
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2025
Journal Article
Mean arterial pressure in critically ill adults receiving vasopressors: a multicentre, observational study
White, Kyle C., Quick, Lachlan, Durkin, Zachary, McCullough, James, Laupland, Kevin B., Blank, Sebastiaan, Attokaran, Antony G., Kumar, Aashish, Shekar, Kiran, Garrett, Peter, Meyer, Jason, Tabah, Alexis, Ramanan, Mahesh, Luke, Stephen, Chaba, Anis, Bellomo, Rinaldo, Lamontagne, François, Young, Paul J., Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Phillipa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden ... Keogh, Sam (2025). Mean arterial pressure in critically ill adults receiving vasopressors: a multicentre, observational study. Critical Care and Resuscitation, 27 (1) 100103, 1-8. doi: 10.1016/j.ccrj.2025.100103
2025
Journal Article
Correction: Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults
Badulak, Jenelle, Abrams, Darryl, Luks, Andrew M., Zakhary, Bishoy, Conrad, Steven A., Bartlett, Robert, MacLaren, Graeme, Vercaemst, Leen, Lorusso, Roberto, Broman, Lars Mikael, Agerstrand, Cara, Price, Susanna, Combes, Alain, Peek, Giles, Fan, Eddy, Shekar, Kiran, Fraser, John, Brodie, Daniel and on behalf of the Extracorporeal Life Support Organization (ELSO) (2025). Correction: Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults. Intensive Care Medicine, 51 (3), 1-2. doi: 10.1007/s00134-025-07809-0
2025
Journal Article
Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland
Flaws, Dylan, White, Kyle, Edwards, Felicity, Baker, Stuart, Senthuran, Siva, Ramanan, Mahesh, Attokaran, Antony G, Kumar, Aashish, McCullough, James, Shekar, Kiran, McIlroy, Philippa, Tabah, Alexis, Luke, Stephen, Garrett, Peter, Laupland, Kevin B, on behalf of the Queensland Critical Care Research Network (QCCRN), Denny, Kerina J, Tallott, Mandy, Marshall, Andrea, Moore, David, Sane, Sunil, Morrison, Lynette, Dipplesman, Pam, Nasser, Ahmad, Stewart, David, Shah, Vikram, Suliman, Adam, Meyer, Jason, Doola, Ra’eesa ... Keogh, Sam (2025). Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland. BMC Psychiatry, 25 (1) 118, 1-8. doi: 10.1186/s12888-025-06520-0
2025
Journal Article
Monitoring Hemostatic Function during Cardiac Surgery with Point-of-Care Viscoelastic Assays: A Narrative Review
Ong, Brandon Jin An, See Tow, Hui Xin, Fong, Alyssa Tze Wei, Ling, Ryan Ruiyang, Shekar, Kiran, Teoh, Kristine, Ti, Lian Kah, MacLaren, Graeme, Fan, Bingwen Eugene and Ramanathan, Kollengode (2025). Monitoring Hemostatic Function during Cardiac Surgery with Point-of-Care Viscoelastic Assays: A Narrative Review. Seminars in Thrombosis and Hemostasis. doi: 10.1055/s-0045-1802573
2025
Journal Article
Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study
Abdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24
2025
Journal Article
Impact of mild hypercapnia in critically ill patients with metabolic acidosis
Serpa Neto, Ary, Nasser, Ahmad, Marella, Prashanti, Fujii, Tomoko, Takahashi, Kazunari, Laupland, Kevin, Tabah, Alexis, Attokaran, Antony G., Kumar, Aashish, McCullough, James, Shekar, Kiran, Garrett, Peter, Blank, Sebastiaan, Senthuran, Siva, Luke, Stephen, McNamara, Mairead, Bellomo, Rinaldo and White, Kyle (2025). Impact of mild hypercapnia in critically ill patients with metabolic acidosis. Journal of Critical Care, 85 154936, 154936. doi: 10.1016/j.jcrc.2024.154936
2025
Journal Article
Extracorporeal Life Support Organization 2024 Guideline for early rehabilitation or mobilization of adult patients on extracorporeal membrane oxygenation
Ramsey, Stephen, Shehatta, Ahmed Labib, Ramanathan, Kollengode, Shekar, Kiran, Brodie, Daniel, Diaz, Rodrigo, Roberts, Abigail, Cruz, Sherene, Hodgson, Carol, Zakhary, Bishoy, Reviewers:, Herr, Daniel, Ramanan, Raj, Broman, Lars, Riera, Jordi, O’Neil, Erika and Peek, Giles (2025). Extracorporeal Life Support Organization 2024 Guideline for early rehabilitation or mobilization of adult patients on extracorporeal membrane oxygenation. ASAIO Journal, 71 (3), 187-199. doi: 10.1097/mat.0000000000002375
2025
Journal Article
Hemodynamics of Veno-Pulmonary Extracorporeal Membrane Oxygenation with Varying Right Ventricular Function in a Mock Circulatory Loop
Chand, Prashant, Yusuff, Hakeem, Zochios, Vasileios, Wickramarachchi, Avishka, Joyce, Christopher, Gregory, Shaun, Stephens, Andrew and Shekar, Kiran (2025). Hemodynamics of Veno-Pulmonary Extracorporeal Membrane Oxygenation with Varying Right Ventricular Function in a Mock Circulatory Loop. ASAIO Journal, 71 (9) 10.1097/MAT.0000000000002410, 727-735. doi: 10.1097/MAT.0000000000002410
2025
Conference Publication
Postcardiotomy extracorporeal membrane oxygenation in patients older than 70 years: Characteristics, outcomes, and variables associated with mortality
Makhoul, Maged, Mariani, Silvia, van Bussel, Bas C.T., Wiedeman, Dominik, Saeed, Diyar, Di Mauro, Michele, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Sacha Matteucci, Marco L., Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung ... Lorusso, Roberto (2025). Postcardiotomy extracorporeal membrane oxygenation in patients older than 70 years: Characteristics, outcomes, and variables associated with mortality. Elsevier B.V.. doi: 10.1016/j.xjon.2025.04.004
2025
Journal Article
Postcardiotomy extracorporeal membrane oxygenation after elective, urgent, and emergency cardiac operations: Insights from the PELS observational study
Mariani, Silvia, Perazzo, Alvaro, De Piero, Maria Elena, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Lehmann, Sven, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen ... Lorusso, Roberto (2025). Postcardiotomy extracorporeal membrane oxygenation after elective, urgent, and emergency cardiac operations: Insights from the PELS observational study. JTCVS Open, 24, 280-310. doi: 10.1016/j.xjon.2025.01.018
2025
Journal Article
Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation
Morales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc
2024
Journal Article
Intensive care unit-onset bloodstream infections represent a distinct category of hospital-onset infections: A multicentre, retrospective cohort study. Queensland Critical Care Network (QCCRN)
Tabah, Alexis, Edwards, Felicity, Ramanan, Mahesh, White, Kyle C., Shekar, Kiran, Mcilroy, Philippa, Attokaran, Antony, Senthuran, Siva, Mccullough, James, Kumar, Aashish, Luke, Stephen, Bhadange, Neeraj, Garrett, Peter and Laupland, Kevin B. (2024). Intensive care unit-onset bloodstream infections represent a distinct category of hospital-onset infections: A multicentre, retrospective cohort study. Queensland Critical Care Network (QCCRN). Journal of the Association of Medical Microbiology and Infectious Disease Canada (Jammi), 9 (4), 229-238. doi: 10.3138/jammi-2024-0023
2024
Journal Article
Rapid uptake of adjunctive corticosteroids for critically ill adults with septic shock following publication of ADRENAL trial. a multicenter, retrospective analysis of prescribing practices in Queensland Intensive Care Units
White, Kyle C., Chaba, Anis, Meyer, Jason, Ramanan, Mahesh, Tabah, Alexis, Attokaran, Antony G., Kumar, Aashish, McCullough, James, Shekar, Kiran, Garrett, Peter, McIlroy, Philippa, Senthuran, Siva, Luke, Stephen, Laupland, Kevin B. and on behalf of the Queensland Critical Care Research Network (QCCRN) (2024). Rapid uptake of adjunctive corticosteroids for critically ill adults with septic shock following publication of ADRENAL trial. a multicenter, retrospective analysis of prescribing practices in Queensland Intensive Care Units. Anaesthesia Critical Care and Pain Medicine, 43 (6) 101435, 1-11. doi: 10.1016/j.accpm.2024.101435
2024
Journal Article
Outcomes of adult patients With COVID-19 transitioning from venovenous to venoarterial or hybrid extracorporeal membrane oxygenation in the extracorporeal life support organization registry
Nguyen, Khoa, Altibi, Ahmed, Prasad, Pooja, Mukundan, Srini, Shekar, Kiran, Ramanathan, Kollengode and Zakhary, Bishoy (2024). Outcomes of adult patients With COVID-19 transitioning from venovenous to venoarterial or hybrid extracorporeal membrane oxygenation in the extracorporeal life support organization registry. ASAIO Journal, 70 (12), 1040-1045. doi: 10.1097/mat.0000000000002243
2024
Journal Article
ICU-acquired hypernatremia: prevalence, patient characteristics, trajectory, risk factors, and outcomes
Nasser, Ahmad, Chaba, Anis, Laupland, Kevin B., Ramanan, Mahesh, Tabah, Alexis, Attokaran, Antony G., Kumar, Aashish, McCullough, James, Shekar, Kiran, Garrett, Peter, McIlroy, Philippa, Luke, Stephen, Senthuran, Siva, Bellomo, Rinaldo, White, Kyle C., Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Philippa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam ... on behalf of the Queensland Critical Care Research Network (QCCRN) (2024). ICU-acquired hypernatremia: prevalence, patient characteristics, trajectory, risk factors, and outcomes. Critical Care and Resuscitation, 26 (4), 303-310. doi: 10.1016/j.ccrj.2024.09.003
2024
Journal Article
Timing of adjunctive vasopressin initiation for septic shock patients and hospital mortality: a multicentre observational study
White, Kyle C., Costa-Pinto, Rahul, Chaba, Anis, McIlroy, Philippa, Senthuran, Siva, Luke, Stephen, Attokaran, Antony G., Garrett, Peter, Ramanan, Mahesh, Tabah, Alexis, Shekar, Kiran, Laupland, Kevin B., White, Hayden, McCullough, James, Udy, Andrew, Eastwood, Glenn, Bellomo, Rinaldo, Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Pip, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil ... Keogh, Sam (2024). Timing of adjunctive vasopressin initiation for septic shock patients and hospital mortality: a multicentre observational study. Critical Care and Resuscitation, 26 (4), 295-302. doi: 10.1016/j.ccrj.2024.09.002
2024
Journal Article
Features and outcomes of females and males requiring postcardiotomy extracorporeal life support
Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne-Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo ... Solinas, Marco (2024). Features and outcomes of females and males requiring postcardiotomy extracorporeal life support. The Journal of Thoracic and Cardiovascular Surgery, 168 (6), 1701-1711.e30. doi: 10.1016/j.jtcvs.2024.04.033
2024
Journal Article
Sepsis‐associated acute kidney injury in patients with chronic kidney disease: patient characteristics, prevalence, timing, trajectory, treatment and associated outcomes
White, Kyle C., Bellomo, Rinaldo, Tabah, Alexis, Attokaran, Antony G., White, Hayden, McCullough, James, Shekar, Kiran, Ramanan, Mahesh, Garrett, Peter, McIlroy, Philippa, Senthuran, Siva, Luke, Stephen, Serpa‐Neto, Ary, Larsen, Tom, Laupland, Kevin B. and the Queensland Critical Care Research Network (QCCRN) (2024). Sepsis‐associated acute kidney injury in patients with chronic kidney disease: patient characteristics, prevalence, timing, trajectory, treatment and associated outcomes. Nephrology, 29 (12), 838-848. doi: 10.1111/nep.14392
2024
Journal Article
Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults
Badulak, Jenelle, Abrams, Darryl, Luks, Andrew M., Zakhary, Bishoy, Conrad, Steven A., Bartlett, Robert, MacLaren, Graeme, Vercaemst, Leen, Lorusso, Roberto, Broman, Lars Mikael, Agerstrand, Cara, Price, Susanna, Combes, Alain, Peek, Giles, Fan, Eddy, Shekar, Kiran, Fraser, John and Brodie, Daniel (2024). Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults. Intensive Care Medicine, 50 (12), 1994-2004. doi: 10.1007/s00134-024-07645-8
2024
Journal Article
Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005-2022. A binational, registry-based study
Ling, Ryan Ruiyang, Ponnapa Reddy, Mallikarjuna, Subramaniam, Ashwin, Moran, Benjamin, Ramanathan, Kollengode, Ramanan, Mahesh, Burrell, Aidan, Pilcher, David and Shekar, Kiran (2024). Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005-2022. A binational, registry-based study. Intensive Care Medicine, 50 (11), 1861-1872. doi: 10.1007/s00134-024-07609-y
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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