
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2018
Conference Publication
Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock
Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, A.C., See Hoe, L., Pedersen, S., Fauzi, M., Pimenta, L., Van Haren, F., Shekar, K., Anstey, C., Tung, J.P., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock. 9th Congress of the World Federation of Pediatric Intensive & Critical Care Societies (WFPICCS 2018), Singapore, 9-13 June 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000538016.15507.8c
2018
Journal Article
Patient selection for VV ECMO: have we found the crystal ball?
Ahuja, Abhilasha and Shekar, Kiran (2018). Patient selection for VV ECMO: have we found the crystal ball?. Journal of Thoracic Disease, 10 (Suppl 17), S1979-S1981. doi: 10.21037/jtd.2018.05.83
2018
Journal Article
MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload
Ribeiro Junior, Rogério Faustino, Dabkowski, Erinne Rose, Shekar, Kadambari Chandra, O Connell, Kelly A., Hecker, Peter A. and Murphy, Michael P. (2018). MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload. Free Radical Biology and Medicine, 117, 18-29. doi: 10.1016/j.freeradbiomed.2018.01.012
2018
Journal Article
Optimising drug dosing in patients receiving extracorporeal membrane oxygenation
Cheng, Vesa, Abdul-Aziz, Mohd-Hafiz, Roberts, Jason A. and Shekar, Kiran (2018). Optimising drug dosing in patients receiving extracorporeal membrane oxygenation. Journal of Thoracic Disease, 10 (Suppl 5), S629-S641. doi: 10.21037/jtd.2017.09.154
2018
Journal Article
An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma
Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1073, 118-122. doi: 10.1016/j.jchromb.2017.12.006
2018
Conference Publication
Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock
See Hoe, L., Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, C., Engkilde-Pedersen, S., Esguerra, A., Fauzi, M., Pretti Pimenta, L., Simonova, G., Van Haren, F., Shekar, K., Anstey, C., Tung, J., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2018.06.129
2018
Book Chapter
Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support
Shekar, Kiran, Obonyo, Nchafatso and Fraser, John F. (2018). Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support. Mechanical circulatory and respiratory support. (pp. 441-468) edited by Shaun D. Gregory, Michael C. Stevens and John F. Fraser. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810491-0.00014-X
2018
Conference Publication
Does dosing of piperacillin-tazobactam in critically ill patients on ECMO need to change? A pharmacokinetics study
Cheng, V., Shekar, K., Abdul-Aziz, M.H., Buscher, H., Corley, A., Diehl, A., Gilder, E., Jarrett, P., Lye, I., McGuinness, S., Parke, R., Pellegrino, V., Reynolds, C., Wallis, S. C., Welch, S., Zacharias, D., Fraser, J. F. and Roberts, J. A. (2018). Does dosing of piperacillin-tazobactam in critically ill patients on ECMO need to change? A pharmacokinetics study. European Society of Intensive Care Medicine Annual Congress, Paris, France, 20-24 October 2018. Heidelberg, Germany: Springer.
2018
Conference Publication
Does dosing of ceftriaxone in critically ill patients on ECMO need to change? A pharmacokinetics study
Cheng, V., Shekar, K., Abdul-Aziz, M. H., Buscher, H., Corley, A., Diehl, A., Gilder, A., Jarrett, P., Lye, I., McGuinness, S., Parke, R., Pellegrino, V., Reynolds, C., Wallis, S. C., Welch, S., Zacharias, D., Fraser, J. F. and Roberts, J. A. (2018). Does dosing of ceftriaxone in critically ill patients on ECMO need to change? A pharmacokinetics study. European Society of Intensive Care Medicine Annual Congress, Paris, France, 20-24 October 2018. Heidelberg, Germany: Springer.
2018
Conference Publication
Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation
Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, Hoe, See Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Hashairi Mohd, Pretti, Pimenta Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation. -, -, 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2018
Journal Article
An ovine model of hyperdynamic endotoxemia and vital organ metabolism
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai Ching, Hoe, Louise See, Hay, Karen, Van Haren, Frank, Tung, John-Paul, Cullen, Louise, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). An ovine model of hyperdynamic endotoxemia and vital organ metabolism. Shock, 49 (1), 99-107. doi: 10.1097/SHK.0000000000000904
2018
Journal Article
Unplanned autotransplantation for complex multi-valve replacement in a super morbid obese female: the challenge of intraoperative decision making
McDonald, Charles, Dallimore, Daniel, Oates, Mathew, Shekar, Kiran and Thomson, Bruce (2018). Unplanned autotransplantation for complex multi-valve replacement in a super morbid obese female: the challenge of intraoperative decision making. Journal of Extra-Corporeal Technology, 50 (4), 248-251.
2018
Book Chapter
Antibiotic dosing during extracorporeal membrane oxygenation
Abdul-Aziz, M. H., Shekar, Kiran and Roberts, Jason A. (2018). Antibiotic dosing during extracorporeal membrane oxygenation. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. (pp. 151-171) edited by Andrew A. Udy, Jason A. Roberts and Jeffrey Lipman. Gateway East, Singapore: Springer . doi: 10.1007/978-981-10-5336-8_8
2017
Journal Article
Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy
Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Fraser, John F, Smith, Maree T and Ghassabian, Sussan (2017). Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy. Drug metabolism reviews, 50 (2), 1-16. doi: 10.1080/03602532.2017.1417423
2017
Journal Article
Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
Sinnah, Fabrice, Shekar, Kiran, Abdul-Aziz, Mohd H, Buscher, Hergen, Diab, Sara D., Fisquet, Stephanie, Fung, Yoke L., McDonald, Charles I., Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan, Xie, Jiao, Fraser, John F., Roberts, Jason A. and ASAP ECMO investigators (2017). Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation. Critical Care and Resuscitation, 19 (Suppl 1), 8-14.
2017
Journal Article
Appraising extracorporeal life support — current and future roles in adult intensive care
Shekar, Kiran, Brodie, Daniel, Fraser, John and MacLaren, Graeme (2017). Appraising extracorporeal life support — current and future roles in adult intensive care. Critical Care and Resuscitation, 19, 5-7.
2017
Journal Article
Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support
Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Diab, Sara D., Dunster, Kimble R., Spanevello, Michelle M., McDonald, Charles I., Tung, John-Paul, Pecheniuk, Natalie M., Hay, Karen, Shekar, Kiran and Fraser, John F. (2017). Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support. Critical Care, 21 (1) 191, 1-9. doi: 10.1186/s13054-017-1788-9
2017
Journal Article
Successful provision of inter-hospital extracorporeal cardiopulmonary resuscitation for acute post-partum pulmonary embolism
McDonald, C., Laurie, J., Janssens, S., Zazulak, C., Kotze, P. and Shekar, K. (2017). Successful provision of inter-hospital extracorporeal cardiopulmonary resuscitation for acute post-partum pulmonary embolism. International Journal of Obstetric Anesthesia, 30, 65-68. doi: 10.1016/j.ijoa.2017.01.003
2017
Journal Article
The effects of the introduction of an adult ECMO program on statewide referral patterns, casemix and outcomes in patients with acute respiratory distress syndrome or pneumonia
Mullany, Dan, Shekar, Kiran, Ziegenfuss, Marc, Joyce, Christopher, Pilcher, David, Dobson, Annette and Fraser, John F. (2017). The effects of the introduction of an adult ECMO program on statewide referral patterns, casemix and outcomes in patients with acute respiratory distress syndrome or pneumonia. Intensive Care Medicine, 43 (7), 1065-1066. doi: 10.1007/s00134-017-4771-7
2017
Conference Publication
Potential posaconazole sequestration during extracorporeal membrane oxygentation: Results from an ex-vivo experiment
Lyster, H., Pitt, T., Maunz, O., Saez, D. Garcia, Tiller, J., Leaver, N., Roberts, J., Shekar, K., Brown, D., Mills, J., Carby, M., Simon, A. and Reed, A. (2017). Potential posaconazole sequestration during extracorporeal membrane oxygentation: Results from an ex-vivo experiment. 37th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), San Diego, CA United States, 5-8 April 2017. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2017.01.055
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
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