
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2023
Journal Article
Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest in Australia: a narrative review
Dennis, Mark, Shekar, Kiran, Burrell, Aidan J. C., Austin, Danielle, Anderson, David, Bernard, Stephen, Burns, Brian, Buscher, Hergen, Christie, Gayle, Collett, Luke, Coggins, Andrew, Doan, Tan, Dhanani, Jayesh, Finn, Judith, Fisher, Caleb, Ferguson, Ian, Forrest, Paul, Gill, Denzil, Granger, Emily, Higgins, Lisa, Hodgson, Carol, Jones, Daryl, Kruit, Natalie, La Gerche, Andre, Marasco, Silvana, Maruno, Kevin, McCanny, Peter, Moylan, Emily, Nanjayya, Vinod ... Winearls, James (2023). Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest in Australia: a narrative review. Medical Journal of Australia, 220 (1), 46-53. doi: 10.5694/mja2.52130
2023
Journal Article
Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis
Low, Christopher Jer Wei, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Ho, Maxz Jian Chen, Chen, Ying, Lorusso, Roberto, MacLaren, Graeme, Shekar, Kiran and Brodie, Daniel (2023). Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis. The Lancet Respiratory Medicine, 11 (10), 883-893. doi: 10.1016/s2213-2600(23)00137-6
2023
Journal Article
Heterogeneity in clinical practices for post‐cardiotomy extracorporeal life support: a pilot survey from the PELS‐1 multicenter study
Mariani, Silvia, Bari, Gabor, Ravaux, Justine M., van Bussel, Bas C. T., De Piero, Maria Elena, Schaefer, Ann‐Kristin, Jawad, Khalil, Pozzi, Matteo, Loforte, Antonio, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Hou, Xiaotong, Bunge, Jeroen J. H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Costetti, Alessandro, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Schmid, Chistof, Raffa, Giuseppe Maria, Castillo, Roberto, Wang, I‐wen ... Roberto Lorusso1, the PELS‐1 Investigators (2023). Heterogeneity in clinical practices for post‐cardiotomy extracorporeal life support: a pilot survey from the PELS‐1 multicenter study. Artificial Organs, 47 (10), 1641-1653. doi: 10.1111/aor.14601
2023
Journal Article
Determinants of 90-day case fatality among older patients admitted to intensive care units: A retrospective cohort study
Marella, Prashanti, Ramanan, Mahesh, Shekar, Kiran, Tabah, Alexis and Laupland, Kevin B. (2023). Determinants of 90-day case fatality among older patients admitted to intensive care units: A retrospective cohort study. Australian Critical Care, 37 (1), 18-24. doi: 10.1016/j.aucc.2023.07.039
2023
Journal Article
Blend to limit oxgyen in ECMO: a randomised controlled registry trial: study protocol and statistical analysis plan
Burrell, Aidan, Ng, Sze, Ottosen, Kelly, Bailey, Michael, Buscher, Hergen, Fraser, John, Udy, Andrew, Gattas, David, Totaro, Richard, Bellomo, Rinaldo, Forrest, Paul, Martin, Emma, Reid, Liadain, Ziegenfuss, Marc, Eastwood, Glenn, Higgins, Alisa, Hodgson, Carol, Litton, Edward, Nair, Priya, Orford, Neil, Pellegrino, Vince, Shekar, Kiran, Trapani, Tony and Pilcher, David (2023). Blend to limit oxgyen in ECMO: a randomised controlled registry trial: study protocol and statistical analysis plan. Critical Care and Resuscitation, 25 (3), 118-125. doi: 10.1016/j.ccrj.2023.06.001
2023
Conference Publication
Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomised controlled trials and propensity score matched studies
Wei Low, Christopher Jer, Ruiyang Ling, Ryan, Xin Ling Lau, Michele Petrova, Hui Liu, Nigel Sheng, Tan, Melissa, Seng Tan, Chuen, Lynn Lim, Shir, Rochwerg, Bram, Combes, Alain, Brodie, Daniel, Shekar, Kiran, Price, Susanna, MacLaren, Graeme and Ramanathan, Kollengode (2023). Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomised controlled trials and propensity score matched studies. 34th Annual ELSO Conference, Seattle, WA United States, 28 September - 1 October 2023. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mat.0000990548.99398.1d
2023
Conference Publication
Early versus late extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest (RAPID): a target-trial emulation of the ELSO registry
Ruiyang Ling, Ryan, Gu, Tianyuan, Choo Tai, Bee, Seung Jung, Jae, Anders, Marc, Shekar, Kiran, Brodie, Daniel, MacLaren, Graeme and Ramanathan, Kollengode (2023). Early versus late extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest (RAPID): a target-trial emulation of the ELSO registry. 34th Annual ELSO Conference, Seattle, WA United States, 27 September - 1 October 2023. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mat.0000990716.55505.ec
2023
Journal Article
Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study
White, Kyle C., Serpa-Neto, Ary, Hurford, Rod, Clement, Pierre, Laupland, Kevin B., See, Emily, McCullough, James, White, Hayden, Shekar, Kiran, Tabah, Alexis, Ramanan, Mahesh, Garrett, Peter, Attokaran, Antony G., Luke, Stephen, Senthuran, Siva, McIlroy, Philippa, Bellomo, Rinaldo, Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Pip, Nash, Ben, McCullough, James, Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil, Morrison, Lynette ... on behalf of the Queensland Critical Care Research Network (QCCRN) (2023). Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study. Intensive Care Medicine, 49 (9), 1079-1089. doi: 10.1007/s00134-023-07138-0
2023
Journal Article
Patient and management variables associated with survival after postcardiotomy extracorporeal membrane oxygenation in adults: The PELS‐1 Multicenter Cohort Study
Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C. T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J. H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L. Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I‐wen, Jung, Jae‐Seung ... on behalf of the PELS-1 Investigators (2023). Patient and management variables associated with survival after postcardiotomy extracorporeal membrane oxygenation in adults: The PELS‐1 Multicenter Cohort Study. Journal of the American Heart Association, 12 (14) e029609, e029609. doi: 10.1161/jaha.123.029609
2023
Journal Article
Is it time to put low-flow extracorporeal carbon dioxide removal to REST?*
Worku, Elliott, Schmidt, Matthieu and Shekar, Kiran (2023). Is it time to put low-flow extracorporeal carbon dioxide removal to REST?*. Critical Care Medicine, 51 (7), 973-976. doi: 10.1097/ccm.0000000000005889
2023
Journal Article
Venovenous extracorporeal CO2 removal to support ultraprotective ventilation in moderate-severe acute respiratory distress syndrome: a systematic review and meta-analysis of the literature
Worku, Elliott, Brodie, Daniel, Ling, Ryan Ruiyang, Ramanathan, Kollengode, Combes, Alain and Shekar, Kiran (2023). Venovenous extracorporeal CO2 removal to support ultraprotective ventilation in moderate-severe acute respiratory distress syndrome: a systematic review and meta-analysis of the literature. Perfusion, 38 (5), 1062-1079. doi: 10.1177/02676591221096225
2023
Journal Article
Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation
Lyster, Haifa, Shekar, Kiran, Watt, Kevin, Reed, Anna, Roberts, Jason A. and Abdul-Aziz, Mohd-Hafiz (2023). Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation. Clinical Pharmacokinetics, 62 (7), 931-942. doi: 10.1007/s40262-023-01264-0
2023
Journal Article
Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID-19 severe ARDS: an international Delphi study
Rabie, Ahmed A., Elhazmi, Alyaa, Azzam, Mohamed H., Abdelbary, Akram, Labib, Ahmed, Combes, Alain, Zakhary, Bishoy, MacLaren, Graeme, Barbaro, Ryan P., Peek, Giles J., Antonini, Marta Velia, Shekar, Kiran, Al‐Fares, Abdulrahman, Oza, Pranay, Mehta, Yatin, Alfoudri, Huda, Ramanathan, Kollengode, Ogino, Mark, Raman, Lakshmi, Paden, Matthew, Brodie, Daniel and Bartlett, Robert (2023). Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID-19 severe ARDS: an international Delphi study. Annals of Intensive Care, 13 (1) 36, 1-12. doi: 10.1186/s13613-023-01126-9
2023
Journal Article
Excess burden of critical illness related to inflammatory bowel disease
Laupland, Kevin B, Shekar, Kiran, Tabah, Alexis, Clement, Pierre, Edwards, Felicity and Ramanan, Mahesh (2023). Excess burden of critical illness related to inflammatory bowel disease. Internal Medicine Journal, 53 (5), 812-818. doi: 10.1111/imj.15672
2023
Journal Article
Veno-Pulmonary Arterial Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Should We Consider Mechanical Support of the Pulmonary Circulation From the Outset?
Zochios, Vasileios, Yusuff, Hakeem, Antonini, Marta Velia, Schmidt, Matthieu, Shekar, Kiran and for Protecting the Right Ventricle Network (PRORVnet) (2023). Veno-Pulmonary Arterial Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Should We Consider Mechanical Support of the Pulmonary Circulation From the Outset?. ASAIO Journal, 69 (6), 511-518. doi: 10.1097/mat.0000000000001930
2023
Journal Article
The Relation between Obesity and Mortality in Postcardiotomy Veno-arterial Membrane Oxygenation
Heuts, Samuel, Mariani, Silvia, van Bussel, C.T., Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan ... on behalf of the PELS-1 Investigators (2023). The Relation between Obesity and Mortality in Postcardiotomy Veno-arterial Membrane Oxygenation. The Annals of Thoracic Surgery, 116 (1), 147-154. doi: 10.1016/j.athoracsur.2023.03.025
2023
Journal Article
Institution-free days after critical illness: A multicenter retrospective study
Marella, Prashanti, Laupland, Kevin B., Shekar, Kiran, Tabah, Alexis, Edwards, Felicity and Ramanan, Mahesh (2023). Institution-free days after critical illness: A multicenter retrospective study. Journal of Critical Care, 74 154253, 1-7. doi: 10.1016/j.jcrc.2023.154253
2023
Journal Article
Haematological trends and transfusion during adult extracorporeal membrane oxygenation: a single centre study
Worku, Elliott T., Win, April M., Parmar, Dinesh, Anstey, Chris and Shekar, Kiran (2023). Haematological trends and transfusion during adult extracorporeal membrane oxygenation: a single centre study. Journal of Clinical Medicine, 12 (7) 2629, 1-18. doi: 10.3390/jcm12072629
2023
Journal Article
90-day case-fatality in critically ill patients with chronic liver disease influenced by presence of portal hypertension, results from a multicentre retrospective cohort study
White, Kyle, Tabah, Alexis, Ramanan, Mahesh, Shekar, Kiran, Edwards, Felicity and Laupland, Kevin B. (2023). 90-day case-fatality in critically ill patients with chronic liver disease influenced by presence of portal hypertension, results from a multicentre retrospective cohort study. Journal of Intensive Care Medicine, 38 (1), 1-10. doi: 10.1177/08850666221100408
2023
Book Chapter
Ethical challenges and quality assurance of extracorporeal membrane oxygenation
Ramanathan, Kollengode, Shekar, Kiran and Dhundi, Ujwal (2023). Ethical challenges and quality assurance of extracorporeal membrane oxygenation. Cardiopulmonary bypass: advances in extracorporeal life support. (pp. 1023-1031) Amsterdam: Academic Press. doi: 10.1016/b978-0-443-18918-0.00065-6
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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