
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2021
Journal Article
Erratum: Trends in 28-Day mortality of critical care patients with coronavirus disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021 (Critical Care Medicine (2021) 49 (1895-1900) DOI: 10.1097/CCM.0000000000005184)
Lim, Zheng Jie, Reddy, Mallikarjuna Ponnapa, Randall Curtis, J., Afroz, Afsana, Billah, Baki, Hayek, Salim S., Leaf, David E., Miles, Jeremy A., Yuriditsky, Eugene, Jones, Daryl, Shekar, Kiran and Subramaniam, Ashwin (2021). Erratum: Trends in 28-Day mortality of critical care patients with coronavirus disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021 (Critical Care Medicine (2021) 49 (1895-1900) DOI: 10.1097/CCM.0000000000005184). Critical Care Medicine, 49 (12). doi: 10.1097/CCM.0000000000005385
2021
Journal Article
Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis
Poon, Wynne Hsing, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Yang, Isabelle Xiaorui, Tan, Chuen Seng, Schmidt, Matthieu and Shekar, Kiran (2021). Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Critical Care, 25 (1) 292, 292. doi: 10.1186/s13054-021-03723-1
2021
Journal Article
Reconciling the obesity paradox: obese patients suffer the highest critical illness associated mortality rates
Laupland, Kevin B., Edwards, Felicity, Ramanan, Mahesh, Shekar, Kiran and Tabah, Alexis (2021). Reconciling the obesity paradox: obese patients suffer the highest critical illness associated mortality rates. Journal of Critical Care, 66, 75-77. doi: 10.1016/j.jcrc.2021.08.005
2021
Journal Article
Non-home discharge after cardiac surgery in Australia and New Zealand: a cross-sectional study
Ramanan, Mahesh, Kumar, Aashish, Anstey, Chris and Shekar, Kiran (2021). Non-home discharge after cardiac surgery in Australia and New Zealand: a cross-sectional study. BMJ Open, 11 (12) e049187, e049187. doi: 10.1136/bmjopen-2021-049187
2021
Journal Article
Erratum: A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with coronavirus disease 2019 (Critical Care Medicine (2019) 49 (901-911) DOI: 10.1097/CCM.0000000000004950)
Lim, Zheng Jie, Reddy, Mallikarjuna Ponnapa, Randall Curtis, J., Afroz, Afsana, Billah, Baki, Hayek, Salim S., Leaf, David E., Miles, Jeremy A., Yuriditsky, Eugene, Jones, Daryl, Shekar, Kiran and Subramaniam, Ashwin (2021). Erratum: A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with coronavirus disease 2019 (Critical Care Medicine (2019) 49 (901-911) DOI: 10.1097/CCM.0000000000004950). Critical Care Medicine, 49 (12). doi: 10.1097/CCM.0000000000005384
2021
Journal Article
The association of oxygenation, carbon dioxide removal, and mechanical ventilation practices on survival during venoarterial extracorporeal membrane oxygenation
Justus, Angelo, Burrell, Aidan, Anstey, Chris, Cornmell, George, Brodie, Daniel and Shekar, Kiran (2021). The association of oxygenation, carbon dioxide removal, and mechanical ventilation practices on survival during venoarterial extracorporeal membrane oxygenation. Frontiers in Medicine, 8 756280, 756280. doi: 10.3389/fmed.2021.756280
2021
Journal Article
What determines the arterial partial pressure of carbon dioxide on venovenous extracorporeal membrane oxygenation?
Joyce, Christopher J., Udy, Andrew, Weeden, Mark, Shekar, Kiran and Cook, David A. (2021). What determines the arterial partial pressure of carbon dioxide on venovenous extracorporeal membrane oxygenation?. ASAIO Journal, 68 (8), 1093-1103. doi: 10.1097/mat.0000000000001604
2021
Journal Article
Feasibility of non-invasive nitric oxide gas inhalation to prevent endotracheal intubation in patients with acute hypoxemic respiratory failure: a single-centre experience
Shekar, Kiran, Varkey, Sneha, Cornmell, George, Parsons, Leanne, Tol, Maneesha, Siuba, Matthew and Ramanan, Mahesh (2021). Feasibility of non-invasive nitric oxide gas inhalation to prevent endotracheal intubation in patients with acute hypoxemic respiratory failure: a single-centre experience. Nitric Oxide, 116, 35-37. doi: 10.1016/j.niox.2021.08.005
2021
Journal Article
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Fraser, John F., Shekar, Kiran, Roberts, Jason A. and on behalf of ASAP ECMO Investigators (2021). Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Antimicrobial Agents and Chemotherapy, 65 (11) e01438-21, 1-11. doi: 10.1128/aac.01438-21
2021
Journal Article
Systematic review and meta-analysis of the characteristics and outcomes of readmitted COVID-19 survivors
Subramaniam, Ashwin, Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna and Shekar, Kiran (2021). Systematic review and meta-analysis of the characteristics and outcomes of readmitted COVID-19 survivors. Internal Medicine Journal, 51 (11), 1773-1780. doi: 10.1111/imj.15350
2021
Journal Article
Correction to: Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis
Ramanathan, Kollengode, Shekar, Kiran, Ling, Ryan Ruiyang, Barbaro, Ryan P, Wong, Suei Nee, Tan, Chuen Seng, Rochwerg, Bram, Fernando, Shannon M, Takeda, Shinhiro, MacLaren, Graeme, Fan, Eddy and Brodie, Daniel (2021). Correction to: Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Critical Care, 25 (1) 375, 375. doi: 10.1186/s13054-021-03714-2
2021
Journal Article
Fluid resuscitation after cardiac surgery in the intensive care unit: a bi-national survey of clinician practice. (The FRACS-ICU clinician survey)
Ramanan, Mahesh, Roberts, Shaun, Adrian McCullough, James, Naidoo, Rishendran, Rapchuk, Ivan, Matebele, Mbakise, Tabah, Alexis, Kruger, Peter, Smith, Julian and Shekar, Kiran (2021). Fluid resuscitation after cardiac surgery in the intensive care unit: a bi-national survey of clinician practice. (The FRACS-ICU clinician survey). Annals of Cardiac Anaesthesia, 24 (4), 441-446. doi: 10.4103/aca.ACA_190_20
2021
Journal Article
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications
Abrams, Darryl, MacLaren, Graeme, Lorusso, Roberto, Price, Susanna, Yannopoulos, Demetris, Vercaemst, Leen, Bělohlávek, Jan, Taccone, Fabio S., Aissaoui, Nadia, Shekar, Kiran, Garan, A. Reshad, Uriel, Nir, Tonna, Joseph E., Jung, Jae Seung, Takeda, Koji, Chen, Yih-Sharng, Slutsky, Arthur S., Combes, Alain and Brodie, Daniel (2021). Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Medicine, 48 (1), 1-15. doi: 10.1007/s00134-021-06514-y
2021
Journal Article
ELSO interim guidelines for venoarterial extracorporeal membrane oxygenation in adult cardiac patients
Lorusso, Roberto, Shekar, Kiran, MacLaren, Graeme, Schmidt, Matthieu, Pellegrino, Vincent, Meyns, Bart, Haft, Jonathan, Vercaemst, Leen, Pappalardo, Federico, Bermudez, Christian, Belohlavek, Jan, Hou, Xiaotong, Boeken, Udo, Castillo, Roberto, Donker, Dirk W, Abrams, Darryl, Ranucci, Marco, Hryniewicz, Kasia, Chavez, Ivan, Chen, Yih-Sharng, Salazar, Leonardo and Whitman, Glenn (2021). ELSO interim guidelines for venoarterial extracorporeal membrane oxygenation in adult cardiac patients. ASAIO Journal, 67 (8), 827-844. doi: 10.1097/MAT.0000000000001510
2021
Journal Article
Assessing need for extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest using Power BI for data visualisation
Ramanan, Mahesh, Gill, Denzil, Doan, Tan, Bosley, Emma, Rashford, Stephen, Dennis, Mark and Shekar, Kiran (2021). Assessing need for extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest using Power BI for data visualisation. Emergency Medicine Australasia, 33 (4), 685-690. doi: 10.1111/1742-6723.13704
2021
Journal Article
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
Arabi, Yaseen M., Gordon, Anthony C., Derde, Lennie P. G., Nichol, Alistair D., Murthy, Srinivas, Beidh, Farah Al, Annane, Djillali, Swaidan, Lolowa Al, Beane, Abi, Beasley, Richard, Berry, Lindsay R., Bhimani, Zahra, Bonten, Marc J. M., Bradbury, Charlotte A., Brunkhorst, Frank M., Buxton, Meredith, Buzgau, Adrian, Cheng, Allen, De Jong, Menno, Detry, Michelle A., Duffy, Eamon J., Estcourt, Lise J., Fitzgerald, Mark, Fowler, Rob, Girard, Timothy D., Goligher, Ewan C., Goossens, Herman, Haniffa, Rashan, Higgins, Alisa M. ... on behalf of the REMAP-CAP Investigators (2021). Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Medicine, 47 (8), 867-886. doi: 10.1007/s00134-021-06448-5
2021
Journal Article
Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)
Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11 667680, 1-8. doi: 10.3389/fcimb.2021.667680
2021
Journal Article
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India
Rabie, Ahmed A., Azzam, Mohamed H., Al-Fares, Abdulrahman A., Abdelbary, Akram, Mufti, Hani N., Hassan, Ibrahim F., Chakraborty, Arpan, Oza, Pranay, Elhazmi, Alyaa, Alfoudri, Huda, Pooboni, Suneel Kumar, Alharthy, Abdulrahman, Brodie, Daniel, Zakhary, Bishoy, Shekar, Kiran, Antonini, Marta Velia, Barrett, Nicholas A., Peek, Giles, Combes, Alain and Arabi, Yaseen M. (2021). Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India. Intensive Care Medicine, 47 (8), 887-895. doi: 10.1007/s00134-021-06451-w
2021
Journal Article
A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with voronavirus disease 2019
Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna, Curtis, J. Randall, Afroz, Afsana, Billah, Baki, Sheth,, Vishad, Hayek, Salim S., Leaf, David E., Miles, Jeremy A., Shah, Priyank, Yuriditsky, Eugene, Jones, Daryl, Shekar, Kiran and Subramaniam, Ashwin (2021). A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with voronavirus disease 2019. Critical Care Medicine, 49 (6), 901-911. doi: 10.1097/ccm.0000000000004950
2021
Journal Article
Management of adult patients supported with venovenous extracorporeal membrane oxygenation (VV ECMO): guideline from the Extracorporeal Life Support Organization (ELSO)
Tonna, Joseph E., Abrams, Darryl, Brodie, Daniel, Greenwood, John C., Rubio Mateo-Sidron, Jose Alfonso, Usman, Asad, Fan, Eddy, Barrett, Nicholas, Schmidt, Matthieu, Mueller, Thomas, Combes, Alain and Shekar, Kiran (2021). Management of adult patients supported with venovenous extracorporeal membrane oxygenation (VV ECMO): guideline from the Extracorporeal Life Support Organization (ELSO). ASAIO Journal, 67 (6), 601-610. doi: 10.1097/MAT.0000000000001432
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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