Professor Darryl Eyles
Professor

Darryl Eyles

Email: 
Phone: 
+61 7 334 66370

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

248 works between 1989 and 2024
All (248) Journal Article (176) Book Chapter (8) Conference Publication (63) Other Outputs (1)

61 - 80 of 248 works

2017

Journal Article

Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults

Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W. and van Swinderen, Bruno (2017). Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults. Frontiers in Psychiatry, 8 (FEB) 22, 22. doi: 10.3389/fpsyt.2017.00022

Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults

2017

Journal Article

Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples

Smith, Chloe A., Sun, Cong, Pezic, Angela , Rodda, Christine, Cameron, Fergus, Allen, Katie, Craig, Maria E. , Carlin, John, Dwyer, Terry, Lucas, Robyn M., Eyles, Darryl W. , Kemp, Andrew S., Ellis, Justine A. and Ponsonby, Anne-Louise (2017). Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples. Neonatology, 111 (2), 153-161. doi: 10.1159/000448680

Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples

2017

Conference Publication

Prevalence and Correlates of Suboptimal Vitamin D Status in People Living with Psychotic Disorders: Data From the Australian Survey of High Impact Psychosis

Suetani, S., Saha, S., Eyles, D., Scott, J. and McGrath, J. (2017). Prevalence and Correlates of Suboptimal Vitamin D Status in People Living with Psychotic Disorders: Data From the Australian Survey of High Impact Psychosis. RANZCP 2017 Congress, Adelaide, Australia, 30 April - 4 May 2017. London, United Kingdom: Sage Publications. doi: 10.1177/0004867417702054

Prevalence and Correlates of Suboptimal Vitamin D Status in People Living with Psychotic Disorders: Data From the Australian Survey of High Impact Psychosis

2016

Journal Article

Developmental vitamin D deficiency and autism: putative pathogenic mechanisms

Ali, Asad, Cui, Xiaoying and Eyles, Darryl (2016). Developmental vitamin D deficiency and autism: putative pathogenic mechanisms. Journal of Steroid Biochemistry and Molecular Biology, 175, 108-118. doi: 10.1016/j.jsbmb.2016.12.018

Developmental vitamin D deficiency and autism: putative pathogenic mechanisms

2016

Journal Article

Gestational vitamin D deficiency and autism-related traits: the Generation R Study

Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F., Jaddoe, V. W., Tiemeier, H. and McGrath, J. J. (2016). Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Molecular Psychiatry, 23 (2), 240-246. doi: 10.1038/mp.2016.213

Gestational vitamin D deficiency and autism-related traits: the Generation R Study

2016

Journal Article

Vitamin D signaling and the differentiation of developing dopamine systems

Pertile, Renata A. N., Cui, Xiaoying and Eyles, Darryl W. (2016). Vitamin D signaling and the differentiation of developing dopamine systems. Neuroscience, 333, 193-203. doi: 10.1016/j.neuroscience.2016.07.020

Vitamin D signaling and the differentiation of developing dopamine systems

2016

Journal Article

Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents

Moe, Aung Aung Kywe, Kurniawan, Nyoman D., Alexander, Suzanne, Cui, Xiaoying, Burne, Thomas H. J. and Eyles, Darryl W. (2016). Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents. Neuropharmacology, 108, 264-274. doi: 10.1016/j.neuropharm.2016.04.035

Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents

2016

Journal Article

Neural changes induced by antipsychotic administration in adolescence: a review of studies in laboratory rodents

Moe, Aung Aung Kywe, Scott, James G., Burne, Thomas H. J. and Eyles, Darryl W. (2016). Neural changes induced by antipsychotic administration in adolescence: a review of studies in laboratory rodents. Journal of Psychopharmacology, 30 (8), 771-794. doi: 10.1177/0269881116654776

Neural changes induced by antipsychotic administration in adolescence: a review of studies in laboratory rodents

2016

Journal Article

The relationship between vitamin D status and allergic diseases in New Zealand preschool children

Cairncross, Carolyn, Grant, Cameron, Stonehouse, Welma, Conlon, Cath, McDonald, Barry, Houghton, Lisa, Eyles, Darryl, Camargo, Carlos A., Coad, Jane and von Hurst, Pamela (2016). The relationship between vitamin D status and allergic diseases in New Zealand preschool children. Nutrients, 8 (6) 326, 326. doi: 10.3390/nu8060326

The relationship between vitamin D status and allergic diseases in New Zealand preschool children

2016

Journal Article

Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

Miliku, Kozeta, Vinkhuyzen, Anna, Blanken, Laura M. E., McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Hofman, Albert, Tiemeier, Henning, Steegers, Eric A. P., Gaillard, Romy and Jaddoe, Vincent W. V. (2016). Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. American Journal of Clinical Nutrition, 103 (6), 1514-1522. doi: 10.3945/ajcn.115.123752

Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

2016

Journal Article

Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study

Gazibara, Tatjana, Elbert, Niels J., den Dekker, Herman T., de Jongste, Johan C., Reiss, Irwin, McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Tiemeier, Henning, Jaddoe, Vincent W. V., Pasmans, Suzanne G. M. A. and Duijts, Liesbeth (2016). Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study. Pediatric Allergy and Immunology, 27 (3), 283-289. doi: 10.1111/pai.12530

Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study

2016

Journal Article

Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS

Kvaskoff, David, Heath, Alicia K., Simila, Henry A., Ko, Pauline, English, Dallas R. and Eyles, Darryl W. (2016). Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS. Clinical Chemistry, 62 (4), 639-646. doi: 10.1373/clinchem.2015.251538

Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS

2016

Journal Article

25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study

Heath, Alicia K., Williamson, Elizabeth J., Kvaskoff, David, Hodge, Allison M., Ebeling, Peter R., Baglietto, Laura, Neale, Rachel E., Giles, Graham G., Eyles, Darryl W. and English, Dallas R. (2016). 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutrition, 20 (10), 1775-1784. doi: 10.1017/S1368980016000501

25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study

2016

Journal Article

The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem, Kathie, Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2016). The impact of vitamin D deficiency on behaviour and brain function in rodents. Current Opinion in Behavioral Sciences, 7, 47-52. doi: 10.1016/j.cobeha.2015.11.012

The impact of vitamin D deficiency on behaviour and brain function in rodents

2016

Journal Article

Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context

Lefevre, Emilia M., Eyles, Darryl W. and Burne, Thomas H. J. (2016). Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context. Behavioural Brain Research, 298 (Part B), 241-245. doi: 10.1016/j.bbr.2015.11.014

Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context

2016

Journal Article

Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study

Gazibara, Tatjana, den Dekker, Herman T., de Jongste, Johan C., McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Reiss, Irwin, Franco, Oscar H., Tiemeier, Henning, Jaddoe, Vincent W. V. and Duijts, Liesbeth (2016). Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study. Clinical and Experimental Allergy, 46 (2), 337-346. doi: 10.1111/cea.12645

Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study

2016

Book Chapter

Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency.

Eyles, D.W. and Dean, A.J. (2016). Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency.. Modeling the Psychopathological Dimensions of Schizophrenia — From Molecules to Behavior . (pp. 243-264) edited by Mikhail V. Pletnikov and John L. Waddington. London, United Kingdom: Academic Press (Elsevier Inc). doi: 10.1016/B978-0-12-800981-9.00015-8

Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency.

2016

Journal Article

Predictors of vitamin D status in New Zealand preschool children

Cairncross, C.T., Stonehouse, W., Conlon, C. A., Grant, C. C., McDonald, B., Houghton, L. A., Eyles, Darryl, Camargo Jr, C. A., Coad, J. and von Hurst, P. R. (2016). Predictors of vitamin D status in New Zealand preschool children. Maternal and Child Nutrition, 13 (3) e12340, e12340. doi: 10.1111/mcn.12340

Predictors of vitamin D status in New Zealand preschool children

2015

Journal Article

Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator

Cui, X., Pertile, R., Liu, P. and Eyles, D. W. (2015). Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience, 304, 90-100. doi: 10.1016/j.neuroscience.2015.07.048

Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator

2015

Conference Publication

Developmental vitamin D deficient rat model of autism spectrum disorder

Ali, A., Eyles, D. and Cui, X. (2015). Developmental vitamin D deficient rat model of autism spectrum disorder. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Developmental vitamin D deficient rat model of autism spectrum disorder

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Completed supervision

Enquiries

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