![Professor Darryl Eyles](/sites/default/files/profiles/6537.jpeg)
Overview
Background
Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.
Availability
- Professor Darryl Eyles is:
- Available for supervision
Fields of research
Qualifications
- Postgraduate Diploma, Griffith University
Research impacts
The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.
Works
Search Professor Darryl Eyles’s works on UQ eSpace
2007
Conference Publication
Developmental vitamin D deficiency; A candidate risk factor for schizophrenia
Eyles, DW, Burne, T, Cui, X, Kesby, J, Ko, P and McGrath, J (2007). Developmental vitamin D deficiency; A candidate risk factor for schizophrenia. 10th International Congress on Schizophrenia Research, Savannah GA, APR 02-06, 2005. OXFORD: OXFORD UNIV PRESS.
2007
Conference Publication
Developmental vitamin D deficiency, postnatal development and adult behaviour in Sprague-Dawley rats
Burne, T. H., O'Loan, J., Kesby, J., McGrath, J. J. and Eyles, D. W. (2007). Developmental vitamin D deficiency, postnatal development and adult behaviour in Sprague-Dawley rats. 10th International Congress on Schizophrenia Research, Savannah, GA, United States, 02-06 April 2005. Oxford, United Kingdom: Oxford University Press.
2007
Journal Article
Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain
Eyles, D., Almeras, L., Benech, P., Patatian, A., Mackay-Sim, A., McGrath, J. and Feron, F. (2007). Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. Journal of Steriod Biochemistry and Molecular Biology, 103 (3-5), 538-545. doi: 10.1016/j.jsbmb.2006.12.096
2007
Journal Article
No association between serum 25-Hydroxyvitamin D3 level and performance on psychometric tests in NHANes III
McGrath, J. J., Scragg, R., Chant, D. C., Eyles, D., Burne, T. H. J. and Obradovic, D. (2007). No association between serum 25-Hydroxyvitamin D3 level and performance on psychometric tests in NHANes III. Neuroepidemiology, 29 (1-2), 49-54. doi: 10.1159/000108918
2007
Journal Article
Vitamin D deficiency during various stages of pregnancy in the rat: Its impact on development and behavior in adult offspring
O'Loan, Jonathan, Eyles, Darryl W., Kesby, James, Ko, Pauline, McGrath, John J. and Burne, Thomas H. J. (2007). Vitamin D deficiency during various stages of pregnancy in the rat: Its impact on development and behavior in adult offspring. Psychoneuroendocrinology, 32 (3), 227-234. doi: 10.1016/j.psyneuen.2006.12.006
2006
Conference Publication
Developmental vitamin D deficiency alters adult behaviour: An informative animal model of schizophrenia
Burne, T. H. J., Kesby, J., OLoan, J., McGrath, J. J., Mackay-Sim, A. and Eyles, D. W. (2006). Developmental vitamin D deficiency alters adult behaviour: An informative animal model of schizophrenia. XIIIth Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2006.01.006
2006
Journal Article
Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function
Eyles, D. W., Rogers, F., Buller, K., McGrath, J. J., Ko, P., French, K. and Burne, T. H. J. (2006). Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function. Psychoneuroendocrinology, 31 (8), 958-964. doi: 10.1016/j.psyneuen.2006.05.006
2006
Conference Publication
The DVD animal model of schizophrenia: Early gestational hypovitaminosis D reduces neonatal brain GDNF
Eyles, D. W., O'Loan, J., Burne, T. H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Early gestational hypovitaminosis D reduces neonatal brain GDNF. 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February, 2006. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.schres.2006.01.006
2006
Journal Article
Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
Burne, Thomas H.J., OLoan, Jonathon, McGrath, John J. and Eyles, Darryl W. (2006). Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint. Behavioural Brain Research, 174 (1), 119-124. doi: 10.1016/j.bbr.2006.07.015
2006
Conference Publication
Animal models for schizophrenia, why do we bother?
Eyles, D. (2006). Animal models for schizophrenia, why do we bother?. ASC 2006, Fremantle, WA Australia, 21-23 August 2006. London, United Kingdom: SAGE Publications.
2006
Conference Publication
Developmental vitamin D Depletion alters adult rat behaviour and response to psychomimetic drugs: a relevant model for schizophrenia
Kesby, J. P., OLoan, J., Burne, T. H., McGrath, J. and Eyles, D. W. (2006). Developmental vitamin D Depletion alters adult rat behaviour and response to psychomimetic drugs: a relevant model for schizophrenia. Australasian Schizophrenia Conference, Fremantle, 21-23 August 2006. Abingdon, England: Informa Healthcare. doi: 10.1111/j.1440-1614.2006.01859_2.x
2006
Conference Publication
The DVD animal model of schizophrenia: Effects of low maternal vitamin D on brain dopamine
Eyles, D. W., Ko, P., Kesby, J. P., Burne, H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Effects of low maternal vitamin D on brain dopamine. XIIIth Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2006.01.006
2006
Journal Article
Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia
Kesby, James P., Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2006). Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia. Biological Psychiatry, 60 (6), 591-596. doi: 10.1016/j.biopsych.2006.02.033
2006
Conference Publication
From biological marker to endophenotype: the role of animal models
Eyles, D., Burne, T. and McGrath, J. (2006). From biological marker to endophenotype: the role of animal models. Brainwaves’ - The Australasian Society for Psychiatric Research Annual Meeting 2006, Sydney, Australia, 6-8 December 2006. doi: 10.1017/S0924270800032312
2006
Book Chapter
Prenatal Vitamin D Deficiency and Brain Development
Burne, T. H. J., McGrath, J. J., MacKay-Sim, A. and Eyles, D. W. (2006). Prenatal Vitamin D Deficiency and Brain Development. Vitamin D: New Research. (pp. 153-172) edited by Veronica D. Stolzt. USA: Nova Science Publishers Inc.
2005
Journal Article
Seasonal variation in birth weight
McGrath, John J., Burne, Thomas H. and Eyles, Darryl W. (2005). Seasonal variation in birth weight. Canadian Medical Association Journal, 173 (7), 733-733. doi: 10.1503/cmaj.1050100
2005
Journal Article
The association between birth weight, season of birth and latitude
McGrath, John J., Barnett, Adrian G. and Eyles, Darryl W. (2005). The association between birth weight, season of birth and latitude. Annals of Human Biology, 32 (5), 547-559. doi: 10.1080/03014460500154699
2005
Journal Article
Season of birth and risk of brain tumors in adults
Ko, P., Eyles, D., Burne, T., Mackay-Sim, A. and McGrath, J. J. (2005). Season of birth and risk of brain tumors in adults. Neurology, 64 (7), 1317-1317. doi: 10.1212/WNL.64.7.1317
2005
Conference Publication
Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D
Burne, T., Kesby, J. P., Feron, F., Eyles, D. W., Mackay-Sim, A. and McGrath, J. (2005). Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, 3 January - 2 February. Australia: Australian Neuroscience Society Inc..
2005
Journal Article
Developmental Vitamin D-3 deficiency alters the adult rat brain
Feron, F, Burne, THJ, Brown, J, Smith, E, McGrath, JJ, Mackay-Sim, A and Eyles, DW (2005). Developmental Vitamin D-3 deficiency alters the adult rat brain. Brain Research Bulletin, 65 (2), 141-148. doi: 10.1016/j.brainresbull.2004.12.007
Funding
Current funding
Past funding
Supervision
Availability
- Professor Darryl Eyles is:
- Available for supervision
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Supervision history
Completed supervision
-
2024
Doctor Philosophy
Stress and dopamine in the dorsal striatum: exploration of potentially causative mechanisms in schizophrenia
Principal Advisor
Other advisors: Dr James Kesby
-
2024
Doctor Philosophy
Two novel animal models to selectively increase dorsal striatal dopamine release: Implications for schizophrenia
Principal Advisor
-
2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Principal Advisor
Other advisors: Honorary Professor Jake Gratten, Professor Dan Siskind
-
2023
Doctor Philosophy
Developmental Vitamin D-deficiency rat model: Exploration of autism-relevant phenotypes, gut health and placental inflammation
Principal Advisor
-
2021
Master Philosophy
Prenatal Hypoxia Alters the Ontogeny of Dopamine Neurons
Principal Advisor
Other advisors: Dr Wei Luan
-
2019
Doctor Philosophy
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): A New Animal Model of Relevance to Schizophrenia
Principal Advisor
-
2018
Doctor Philosophy
Developmental vitamin D deficiency rat model of Autism Spectrum Disorder
Principal Advisor
-
2018
Master Philosophy
Maternal Immune Activation adversely affects the ontogeny of dopamine neurons. Is Vitamin D neuroprotective?
Principal Advisor
Other advisors: Dr Wei Luan
-
2016
Doctor Philosophy
Evaluating long-term consequences of adolescent antipsychotic exposure
Principal Advisor
Other advisors: Professor Thomas Burne
-
2010
Doctor Philosophy
The impact of developmental vitamin D deficiency on brain neurochemistry and behaviour in Sprague-Dawley rats
Principal Advisor
Other advisors: Professor Thomas Burne
-
2009
Doctor Philosophy
The effect of developmental vitamin D3 deficiency on brain development, immune function and behaviour in the adult rat
Principal Advisor
Other advisors: Professor Thomas Burne, Professor John McGrath
-
2016
Doctor Philosophy
Establishing novel cognitive tasks in animal models relevant to schizophrenia
Associate Advisor
Other advisors: Professor Thomas Burne
-
2012
Doctor Philosophy
Brain Development and Behaviour in Developmentally Vitamin D-Deficient Mice
Associate Advisor
Other advisors: Professor Thomas Burne
-
2016
Doctor Philosophy
Neural mechanisms of MK-801 induced sensitisation
Joint Principal Advisor
Other advisors: Professor Thomas Burne
-
2012
Doctor Philosophy
The effects of Advanced Paternal Age (APA) on behavioural and brain structural phenotypes in C57BL/6J mice.
Joint Principal Advisor
Other advisors: Professor Thomas Burne
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