
Overview
Background
Shekar is a Senior Intensive Care Specialist and the Director of Research in the Adult Intensive Care Service at the Prince Charles Hospital. He holds academic appointments as a Professor at the University of Queensland, Adjunct Professor at Queensland University of Technology and Associate Professor at Bond University, Gold Coast. Shekar is the recipient of the Metro North Hospital and Health Service Clinician Research Fellowship and the Queeensland Health Research Fellowship. Shekar specialises in the design and conduct of both pre-clinical and clinical studies. His ongoing research programs, “The NO Tube Project” and “ The Budget ICU Project”, bring together clinicians, multidisciplinary allied health professionals, engineers, scientists, health economists, industry and policy experts to minimise the burden of invasive mechanical ventilation in intensive care units and to improve access to intensive care services around the world. His current body of research includes the pathophysiology of cardiorespiratory failure, sepsis and extracorporeal life support (ECLS). Shekar has significant experience in conducting mechanistic research in large animal models of lung injury, mechanical ventilation, sepsis and ECLS. His pioneering work in drug pharmacokinetics in adult patients on ECLS was recognised globally. He is the chief investigator of an ongoing international multi-centre clinical study that aims to develop drug dosing guidelines for ECLS patients. Shekar has secured over $20 million in grant funding, published over 300 peer-reviewed articles, 60 conference abstracts, 14 book chapters and has delivered over 100 national and international lectures. He regularly reviews articles for leading journals and competitive grant applications. He is routinely involved with bedside teaching and simulation exercises, as well as supervision of RHD students. Shekar has collaborated extensively both nationally and internationally. He is a member of the Scientific Committee of the International ECMO Network. He is the global research lead for Extracorporeal Life Support Organisation (ELSO) Education Taskforce and is a member of the Asia-Pacific ELSO Steering and Education Committee. He is also the Chair of the global ELSO COVID-19 working group. Shekar contributes to the Australia and New Zealand Intensive Care Society COVID-19 Guideline Committee and is the Co-Chair of the National COVID-19 Clinical Evidence Taskforce Hospital and Acute Care Panel. He has significant experience with Clinical Information Systems (CIS) and is the Chair of the CIS Special User Group in Queensland.
Availability
- Professor Kiran Shekar is:
- Available for supervision
- Media expert
Research interests
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Extracorporeal membrane oxygenation
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Respiratory failure and minimising the burden of invasive mechanical ventilation
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PK/PD on Extracorporeal membrane oxygenation support
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Cardiogenic Shock and Mechanical Circulatory Support
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Microcirculation on temporary Mechanical Circulatory Support
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Building a budget intensive care unit to improve intensive care access in resource poor countries
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Standardising ECMO education to bridge the variability in global ECMO outcomes
Works
Search Professor Kiran Shekar’s works on UQ eSpace
2014
Journal Article
Macro- and micronutrient disposition in an ex vivo model of extracorporeal membrane oxygenation
Estensen, Kristine, Shekar, Kiran, Robins, Elissa, McDonald, Charles, Barnett, Adrian G. and Fraser, John F. (2014). Macro- and micronutrient disposition in an ex vivo model of extracorporeal membrane oxygenation. Intensive Care Medicine Experimental, 2 (1) 29, 29. doi: 10.1186/s40635-014-0029-7
2014
Journal Article
PC6 acupoint stimulation for the prevention of postcardiac surgery nausea and vomiting: a protocol for a two-group, parallel, superiority randomised clinical trial
Cooke, Marie, Rickard, Claire, Rapchuk, Ivan, Shekar, Kiran, Marshall, Andrea P., Comans, Tracy, Doi, Suhail, McDonald, John and Spooner, Amy (2014). PC6 acupoint stimulation for the prevention of postcardiac surgery nausea and vomiting: a protocol for a two-group, parallel, superiority randomised clinical trial. BMJ Open, 4 (11) 006179, 1-6. doi: 10.1136/bmjopen-2014-006179
2014
Journal Article
The rapidly evolving use of extracorporeal life support (ECLS) in adults
Mullany, Dan, Shekar, Kiran, Platts, David and Fraser, John (2014). The rapidly evolving use of extracorporeal life support (ECLS) in adults. Heart, Lung and Circulation, 23 (11), 1091-1092. doi: 10.1016/j.hlc.2014.04.009
2014
Journal Article
Can timely ECMO initiation mitigate pre-ECMO risk factors for acute kidney injury?
Shekar, Kiran and Fraser, John F. (2014). Can timely ECMO initiation mitigate pre-ECMO risk factors for acute kidney injury?. Annals of Thoracic Surgery, 98 (4), 1523-1523. doi: 10.1016/j.athoracsur.2014.05.055
2014
Journal Article
ARDS: rest the lungs or the ventilator?
Shekar, Kiran (2014). ARDS: rest the lungs or the ventilator?. Intensive Care Medicine, 40 (8), 1184-1184. doi: 10.1007/s00134-014-3386-5
2014
Journal Article
Different rectal toxicity tolerance with and without simultaneous conventionally-fractionated pelvic lymph node treatment in patients receiving hypofractionated prostate radiotherapy
McDonald, Andrew M, Baker, Christopher B, Popple, Richard A, Shekar, Kiran, Yang, Eddy S, Jacob, Rojymon, Cardan, Rex, Kim, Robert Y and Fiveash, John B (2014). Different rectal toxicity tolerance with and without simultaneous conventionally-fractionated pelvic lymph node treatment in patients receiving hypofractionated prostate radiotherapy. Radiation oncology (London, England), 9 (1) 129, 129. doi: 10.1186/1748-717X-9-129
2014
Journal Article
An age-of-blood transfusion trial in the trauma setting is crucial and animal models may help inform trial design
Milford, Elissa M., Reade, Michael C., Colone, Lieutenant, Shekar, Kiran, Tung, John-Paul and Fraser, John F. (2014). An age-of-blood transfusion trial in the trauma setting is crucial and animal models may help inform trial design. Critical Care and Resuscitation, 16 (2), 149-150.
2014
Journal Article
Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: A comprehensive review
Shekar, Kiran, Mullany, Daniel V., Thomson, Bruce, Ziegenfuss, Marc, Platts, David G. and Fraser, John F. (2014). Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: A comprehensive review. Critical Care, 18 (2) 219. doi: 10.1186/cc13865
2014
Journal Article
Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
Chemonges, Saul, Shekar, Kiran, Tung, John-Paul, Dunster, Kimble R., Diab, Sara, Platts, David, Watts, Ryan P., Gregory, Shaun D., Foley, Samuel, Simonova, Gabriela, McDonald, Charles, Hayes, Rylan, Bellpart, Judith, Timms, Daniel, Chew, Michelle, Fung, Yoke L., Toon, Michael, Maybauer, Marc O. and Fraser, John F. (2014). Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. BioMed Research International, 2014 (468309) 468309, 1-17. doi: 10.1155/2014/468309
2014
Journal Article
Ventilator-induced lung injury
Shekar, Kiran and Fraser, John F. (2014). Ventilator-induced lung injury. New England Journal of Medicine, 370 (10), 979-979. doi: 10.1056/NEJMc1400293
2014
Journal Article
Extracorporeal respiratory support: breaking conventions?
Shekar, K (2014). Extracorporeal respiratory support: breaking conventions?. Anaesthesia and intensive care, 42 (2), 175-7. doi: 10.1177/0310057X1404200202
2014
Journal Article
A novel echocardiographic imaging technique, intracatheter echocardiography, to guide veno-venous extracorporeal membrane oxygenation cannulae placement in a validated ovine model
Platts, David G., Hilton, Andrew, Diab, Sara, McDonald, Charles, Tunbridge, Matthew, Chemonges, Saul, Dunster, Kimble R., Shekar, Kiran, Burstow, Darryl J. and Fraser, John F. (2014). A novel echocardiographic imaging technique, intracatheter echocardiography, to guide veno-venous extracorporeal membrane oxygenation cannulae placement in a validated ovine model. Intensive Care Medicine Experimental, 2 (2) 2, 1-13. doi: 10.1186/2197-425X-2-2
2014
Journal Article
Transfusion of packed red blood cells reduces selenium levels and increases lipid peroxidation in an in vivo ovine model
McDonald, C. I., Fraser, J. F., Shekar, K., Dunster, K. R., Thom, O. and Fung, Y. L. (2014). Transfusion of packed red blood cells reduces selenium levels and increases lipid peroxidation in an in vivo ovine model. Transfusion Medicine, 24 (1), 50-54. doi: 10.1111/tme.12087
2014
Journal Article
Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in rett syndrome
Cuddapah, Vishnu Anand, Pillai, Rajesh B., Shekar, Kiran V., Lane, Jane B., Motil, Kathleen J., Skinner, Steven A., Tarquinio, Daniel Charles, Glaze, Daniel G., McGwin, Gerald, Kaufmann, Walter E., Percy, Alan K., Neul, Jeffrey L. and Olsen, Michelle L. (2014). Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in rett syndrome. Journal of Medical Genetics, 51 (3), 152-158. doi: 10.1136/jmedgenet-2013-102113
2014
Journal Article
A preliminary investigation into adrenal responsiveness and outcomes in patients with cardiogenic shock after acute myocardial infarction
Tol, Maneesha M., Shekar, Kiran, Barnett, Adrian G., McGree, James, McWhinney, Brett C., Ziegenfuss, Marc, Ungerer, Jacobus P. and Fraser, John F. (2014). A preliminary investigation into adrenal responsiveness and outcomes in patients with cardiogenic shock after acute myocardial infarction. Journal of Critical Care, 29 (3), 470.e1-470.e6. doi: 10.1016/j.jcrc.2014.01.020
2014
Conference Publication
Evidence of ECMO induced changes to haemostasis in an ovine model
Foley, S., Fung, L., Simonova, G., Solano, C., Diab, S., Dunster, K., McDonald, C., Shekar, K. and Fraser, J. (2014). Evidence of ECMO induced changes to haemostasis in an ovine model. 38th Australian and New Zealand Scientific Meeting on Intensive Care and the 19th Annual Paediatric and Neonatal intensive Care Conference, Hobart, Australia, October, 2013. Philadelphia, United States: Elsevier. doi: 10.1016/j.aucc.2013.10.057
2013
Journal Article
Can optimal drug dosing during ECMO improve outcomes?
Shekar, Kiran, Fraser, John F. and Roberts, Jason A. (2013). Can optimal drug dosing during ECMO improve outcomes?. Intensive Care Medicine, 39 (12), 2237-2237. doi: 10.1007/s00134-013-3080-z
2013
Journal Article
To ventilate, oscillate, or cannulate?
Shekar, Kiran, Davies, Andrew R., Mullany, Daniel V., Tiruvoipati, Ravindranath and Fraser, John F. (2013). To ventilate, oscillate, or cannulate?. Journal of Critical Care, 28 (5), 655-662. doi: 10.1016/j.jcrc.2013.04.009
2013
Journal Article
Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage
Fung, Y. L., Tung, J. P., Foley, S. R., Simonova, G., Thom, O., Staib, A., Collier, J., Dunster, K. R., Solano, C., Shekar, K., Chew, M. S. and Fraser, J. F. (2013). Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage. Vox Sanguinis, 105 (2), 150-158. doi: 10.1111/vox.12032
2013
Journal Article
Depletion of myocardial glucose is observed during endotoxaemic but not haemorrhagic shock in a porcine model
Chew M. S., Shekar K., Brand B. A., Norin C. and Barnett A. G. (2013). Depletion of myocardial glucose is observed during endotoxaemic but not haemorrhagic shock in a porcine model. Critical Care, 17 (4) R164. doi: 10.1186/cc12843
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kiran Shekar is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Associate Advisor
Other advisors: Professor Jeffrey Lipman
Completed supervision
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2019
Doctor Philosophy
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
Media
Enquiries
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