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Professor Kiran Shekar
Professor

Kiran Shekar

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Overview

Background

Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.

Availability

Professor Kiran Shekar is:
Available for supervision
Media expert

Research interests

  • Extracorporeal membrane oxygenation

  • Respiratory failure and minimising the burden of invasive mechanical ventilation

  • PK/PD on Extracorporeal membrane oxygenation support

  • Cardiogenic Shock and Mechanical Circulatory Support

  • Microcirculation on temporary Mechanical Circulatory Support

  • Building a budget intensive care unit to improve intensive care access in resource poor countries

  • Standardising ECMO education to bridge the variability in global ECMO outcomes

Works

Search Professor Kiran Shekar’s works on UQ eSpace

308 works between 2008 and 2025

241 - 260 of 308 works

2016

Journal Article

Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support

Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Dunster, Kimble R., Diab, Sara D., Tung, John-Paul, Minchinton, Robyn M., McDonald, Charles I., Anstey, Chris M., Shekar, Kiran and Fraser, John F. (2016). Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support. AJP - Lung Cellular and Molecular Physiology, 311 (6), L1202-L1212. doi: 10.1152/ajplung.00296.2016

Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support

2016

Journal Article

Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit

Platts, David G., McDonald, Charles, Shekar, Kiran, Burstow, Darryl J., Mullany, Daniel, Ziegenfuss, Marc, Diab, Sara and Fraser, John F. (2016). Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit. Intensive Care Medicine Experimental, 4 (1) 7, 7. doi: 10.1186/s40635-016-0079-0

Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit

2016

Journal Article

High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation

Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John, Smith, Maree T. and Ghassabian, Sussan (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, 1038, 80-87. doi: 10.1016/j.jchromb.2016.10.038

High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation

2016

Journal Article

Association between post-sternotomy tracheostomy and deep sternal wound infection: a retrospective analysis

Tsai, Yi-Chin, Phan, Kevin, Stroebel, Andrie, Williams, Livia, Nicotra, Lisa, Drake, Lesley, Ryan, Elizabeth, McGree, James, Tesar, Peter and Shekar, Kiran (2016). Association between post-sternotomy tracheostomy and deep sternal wound infection: a retrospective analysis. Journal of Thoracic Disease, 8 (11), 3294-3300. doi: 10.21037/jtd.2016.11.70

Association between post-sternotomy tracheostomy and deep sternal wound infection: a retrospective analysis

2016

Journal Article

Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery

McDonald, C., Fraser, J., Shekar, K., Clarke, A., Coombes, J., Barnett, A., Pearse, B. and Fung, L. (2016). Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery. European Journal of Clinical Nutrition, 70 (10), 1138-1143. doi: 10.1038/ejcn.2016.125

Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery

2016

Other Outputs

Sick patients, starved circuits and sticky drugs: understanding pharmacokinetics during extracorporeal membrane oxygenation to optimise drug dosing and improve patient outcomes

Shekar, Kiran (2016). Sick patients, starved circuits and sticky drugs: understanding pharmacokinetics during extracorporeal membrane oxygenation to optimise drug dosing and improve patient outcomes. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2016.789

Sick patients, starved circuits and sticky drugs: understanding pharmacokinetics during extracorporeal membrane oxygenation to optimise drug dosing and improve patient outcomes

2016

Journal Article

Mechanical circulatory support in the new era: an overview

Shekar, Kiran, Gregory, Shaun D. and Fraser, John F. (2016). Mechanical circulatory support in the new era: an overview. Critical Care, 20 (1) 66, 66.1-66.12. doi: 10.1186/s13054-016-1235-3

Mechanical circulatory support in the new era: an overview

2016

Journal Article

Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review

Obonyo, Nchafatso G., Fanning, Jonathon P., Ng, Angela S. Y., Pimenta, Leticia P., Shekar, Kiran, Platts, David G., Maitland, Kathryn and Fraser, John F. (2016). Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Medicine Experimental, 4 (1) 38, 1-16. doi: 10.1186/s40635-016-0112-3

Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review

2016

Journal Article

The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association?

Kilburn, Daniel J., Shekar, Kiran and Fraser, John F. (2016). The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association?. BioMed Research International, 2016 1094296, 1094296-14. doi: 10.1155/2016/1094296

The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association?

2015

Journal Article

Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Shekar, Kiran, Roberts, Jason A., Barnett, Adrian G., Diab, Sara, Wallis, Steven C., Fung, Yoke L. and Fraser, John F. (2015). Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models. Critical Care, 19 (1) 437, 1-11. doi: 10.1186/s13054-015-1151-y

Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

2015

Journal Article

Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h

Hayes, Rylan A., Foley, Samuel, Shekar, Kiran, Diab, Sara, Dunster, Kimble R., McDonald, Charles and Fraser, John F. (2015). Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h. Blood Coagulation and Fibrinolysis, 26 (7), 816-822. doi: 10.1097/MBC.0000000000000360

Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h

2015

Journal Article

Successful conservative management of an iatrogenic ECMO cannula--related inferior vena cava injury

Bhaskar, B., Mullany, D., Parmar, D., Ziengenfuss, M. and Shekar, K. (2015). Successful conservative management of an iatrogenic ECMO cannula--related inferior vena cava injury. Anaesthesia and Intensive Care, 43 (3), 418-419.

Successful conservative management of an iatrogenic ECMO cannula--related inferior vena cava injury

2015

Journal Article

Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study

Shekar, Kiran, Roberts, Jason A, Mcdonald, Charles I, Ghassabian, Sussan, Anstey, Chris, Wallis, Steven C, Mullany, Daniel V, Fung, Yoke L and Fraser, John F (2015). Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study. Critical Care, 19 (164) 164, 164. doi: 10.1186/s13054-015-0891-z

Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study

2015

Journal Article

The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model

McDonald, Charles I, Fung, Yoke Lin, Shekar, Kiran, Diab, Sara D, Dunster, Kimble R, Passmore, Margaret R, Foley, Samuel R, Simonova, Gabriela, Platts, David and Fraser, John F (2015). The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model. Journal of Trace Elements in Medicine and Biology, 30, 4-10. doi: 10.1016/j.jtemb.2015.01.004

The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model

2015

Journal Article

Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure

Rateesh, Shruti, Shekar, Kiran, Naidoo, Rishendran, Mittal, Dolly and Bhaskar, Balu (2015). Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure. Circulation: Heart Failure, 8 (2), 381-383. doi: 10.1161/CIRCHEARTFAILURE.115.002080

Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure

2015

Journal Article

Feasibility of perflutren microsphere contrast transthoracic echocardiography in the visualization of ventricular endocardium during venovenous extracorporeal membrane oxygenation in a validated ovine model

Platts, David G., Diab, Sara, Dunster, Kimble R., Shekar, Kiran, Burstow, Darryl J., Sim, Beatrice, Tunbridge, Matthew, McDonald, Charles, Chemonges, Saul, Chan, Jonathan and Fraser, John F. (2015). Feasibility of perflutren microsphere contrast transthoracic echocardiography in the visualization of ventricular endocardium during venovenous extracorporeal membrane oxygenation in a validated ovine model. Echocardiography, 32 (3), 548-556. doi: 10.1111/echo.12695

Feasibility of perflutren microsphere contrast transthoracic echocardiography in the visualization of ventricular endocardium during venovenous extracorporeal membrane oxygenation in a validated ovine model

2015

Conference Publication

Association between post-sternotomy tracheostomy and deep sternal wound infection

Tsai, Yi-Chin, Phan, Kevin, Stroebel, Andrie, Williams, Livia, Nicotra, Lisa, Drake, Lesley, Ryan, Elizabeth, McGree, James, Tesar, Peter and Shekar, Kiran (2015). Association between post-sternotomy tracheostomy and deep sternal wound infection. Australia and New Zealand Society of Cardio-thoracic Surgeons’ Annual Scientific Meeting, Gold Coast, QLD Australia, 9-12 November 2014. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2014.12.105

Association between post-sternotomy tracheostomy and deep sternal wound infection

2014

Journal Article

The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

Shekar, Kiran, Fraser, John F., Taccone, Fabio Silvio, Welch, Susan, Wallis, Steven C., Mullany, Daniel V., Lipman, Jeffrey and Roberts, Jason A. (2014). The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Critical Care, 18 (6) 565, 1-9. doi: 10.1186/s13054-014-0565-2

The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

2014

Journal Article

Reduced radiation tolerance of penile structures associated with dose-escalated hypofractionated prostate radiotherapy

McDonald, Andrew M., Baker, Christopher B., Shekar, Kiran, Popple, Richard A., Clark, Grant M., Yang, Eddy S., Jacob, Rojymon, Kim, Robert Y. and Fiveash, John B. (2014). Reduced radiation tolerance of penile structures associated with dose-escalated hypofractionated prostate radiotherapy. Urology, 84 (6), 1383-1388. doi: 10.1016/j.urology.2014.07.060

Reduced radiation tolerance of penile structures associated with dose-escalated hypofractionated prostate radiotherapy

2014

Journal Article

Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

Donadello, Katia, Roberts, Jason A., Cristallini, Stefano, Beumier, Marjorie, Shekar, Kiran, Jacobs, Frederique, Belhaj, Asmae, Vincent, Jean-Louis, de Backer, Daniel and Taccone, Fabio Silvio (2014). Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study. Critical Care, 18 (632) 632, 1-10. doi: 10.1186/s13054-014-0632-8

Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

Funding

Current funding

  • 2025 - 2030
    Integrating sequencing technologies for bloodstream infection and sepsis diagnostics in critically-ill patients
    NHMRC MRFF Genomics Health Futures Mission
    Open grant
  • 2025 - 2030
    ROAD RCT: Resistance Optimised Antibiotic Dosing in critically ill patients - a Randomised Controlled Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2023 - 2028
    A national critical care research platform to ensure high quality sepsis care in Australian ICUs (MRFF EMCR led by Monash University)
    Monash University
    Open grant
  • 2022 - 2026
    PRecision Ecmo in CardIogenic Shock Evaluation: PRECISE Study (MRFF grant administered by Monash University)
    Monash University
    Open grant

Past funding

  • 2019
    Establishing UQ Centre for Clinical Research as the centre for Aerosol therapy in critical care by optimising particle size of aerosols for effective drug delivery.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    Imaging the Microcirculation in Critical Care Research
    NHMRC Equipment Grant
    Open grant

Supervision

Availability

Professor Kiran Shekar is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project

    Associate Advisor

    Other advisors: Professor Jeffrey Lipman

Completed supervision

Media

Enquiries

Contact Professor Kiran Shekar directly for media enquiries about their areas of expertise.

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