
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2016
Journal Article
Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support
Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Dunster, Kimble R., Diab, Sara D., Tung, John-Paul, Minchinton, Robyn M., McDonald, Charles I., Anstey, Chris M., Shekar, Kiran and Fraser, John F. (2016). Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support. AJP - Lung Cellular and Molecular Physiology, 311 (6), L1202-L1212. doi: 10.1152/ajplung.00296.2016
2016
Journal Article
Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit
Platts, David G., McDonald, Charles, Shekar, Kiran, Burstow, Darryl J., Mullany, Daniel, Ziegenfuss, Marc, Diab, Sara and Fraser, John F. (2016). Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit. Intensive Care Medicine Experimental, 4 (1) 7, 7. doi: 10.1186/s40635-016-0079-0
2016
Journal Article
High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation
Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John, Smith, Maree T. and Ghassabian, Sussan (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, 1038, 80-87. doi: 10.1016/j.jchromb.2016.10.038
2016
Journal Article
Association between post-sternotomy tracheostomy and deep sternal wound infection: a retrospective analysis
Tsai, Yi-Chin, Phan, Kevin, Stroebel, Andrie, Williams, Livia, Nicotra, Lisa, Drake, Lesley, Ryan, Elizabeth, McGree, James, Tesar, Peter and Shekar, Kiran (2016). Association between post-sternotomy tracheostomy and deep sternal wound infection: a retrospective analysis. Journal of Thoracic Disease, 8 (11), 3294-3300. doi: 10.21037/jtd.2016.11.70
2016
Journal Article
Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery
McDonald, C., Fraser, J., Shekar, K., Clarke, A., Coombes, J., Barnett, A., Pearse, B. and Fung, L. (2016). Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery. European Journal of Clinical Nutrition, 70 (10), 1138-1143. doi: 10.1038/ejcn.2016.125
2016
Other Outputs
Sick patients, starved circuits and sticky drugs: understanding pharmacokinetics during extracorporeal membrane oxygenation to optimise drug dosing and improve patient outcomes
Shekar, Kiran (2016). Sick patients, starved circuits and sticky drugs: understanding pharmacokinetics during extracorporeal membrane oxygenation to optimise drug dosing and improve patient outcomes. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2016.789
2016
Journal Article
Mechanical circulatory support in the new era: an overview
Shekar, Kiran, Gregory, Shaun D. and Fraser, John F. (2016). Mechanical circulatory support in the new era: an overview. Critical Care, 20 (1) 66, 66.1-66.12. doi: 10.1186/s13054-016-1235-3
2016
Journal Article
Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review
Obonyo, Nchafatso G., Fanning, Jonathon P., Ng, Angela S. Y., Pimenta, Leticia P., Shekar, Kiran, Platts, David G., Maitland, Kathryn and Fraser, John F. (2016). Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Medicine Experimental, 4 (1) 38, 1-16. doi: 10.1186/s40635-016-0112-3
2016
Journal Article
The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association?
Kilburn, Daniel J., Shekar, Kiran and Fraser, John F. (2016). The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association?. BioMed Research International, 2016 1094296, 1094296-14. doi: 10.1155/2016/1094296
2015
Journal Article
Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models
Shekar, Kiran, Roberts, Jason A., Barnett, Adrian G., Diab, Sara, Wallis, Steven C., Fung, Yoke L. and Fraser, John F. (2015). Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models. Critical Care, 19 (1) 437, 1-11. doi: 10.1186/s13054-015-1151-y
2015
Journal Article
Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h
Hayes, Rylan A., Foley, Samuel, Shekar, Kiran, Diab, Sara, Dunster, Kimble R., McDonald, Charles and Fraser, John F. (2015). Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h. Blood Coagulation and Fibrinolysis, 26 (7), 816-822. doi: 10.1097/MBC.0000000000000360
2015
Journal Article
Successful conservative management of an iatrogenic ECMO cannula--related inferior vena cava injury
Bhaskar, B., Mullany, D., Parmar, D., Ziengenfuss, M. and Shekar, K. (2015). Successful conservative management of an iatrogenic ECMO cannula--related inferior vena cava injury. Anaesthesia and Intensive Care, 43 (3), 418-419.
2015
Journal Article
Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study
Shekar, Kiran, Roberts, Jason A, Mcdonald, Charles I, Ghassabian, Sussan, Anstey, Chris, Wallis, Steven C, Mullany, Daniel V, Fung, Yoke L and Fraser, John F (2015). Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study. Critical Care, 19 (164) 164, 164. doi: 10.1186/s13054-015-0891-z
2015
Journal Article
The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model
McDonald, Charles I, Fung, Yoke Lin, Shekar, Kiran, Diab, Sara D, Dunster, Kimble R, Passmore, Margaret R, Foley, Samuel R, Simonova, Gabriela, Platts, David and Fraser, John F (2015). The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model. Journal of Trace Elements in Medicine and Biology, 30, 4-10. doi: 10.1016/j.jtemb.2015.01.004
2015
Journal Article
Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure
Rateesh, Shruti, Shekar, Kiran, Naidoo, Rishendran, Mittal, Dolly and Bhaskar, Balu (2015). Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure. Circulation: Heart Failure, 8 (2), 381-383. doi: 10.1161/CIRCHEARTFAILURE.115.002080
2015
Journal Article
Feasibility of perflutren microsphere contrast transthoracic echocardiography in the visualization of ventricular endocardium during venovenous extracorporeal membrane oxygenation in a validated ovine model
Platts, David G., Diab, Sara, Dunster, Kimble R., Shekar, Kiran, Burstow, Darryl J., Sim, Beatrice, Tunbridge, Matthew, McDonald, Charles, Chemonges, Saul, Chan, Jonathan and Fraser, John F. (2015). Feasibility of perflutren microsphere contrast transthoracic echocardiography in the visualization of ventricular endocardium during venovenous extracorporeal membrane oxygenation in a validated ovine model. Echocardiography, 32 (3), 548-556. doi: 10.1111/echo.12695
2015
Conference Publication
Association between post-sternotomy tracheostomy and deep sternal wound infection
Tsai, Yi-Chin, Phan, Kevin, Stroebel, Andrie, Williams, Livia, Nicotra, Lisa, Drake, Lesley, Ryan, Elizabeth, McGree, James, Tesar, Peter and Shekar, Kiran (2015). Association between post-sternotomy tracheostomy and deep sternal wound infection. Australia and New Zealand Society of Cardio-thoracic Surgeons’ Annual Scientific Meeting, Gold Coast, QLD Australia, 9-12 November 2014. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2014.12.105
2014
Journal Article
The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study
Shekar, Kiran, Fraser, John F., Taccone, Fabio Silvio, Welch, Susan, Wallis, Steven C., Mullany, Daniel V., Lipman, Jeffrey and Roberts, Jason A. (2014). The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Critical Care, 18 (6) 565, 1-9. doi: 10.1186/s13054-014-0565-2
2014
Journal Article
Reduced radiation tolerance of penile structures associated with dose-escalated hypofractionated prostate radiotherapy
McDonald, Andrew M., Baker, Christopher B., Shekar, Kiran, Popple, Richard A., Clark, Grant M., Yang, Eddy S., Jacob, Rojymon, Kim, Robert Y. and Fiveash, John B. (2014). Reduced radiation tolerance of penile structures associated with dose-escalated hypofractionated prostate radiotherapy. Urology, 84 (6), 1383-1388. doi: 10.1016/j.urology.2014.07.060
2014
Journal Article
Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study
Donadello, Katia, Roberts, Jason A., Cristallini, Stefano, Beumier, Marjorie, Shekar, Kiran, Jacobs, Frederique, Belhaj, Asmae, Vincent, Jean-Louis, de Backer, Daniel and Taccone, Fabio Silvio (2014). Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study. Critical Care, 18 (632) 632, 1-10. doi: 10.1186/s13054-014-0632-8
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
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