
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2021
Journal Article
Development and implementation of a clinical information system–based protocol to improve nurse satisfaction of end-of-life care in a single intensive care unit
Pachchigar, R., Blackwell, N., Webb, L., Francis, K., Pahor, K., Thompson, A., Cornmell, G., Anstey, C., Ziegenfuss, M. and Shekar, K. (2021). Development and implementation of a clinical information system–based protocol to improve nurse satisfaction of end-of-life care in a single intensive care unit. Australian Critical Care, 35 (3), 273-278. doi: 10.1016/j.aucc.2021.05.003
2021
Journal Article
Ceftriaxone exposure in patients undergoing extracorporeal membrane oxygenation
Gijsen, Matthias, Annaert, Pieter, Shekar, Kiran, Roberts, Jason A., Wauters, Joost and Spriet, Isabel (2021). Ceftriaxone exposure in patients undergoing extracorporeal membrane oxygenation. International Journal of Antimicrobial Agents, 57 (5) 106326, 106326. doi: 10.1016/j.ijantimicag.2021.106326
2021
Journal Article
ECMO for COVID-19: Updated 2021 Guidelines from the Extracorporeal Life Support Organization (ELSO)
Badulak, Jenelle, Antonini, M. Velia, Stead, Christine M., Shekerdemian, Lara, Raman, Lakshmi, Paden, Matthew L., Agerstrand, Cara, Bartlett, Robert H., Barrett, Nicholas, Combes, Alain, Lorusso, Roberto, Mueller, Thomas, Ogino, Mark T., Peek, Giles, Pellegrino, Vincent, Rabie, Ahmed A., Salazar, Leonardo, Schmidt, Matthieu, Shekar, Kiran, MacLaren, Graeme and Brodie, Daniel (2021). ECMO for COVID-19: Updated 2021 Guidelines from the Extracorporeal Life Support Organization (ELSO). ASAIO Journal, 67 (5), 485-495. doi: 10.1097/MAT.0000000000001422
2021
Journal Article
Long-term outcome of prolonged critical illness: a multicentered study in North Brisbane, Australia
Laupland, Kevin B., Ramanan, Mahesh, Shekar, Kiran, Edwards, Felicity, Clement, Pierre and Tabah, Alexis (2021). Long-term outcome of prolonged critical illness: a multicentered study in North Brisbane, Australia. PLoS One, 16 (4) e0249840, e0249840. doi: 10.1371/journal.pone.0249840
2021
Journal Article
Personal protective equipment preparedness in intensive care units during the coronavirus disease 2019 pandemic: an Asia-Pacific follow-up survey
Gullapalli, Navya, Jie Lim, Zheng, Ramanathan, Kollengode, Bihari, Shailesh, Haji, Jumana, Shekar, Kiran, Tat Wong, Wai, Rajamani, Arvind and Subramaniam, Ashwin (2021). Personal protective equipment preparedness in intensive care units during the coronavirus disease 2019 pandemic: an Asia-Pacific follow-up survey. Australian Critical Care, 35 (1), 5-12. doi: 10.1016/j.aucc.2021.02.007
2021
Journal Article
Elevated Venous to Arterial Carbon Dioxide Gap and Anion Gap Are Associated with Poor Outcome in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support
McDonald, Charles I., Brodie, Daniel, Schmidt, Matthieu, Hay, Karen and Shekar, Kiran (2021). Elevated Venous to Arterial Carbon Dioxide Gap and Anion Gap Are Associated with Poor Outcome in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support. ASAIO Journal, 67 (3), 263-269. doi: 10.1097/mat.0000000000001215
2021
Journal Article
Prone positioning of patients during venovenous extracorporeal membrane oxygenation
Shekar, Kiran, Ramanathan, Kollengode and Brodie, Daniel (2021). Prone positioning of patients during venovenous extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 18 (3), 421-423. doi: 10.1513/AnnalsATS.202011-1444ED
2021
Journal Article
Venoarterial extracorporeal membrane oxygenation for postcardiotomy shock - analysis of the extracorporeal life support organization registry
Kowalewski, Mariusz, Zieliński, Kamil, Brodie, Daniel, MacLaren, Graeme, Whitman, Glenn, Raffa, Giuseppe M., Boeken, Udo, Shekar, Kiran, Chen, Yih-Sharng, Bermudez, Christian, D'Alessandro, David, Hou, Xiaotong, Haft, Jonathan, Belohlavek, Jan, Dziembowska, Inga, Suwalski, Piotr, Alexander, Peta, Barbaro, Ryan P., Gaudino, Mario, Di Mauro, Michele, Maessen, Jos and Lorusso, Roberto (2021). Venoarterial extracorporeal membrane oxygenation for postcardiotomy shock - analysis of the extracorporeal life support organization registry. Critical Care Medicine, 49 (7), 1-11. doi: 10.1097/CCM.0000000000004922
2021
Journal Article
Intensive care digital health response to emerging infectious disease outbreaks such as COVID-19
Kirrane, Marianne D., Shrapnel, Sally, Ramanan, Mahesh, Clement, Pierre, Fraser, John F., Laupland, Kevin B., Sullivan, Clair M. and Shekar, Kiran (2021). Intensive care digital health response to emerging infectious disease outbreaks such as COVID-19. Anaesthesia and Intensive Care, 49 (2), 0310057X2097577-111. doi: 10.1177/0310057x20975777
2021
Journal Article
Extracorporeal membrane oxygenation and coronavirus disease 2019
Shekar, Kiran, Worku, Elliott and Brodie, Daniel (2021). Extracorporeal membrane oxygenation and coronavirus disease 2019. JAMA Surgery, 156 (4), 400-401. doi: 10.1001/jamasurg.2020.6631
2021
Journal Article
Concurrent use of renal replacement therapy during extracorporeal membrane oxygenation support: a systematic review and meta-analysis
Mitra, Saikat, Ling, Ryan Ruiyang, Tan, Chuen Seng, Shekar, Kiran, MacLaren, Graeme and Ramanathan, Kollengode (2021). Concurrent use of renal replacement therapy during extracorporeal membrane oxygenation support: a systematic review and meta-analysis. Journal of Clinical Medicine, 10 (2) 241, 241-13. doi: 10.3390/jcm10020241
2021
Journal Article
Current understanding of leukocyte phenotypic and functional modulation during extracorporeal membrane oxygenation: a narrative review
Ki, Katrina K., Millar, Jonathan E., Langguth, Daman, Passmore, Margaret R., McDonald, Charles I., Shekar, Kiran, Shankar-Hari, Manu, Cho, Hwa Jin, Suen, Jacky Y. and Fraser, John F. (2021). Current understanding of leukocyte phenotypic and functional modulation during extracorporeal membrane oxygenation: a narrative review. Frontiers in Immunology, 11 600684, 600684. doi: 10.3389/fimmu.2020.600684
2021
Journal Article
Prone positioning of nonintubated patients with Coronavirus disease 2019 - A systematic review and meta-analysis
Ponnapa Reddy, Mallikarjuna, Subramaniam, Ashwin, Afroz, Afsana, Billah, Baki, Lim, Zheng Jie, Zubarev, Alexandr, Blecher, Gabriel, Tiruvoipati, Ravindranath, Ramanathan, Kollengode, Wong, Suei Nee, Brodie, Daniel, Fan, Eddy and Shekar, Kiran (2021). Prone positioning of nonintubated patients with Coronavirus disease 2019 - A systematic review and meta-analysis. Critical Care Medicine, 49 (10), E1001-E1014. doi: 10.1097/CCM.0000000000005086
2021
Journal Article
Cytokine adsorption during ECMO for COVID-19-related ARDS
Shekar, Kiran, McAuley, Daniel F and Brodie, Daniel (2021). Cytokine adsorption during ECMO for COVID-19-related ARDS. The Lancet Respiratory Medicine, 9 (7), 680-682. doi: 10.1016/S2213-2600(21)00207-1
2021
Journal Article
Impact of an aerosol box on time to tracheal intubation: systematic review and meta-analysis
Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna, Karalapillai, Dharshi, Shekar, Kiran and Subramaniam, Ashwin (2021). Impact of an aerosol box on time to tracheal intubation: systematic review and meta-analysis. British Journal of Anaesthesia, 126 (3), e122-e125. doi: 10.1016/j.bja.2020.11.036
2020
Journal Article
The effect of hyperoxia on inflammation and platelet responses in an ex vivo extracorporeal membrane oxygenation circuit
Passmore, Margaret R., Ki, Katrina K., Chan, Chris H. H., Lee, Talvin, Bouquet, Mahé, Wood, Emily S., Raman, Sainath, Rozencwajg, Sacha, Burrell, Aidan J. C., McDonald, Charles I., Langguth, Daman, Shekar, Kiran, Malfertheiner, Maximilian V., Fraser, John F. and Suen, Jacky Y. (2020). The effect of hyperoxia on inflammation and platelet responses in an ex vivo extracorporeal membrane oxygenation circuit. Artificial Organs, 44 (12) aor.13771, 1276-1285. doi: 10.1111/aor.13771
2020
Journal Article
Will not breathing on extracorporeal membrane oxygenation help one survive acute respiratory distress syndrome?*
Shekar, Kiran, McAuley, Daniel F. and Brodie, Daniel (2020). Will not breathing on extracorporeal membrane oxygenation help one survive acute respiratory distress syndrome?*. Critical Care Medicine, 48 (12), 1901-1904. doi: 10.1097/ccm.0000000000004647
2020
Journal Article
Extracorporeal life support for adults with acute respiratory distress syndrome
Combes, Alain, Schmidt, Matthieu, Hodgson, Carol L., Fan, Eddy, Ferguson, Niall D., Fraser, John F., Jaber, Samir, Pesenti, Antonio, Ranieri, Marco, Rowan, Kathryn, Shekar, Kiran, Slutsky, Arthur S. and Brodie, Daniel (2020). Extracorporeal life support for adults with acute respiratory distress syndrome. Intensive Care Medicine, 46 (12), 2464-2476. doi: 10.1007/s00134-020-06290-1
2020
Journal Article
Protocol-driven daily optimisation of venovenous extracorporeal membrane oxygenation blood flows: an alternate paradigm?
Shekar, Kiran, Buscher, Hergen and Brodie, Daniel (2020). Protocol-driven daily optimisation of venovenous extracorporeal membrane oxygenation blood flows: an alternate paradigm?. Journal of Thoracic Disease, 12 (11), 6854-6860. doi: 10.21037/jtd-20-1515
2020
Journal Article
Incidence and outcome of out-of-hospital cardiac arrests in the COVID-19 era: A systematic review and meta-analysis
Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna, Afroz, Afsana, Billah, Baki, Shekar, Kiran and Subramaniam, Ashwin (2020). Incidence and outcome of out-of-hospital cardiac arrests in the COVID-19 era: A systematic review and meta-analysis. Resuscitation, 157, 248-258. doi: 10.1016/j.resuscitation.2020.10.025
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
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