
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2024
Conference Publication
Sedative Pharmacodynamics in Patients Supported With Extracorporeal Membrane Oxygenation
Morales Castro, D., Balzani, E., Abdul-Aziz, M.H., Wong, I., Turgeon, J., Tisminetzky, M., Jurado-Camacho, L.F., Morris, I., Dresser, L., Granton, J.T., Pang, K.S., Uetrecht, J., Chen, E., Shekar, K. and Fan, E. (2024). Sedative Pharmacodynamics in Patients Supported With Extracorporeal Membrane Oxygenation. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5531
2024
Journal Article
Correction: achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9
2024
Journal Article
Cannabis use disorders and outcome of admission to intensive care: A retrospective multi-centre cohort study
Renger, Laura, Dhanani, Jayesh, Milford, Elissa, Tabah, Alexis, Shekar, Kiran, Ramanan, Mahesh and Laupland, Kevin B. (2024). Cannabis use disorders and outcome of admission to intensive care: A retrospective multi-centre cohort study. Journal of Critical Care, 80 154504, 154504. doi: 10.1016/j.jcrc.2023.154504
2024
Journal Article
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 539-547. doi: 10.1007/s00134-024-07353-3
2024
Journal Article
" Blend to Limit OxygEN in ECMO: A RanDomised ControllEd Registry (BLENDER) trial: Study protocol and statistical analysis plan " (vol 25, pg 118, 2023)
Burrell, Aidan, Ng, Sze, Ottosen, Kelly, Bailey, Michael, Buscher, Hergen, Fraser, John, Udy, Andrew, Gattas, David, Totaro, Richard, Bellomo, Rinaldo, Forrest, Paul, Martin, Emma, Reid, Liadain, Ziegenfuss, Marc, Eastwood, Glenn, Higgins, Alisa, Hodgson, Carol, Litton, Edward, Nair, Priya, Orford, Neil, Pellegrino, Vince, Shekar, Kiran, Trapani, Tony and Pilcher, David (2024). " Blend to Limit OxygEN in ECMO: A RanDomised ControllEd Registry (BLENDER) trial: Study protocol and statistical analysis plan " (vol 25, pg 118, 2023). Critical Care and Resuscitation, 26 (1), 60-60. doi: 10.1016/j.ccrj.2024.01.003
2024
Journal Article
An international survey of extracorporeal membrane oxygenation education and credentialing practices
Patel, Bhoumesh, Said, Ahmed S., Justus, Angelo, Abrams, Darryl, Pham, Tái, Antonini, Marta Velia, Moore, Elizabeth, Shekar, Kiran and Zakhary, Bishoy (2024). An international survey of extracorporeal membrane oxygenation education and credentialing practices. ATS Scholar, 5 (1), 71-83. doi: 10.34197/ats-scholar.2022-0132oc
2024
Journal Article
Ventilatory strategies during venovenous ECMO in ARDS: PEEPing at the elephant in the room
Ling, Ryan Ruiyang, Ramanathan, Kollengode and Shekar, Kiran (2024). Ventilatory strategies during venovenous ECMO in ARDS: PEEPing at the elephant in the room. Journal of Critical Care, 79 154407, 1-2. doi: 10.1016/j.jcrc.2023.154407
2024
Journal Article
Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies
Low, Christopher Jer Wei, Ling, Ryan Ruiyang, Lau, Michele Petrova Xin Ling, Liu, Nigel Sheng Hui, Tan, Melissa, Tan, Chuen Seng, Lim, Shir Lynn, Rochwerg, Bram, Combes, Alain, Brodie, Daniel, Shekar, Kiran, Price, Susanna, MacLaren, Graeme and Ramanathan, Kollengode (2024). Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies. Intensive Care Medicine, 50 (2), 209-221. doi: 10.1007/s00134-023-07278-3
2024
Journal Article
Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis
Harris, Patrick N. A., Bauer, Michelle J., Lüftinger, Lukas, Beisken, Stephan, Forde, Brian M., Balch, Ross, Cotta, Menino, Schlapbach, Luregn, Raman, Sainath, Shekar, Kiran, Kruger, Peter, Lipman, Jeff, Bialasiewicz, Seweryn, Coin, Lachlan, Roberts, Jason A., Paterson, David L. and Irwin, Adam D. (2024). Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis. Microbiology Spectrum, 12 (2) e0306523, 1-16. doi: 10.1128/spectrum.03065-23
2024
Journal Article
Weaning From Venovenous Extracorporeal Membrane Oxygenation - The Regensburg Way?
Worku, Elliott, Brodie, Daniel and Shekar, Kiran (2024). Weaning From Venovenous Extracorporeal Membrane Oxygenation - The Regensburg Way?. Critical Care Medicine, 52 (1), 147-150. doi: 10.1097/CCM.0000000000006077
2024
Journal Article
Adult highlights from the Extracorporeal Life Support Organization Registry: 2017–2022
Rali, Aniket S., Abbasi, Adeel, Alexander, Peta M. A., Anders, Marc M., Arachchillage, Deepa J., Barbaro, Ryan P., Fox, Alexander D., Friedman, Matthew L., Malfertheiner, Maximilian V., Ramanathan, Kollengode, Riera, Jordi, Rycus, Peter, Schellongowski, Peter, Shekar, Kiran, Tonna, Joseph E., Zaaqoq, Akram M. and on behalf of ELSO Scientific Oversight Committee (2024). Adult highlights from the Extracorporeal Life Support Organization Registry: 2017–2022. ASAIO Journal, 70 (1), 1-7. doi: 10.1097/mat.0000000000002038
2024
Conference Publication
OUTCOMES ON VENOVENOUS CONVERSION TO VENOARTERIAL OR HYBRID ECMO IN ADULT PATIENTS WITH COVID-19
Nguyen, Khoa, Altibi, Ahmed, Prasad, Pooja, Mukundan, Srini, Shekar, Kiran, Ramanathan, Ram and Zakhary, Bishoy (2024). OUTCOMES ON VENOVENOUS CONVERSION TO VENOARTERIAL OR HYBRID ECMO IN ADULT PATIENTS WITH COVID-19. 53RD CRITICAL CARE CONGRESS of the SOCIETY-OF-CRITICAL-CARE-MEDICINE (SCCM), Phoenix Ar, Jan 21-24, 2024. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/01.ccm.0000998964.28890.b0
2024
Journal Article
From protecting the lung to protecting the heart and the lung in acute respiratory distress syndrome
Zaaqoq, Akram M., Yusuff, Hakeem, Shekar, Kiran, Antonini, Marta V. and Zochios, Vasileios (2024). From protecting the lung to protecting the heart and the lung in acute respiratory distress syndrome. Journal of Cardiothoracic and Vascular Anesthesia, 38 (1), 342-343. doi: 10.1053/j.jvca.2023.10.029
2024
Journal Article
Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation
Burrell, Aidan, Bailey, Michael J., Bellomo, Rinaldo, Buscher, Hergen, Eastwood, Glenn, Forrest, Paul, Fraser, John F., Fulcher, Bentley, Gattas, David, Higgins, Alisa M., Hodgson, Carol L., Litton, Edward, Martin, Emma-Leah, Nair, Priya, Ng, Sze J., Orford, Neil, Ottosen, Kelly, Paul, Eldho, Pellegrino, Vincent, Reid, Liadain, Shekar, Kiran, Totaro, Richard J., Trapani, Tony, Udy, Andrew, Ziegenfuss, Marc, Pilcher, David, on behalf of The BLENDER Trial Investigators, EXCEL Registry, ECMONet and the Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group and Centre for Outcomes and Resource Evaluation, Hodgson, Carol L., Totaro, Richard J. ... Schmidt, Matthieu (2024). Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation. Intensive Care Medicine, 50 (9), 1470-1483. doi: 10.1007/s00134-024-07564-8
2023
Journal Article
Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study
Novy, Emmanuel, Abdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Levkovich, Bianca J., McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Parker, Suzanne, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2023). Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 68 (1) e0120123, e0120123. doi: 10.1128/aac.01201-23
2023
Journal Article
The importance of timing in post-cardiotomy veno-arterial extracorporeal membrane oxygenation: a descriptive multicenter observational study
Mariani, Silvia, Wang, I-wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae-Seung ... Solinas, Marco (2023). The importance of timing in post-cardiotomy veno-arterial extracorporeal membrane oxygenation: a descriptive multicenter observational study. The Journal of Thoracic and Cardiovascular Surgery, 166 (6), 1670-1682.e33. doi: 10.1016/j.jtcvs.2023.04.042
2023
Journal Article
Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis
Tran, Alexandre, Rochwerg, Bram, Fan, Eddy, Belohlavek, Jan, Suverein, Martje M., Poll, Marcel C.G. van de, Lorusso, Roberto, Price, Susanna, Yannopoulos, Demetris, MacLaren, Graeme, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Thiara, Sonny, Tonna, Joseph E., Shekar, Kiran, Hodgson, Carol L., Scales, Damon C., Sandroni, Claudio, Nolan, Jerry P., Slutsky, Arthur S., Combes, Alain, Brodie, Daniel and Fernando, Shannon M. (2023). Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation, 193 110004, 1-9. doi: 10.1016/j.resuscitation.2023.110004
2023
Journal Article
On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation
Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Conci, Luca, Szalkiewicz, Philipp, De Piero, Maria Elena, Heuts, Samuel, Ravaux, Justine, van der Horst, Iwan C.C., Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio ... Solinas, Marco (2023). On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation. Annals of Thoracic Surgery, 116 (5), 1079-1089. doi: 10.1016/j.athoracsur.2023.05.045
2023
Journal Article
Corrigendum to “Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study” [Resuscitation 192 (2023) 109989]
Kruit, Natalie, Burrell, Aidan, Tian, David, Barrett, Nicholas, Bělohlávek, Jan, Bernard, Stephen, Braude, Darren, Buscher, Hergen, Chen, Yih-Sharng, Donker, Dirk W., Finney, Simon, Forrest, Paul, Fowles, Jo-anne, Hifumi, Toru, Hodgson, Carol, Hutin, Alice, Inoue, Akihiko, Jung, Jae-Seung, Kruse, JM, Lamhaut, Lionel, Ming-Hui Lin, Richard, Reis Miranda, Dinis, Müller, Thomas, Bhagyalakshmi Nanjayya, Vinodh, Nickson, Christopher, Pellegrino, Vin, Plunkett, Brian, Richardson, Carla, Alexander Richardson, Sacha ... Dennis, Mark (2023). Corrigendum to “Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study” [Resuscitation 192 (2023) 109989]. Resuscitation, 194 110046, 1-2. doi: 10.1016/j.resuscitation.2023.110046
2023
Journal Article
Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study
Kruit, Natalie, Burrell, Aidan, Tian, David, Barrett, Nicholas, Bělohlávek, Jan, Bernard, Stephen, Braude, Darren, Buscher, Hergen, Chen, Yih-Sharng, Donker, Dirk W., Finney, Simon, Forrest, Paul, Fowles, Jo-anne, Hifumi, Toru, Hodgson, Carol, Hutin, Alice, Inoue, Akihiko, Jung, Jae-Seung, Kruse, JM, Lamhaut, Lionel, Ming-Hui Lin, Richard, Reis Miranda, Dinis, Müller, Thomas, Bhagyalakshmi Nanjayya, Vinodh, Nickson, Christopher, Pellegrino, Vin, Plunkett, Brian, Richardson, Carla, Alexander Richardson, Sacha ... Dennis, Mark (2023). Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study. Resuscitation, 192 109989, 192. doi: 10.1016/j.resuscitation.2023.109989
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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