
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2013
Journal Article
Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem
Hayes, R. A., Shekar, K. and Fraser, J. F. (2013). Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem. Perfusion, 28 (3), 184-193. doi: 10.1177/0267659112473172
2013
Journal Article
The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation
Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013). The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 (1) 7, 7.1-7.10. doi: 10.1186/1471-2253-13-7
2013
Journal Article
Single-centre experience of donation after cardiac death
Kumar, Raj, Shekar, Kiran and Fraser, John F. (2013). Single-centre experience of donation after cardiac death. Medical Journal of Australia, 198 (2), 87-88. doi: 10.5694/mja12.11502
2013
Journal Article
Hyperoxic damage and the need for optimised oxygenation practices
Hayes, Rylan A., Shekar, Kiran and Fraser, John F. (2013). Hyperoxic damage and the need for optimised oxygenation practices. Critical Care, 17 (4) 441, 441. doi: 10.1186/cc12802
2013
Conference Publication
The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function
Platts, D., Diab, S., MacDonald, M., Chemonges, S., Dunster, K., Shekar, K., Burstow, D., Mullany, D. and Fraser, D. (2013). The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function. 2013 ANZSCTS Annual Scientific Meeting, Darwin, NT Australia, 22 - 25 August 2013. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2013.05.474
2013
Conference Publication
Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model
Platts, D., Hilton, A., Diab, S., MacDonald, C., Tunbridge, M., Chemonges, S., Dunster, K., Shekar, K., Burstow, D. and Fraser, J. (2013). Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model. CSANZ 2013: 61st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand; in conjunction with the 37th Annual Scientific Meeting of the International Society for Heart Research, Gold Coast, QLD, Australia, 8-11 August, 2013. Chatswood, NSW, Australia: Elsevier Australia. doi: 10.1016/j.hlc.2013.05.429
2012
Journal Article
Drotrecogin alfa (activated) falls amid continuing enthusiasm to normalise physiology in ICU patients
Shekar, Kiran and Fraser, John F. (2012). Drotrecogin alfa (activated) falls amid continuing enthusiasm to normalise physiology in ICU patients. Critical Care and Resuscitation, 14 (4), 324-324. doi: 10.1016/s1441-2772(23)01775-1
2012
Journal Article
Massive bilateral pulmonary emboli, paradoxical embolus and the knot of life
Platts, David, Shekar, Kiran, Senz, Ainslie and Thomson, Bruce (2012). Massive bilateral pulmonary emboli, paradoxical embolus and the knot of life. European Heart Journal, 33 (24), 3077-3077. doi: 10.1093/eurheart/ehs256
2012
Journal Article
ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO
Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 (1) 29, 29.1-29.9. doi: 10.1186/1471-2253-12-29
2012
Journal Article
Sedation during extracorporeal membrane oxygenation-why more is less
Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012). Sedation during extracorporeal membrane oxygenation-why more is less. Anaesthesia and Intensive Care, 40 (6), 1067-1069.
2012
Journal Article
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?
Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 (3), 726-727. doi: 10.1093/jac/dks435
2012
Journal Article
Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation
Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 (5) R194, R194.1-R194.7. doi: 10.1186/cc11679
2012
Journal Article
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS
Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012). High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903, 126-133. doi: 10.1016/j.jchromb.2012.07.005
2012
Journal Article
Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models
Mullany, Daniel V., Bull, Taressa N., Hunt, William, Shekar, Kiran, Thomson, Bruce, Fraser, John F. and Ziegenfuss, Marc (2012). Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models. Critical Care and Resuscitation, 14 (2), 119-29.
2012
Journal Article
Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions
Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I., Dunster, Kimble R., Fisquet, Stephanie, Platts, David G., Stewart, David, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.
2012
Journal Article
Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions
Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.
2012
Journal Article
Post-operative deep sternal wound infections: making an early microbiological diagnosis
Chaudhuri, Alex, Shekar, Kiran and Coulter, Chris (2012). Post-operative deep sternal wound infections: making an early microbiological diagnosis. European Journal of Cardio-Thoracic Surgery, 41 (6), 1304-1308. doi: 10.1093/ejcts/ezr239
2012
Journal Article
Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models
Mullany, Daniel V., Bull, Taressa N., Hunt, William, Shekar, Kiran, Thomson, Bruce, Fraser, John F. and Ziegenfuss, Marc (2012). Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models. Critical Care and Resuscitation, 14 (2), 119-129.
2012
Journal Article
Donation after cardiac death in Queensland: review of the pilot project
Kumar, R., Shekar, K., Widdicombe, N. and Fraser, J. F. (2012). Donation after cardiac death in Queensland: review of the pilot project. Anaesthesia and Intensive Care, 40 (3), 517-522. doi: 10.1177/0310057x1204000319
2012
Conference Publication
Extracorporeal lessons from sheep
Fung, Y.L., Diab, S., Dunster, K., Foley, S.R., McDonald, C.I., Passmore, M., Platts, D., Simonova, G., Shekar, K., Stewart, D. and Fraser, J.F. (2012). Extracorporeal lessons from sheep. 32nd International Congress of the International Society of Blood Transfusion in joint cooperation with the 10th Congress of AMMTAC, Cancun, Mexico, 7-12 July 2012. Oxford, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/j.1423-0410.2012.01615_1.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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