Overview
Background
Prof Siskind trained as a psychiatrist in Australia and the United States. He graduated from medicine at the University of Queensland in 1998. After working with Doctors Without Borders in Chechnya in 2000, he became interested in psychiatry. He moved to Boston in 2002, where he did his psychiatry residency at Boston University and a Master of Public Health at Harvard University. He returned to Brisbane in June 2008 as a clinical academic psychiatrist at the Metro South Addiction and Mental Health Service. He completed his Ph.D in Feb 2014. His research interests include clozapine and treatment refractory schizophrenia, the physical health of people with severe and persistent mental illness, supported accommodation, assertive community treatment and mental health services research. He was awarded an NHMRC Investigator Grant as a Leadership Fellow (L1 2027-2031) an Emerging Leadership Fellow (EL2 2021-2025) and an NHMRC Early Career Fellowship (ECF 2016-2019). He has a current CIA MRFF RCRDUN grant looking at treatments to reduce cardiometabolic morbidity among people with schizophrenia. He was the SIRS 2026 Outstanding Clinical and Community Research Award recipient, and was elected to the Australian Academy of Health and Medical Sciences in 2025. He has over 350 peer reviewed publications, including first author in the highly ranked Lancet, World Psychiatry, Lancet Psychiatry, BJPsych, ANZJP, & Schizophrenia Bulletin. He is a named investigator on over $65 million in competitive research grants, with over $9 million as CIA.
Availability
- Professor Dan Siskind is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Schizophrenia
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Physical Health Comorbidity
Research impacts
Prof Siskind's research has had direct, measurable impact on clinical practice and policy. His landmark studies on clozapine-associated neutropenia demonstrated that routine monitoring could safely cease after two years, evidence that has driven the removal of long-term monitoring mandates by regulators — improving safe and quality access to clozapine for more than 2.5 million people globally. His work establishing optimal plasma clozapine reference ranges is now used by pathology providers across Australia, while his findings on antipsychotic-associated metabolic risk and weight gain have been incorporated into international guidelines and adopted into clinical practice, with metformin augmentation now regularly prescribed for patients commencing antipsychotics. His Lancet Psychiatry Commission on physical health in people with mental illness helped set the global agenda for integrating physical and mental healthcare, informing policy from the WHO, OECD, and across multiple countries. As Chair of the INTEGRATE Steering Committee, he led development of the first consensus-based, algorithmic international guidelines for schizophrenia treatment, which have been endorsed by peak bodies. Through sustained engagement with regulators, professional colleges and health services, Prof Siskind has ensured his research translates rapidly from bench to bedside to policy, cementing his reputation as a global leader in schizophrenia care.
Works
Search Professor Dan Siskind’s works on UQ eSpace
2025
Journal Article
Relapse in schizophrenia: a systematic review of criteria for clinical studies and international consensus guidelines to improve them
Howes, Oliver D., Bukala, Bernard R., Chen, Eric Y.H., Correll, Christoph U., Hasan, Alkomiet, Honer, William G., Kane, John M., Leucht, Stefan, Siafis, Spyridon, Agid, Ofer, Akena, Dickens, Arango, Celso, Atwoli, Lukoye, Barnes, Thomas R.E., Birnbaum, Michael L., Bitter, Istvan, Breier, Alan, Buchanan, Robert W., Citrome, Leslie, Cotter, David R., Crossley, Nicolas, Davidson, Michael, de Bartolomeis, Andrea, DeLisi, Lynn E., Dollfus, Sonia, Dursun, Serdar M., Ebdrup, Bjørn H., Elkis, Helio, Emsley, Robin ... McCutcheon, Robert A. (2025). Relapse in schizophrenia: a systematic review of criteria for clinical studies and international consensus guidelines to improve them. American Journal of Psychiatry, 182 (11), 969-983. doi: 10.1176/appi.ajp.20241040
2025
Journal Article
Clozapine and anti-cancer agents: A systematic literature review of case reports
Honor, Amity, Parmenter, Joseph, Marsh, Rodney, Siskind, Dan and Warren, Nicola (2025). Clozapine and anti-cancer agents: A systematic literature review of case reports. CNS Spectrums, 30 (1) e76, 1-9. doi: 10.1017/s1092852925100576
2025
Journal Article
Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission
Halstead, Sean, Yap, Chloe X., Warren, Nicola, Agarwal, Sri Mahavir, Brand, Bodyl A., Chan, Sherry Kit Wa, Cipriani, Andrea, Correll, Christoph U., Crossley, Nicolas, D’Ambrosio, Enrico, Emsley, Robin, Firth, Joseph, Gaughran, Fiona, Gee, Siobhan, Hahn, Margaret, Hayes, Joseph F, Heald, Adrian, Howes, Oliver D, Kane, John M, Kapi, Maria, Leucht, Stefan, Meyer, Nicholas, O’Donoghue, Brian, Okeke, Emmanuel, Perry, Benjamin I, Solmi, Marco, Sommer, Iris E, Srivastava, Vivek, Taipale, Heidi ... Lancet Psychiatry Physical Health Commission Consortium (2025). Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission. The Lancet Psychiatry, 12 (9), 673-699. doi: 10.1016/s2215-0366(25)00162-2
2025
Journal Article
Efficacy of user self-led and human-supported digital health interventions for people with schizophrenia: a systematic review and meta-analysis
Arnautovska, Urska, Trott, Mike, Vitangcol, Kathryn Jemimah, Milton, Alyssa, Brown, Ellie, Warren, Nicola, Leucht, Stefan, Firth, Joseph and Siskind, Dan (2025). Efficacy of user self-led and human-supported digital health interventions for people with schizophrenia: a systematic review and meta-analysis. Schizophrenia Bulletin, 51 (5) sbae143, 1402-1416. doi: 10.1093/schbul/sbae143
2025
Journal Article
Experiences of tobacco smoking and quitting among mental health consumers
Roennfeldt, Helena, Wyder, Marianne, Gartner, Coral, Holland, Alice, Elvidge, Norah, Siskind, Dan and Puljević, Cheneal (2025). Experiences of tobacco smoking and quitting among mental health consumers. Health Expectations, 28 (4) e70377, e70377. doi: 10.1111/hex.70377
2025
Journal Article
Relationship between blood-cerebrospinal fluid barrier integrity, cardiometabolic, and inflammatory factors in schizophrenia-spectrum disorders
Yakimov, Vladislav, Jäger, Iris, Roell, Lukas, Boudriot, Emanuel, Meisinger, Verena, Campana, Mattia, Krčmář, Lenka, Halstead, Sean, Warren, Nicola, Siskind, Dan, Maurus, Isabel, Hasan, Alkomiet, Falkai, Peter, Schmitt, Andrea, Raabe, Florian J., Keeser, Daniel, Wagner, Elias and Moussiopoulou, Joanna (2025). Relationship between blood-cerebrospinal fluid barrier integrity, cardiometabolic, and inflammatory factors in schizophrenia-spectrum disorders. Brain, Behavior, and Immunity - Health, 47 101024, 101024. doi: 10.1016/j.bbih.2025.101024
2025
Journal Article
Real-world effectiveness of clozapine augmentation with antidepressants: within-subject data evidence from two European nationwide cohorts
Taipale, Heidi, Siskind, Dan, Tanskanen, Antti, Mittendorfer-Rutz, Ellenor, Correll, Christoph U and Tiihonen, Jari (2025). Real-world effectiveness of clozapine augmentation with antidepressants: within-subject data evidence from two European nationwide cohorts. The Lancet Psychiatry, 12 (8), 568-578. doi: 10.1016/S2215-0366(25)00163-4
2025
Conference Publication
Medicinal cannabis an mental health hospitalisation: an observational study
Puris, F., Bodnar, N., Winckel, K., Smith, L., Siskind, D., McArdle, P. and Tanzer, T. (2025). Medicinal cannabis an mental health hospitalisation: an observational study. 36th CINP World Congress Neuropsychopharmacology - CINP-AsCNP 2025 Joint Congress, Melbourne, VIC Australia, 15-18 June 2025. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ijnp/pyaf052.165
2025
Journal Article
Rates of metabolic syndrome in Queensland adult community mental health consumers with schizophrenia and related disorders: a brief report
Trott, Mike, Plever, Sally, Anzolin, Mellisa, McCarthy, Irene and Siskind, Dan (2025). Rates of metabolic syndrome in Queensland adult community mental health consumers with schizophrenia and related disorders: a brief report. Australasian Psychiatry, 33 (4), 731-735. doi: 10.1177/10398562251358760
2025
Journal Article
Polypharmacy in psychiatry: evidence-based medicine or a Sisyphean solution?
Halstead, Sean, Yap, Chloe X., Siskind, Dan and Warren, Nicola (2025). Polypharmacy in psychiatry: evidence-based medicine or a Sisyphean solution?. Australian and New Zealand Journal of Psychiatry, 59 (8), 661-664. doi: 10.1177/00048674251353428
2025
Journal Article
Efficacy and safety of semaglutide versus placebo for people with schizophrenia on clozapine with obesity (COaST): a phase 2, multi-centre, participant and investigator- blinded, randomised controlled trial in Australia
Siskind, Dan, Baker, Andrea, Arnautovska, Urska, Warren, Nicola, Russell, Anthony, DeMonte, Veronica, Halstead, Sean, Iyer, Ravi, Korman, Nicole, McKeon, Gemma, Medland, Sarah, Parker, Stephen, Stedman, Terry and Trott, Mike (2025). Efficacy and safety of semaglutide versus placebo for people with schizophrenia on clozapine with obesity (COaST): a phase 2, multi-centre, participant and investigator- blinded, randomised controlled trial in Australia. The Lancet Psychiatry, 12 (7), 493-503. doi: 10.1016/S2215-0366(25)00129-4
2025
Journal Article
Do internalising or externalising behaviours in adolescence mediate the child maltreatment-alcohol substance use relationship?
Trott, Mike, Bull, Claudia, Najman, Jake Moses, Siskind, Dan, Arnautovska, Urska and Kisely, Steve (2025). Do internalising or externalising behaviours in adolescence mediate the child maltreatment-alcohol substance use relationship?. Addiction, 120 (7), 1413-1421. doi: 10.1111/add.70016
2025
Journal Article
Schizophrenia, Nutrition and Choices in Kilojoules (SNaCK): protocol for a feasibility and acceptability randomised controlled trial of two dietary interventions
Johnston, Donni, Arnautovska, Urska, Baker, Andrea, Hickman, Ingrid J., Mayr, Hannah L., Korman, Nicole, Marx, Wolfgang, Murray, Eryn, Warren, Nicola, Weighell, Sarah, De Monte, Veronica, McKeon, Gemma, Siskind, Dan and Teasdale, Scott B. (2025). Schizophrenia, Nutrition and Choices in Kilojoules (SNaCK): protocol for a feasibility and acceptability randomised controlled trial of two dietary interventions. BJPsych Open, 11 (4) e159, e159. doi: 10.1192/bjo.2025.10070
2025
Journal Article
[Corrigendum] An effectiveness trial of an exercise physiologist service to improve quality of life in adults with severe mental illness: Protocol for the MOVEMENT Study
Chapman, Justin, Siskind, Dan, Yung, Alison, Lee, Yong Yi, Arnautovska, Urska, Scott, James, Burke, Kylie, Malacova, Eva, Korman, Nicole, Wyder, Marianne, Doohan, Meg, Keating, Shelley, Parker, Stephen, Walker, Max, Hu, Di, O'Brien, Jake, Lau, Geoffrey, Pratt, Gregory, Rosenbaum, Simon, Curtis, Jackie, Chatterton, Mary Lou, Simmons, Lisa and Wheeler, Amanda (2025). [Corrigendum] An effectiveness trial of an exercise physiologist service to improve quality of life in adults with severe mental illness: Protocol for the MOVEMENT Study . Neuropsychiatric Disease and Treatment, 21 1507. doi: 10.2147/ndt.s555929
2025
Journal Article
A novel discovery platform for targeted drug repurposing: application for psychiatric disorders
Berk, Michael, Kim, Jee Hyun, Williams, Lana J, Liu, Zoe S J, Siskind, Dan, Panizzutti, Bruna, Yung, Alison R and Walder, Ken (2025). A novel discovery platform for targeted drug repurposing: application for psychiatric disorders. The Lancet Psychiatry, 12 (7), 535-542. doi: 10.1016/S2215-0366(25)00066-5
2025
Journal Article
International Guidelines for the Algorithmic Treatment of Schizophrenia (INTEGRATE) – Authors' reply
McCutcheon, Robert A, Pillinger, Toby and Siskind, Dan (2025). International Guidelines for the Algorithmic Treatment of Schizophrenia (INTEGRATE) – Authors' reply. The Lancet Psychiatry, 12 (7), 480-481. doi: 10.1016/s2215-0366(25)00142-7
2025
Journal Article
An effectiveness trial of an exercise physiologist service to improve quality of life in adults with severe mental illness: Protocol for the MOVEMENT Study
Chapman, Justin, Siskind, Dan, Yung, Alison, Lee, Yong Yi, Arnautovska, Urska, Scott, James, Burke, Kylie, Malacova, Eva, Korman, Nicole, Wyder, Marianne, Doohan, Meg, Keating, Shelley, Parker, Stephen, Walker, Max, Hu, Di, O'Brien, Jake, Lau, Geoffrey, Pratt, Gregory, Rosenbaum, Simon, Curtis, Jackie, Chatterton, Mary Lou, Simmons, Lisa and Wheeler, Amanda (2025). An effectiveness trial of an exercise physiologist service to improve quality of life in adults with severe mental illness: Protocol for the MOVEMENT Study. Neuropsychiatric Disease and Treatment, Volume 21, 1399-1408. doi: 10.2147/ndt.s530837
2025
Journal Article
A novel digital intervention to facilitate diabetes self-management among people with schizophrenia and related disorders: development and acceptability testing of SMART
Arnautovska, Urska, Ritchie, Gabrielle, Soole, Rebecca, Menon, Anish, Korman, Nicole, Milton, Alyssa, Varnfield, Marlien, Kelly, Jaimon, Jansen, Pieter, Baker, Andrea, Ireland, Derek, Russell, Anthony, Chapman, Justin, Mulligan, Kathleen, Hirani, Shashivadan, Vitangcol, Kathryn, McKeon, Gemma and Siskind, Dan (2025). A novel digital intervention to facilitate diabetes self-management among people with schizophrenia and related disorders: development and acceptability testing of SMART. Neuropsychiatric Disease and Treatment, 21, 1289-1305. doi: 10.2147/ndt.s513272
2025
Journal Article
The value of mental science: we publish what matters
Malhi, Gin S., Adlington, Katherine, Al-Diwani, Adam, Ali, Shehzad, Arya, Rina, Baldwin, David S., Batley, Prathiba, Bell, Erica, Berrios, German, Beveridge, Allan, Bhat, Mohan, Bhugra, Dinesh, Biswas, Asit, Byford, Sarah, Campbell, Colin, Cass, Hilary, Chadda, Rakesh K., Chamberlain, Samuel R., Chevance, Astrid, Comasco, Erika, Cookson, John, Costello, Harry, Critchley, Hugo D., Cuijpers, Pim, de Cates, Angharad N., De Giorgi, Riccardo, de Oliveira, Claire, Drummond, Colin, Feng, Jianfeng ... Fernandez-Egea, Emilio (2025). The value of mental science: we publish what matters. British Journal of Psychiatry, 227 (1), 429-433. doi: 10.1192/bjp.2025.118
2025
Journal Article
Effectiveness of clozapine augmentation with specific doses of other antipsychotics in schizophrenia: a meta-analysis from two nationwide cohorts
Tiihonen, Jari, Tanskanen, Antti, Mittendorfer-Rutz, Ellenor, Howes, Oliver D., Correll, Christoph U., Siskind, Dan and Taipale, Heidi (2025). Effectiveness of clozapine augmentation with specific doses of other antipsychotics in schizophrenia: a meta-analysis from two nationwide cohorts. World Psychiatry, 24 (2), 250-259. doi: 10.1002/wps.21316
Funding
Current funding
Supervision
Availability
- Professor Dan Siskind is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Food and nutrition security in individuals with severe mental illness
Principal Advisor
Other advisors: Dr Urska Arnautovska
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Doctor Philosophy
Manifestations, impacts, and clinical implications of physical multimorbidity in people living with severe mental illness
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Steve Kisely
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Master Philosophy
A quantitative and qualitative study of forensic orders in Queensland
Associate Advisor
Other advisors: Professor Steve Kisely, Dr Claudia Bull
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Doctor Philosophy
Smoking Cessation in People with a Serious Mental Illness
Associate Advisor
Other advisors: Professor Steve Kisely, Professor Coral Gartner
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Doctor Philosophy
Measuring cognitive flexibility in rodents
Associate Advisor
Other advisors: Professor Thomas Burne
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Doctor Philosophy
Management of myocarditis among people with schizophrenia commencing clozapine
Associate Advisor
Other advisors: Associate Professor Nicola Warren
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Doctor Philosophy
Genetic determinants of treatment outcomes in mental health: harnessing the shared genetic etiology of mental disorders for precision psychiatry.
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
Completed supervision
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2026
Doctor Philosophy
The Quality and Safe Use of Clozapine
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Michael Barras, Professor Steve Kisely
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2025
Doctor Philosophy
Investigating clozapine rechallenge using granulocyte-colony stimulating factor in people previously experiencing clozapine-associated neutropenia.
Principal Advisor
Other advisors: Professor Steve Kisely
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2021
Doctor Philosophy
Psychiatric clinical decision making in anti-NMDA receptor encephalitis
Principal Advisor
Other advisors: Associate Professor Stefan Blum, Professor Steve Kisely
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2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Honorary Professor Darryl Eyles
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2023
Doctor Philosophy
Measuring and improving cognition in a rodent model relevant to schizophrenia
Associate Advisor
Other advisors: Dr James Kesby, Professor Thomas Burne
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2022
Doctor Philosophy
Nose-to-Brain Delivery of Clozapine in Sol-Gel Systems
Associate Advisor
Other advisors: Associate Professor Harendra Parekh, Dr Preeti Pandey, Dr James Robert Falconer
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2020
Doctor Philosophy
Exploring the characteristics and service needs of carers for adults with mental illness to inform mental health service planning
Associate Advisor
Other advisors: Associate Professor Meredith Harris
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2020
Doctor Philosophy
Who receives what, from whom, and to what effect at clinically operated, community-based residential mental health rehabilitation for Severe and Persistent Mental Illness in Australia?
Associate Advisor
Other advisors: Associate Professor Meredith Harris
Media
Enquiries
Contact Professor Dan Siskind directly for media enquiries about:
- Cardiometabolic co-morbidity of schizophrenia
- Treatment Refractory Schizophrenia
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