
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2023
Journal Article
Optimal settings at initiation of veno-venous extracorporeal membrane oxygenation: An exploratory in-silico study
Joyce, Christopher J., Shekar, Kiran and Walsham, James (2023). Optimal settings at initiation of veno-venous extracorporeal membrane oxygenation: An exploratory in-silico study. ASAIO Journal, 69 (1), E28-E34. doi: 10.1097/MAT.0000000000001849
2023
Journal Article
90-day case-fatality in critically ill patients with chronic liver disease influenced by presence of portal hypertension, results from a multicentre retrospective cohort study
White, Kyle, Tabah, Alexis, Ramanan, Mahesh, Shekar, Kiran, Edwards, Felicity and Laupland, Kevin B. (2023). 90-day case-fatality in critically ill patients with chronic liver disease influenced by presence of portal hypertension, results from a multicentre retrospective cohort study. Journal of Intensive Care Medicine, 38 (1), 1-10. doi: 10.1177/08850666221100408
2023
Book Chapter
Ethical challenges and quality assurance of extracorporeal membrane oxygenation
Ramanathan, Kollengode, Shekar, Kiran and Dhundi, Ujwal (2023). Ethical challenges and quality assurance of extracorporeal membrane oxygenation. Cardiopulmonary bypass: advances in extracorporeal life support. (pp. 1023-1031) Amsterdam: Academic Press. doi: 10.1016/b978-0-443-18918-0.00065-6
2023
Book Chapter
Extracorporeal life support in accidental hypothermia
Mitra, Saikat, Swol, Justyna, Ramanathan, Kollengode and Shekar, Kiran (2023). Extracorporeal life support in accidental hypothermia. Cardiopulmonary bypass: advances in extracorporeal life support. (pp. 1187-1195) edited by Kaan Kırali, Joseph S. Coselli and Afksendiyos Kalangos. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-443-18918-0.00076-0
2022
Journal Article
Reply to Fillatre, et al. and Li, et al
Abdul-Aziz, Mohd H., Roberts, Jason A. and Shekar, Kiran (2022). Reply to Fillatre, et al. and Li, et al. American Journal of Respiratory and Critical Care Medicine, 207 (7), 952-953. doi: 10.1164/rccm.202211-2140LE
2022
Journal Article
Outcomes of prolonged ICU stay for patients undergoing cardiac surgery in Australia and New Zealand
Shah, Vikram, Ahuja, Abhilasha, Kumar, Aashish, Anstey, Chris, Thang, Christopher, Guo, Linda, Shekar, Kiran and Ramanan, Mahesh (2022). Outcomes of prolonged ICU stay for patients undergoing cardiac surgery in Australia and New Zealand. Journal of Cardiothoracic and Vascular Anesthesia, 36 (12), 4313-4319. doi: 10.1053/j.jvca.2022.08.026
2022
Journal Article
Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis
Reddy, Mallikarjuna Ponnapa, Subramaniam, Ashwin, Chua, Clara, Ling, Ryan Ruiyang, Anstey, Christopher, Ramanathan, Kollengode, Slutsky, Arthur S and Shekar, Kiran (2022). Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis. The Lancet Respiratory Medicine, 10 (12), 1178-1188. doi: 10.1016/s2213-2600(22)00393-9
2022
Journal Article
A novel barrier device and method for protection against airborne pathogens during endotracheal intubation
Alonso, Julio M., Lipman, Jeffrey and Shekar, Kiran (2022). A novel barrier device and method for protection against airborne pathogens during endotracheal intubation. European Journal of Anaesthesiology, 39 (11), 900-903. doi: 10.1097/EJA.0000000000001731
2022
Journal Article
Need for tracheostomy in major head and neck ablative surgery: a paradigm shift during the COVID-19 pandemic
Quach, H., McGuire, B., Wallace, C. and Shekar, K. (2022). Need for tracheostomy in major head and neck ablative surgery: a paradigm shift during the COVID-19 pandemic. Annals of the Royal College of Surgeons of England, 104 (9), 700-702. doi: 10.1308/rcsann.2021.0327
2022
Journal Article
Impact of frailty on clinical outcomes in patients with and without COVID-19 pneumonitis admitted to intensive care units in Australia and New Zealand: a retrospective registry data analysis
Subramaniam, Ashwin, Shekar, Kiran, Anstey, Christopher, Tiruvoipati, Ravindranath and Pilcher, David (2022). Impact of frailty on clinical outcomes in patients with and without COVID-19 pneumonitis admitted to intensive care units in Australia and New Zealand: a retrospective registry data analysis. Critical Care, 26 (1) 301, 1-12. doi: 10.1186/s13054-022-04177-9
2022
Journal Article
Invasive mechanical ventilation in patients with acute respiratory distress syndrome receiving extracorporeal support: a narrative review of strategies to mitigate lung injury
Zochios, V., Brodie, D., Shekar, K., Schultz, M. J. and Parhar, K. K.S. (2022). Invasive mechanical ventilation in patients with acute respiratory distress syndrome receiving extracorporeal support: a narrative review of strategies to mitigate lung injury. Anaesthesia, 77 (10), 1137-1151. doi: 10.1111/anae.15806
2022
Journal Article
Microaxial left ventricular assist device in cardiogenic shock: a systematic review and meta-analysis
Tan, Shien Ru, Low, Christopher Jer Wei, Ng, Wei Lin, Ling, Ryan Ruiyang, Tan, Chuen Seng, Lim, Shir Lynn, Cherian, Robin, Lin, Weiqin, Shekar, Kiran, Mitra, Saikat, MacLaren, Graeme and Ramanathan, Kollengode (2022). Microaxial left ventricular assist device in cardiogenic shock: a systematic review and meta-analysis. Life, 12 (10) 1629, 1-16. doi: 10.3390/life12101629
2022
Journal Article
The impact of reduction in intensity of mechanical ventilation upon venovenous ECMO initiation on radiographically assessed lung edema scores: a retrospective observational study
Worku, Elliott T., Yeung, Francis, Anstey, Chris and Shekar, Kiran (2022). The impact of reduction in intensity of mechanical ventilation upon venovenous ECMO initiation on radiographically assessed lung edema scores: a retrospective observational study. Frontiers in Medicine, 9 1005192, 1-10. doi: 10.3389/fmed.2022.1005192
2022
Book Chapter
Pharmacology
Kirk, Christa Jefferis, Abdul-Aziz, Mohd H., Roberts, Jason A., Valencia, Eleonore, Watt, Kevin, MacLaren, Graeme and Shekar, Kiran (2022). Pharmacology. Extracorporeal life support: The ELSO red book. (pp. 643-654) edited by Graeme Maclaren, Daniel Brodie, Roberto Lorusso, Giles Peek, Ravi Thiagarajan and Leen Vercaemst. Ann Arbor, MI, United States: Extracorporeal Life Support Organization.
2022
Journal Article
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software
Roberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2
2022
Journal Article
Direct oral anticoagulants in atrial fibrillation following cardiac surgery: a systematic review and meta-analysis with trial sequential analysis
Koh, Kylynn K., Ling, Ryan R., Tan, Shaun Y.S., Chen, Ying, Fan, Bingwen E., Shekar, Kiran, Sule, Jai A., Subbian, Senthil K. and Ramanathan, Kollengode (2022). Direct oral anticoagulants in atrial fibrillation following cardiac surgery: a systematic review and meta-analysis with trial sequential analysis. British Journal of Anaesthesia, 129 (2), 154-162. doi: 10.1016/j.bja.2022.05.010
2022
Journal Article
Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection control strategies in healthcare workers
Subramaniam, Ashwin, Reddy, Mallikarjuna, Kadam, Umesh, Zubarev, Alexander, Lim, Zheng, Anstey, Chris, Bihari, Shailesh, Haji, Jumana, Luo, Jinghang, Mitra, Saikat, Ramanathan, Kollengode, Rajamani, Arvind, Rubulotta, Francesca, Svensk, Erik and Shekar, Kiran (2022). Development and validation of a tool to appraise guidelines on SARS-CoV-2 infection control strategies in healthcare workers. Australian Critical Care, 35 (4), 415-423. doi: 10.1016/j.aucc.2021.06.015
2022
Journal Article
SARS-CoV-2 transmission risk to healthcare workers performing tracheostomies: a systematic review
Subramaniam, Ashwin, Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna, Mitchell, Hayden and Shekar, Kiran (2022). SARS-CoV-2 transmission risk to healthcare workers performing tracheostomies: a systematic review. ANZ Journal of Surgery, 92 (7-8), 1614-1625. doi: 10.1111/ans.17814
2022
Journal Article
Population pharmacokinetics of ciprofloxacin in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Levkovich, Bianca J., Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Roberts, Jason A., Shekar, Kiran, Fraser, John F. and ASAP ECMO Investigators (2022). Population pharmacokinetics of ciprofloxacin in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Anaesthesia Critical Care and Pain Medicine, 41 (3) 101080, 1-6. doi: 10.1016/j.accpm.2022.101080
2022
Journal Article
Reply Letter to the Editor Regarding the ELSO Interim Guidelines for Veno-Arterial Extracorporeal Membrane Oxygenation in Adult Cardiac Patients
Lorusso, Roberto, Bartlett, Robert H., Shekar, Kiran, MacLaren, Graeme, Schmidt, Matthieu, Pellegrino, Vincent, Meyns, Bart, Haft, Jonathan, Vercaemst, Leen, Pappalardo, Federico, Bermudez, Christian, Belohlavek, Jan, Hou, Xiaotong, Boeken, Udo, Castillo, Roberto, Donker, Dirk W., Abrams, Darryl, Ranucci, Marco, Hryniewicz, Kasia, Chavez, Ivan, Chen, Yih-Sharng, Salazar, Leonardo and Whitman, Glenn (2022). Reply Letter to the Editor Regarding the ELSO Interim Guidelines for Veno-Arterial Extracorporeal Membrane Oxygenation in Adult Cardiac Patients. ASAIO Journal, 68 (6), E111-E112. doi: 10.1097/MAT.0000000000001701
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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