Overview
Background
Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.
Availability
- Professor Darryl Eyles is:
- Available for supervision
Fields of research
Qualifications
- Postgraduate Diploma, Griffith University
Research impacts
The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.
Works
Search Professor Darryl Eyles’s works on UQ eSpace
2012
Conference Publication
Interferon-beta is associated with higher serum 25-hydroxyvitamin D and both interact to modulate relapse risk in multiple sclerosis
Simpson, S., Stewart, N., van der Mei, I., Ponsonby, A., Blizzard, L., Dwyer, T., Pittas, F., Eyles, D., Ko, P. and Taylor, B.V. (2012). Interferon-beta is associated with higher serum 25-hydroxyvitamin D and both interact to modulate relapse risk in multiple sclerosis. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.
2012
Conference Publication
Prenatal vitamin D deficiency alters dopamine and glutamate metabolism in rat brain
Burne, Thomas H., Kesby, James P., Turner, Karly, Suzy, Alexander, McGrath, John J. and Eyles, Darryl W. (2012). Prenatal vitamin D deficiency alters dopamine and glutamate metabolism in rat brain. 3rd Biennial Schizophrenia International Research Conference, Florence, Italy, 14-18 April 2012. Amsterdam, Netherlands: Elsevier.
2012
Conference Publication
Increased de novo copy number variants in the offspring of older males
McGrath, John J., Flatscher-Bader, Traute, Foldi, Claire J., Chong, Suyinn, Whitelaw, Emma, Moser, Ralf J., Burne, Thomas H.J and Eyles, Darryl W. (2012). Increased de novo copy number variants in the offspring of older males. 3rd Biennial Schizophrenia International Research Conference, Florence, Italy, 14-18 April 2012. AMSTERDAM: Elsevier. doi: 10.1016/s0920-9964(12)70013-0
2011
Journal Article
The effects of vitamin D on brain development and adult brain function
James Kesby, Eyles, Darryl, Burne, Thomas H.J. and McGrath, John J. (2011). The effects of vitamin D on brain development and adult brain function. Molecular and Cellular Endocrinology, 347 (1-2), 121-127. doi: 10.1016/j.mce.2011.05.014
2011
Journal Article
Effects of vitamin D supplementation on cognitive and emotional functioning in young adults: a randomised controlled trial
Dean, Angela J., Bellgrove, Mark, Hall, Teresa, Phan, Wei Ming Jonathan, Eyles, Darryl, Kvaskoff, David and McGrath, John J. (2011). Effects of vitamin D supplementation on cognitive and emotional functioning in young adults: a randomised controlled trial. PLoS ONE, 6 (11) e25966, e25966.1-e25966.7. doi: 10.1371/journal.pone.0025966
2011
Journal Article
Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats
Tare, Marianne, Emmett, Sarah J., Coleman, Harold A., Skordilis, Con, Eyles, Darryl W., Morley, Ruth and Parkington, Helena C. (2011). Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. Journal of Physiology, 589 (19), 4777-4786. doi: 10.1113/jphysiol.2011.214726
2011
Journal Article
Increased de novo copy number variants in the offspring of older males
Flatscher-Bader, T., Foldi, C. J., Chong, S., Whitelaw, E., Moser, R. J., Burne, T. H. J., Eyles, D. W. and McGrath, J. J. (2011). Increased de novo copy number variants in the offspring of older males. Translational Psychiatry, 1 (Article # e34) e34, e34-e34. doi: 10.1038/tp.2011.30
2011
Journal Article
Vitamin D in fetal brain development
Eyles, Darryl, Burne, Thomas and McGrath, John (2011). Vitamin D in fetal brain development. Seminars in Cell and Developmental Biology, 22 (6), 629-636. doi: 10.1016/j.semcdb.2011.05.004
2011
Journal Article
Vitamin D and the brain
Harms, Lauren R., Burne, Thomas H. J., Eyles, Darryl W. and McGrath, John J. (2011). Vitamin D and the brain. Best Practice and Research: Clinical Endocrinology and Metabolism, 25 (4), 657-669. doi: 10.1016/j.beem.2011.05.009
2011
Journal Article
New perspectives on rodent models of advanced paternal age: Relevance to autism
Foldi, Claire J., Eyles, Darryl W., Flatscher-Bader, Traute, McGrath, John J. and Burne, Thomas H. J. (2011). New perspectives on rodent models of advanced paternal age: Relevance to autism. Frontiers in Behavioral Neuroscience, 5 (32) 32, 1-7. doi: 10.3389/fnbeh.2011.00032
2011
Journal Article
Infection with the wMel and wMelPop strains of Wolbachia leads to higher levels of melanization in the hemolymph of Drosophila melanogaster, Drosophila simulans and Aedes aegypti
Thomas, P, Kenny, N, Eyles, D, Moreira, LA, O'Neill, SL and Asgari, S (2011). Infection with the wMel and wMelPop strains of Wolbachia leads to higher levels of melanization in the hemolymph of Drosophila melanogaster, Drosophila simulans and Aedes aegypti. Developmental and Comparative Immunology, 35 (3), 360-365. doi: 10.1016/j.dci.2010.11.007
2011
Journal Article
The Effects of breeding protocol in C57BL/6J mice on adult offspring behaviour
Foldi, Claire J., Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2011). The Effects of breeding protocol in C57BL/6J mice on adult offspring behaviour. Plos One, 6 (3) e18152, e18152-1-e18152-7. doi: 10.1371/journal.pone.0018152
2011
Journal Article
The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti
Moreira, Luciano A., Ye, Yixin H., Turner, Karly, Eyles, Darryl W., McGraw, Elizabeth A. and O'Neill, Scott L. (2011). The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti. Parasites and Vectors, 4 (28) 28, 1-5. doi: 10.1186/1756-3305-4-28
2011
Journal Article
Developmental vitamin D (DVD) deficiency alters pup retrieval but not isolation-induced pup ultrasonic vocalizations in the rat
Burne, Thomas H.J., O'Loan, Jonathan, Splatt, Karisha, Alexander, Suzanne, McGrath, John J. and Eyles, Darryl (2011). Developmental vitamin D (DVD) deficiency alters pup retrieval but not isolation-induced pup ultrasonic vocalizations in the rat. Physiology and Behavior, 102 (2), 201-204. doi: 10.1016/j.physbeh.2010.11.006
2011
Conference Publication
Modeling schizophrenia, dopamine ontogeny and the small brain
Eyles, Darryl, Calcagno, B., Formella, I., Van Swinderen, B., Scott, E., Burne, T. and McGrath, J. (2011). Modeling schizophrenia, dopamine ontogeny and the small brain. 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, 2-6 April 2011. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbq173
2011
Book Chapter
The developmental vitamin D (DVD) model of schizophrenia
Eyles, Darryl, Burne, Thomas H.J., Alexander, Suzy, Cui, Xiaoying and McGrath, John J. (2011). The developmental vitamin D (DVD) model of schizophrenia. Animal Models of Schizophrenia and Related Disorders. (pp. 113-125) edited by Patricio O’Donnell and Wolfgang Walz. New York , NY, U.S.A.: Humana Press. doi: 10.1007/978-1-61779-157-4_5
2011
Conference Publication
Modelling cognitive symptoms in the DVD-deficient rodent model of schizophrenia
Burne, Thomas H., Turner, K., Alexander, S., Eyles, D. W. and McGrath, J. (2011). Modelling cognitive symptoms in the DVD-deficient rodent model of schizophrenia. 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, 2-6 April 2011. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbq173
2011
Book Chapter
Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders
Eyles, Darryl, Burne, Thomas and McGrath, John (2011). Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders. Vitamin D. (pp. 565-582) edited by David Feldman, J. Wesley Pike and John S. Adams. Amsterdam, The Netherlands: Academic Press. doi: 10.1016/B978-0-12-381978-9.10032-0
2011
Conference Publication
Developmental Vitamin D deficiency and risk of schizophrenia: a ten-year update
McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2011). Developmental Vitamin D deficiency and risk of schizophrenia: a ten-year update. 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, 2-6 April 2011. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbq173
2011
Conference Publication
Maternal vitamin D deficiency effects offspring bone quality throughout the lifecourse
Lanham, Stuart, Roberts, Carol, Habgood, Angela, Alexander, Suzanne, Burne, Thomas H. J., Eyles, Darryl W., Trueman, Clive N., Cooper, Matthew, Cooper, Cyrus, McGrath, John J. and Oreffo, Richard O. C. (2011). Maternal vitamin D deficiency effects offspring bone quality throughout the lifecourse. World Congress on Developmental Origins of Health and Disease (7th, DOHaD, 2011), Portland, Oregon, U.S.A., 18-21 September 2011. CAMBRIDGE: CAMBRIDGE UNIV PRESS. doi: 10.1017/S2040174411000481
Funding
Current funding
Past funding
Supervision
Availability
- Professor Darryl Eyles is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia
Associate Advisor
Other advisors: Dr James Kesby
Completed supervision
-
2024
Doctor Philosophy
Two novel animal models to selectively increase dorsal striatal dopamine release: Implications for schizophrenia
Principal Advisor
-
2024
Doctor Philosophy
Stress and dopamine in the dorsal striatum: exploration of potentially causative mechanisms in schizophrenia
Principal Advisor
Other advisors: Dr James Kesby
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2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Principal Advisor
Other advisors: Honorary Professor Jake Gratten, Professor Dan Siskind
-
2023
Doctor Philosophy
Developmental Vitamin D-deficiency rat model: Exploration of autism-relevant phenotypes, gut health and placental inflammation
Principal Advisor
-
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2019
Doctor Philosophy
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): A New Animal Model of Relevance to Schizophrenia
Principal Advisor
-
2018
Doctor Philosophy
Developmental vitamin D deficiency rat model of Autism Spectrum Disorder
Principal Advisor
-
2018
Master Philosophy
Maternal Immune Activation adversely affects the ontogeny of dopamine neurons. Is Vitamin D neuroprotective?
Principal Advisor
-
2016
Doctor Philosophy
Evaluating long-term consequences of adolescent antipsychotic exposure
Principal Advisor
Other advisors: Professor Thomas Burne
-
2010
Doctor Philosophy
The impact of developmental vitamin D deficiency on brain neurochemistry and behaviour in Sprague-Dawley rats
Principal Advisor
Other advisors: Professor Thomas Burne
-
2009
Doctor Philosophy
The effect of developmental vitamin D3 deficiency on brain development, immune function and behaviour in the adult rat
Principal Advisor
Other advisors: Professor Thomas Burne, Professor John McGrath
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2016
Doctor Philosophy
Establishing novel cognitive tasks in animal models relevant to schizophrenia
Associate Advisor
Other advisors: Professor Thomas Burne
-
2012
Doctor Philosophy
Brain Development and Behaviour in Developmentally Vitamin D-Deficient Mice
Associate Advisor
Other advisors: Professor Thomas Burne
-
2016
Doctor Philosophy
Neural mechanisms of MK-801 induced sensitisation
Joint Principal Advisor
Other advisors: Professor Thomas Burne
-
2012
Doctor Philosophy
The effects of Advanced Paternal Age (APA) on behavioural and brain structural phenotypes in C57BL/6J mice.
Joint Principal Advisor
Other advisors: Professor Thomas Burne
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