Professor Darryl Eyles
Professor

Darryl Eyles

Email: 
Phone: 
+61 7 334 66370

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

248 works between 1989 and 2024
All (248) Journal Article (176) Book Chapter (8) Conference Publication (63) Other Outputs (1)

1 - 20 of 248 works

2024

Journal Article

Absence of Association between Maternal Adverse Events and Long-Term Gut Microbiome Outcomes in the Australian Autism Biobank

Vasileva, Svetlina, Yap, Chloe X., Whitehouse, Andrew J.O., Gratten, Jacob and Eyles, Darryl (2024). Absence of Association between Maternal Adverse Events and Long-Term Gut Microbiome Outcomes in the Australian Autism Biobank. Brain, Behavior, & Immunity - Health, 39 100814, 100814. doi: 10.1016/j.bbih.2024.100814

Absence of Association between Maternal Adverse Events and Long-Term Gut Microbiome Outcomes in the Australian Autism Biobank

2024

Journal Article

Neonatal vitamin D and associations with longitudinal changes of eczema up to 25 years of age

Zeng, Rong, Lodge, Caroline J., Koplin, Jennifer J., Lopez, Diego J., Erbas, Bircan, Abramson, Michael J., Eyles, Darryl, Ponsonby, Anne-Louise, Wjst, Matthias, Allen, Katrina, Dharmage, Shyamali C. and Lowe, Adrian J. (2024). Neonatal vitamin D and associations with longitudinal changes of eczema up to 25 years of age. Nutrients, 16 (9) 1303. doi: 10.3390/nu16091303

Neonatal vitamin D and associations with longitudinal changes of eczema up to 25 years of age

2024

Journal Article

Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia

Vasileva, Svetlina S., Yang, Yuanhao, Baker, Andrea, Siskind, Dan, Gratten, Jacob and Eyles, Darryl (2024). Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia. JAMA Psychiatry, 81 (3), 292-302. doi: 10.1001/jamapsychiatry.2023.5371

Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia

2024

Journal Article

Mixture of air pollution, brominated flame retardants, polychlorinated biphenyls, per- and polyfluoroalkyl substances, and organochlorine pesticides in relation to vitamin D concentrations in pregnancy

Berger, Kimberly, Bradshaw, Patrick T., Poon, Victor, Kharrazi, Marty, Eyles, Darryl, Ashwood, Paul, Lyall, Kristen, Volk, Heather E., Ames, Jenn, Croen, Lisa A., Windham, Gayle C. and Pearl, Michelle (2024). Mixture of air pollution, brominated flame retardants, polychlorinated biphenyls, per- and polyfluoroalkyl substances, and organochlorine pesticides in relation to vitamin D concentrations in pregnancy. Environmental Pollution, 340 (Pt 2) 122808, 1-12. doi: 10.1016/j.envpol.2023.122808

Mixture of air pollution, brominated flame retardants, polychlorinated biphenyls, per- and polyfluoroalkyl substances, and organochlorine pesticides in relation to vitamin D concentrations in pregnancy

2024

Other Outputs

TRS-BIOME

Eyles, Darryl, Vasileva, Svetlina, Siskind, Dan, Alexander, Suzy, Gratten, Jake, Ko, Pauline and Vasileva, Svetlina (2024). TRS-BIOME. The University of Queensland. (Dataset) doi: 10.48610/23fd2eb

TRS-BIOME

2024

Book Chapter

Vitamin D, brain development and function

Eyles, Darryl, Cui, Xiaoying and McGrath, John J. (2024). Vitamin D, brain development and function. Feldman and Pike' s vitamin D: volume one: biochemistry, physiology and diagnostics. (pp. 537-562) edited by Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman, Mark Meyer and JoEllen Welsh. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-323-91386-7.00040-4

Vitamin D, brain development and function

2023

Journal Article

Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia

Srivastav, Sunil, Cui, Xiaoying, Varela, Roger Bitencourt, Kesby, James P. and Eyles, Darryl (2023). Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia. Schizophrenia, 9 (1) 69, 69. doi: 10.1038/s41537-023-00397-2

Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia

2023

Journal Article

Vitamin D: a potent regulator of dopaminergic neuron differentiation and function

Pertile, Renata Aparecida Nedel, Brigden, Rachel, Raman, Vanshika, Cui, Xiaoying, Du, Zilong and Eyles, Darryl (2023). Vitamin D: a potent regulator of dopaminergic neuron differentiation and function. Journal of Neurochemistry, 166 (5), 779-789. doi: 10.1111/jnc.15829

Vitamin D: a potent regulator of dopaminergic neuron differentiation and function

2023

Journal Article

Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model

Tamang, Man Kumar, Ali, Asad, Pertile, Renata Nedel, Cui, Xiaoying, Alexander, Suzy, Nitert, Marloes Dekker, Palmieri, Chiara and Eyles, Darryl (2023). Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model. Translational Psychiatry, 13 (1) 204, 1-12. doi: 10.1038/s41398-023-02513-3

Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model

2023

Journal Article

Animal models of relevance to the schizophrenia prodrome

Petty, Alice, Howes, Oliver and Eyles, Darryl (2023). Animal models of relevance to the schizophrenia prodrome. Biological Psychiatry Global Open Science, 3 (1), 22-32. doi: 10.1016/j.bpsgos.2021.12.001

Animal models of relevance to the schizophrenia prodrome

2022

Journal Article

Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders

Cui, Xiaoying and Eyles, Darryl W. (2022). Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders. Nutrients, 14 (20) 4353, 1-20. doi: 10.3390/nu14204353

Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders

2022

Conference Publication

Mixture analysis of air pollution and endocrine disrupting chemicals in relation to Vitamin D concentrations in pregnancy

Berger, Kimberly, Poon, Victor, Kharrazi, Marty, Eyles, Darryl, Lyall, Kristen, Volk, Heather E., Croen, Lisa A., Windham, Gayle and Pearl, Michelle (2022). Mixture analysis of air pollution and endocrine disrupting chemicals in relation to Vitamin D concentrations in pregnancy. ISEE 2022: 34th Annual Conference of the International Society of Environmental Epidemiology, Athens, Greece, 18-21 September 2022. Research Triangle Park, NC United States: National Institute of Environmental Health Sciences. doi: 10.1289/isee.2022.o-op-271

Mixture analysis of air pollution and endocrine disrupting chemicals in relation to Vitamin D concentrations in pregnancy

2022

Journal Article

Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development

Aparecida Nedel Pertile, Renata, Kiltschewskij, Dylan, Geaghan, Michael, Barnett, Michelle, Cui, Xiaoying, Cairns, Murray J. and Eyles, Darryl (2022). Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development. Brain Research, 1789 147953, 147953. doi: 10.1016/j.brainres.2022.147953

Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development

2022

Journal Article

Prenatal hypoxia alters the early ontogeny of dopamine neurons

Brandon, Anastasia, Cui, Xiaoying, Luan, Wei, Ali, Asad Amanat, Pertile, Renata Aparecida Nedel, Alexander, Suzanne Adele and Eyles, Darryl Walter (2022). Prenatal hypoxia alters the early ontogeny of dopamine neurons. Translational Psychiatry, 12 (1) 238, 238. doi: 10.1038/s41398-022-02005-w

Prenatal hypoxia alters the early ontogeny of dopamine neurons

2022

Journal Article

Does the gut microbiome mediate antipsychotic-induced metabolic side effects in schizophrenia?

Vasileva, Svetlina S., Tucker, Jack, Siskind, Dan and Eyles, Darryl (2022). Does the gut microbiome mediate antipsychotic-induced metabolic side effects in schizophrenia?. Expert Opinion on Drug Safety, 21 (5), 1-15. doi: 10.1080/14740338.2022.2042251

Does the gut microbiome mediate antipsychotic-induced metabolic side effects in schizophrenia?

2021

Journal Article

Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

Hussain, Sultana Monira, Wang, Yuanyuan, Heath, Alicia K., Giles, Graham G., English, Dallas R., Eyles, Darryl W., Williamson, Elizabeth J., Graves, Stephen E., Wluka, Anita E. and Cicuttini, Flavia M. (2021). Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study. BMC Musculoskeletal Disorders, 22 (1) 887, 887. doi: 10.1186/s12891-021-04779-4

Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

2021

Journal Article

Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia

Ali, Asad, Alexander, Suzanne, Ko, Pauline, Cuffe, James S. M., Whitehouse, Andrew J. O., McGrath, John J. and Eyles, Darryl (2021). Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia. Nutrients, 13 (12) 4254, 4254. doi: 10.3390/nu13124254

Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia

2021

Journal Article

Developmental inhibition of long intergenic non-coding RNA, HOTAIRM1, impairs dopamine neuron differentiation and maturation

Cui, Xiaoying, Pertile, Renata Ap. Nedel, Du, Zilong, Wei, Wei, Sun, Zichun, Eyles, Darryl W. and Kesby, James P. (2021). Developmental inhibition of long intergenic non-coding RNA, HOTAIRM1, impairs dopamine neuron differentiation and maturation. International Journal of Molecular Sciences, 22 (14) 7268, 7268. doi: 10.3390/ijms22147268

Developmental inhibition of long intergenic non-coding RNA, HOTAIRM1, impairs dopamine neuron differentiation and maturation

2021

Journal Article

How do established developmental risk-factors for schizophrenia change the way the brain develops?

Eyles, Darryl W. (2021). How do established developmental risk-factors for schizophrenia change the way the brain develops?. Translational Psychiatry, 11 (1) 158, 158. doi: 10.1038/s41398-021-01273-2

How do established developmental risk-factors for schizophrenia change the way the brain develops?

2021

Journal Article

Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia-mediated epigenetic changes

Liang, Yujie, Yu, Hong, Ke, Xiaoyin, Eyles, Darryl, Sun, Ruoyu, Wang, Zichen, Huang, Saijun, Lin, Ling, McGrath, John J., Lu, Jianping, Guo, Xiaoling and Yao, Paul (2021). Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia-mediated epigenetic changes. Annals of the New York Academy of Sciences, 1491 (1), 74-88. doi: 10.1111/nyas.14535

Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia-mediated epigenetic changes

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Completed supervision

Enquiries

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