Overview
Background
Prof Siskind trained as a psychiatrist in Australia and the United States. He graduated from medicine at the University of Queensland in 1998. After working with Doctors Without Borders in Chechnya in 2000, he became interested in psychiatry. He moved to Boston in 2002, where he did his psychiatry residency at Boston University and a Master of Public Health at Harvard University. He returned to Brisbane in June 2008 as a clinical academic psychiatrist at the Metro South Addiction and Mental Health Service. He completed his Ph.D in Feb 2014. His research interests include clozapine and treatment refractory schizophrenia, the physical health of people with severe and persistent mental illness, supported accommodation, assertive community treatment and mental health services research. He was awarded an NHMRC Investigator Grant as a Leadership Fellow (L1 2027-2031) an Emerging Leadership Fellow (EL2 2021-2025) and an NHMRC Early Career Fellowship (ECF 2016-2019). He has a current CIA MRFF RCRDUN grant looking at treatments to reduce cardiometabolic morbidity among people with schizophrenia. He was the SIRS 2026 Outstanding Clinical and Community Research Award recipient, and was elected to the Australian Academy of Health and Medical Sciences in 2025. He has over 350 peer reviewed publications, including first author in the highly ranked Lancet, World Psychiatry, Lancet Psychiatry, BJPsych, ANZJP, & Schizophrenia Bulletin. He is a named investigator on over $65 million in competitive research grants, with over $9 million as CIA.
Availability
- Professor Dan Siskind is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Schizophrenia
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Physical Health Comorbidity
Research impacts
Prof Siskind's research has had direct, measurable impact on clinical practice and policy. His landmark studies on clozapine-associated neutropenia demonstrated that routine monitoring could safely cease after two years, evidence that has driven the removal of long-term monitoring mandates by regulators — improving safe and quality access to clozapine for more than 2.5 million people globally. His work establishing optimal plasma clozapine reference ranges is now used by pathology providers across Australia, while his findings on antipsychotic-associated metabolic risk and weight gain have been incorporated into international guidelines and adopted into clinical practice, with metformin augmentation now regularly prescribed for patients commencing antipsychotics. His Lancet Psychiatry Commission on physical health in people with mental illness helped set the global agenda for integrating physical and mental healthcare, informing policy from the WHO, OECD, and across multiple countries. As Chair of the INTEGRATE Steering Committee, he led development of the first consensus-based, algorithmic international guidelines for schizophrenia treatment, which have been endorsed by peak bodies. Through sustained engagement with regulators, professional colleges and health services, Prof Siskind has ensured his research translates rapidly from bench to bedside to policy, cementing his reputation as a global leader in schizophrenia care.
Works
Search Professor Dan Siskind’s works on UQ eSpace
2027
Journal Article
A description of legislative frameworks for mentally ill offenders found not criminally responsible across Australia and New Zealand
Lu, M., Wright, B., Trott, M., Kisely, S., Weller, P., Every-Palmer, S., Siskind, D. and Bull, C. (2027). A description of legislative frameworks for mentally ill offenders found not criminally responsible across Australia and New Zealand. International Journal of Law and Psychiatry, 110 102292. doi: 10.1016/j.ijlp.2026.102292
2026
Journal Article
Efficacy and safety outcomes of different plasma clozapine and norclozapine levels in schizophrenia spectrum disorder: a dose-response meta-analysis exploring “critical” levels
Fornaro, Michele, Lorenzo, Chiara Di, Siskind, Dan and de Bartolomeis, Andrea (2026). Efficacy and safety outcomes of different plasma clozapine and norclozapine levels in schizophrenia spectrum disorder: a dose-response meta-analysis exploring “critical” levels. Psychiatry Research, 365 117340, 1-16. doi: 10.1016/j.psychres.2026.117340
2026
Journal Article
GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data
Davoodian, Najmeh, Williams, Lana J, Berk, Michael, Arnautovska, Urska, Kim, Jee Hyun, McLure, James, Panizzutti, Bruna, Rossell, Susan L, Siskind, Dan, Taipale, Heidi, Taquet, Maxime, Upthegrove, Rachel, Walder, Ken, Yung, Alison R and Mohebbi, Mohammadreza (2026). GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data. The Lancet Psychiatry, 13 (11), 931-942. doi: 10.1016/S2215-0366(26)00276-2
2026
Journal Article
W127. GWAS OF COMMON CLOZAPINE ASSOCIATED ADVERSE DRUG REACTIONS REVEAL NOVEL INSIGHTS INTO THE GENETIC ARCHITECTURE OF CLOZAPINE TREATMENT RESPONSE
Mutema, Anthony, Painter, Jodie, Siskind, Dan, Lind, Penelope A. and Medland, Sarah E. (2026). W127. GWAS OF COMMON CLOZAPINE ASSOCIATED ADVERSE DRUG REACTIONS REVEAL NOVEL INSIGHTS INTO THE GENETIC ARCHITECTURE OF CLOZAPINE TREATMENT RESPONSE. European Neuropsychopharmacology, 111 113245, 113245. doi: 10.1016/j.euroneuro.2026.113245
2026
Journal Article
Hospitalisation and mortality outcomes after second COVID-19 vaccination among Australians living with severe mental illness: Findings from a matched case–control study using national data linkage
Bull, Claudia, Wheeler, Amanda J., Palmer, Victoria J., Lewis, Matthew, Siskind, Dan and Kisely, Steve (2026). Hospitalisation and mortality outcomes after second COVID-19 vaccination among Australians living with severe mental illness: Findings from a matched case–control study using national data linkage. Australian and New Zealand Journal of Psychiatry 00048674261475206, 48674261475206-48674261475206. doi: 10.1177/00048674261475206
2026
Journal Article
Body composition-mediated and drug-related metabolic dysregulation during long-term antipsychotic treatment in youth
Adam, Till J., Hojlund, Mikkel, Pillinger, Toby, McCutcheon, Robert A., Siskind, Dan, DelBello, Melissa P., Welge, Jeffrey A., Taipale, Heidi, Tiihonen, Jari, Chang, Wing Chung, McIntyre, Roger S., Nielsen, Rene E., Fink-Jensen, Anders, Solmi, Marco and Correll, Christoph U. (2026). Body composition-mediated and drug-related metabolic dysregulation during long-term antipsychotic treatment in youth. Nature Mental Health, 4 (10), 1548-1559. doi: 10.1038/s44220-026-00721-6
2026
Journal Article
F78. CLINICAL AND GENETIC DETERMINANTS OF MEDICATION USE AND SERVICE UTILISATION RELATED HEALTHCARE COSTS IN BIPOLAR DISORDER
Lind, Penelope A., Parker, Richard, Siskind, Dan J. and Medland, Sarah E. (2026). F78. CLINICAL AND GENETIC DETERMINANTS OF MEDICATION USE AND SERVICE UTILISATION RELATED HEALTHCARE COSTS IN BIPOLAR DISORDER. European Neuropsychopharmacology, 111 113473, 113473. doi: 10.1016/j.euroneuro.2026.113473
2026
Journal Article
Effects of glucagon-like peptide-1 receptor agonists on anthropometric and adiposity measures in patients with antipsychotic-induced weight gain: a systematic review and meta-analysis
Lee, Songmin, Kim, Min-Gul, Trott, Mike, Siskind, Dan and Kim, Jae Hyun (2026). Effects of glucagon-like peptide-1 receptor agonists on anthropometric and adiposity measures in patients with antipsychotic-induced weight gain: a systematic review and meta-analysis. Journal of Psychopharmacology, 2698811261456190. doi: 10.1177/02698811261456190
2026
Journal Article
F48. BEYOND A SINGLE SCORE: A MULTIVARIATE POLYGENIC RISK PROFILE APPROACH TO PSYCHIATRIC RISK
Ferreira, Andreza, Lind, Penelope A., Moody, Hayley, Hickie, Ian B., Olsen, Catherine, Whiteman, David C., Law, Matthew H., Siskind, Dan J., Martin, Nicholas G., Medland, Richard C. and Medland, Sarah E. (2026). F48. BEYOND A SINGLE SCORE: A MULTIVARIATE POLYGENIC RISK PROFILE APPROACH TO PSYCHIATRIC RISK. European Neuropsychopharmacology, 111 113443, 113443. doi: 10.1016/j.euroneuro.2026.113443
2026
Journal Article
A multidisciplinary perspective on digital health interventions in schizophrenia care: Expanding the 2026 Grading of Recommendations, Assessment, Development and Evaluations guidelines
Arnautovska, Urska, Brown, Ellie, Korman, Nicole, Trott, Mike, Lawn, Sharon, Firth, Joseph, Bialkowski, Agata, Dark, Frances, Siskind, Dan and Milton, Alyssa (2026). A multidisciplinary perspective on digital health interventions in schizophrenia care: Expanding the 2026 Grading of Recommendations, Assessment, Development and Evaluations guidelines. Australian and New Zealand Journal of Psychiatry 00048674261484723, 1-9. doi: 10.1177/00048674261484723
2026
Conference Publication
UNRAVELLING THE MECHANISMS OF CLOZAPINE-INDUCED NEUTROPENIA IN TREATMENT-RESISTANT SCHIZOPHRENIA USING CELLULAR GENOMICS
Yang, Yuanhao, Edwards, Timothy, Parat, Marie-Odile, Neupane, Sabita, Siskind, Dan and Gratten, Jacob (2026). UNRAVELLING THE MECHANISMS OF CLOZAPINE-INDUCED NEUTROPENIA IN TREATMENT-RESISTANT SCHIZOPHRENIA USING CELLULAR GENOMICS. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2026.113704
2026
Journal Article
Change in the life expectancy gap among people with mental illness: a 14-year population-based cohort study in Australia
Trott, Mike, Lawrence, David, Halstead, Sean, Bull, Claudia, Siskind, Dan and Kisely, Steve (2026). Change in the life expectancy gap among people with mental illness: a 14-year population-based cohort study in Australia. The Lancet Regional Health - Western Pacific, 74 101978, 101978-74. doi: 10.1016/j.lanwpc.2026.101978
2026
Journal Article
No evidence for a generalised predictive processing deficit in psychosis: A meta-analysis
Miller-Silva, Chantal, Illingworth, Benjamin J. G., Martey, Kirsten, Mujirishvili, Tamara, de Beer, Franciska, Siskind, Dan and Murray, Graham K. (2026). No evidence for a generalised predictive processing deficit in psychosis: A meta-analysis. Psychological Medicine, 56 e268, 1-16. doi: 10.1017/S0033291726105455
2026
Journal Article
A summary for non‐psychiatrists of the Australian and New Zealand Journal of Psychiatry grading of recommendations, assessment, development and evaluations ( GRADE ) guidelines for the management of schizophrenia
Suetani, Shuichi, Dark, Frances, Every‐Palmer, Susanna, Galletly, Cherrie, O'Donoghue, Brian, Halstead, Sean, Keating, Dolores, Kisely, Steve, Korman, Nicole, Lappin, Julia, Lawn, Sharon, Thompson, Andrew, Warren, Nicola and Siskind, Dan J. (2026). A summary for non‐psychiatrists of the Australian and New Zealand Journal of Psychiatry grading of recommendations, assessment, development and evaluations ( GRADE ) guidelines for the management of schizophrenia. Medical Journal of Australia, 224 (9) e70287, 9. doi: 10.5694/mja2.70287
2026
Journal Article
Incidence of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar-spectrum disorders compared with age-matched and sex-matched individuals in Queensland, Australia: a statewide, hospital cohort study
Halstead, Sean, Warren, Nicola, Kisely, Steve, Arnautovska, Urska, Trott, Mike, Correll, Christoph U., Ebdrup, Bjorn H., Heffernan, Ed, Mohr, Grímur Hognason, McCutcheon, Robert A., Morley, Katherine I., O’Donoghue, Brian, Pillinger, Toby, Sara, Grant, Taipale, Heidi and Siskind, Dan (2026). Incidence of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar-spectrum disorders compared with age-matched and sex-matched individuals in Queensland, Australia: a statewide, hospital cohort study. The Lancet Psychiatry, 13 (9), 771-782. doi: 10.1016/s2215-0366(26)00196-3
2026
Journal Article
The pharmacotherapeutic use of clozapine in older adults: A narrative review
Mulholland, Kate, O’ Donoghue, Brian, Siskind, Dan, McCarthy, Geraldine and Lally, John (2026). The pharmacotherapeutic use of clozapine in older adults: A narrative review. Therapeutic Advances in Psychopharmacology, 16 20451253261481517. doi: 10.1177/20451253261481517
2026
Journal Article
Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records
Fornaro, Michele, Di Lorenzo, Chiara, Steardo, Luca, Veronese, Nicola, Stubbs, Brendon, Vancampfort, Davy, Siskind, Dan and Solmi, Marco (2026). Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records. European Neuropsychopharmacology, 110 112880, 112880-110. doi: 10.1016/j.euroneuro.2026.112880
2026
Journal Article
Temporal patterns and risk factors of clozapine-associated neutropenia: a nationwide population-based cohort study
Wu, Chi-Shin, Northwood, Korinne, Wu, Ming-Shiang, Wang, Shi-Heng, Huang, Wei-Lieh, Liu, Chen-Chung and Siskind, Dan (2026). Temporal patterns and risk factors of clozapine-associated neutropenia: a nationwide population-based cohort study. The Lancet Regional Health Western Pacific, 74 101970. doi: 10.1016/j.lanwpc.2026.101970
2026
Journal Article
Incidence of clozapine-associated neutropenia in patients with schizophrenia: 20-year population-based study in Hong Kong
Zhou, Huiquan, Luo, Hao, Siskind, Dan, Northwood, Korinne, Tang, Jennifer Yee-Man, Lui, Simon S. Y., Lee, Edwin H. M., Kan, Chui-Kwan, Tsui, Chi Fong, Poon, Lap Tak, Leung, Shuk Yan Joey, Wong, Yip Chau, Wong, Jessica Oi Yin and Chan, Sherry Kit Wa (2026). Incidence of clozapine-associated neutropenia in patients with schizophrenia: 20-year population-based study in Hong Kong. The British Journal of Psychiatry, 1-8. doi: 10.1192/bjp.2026.10726
2026
Journal Article
Duration of untreated illness in eating disorders: a comprehensive systematic review and meta-regression
de Geus, Gyselle, Trott, Mike, Monteleone, Alessio Maria, Firth, Joseph, Siskind, Dan, Teasdale, Scott, Arnautovska, Urska, Iyer, Ravi, Stubbs, Brendon, Demidenko, Natasha, Martin, David, Antochi, Ruxandra, Fiedorowicz, Jess G., Austin, Amelia, Schmidt, Ulrike, Wade, Tracey, Fernandez-Aranda, Fernando, Herpertz-Dahlmann, Beate, Hoek, Hans W., Voderholzer, Ulrich, Kolar, David, Zipfel, Stephan, Pike, Kathleen M., Karwautz, Andreas, Wonderlich, Stephen, Smith, Lee, Carfagno, Marco and Solmi, Marco (2026). Duration of untreated illness in eating disorders: a comprehensive systematic review and meta-regression. Journal of Eating Disorders. doi: 10.1186/s40337-026-01731-6
Funding
Current funding
Supervision
Availability
- Professor Dan Siskind is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Food and nutrition security in individuals with severe mental illness
Principal Advisor
Other advisors: Dr Urska Arnautovska
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Doctor Philosophy
Manifestations, impacts, and clinical implications of physical multimorbidity in people living with severe mental illness
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Steve Kisely
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Doctor Philosophy
Management of myocarditis among people with schizophrenia commencing clozapine
Associate Advisor
Other advisors: Associate Professor Nicola Warren
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Doctor Philosophy
Genetic determinants of treatment outcomes in mental health: harnessing the shared genetic etiology of mental disorders for precision psychiatry.
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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Master Philosophy
A quantitative and qualitative study of forensic orders in Queensland
Associate Advisor
Other advisors: Professor Steve Kisely, Dr Claudia Bull, Dr Mike Trott
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Doctor Philosophy
Smoking Cessation in People with a Serious Mental Illness
Associate Advisor
Other advisors: Professor Steve Kisely, Professor Coral Gartner
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Doctor Philosophy
Measuring cognitive flexibility in rodents
Associate Advisor
Other advisors: Professor Thomas Burne
Completed supervision
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2026
Doctor Philosophy
The Quality and Safe Use of Clozapine
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Michael Barras, Professor Steve Kisely
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2025
Doctor Philosophy
Investigating clozapine rechallenge using granulocyte-colony stimulating factor in people previously experiencing clozapine-associated neutropenia.
Principal Advisor
Other advisors: Professor Steve Kisely
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2021
Doctor Philosophy
Psychiatric clinical decision making in anti-NMDA receptor encephalitis
Principal Advisor
Other advisors: Associate Professor Stefan Blum, Professor Steve Kisely
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2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Honorary Professor Darryl Eyles
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2023
Doctor Philosophy
Measuring and improving cognition in a rodent model relevant to schizophrenia
Associate Advisor
Other advisors: Dr James Kesby, Professor Thomas Burne
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2022
Doctor Philosophy
Nose-to-Brain Delivery of Clozapine in Sol-Gel Systems
Associate Advisor
Other advisors: Associate Professor Harendra Parekh, Dr Preeti Pandey, Dr James Robert Falconer
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2020
Doctor Philosophy
Exploring the characteristics and service needs of carers for adults with mental illness to inform mental health service planning
Associate Advisor
Other advisors: Associate Professor Meredith Harris
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2020
Doctor Philosophy
Who receives what, from whom, and to what effect at clinically operated, community-based residential mental health rehabilitation for Severe and Persistent Mental Illness in Australia?
Associate Advisor
Other advisors: Associate Professor Meredith Harris
Media
Enquiries
Contact Professor Dan Siskind directly for media enquiries about:
- Cardiometabolic co-morbidity of schizophrenia
- Treatment Refractory Schizophrenia
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