF assay. Journal of Clinical Microbiology, 51 (12), 4161-4166. doi: 10.1128/JCM.01743-13
2013
Journal Article
The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis
Kleynhans, Leanie, Du Plessis, Nelita, Allie, Nasiema, Jacobs, Muazzam, Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2013). The contraceptive depot medroxyprogesterone acetate impairs mycobacterial control and inhibits cytokine secretion in mice infected with Mycobacterium tuberculosis. Infection and Immunity, 81 (4), 1234-1244. doi: 10.1128/IAI.01189-12
2013
Journal Article
Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response
Cliff, Jacqueline M., Lee, Ji-Sook, Constantinou, Nicholas, Cho, Jang-Eun, Clark, Taane G., Ronacher, Katharina, King, Elizabeth C., Lukey, Pauline T., Duncan, Ken, Van Helden, Paul D., Walzl, Gerhard and Dockrell, Hazel M. (2013). Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. Journal of Infectious Diseases, 207 (1), 18-29. doi: 10.1093/infdis/jis499
2012
Journal Article
Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa
Mlisana, Koleka, Naicker, Nivashnee, Werner, Lise, Roberts, Lindi, Van Loggerenberg, Francois, Baxter, Cheryl, Passmore, Jo-Ann S., Grobler, Anneke C., Sturm, A.Willem, Williamson, Carolyn, Ronacher, Katharina, Walzl, Gerhard and Abdool Karim, Salim S. (2012). Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa. Journal of Infectious Diseases, 206 (1), 6-14. doi: 10.1093/infdis/jis298
2012
Journal Article
Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis
Riou, Catherine, Perez Peixoto, Blas, Roberts, Lindi, Ronacher, Katharina, Walzl, Gerhard, Manca, Claudia, Rustomjee, Roxana, Mthiyane, Thuli, Fallows, Dorothy, Gray, Clive M. and Kaplan, Gilla (2012). Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis. PLoS One, 7 (5) e36886, 123-137. doi: 10.1371/journal.pone.0036886
2011
Journal Article
Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment
Honeyborne, Isobella, McHugh, Timothy D., Phillips, Patrick P.J., Bannoo, Selina, Bateson, Anna, Carroll, Nora, Perrin, Felicity M., Ronacher, Katharina, Wright, Laura, Van Helden, Paul D., Walzl, Gerhard and Gillespie, Stephen H. (2011). Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment. Journal of Clinical Microbiology, 49 (11), 3905-3911. doi: 10.1128/JCM.00547-11
2011
Journal Article
Medroxyprogesterone acetate alters mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users
Kleynhans, Le´anie, du Plessis, Nelita, Black, Gillian F., Loxton, Andre G., Kidd, Martin, van Helden, Paul D., Walzl, Gerhard and Ronacher, Katharina (2011). Medroxyprogesterone acetate alters mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users. Plos One, 6 (9) e24639, e24639. doi: 10.1371/journal.pone.0024639
2011
Journal Article
Immunological biomarkers of tuberculosis
Walzl, Gerhard, Ronacher, Katharina, Hanekom, Willem, Scriba, Thomas J. and Zumla, Alimuddin (2011). Immunological biomarkers of tuberculosis. Nature Reviews Immunology, 11 (5), 343-354. doi: 10.1038/nri2960
2011
Book Chapter
Cytokines in pulmonary tuberculosis
Ronacher, Katharina, Djoba-Siawaya, Joel Fleury and Walzl, Gerhard (2011). Cytokines in pulmonary tuberculosis. Cytokines. (pp. 123-137) edited by Victor R. Preedy and Ross Hunter. Boca Raton, Florida, United States: CRC Press.
2010
Journal Article
Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity
Avenant, Chanel, Ronacher, Katharina, Stubsrud, Elisabeth, Louw, Ann and Hapgood, Janet P. (2010). Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity. Molecular and Cellular Endocrinology, 327 (1-2), 72-88. doi: 10.1016/j.mce.2010.06.007
2009
Journal Article
Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction
Ronacher, Katharina, Hadley, Katie, Avenant, Chanel, Stubsrud, Elisabeth, Simons Jr., S. Stoney, Louw, Ann and Hapgood, Janet P. (2009). Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction. Molecular and Cellular Endocrinology, 299 (2), 219-231. doi: 10.1016/j.mce.2008.10.008
2008
Journal Article
Biomarkers for TB treatment response: Challenges and future strategies
Walzl, Gerhard, Ronacher, Katharina , Djoba Siawaya, Joel Fleury and Dockrell, Hazel M. (2008). Biomarkers for TB treatment response: Challenges and future strategies. Journal of Infection, 57 (2), 103-109. doi: 10.1016/j.jinf.2008.06.007
2008
Journal Article
Differential expression of interleukin-4 (IL-4) and IL-4δ2 mRNA, but not transforming growth factor beta (TGF-β), TGF-βRII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis treatment
Siawaya, Joel Fleury Djoba, Bapela, Nchinya Bennedict, Ronacher, Katharina, Beyers, Nulda, Van Helden, Paul and Walzl, Gerhard (2008). Differential expression of interleukin-4 (IL-4) and IL-4δ2 mRNA, but not transforming growth factor beta (TGF-β), TGF-βRII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis treatment. Clinical and Vaccine Immunology, 15 (8), 1165-1170. doi: 10.1128/CVI.00084-08
2008
Journal Article
Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response
Djoba Siawaya, Joel Fleury, Bapela, Nchinya Bennedict, Ronacher, Katharina, Veenstra, Hanne, Kidd, Martin, Gie, Robert, Beyers, Nulda, van Helden, Paul and Walzl, Gerhard (2008). Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. Journal of Infection, 56 (5), 340-347. doi: 10.1016/j.jinf.2008.02.007
2005
Journal Article
Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes
Hapgood, J. P., Sadie, H., van Biljon, W. and Ronacher, K. (2005). Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. Journal of Neuroendocrinology, 17 (10), 619-638. doi: 10.1111/j.1365-2826.2005.01353.x
2005
Journal Article
Synthetic progestins used in HRT have different glucocorticoid agonist properties
Koubovec, Dominique, Ronacher, Katharina, Stubsrud, Elisabeth, Louw, Ann and Hapgood, Janet P. (2005). Synthetic progestins used in HRT have different glucocorticoid agonist properties. Molecular and Cellular Endocrinology, 242 (1-2), 23-32. doi: 10.1016/j.mce.2005.07.001
2004
Journal Article
Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization
Ronacher, Katharina, Matsiliza, Nosisa, Nkwanyana, Nonhlanhla, Pawson, Adam J. , Adam, Tasneem, Flanagan, Colleen A. , Millar, Robert P. and Katz, Arieh A. (2004). Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for β-arrestin- independent internalization. Endocrinology, 145 (10), 4480-4488. doi: 10.1210/en.2004-0075
Funding
Current funding
Past funding
Supervision
Availability
- Honorary Professor Katharina Ronacher is:
- Available for supervision
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Available projects
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Host-directed therapies for the treatment of intracellular pathogens
Intracellular pathogens are difficutl to eradicate as they hide within host cells to evade the host's immune system. One of these pathogens is Mycobacterium tuberculosis.
Despite effective anti-biotic therapy the majority of "cured" tuberculosis patients continue to have active lung lesions containing live mycobacteria beyond treatment completion. For this reason we have been unable to eradicate this ancient disease, which has been with human kind for over 9000 years. Sub-optimal, non-sterilizing treatment combined with the concurrent rise in antibiotic resistance thus necessitates innovative treatment strategies.
We have identified several promising host-targets and have PhD positions available on this topic in our laboratory. To find out more please contact the Head of the Infection, Immunity and Metabolism Group Katharina Ronacher email: katharina.ronacher@mater.uq.edu.au
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Harnessing oxidised cholesterols to improve viral respiratory infection outcomes
Our laboratory recently identified a role for oxidised cholesterols in the lung during viral respiratory infections. This project investigates the role oxysterols play in the lung during influenza and COVID-19 and how this knowledge can be exploited to improve viral respiratory infection outcomes.
To find out more, please contact the Head of the Infection, Immunity and Metabolism Group A/Prof Katharina Ronacher email:
katharina.ronacher@mater.uq.edu.au
Supervision history
Current supervision
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Doctor Philosophy
The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions
Principal Advisor
Other advisors: Dr Katharine Irvine, Associate Professor Kirsty Short
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Master Philosophy
The interplay of immune and metabolic signals in regulation of early innate immune responses in the lung
Principal Advisor
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Doctor Philosophy
The role of a fatty acid receptor in the lung during respiratory infections and asthma
Principal Advisor
Other advisors: Associate Professor Kirsty Short
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Doctor Philosophy
The role of cholesterol and its derivatives in the lung during infection and inflammation
Principal Advisor
Other advisors: Honorary Professor Vicki Clifton
Completed supervision
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2024
Doctor Philosophy
Characterisation of a Pathogen-Exploited and Host-Defense G Protein-Coupled Receptor During Viral Infections
Principal Advisor
Other advisors: Professor Matt Sweet, Associate Professor Kirsty Short
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2022
Doctor Philosophy
Investigation of the Underlying Mechanisms of Diabetes-induced Susceptibility to Tuberculosis
Principal Advisor
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2022
Doctor Philosophy
The Role of Host Co-morbidities in Influenza Severity
Associate Advisor
Other advisors: Dr Linda Gallo, Associate Professor Kirsty Short
Media
Enquiries
Contact Honorary Professor Katharina Ronacher directly for media enquiries about:
- cholesterol
- diabetes
- host-directed therapies
- infectious diseases
- metabolic diseases
- respiratory infections
- SARS-CoV-2
- tuberculosis
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