Overview
Background
Dr Peta Harvey was appointed to the Institute of Molecular Bioscience NMR Facility in January 2009. Dr Harvey is an instrumental specialist with more than 25 years of experience in the use of NMR techniques as well as the operation, systems management, training and supervision of spectrometer usage. Having applied multinuclear NMR methods during her PhD studies in mechanistic organic chemistry, she has diversified her interests from liver dysfunction and altered drug metabolism in the cirrhotic and aged liver (Canberra Clinical School of University of Sydney) to structural studies of muscle related proteins (Australian National University). More recently whilst at IMB, her particular expertise has extended to the structural and functional characterization of peptides and small proteins with complex cross-linked topologies and the use of such bioactive peptides in drug design.
Availability
- Dr Peta Harvey is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Applied Science, Queensland University of Technology
- Bachelor of Science, Griffith University
- Doctor of Philosophy, Griffith University
Works
Search Professor Peta Harvey’s works on UQ eSpace
2024
Journal Article
Discovery of Five Classes of Bacterial Defensins: Ancestral Precursors of Defensins from Eukarya?
Cardoso, Marlon H., de Lima, Lucas R., Pires, Allan S., Maximiano, Mariana R., Harvey, Peta J., Freitas, Camila G., Costa, Rosiane A., Fensterseifer, Isabel C. M., Rigueiras, Pietra O., Migliolo, Ludovico, Porto, William F., Craik, David J. and Franco, Octávio L. (2024). Discovery of Five Classes of Bacterial Defensins: Ancestral Precursors of Defensins from Eukarya?. ACS Omega. doi: 10.1021/acsomega.4c06956
2024
Journal Article
Recombinant production of the cyclotide kalata B1 by conditional split inteins
Craik, David J, Yayci, Abdulkadir, Huang, Yen-Hua and Harvey, Peta J (2024). Recombinant production of the cyclotide kalata B1 by conditional split inteins. ChemBioChem. doi: 10.1002/cbic.202400591
2024
Journal Article
Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptor
Luo, An, He, Jie, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Kasheverov, Igor E., Kudryavtsev, Denis S., McIntosh, J. Michael, Tsetlin, Victor I., Craik, David J., Zhangsun, Dongting and Luo, Sulan (2024). Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptor. International Journal of Biological Macromolecules, 271 (Part 1) 132472. doi: 10.1016/j.ijbiomac.2024.132472
2024
Journal Article
Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors
Hone, Arik J., Santiago, Ulises, Harvey, Peta J., Tekarli, Bassel, Gajewiak, Joanna, Craik, David J., Camacho, Carlos J. and McIntosh, J. Michael (2024). Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry, 67 (11), 9587-9598. doi: 10.1021/acs.jmedchem.4c00735
2023
Journal Article
The plant defensin Ppdef1 is a novel topical treatment for onychomycosis
van der Weerden, Nicole L., Parisi, Kathy, McKenna, James A., Hayes, Brigitte M., Harvey, Peta J., Quimbar, Pedro, Wevrett, Sean R., Veneer, Prem K., McCorkelle, Owen, Vasa, Shaily, Guarino, Rosemary, Poon, Simon, Gaspar, Yolanda M., Baker, Michael J., Craik, David J., Turner, Rob B., Brown, Marc B., Bleackley, Mark R. and Anderson, Marilyn A. (2023). The plant defensin Ppdef1 is a novel topical treatment for onychomycosis. Journal of Fungi, 9 (11) 1111, 1-16. doi: 10.3390/jof9111111
2023
Journal Article
Structure–activity relationships of alanine scan mutants αO-conotoxins GeXIVA[1,2] and GeXIVA[1,4]
Xu, Pan, Zhang, Panpan, Zhu, Xiaopeng, Wu, Yong, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2023). Structure–activity relationships of alanine scan mutants αO-conotoxins GeXIVA[1,2] and GeXIVA[1,4]. Journal of Medicinal Chemistry, 66 (14), 10092-10107. doi: 10.1021/acs.jmedchem.3c01023
2023
Journal Article
A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812
2023
Journal Article
Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii
Regalado, Laura, Sario, Sara, Mendes, Rafael J., Valle, Javier, Harvey, Peta J., Teixeira, Cátia, Gomes, Paula, Andreu, David and Santos, Conceição (2023). Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii. Insects, 14 (6) 533, 1-15. doi: 10.3390/insects14060533
2023
Journal Article
A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812
2023
Journal Article
Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7
Zhao, Zitong, Pan, Teng, Chen, Shen, Harvey, Peta J., Zhang, Jinghui, Li, Xiao, Yang, Mengke, Huang, Linhong, Wang, Shoushi, Craik, David J., Jiang, Tao and Yu, Rilei (2023). Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7. Journal of Biological Chemistry, 299 (4) 103068, 1-12. doi: 10.1016/j.jbc.2023.103068
Featured
2023
Journal Article
Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis
Jackson, Mark A., Xie, Jing, Nguyen, Linh T. T., Wang, Xiaohan, Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2023). Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. Transgenic Research, 32 (1-2), 121-133. doi: 10.1007/s11248-023-00341-1
2023
Journal Article
Designing antimicrobial peptides using deep learning and molecular dynamic simulations
Cao, Qiushi, Ge, Cheng, Wang, Xuejie, Harvey, Peta J., Zhang, Zixuan, Ma, Yuan, Wang, Xianghong, Jia, Xinying, Mobli, Mehdi, Craik, David J., Jiang, Tao, Yang, Jinbo, Wei, Zhiqiang, Wang, Yan, Chang, Shan and Yu, Rilei (2023). Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics, 24 (2) bbad058, 1-13. doi: 10.1093/bib/bbad058
2023
Journal Article
Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors
Zhu, Xiaopeng, Wang, Shuai, Kaas, Quentin, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2023). Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 66 (3), 2020-2031. doi: 10.1021/acs.jmedchem.2c01786
2022
Journal Article
The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila
Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413
2022
Journal Article
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
2022
Journal Article
Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides
Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284
2022
Journal Article
Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA
Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148
Featured
2021
Journal Article
Modified horseshoe crab peptides target and kill bacteria inside host cells
Amiss, Anna S., von Pein, Jessica B., Webb, Jessica R., Condon, Nicholas D., Harvey, Peta J., Phan, Minh-Duy, Schembri, Mark A., Currie, Bart J., Sweet, Matthew J., Craik, David J., Kapetanovic, Ronan, Henriques, Sónia Troeira and Lawrence, Nicole (2021). Modified horseshoe crab peptides target and kill bacteria inside host cells. Cellular and Molecular Life Sciences, 79 (1) 38, 38. doi: 10.1007/s00018-021-04041-z
2021
Journal Article
Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotides
Hellinger, Roland, Muratspahić, Edin, Devi, Seema, Koehbach, Johannes, Vasileva, Mina, Harvey, Peta J., Craik, David J., Gründemann, Carsten and Gruber, Christian W. (2021). Importance of the cyclic cystine knot structural motif for immunosuppressive effects of cyclotides. ACS Chemical Biology, 16 (11) acschembio.1c00524, 2373-2386. doi: 10.1021/acschembio.1c00524
2021
Journal Article
Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors
Wang, Shuai, Zhu, Xiaopeng, Zhangsun, Manqi, Wu, Yong, Yu, Jinpeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2021). Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 64 (9), 5620-5631. doi: 10.1021/acs.jmedchem.0c02079
Supervision
Availability
- Dr Peta Harvey is:
- Available for supervision
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