Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

141 - 160 of 249 works

2011

Journal Article

Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?

Burne, T. H. J., Scott, E., van Swinderen, B., Hilliard, M., Reinhard, J., Claudianos, C., Eyles, D. W. and McGrath, J. J. (2011). Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?. Molecular Psychiatry, 16 (1), 7-16. doi: 10.1038/mp.2010.35

Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?

2010

Journal Article

Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon

Cui Xiaoying, Pelekanos, Matthew, Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2010). Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. Neuroscience Letters, 486 (3), 220-223. doi: 10.1016/j.neulet.2010.09.057

Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon

2010

Journal Article

Developmental vitamin D deficiency and risk of schizophrenia: A 10-year update

McGrath, John J., Burne, Thomas H., Feron, Francois, Mackay-Sim, Allan and Eyles, Darryl W. (2010). Developmental vitamin D deficiency and risk of schizophrenia: A 10-year update. Schizophrenia Bulletin, 36 (6), 1073-1078. doi: 10.1093/schbul/sbq101

Developmental vitamin D deficiency and risk of schizophrenia: A 10-year update

2010

Journal Article

Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study

McGrath, John J., Eyles, Darryl W., Pedersen, Carsten B., Anderson, Cameron, Ko, Pauline, Burne, Thomas H., Norgaard-Pedersen, Bent, Hougaard, David M. and Mortensen, Preben B. (2010). Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study. Archives of General Psychiatry, 67 (9), 889-894. doi: 10.1001/archgenpsychiatry.2010.110

Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study

2010

Journal Article

The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status

Eyles, Darryl W., Morley, Ruth, Anderson, Cameron, Ko, Pauline, Burne, Thomas, Permezel, Michael, Mortensen, Preben B., Nørgaard-Pedersen, Bent, Hougaard, David M. and McGrath, John J. (2010). The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status. Paediatric and Perinatal Epidemiology, 24 (3), 303-308. doi: 10.1111/j.1365-3016.2010.01105.x

The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status

2010

Journal Article

Vitamin D and autism: Does skin colour modify risk?

Eyles, Darryl (2010). Vitamin D and autism: Does skin colour modify risk?. Acta Paediatrica, 99 (5), 645-647. doi: 10.1111/j.1651-2227.2010.01797.x

Vitamin D and autism: Does skin colour modify risk?

2010

Journal Article

Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice

Foldi, Claire J., Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2010). Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice. European Journal of Neuroscience, 31 (3), 556-564. doi: 10.1111/j.1460-9568.2010.07074.x

Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice

2010

Conference Publication

Attentional performance of DVD-deficient rats in the 5-choice continuous performance test

Burne, Thomas H., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Attentional performance of DVD-deficient rats in the 5-choice continuous performance test. 2nd Schizophrenia International Research Society Conference, Florence, Italy, 10-14 April 2010. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2010.02.442

Attentional performance of DVD-deficient rats in the 5-choice continuous performance test

2010

Conference Publication

Modeling schizophrenia, go big or go small!

Eyles, Darryl (2010). Modeling schizophrenia, go big or go small!. 11th Australasian Schizophrenia Conference, Sydney, Australia, 22-24 September 2010. United Kingdom: Informa Healthcare.

Modeling schizophrenia, go big or go small!

2010

Conference Publication

Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study

McGrath, John J., Eyles, Darryl W., Pedersen, Carsten B., Anderson, Cameron, Ko, Pauline, Burne, Thomas H., Norgaard-Pedersen, Bent, Hougaard, David M. and Mortensen, Preben B. (2010). Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study. 2nd Schizophrenia International Research Society Conference, Florence, Italy, 10-14 April 2010. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2010.02.526

Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study

2010

Journal Article

Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats

Kesby, James P, Cui, Xiaoying, O'Loan, Jonathan, McGrath, John J, Burne, Thomas HJ and Eyles, Darryl W (2010). Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats. Psychopharmacology, 208 (1), 159-168. doi: 10.1007/s00213-009-1717-y

Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats

2010

Conference Publication

A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila

Van Alphen, B., Burne, T. H. J., Eyles, D. W., Mattingley, J., McGrath, J. J. and van Swinderen, B. (2010). A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila. ANS/AuPS 2010 – the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW, Australia, 31 January - 2 February 2010.

A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila

2010

Conference Publication

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

Eyles, Darryl, Cui, Xiaoying, Pelekanos, Matt, Kesby, James, Burne, Tom and McGrath, John (2010). Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny. 2nd Schizophrenia International Research Society Conference, Florence, Italy, 10-14 April 2010. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2010.02.195

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

2010

Conference Publication

Developmental vitamin D(3) deficiency induces alterations in immune organ morphology and function in adult offspring

Harvey, Louise, Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2010). Developmental vitamin D(3) deficiency induces alterations in immune organ morphology and function in adult offspring. 14th Vitamin D Workshop, Brugge, Belgium, 4-8 October, 2009. Oxford, England: Pergamon Press. doi: 10.1016/j.jsbmb.2010.03.050

Developmental vitamin D(3) deficiency induces alterations in immune organ morphology and function in adult offspring

2010

Conference Publication

Environmental risk factors for schizophrenia : Does developmental vitamin D deficiency play a role?

McGrath, John, Eyles, Darryl and Burne, Tom (2010). Environmental risk factors for schizophrenia : Does developmental vitamin D deficiency play a role?. 11th Australasian Schizophrenia Conference, Sydney, Australia, 22-24 September 2010. United Kingdom: Informa Healthcare.

Environmental risk factors for schizophrenia : Does developmental vitamin D deficiency play a role?

2010

Conference Publication

A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations

McGrath, John J., Saha, Sukanta, Burne, Thomas H.J. and Eyles, Darryl W. (2010). A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. 14th Workshop on Vitamin D, Brugge, Belgiun, 4-8 October, 2009. Oxford, England: Pergamon Press. doi: 10.1016/j.jsbmb.2010.03.073

A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations

2010

Conference Publication

Modelling cognitive symptoms in developmental vitamin D-deficient rats

Burne, Thomas H. J., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Modelling cognitive symptoms in developmental vitamin D-deficient rats. 11th Australasian Schizophrenia Conference, Sydney, Australia, 22-24 September 2010. United Kingdom: Informa Healthcare.

Modelling cognitive symptoms in developmental vitamin D-deficient rats

2009

Journal Article

Developmental vitamin D deficiency causes abnormal brain development

Eyles, Darryl, Cui, Xiaoying, Kesby, James, Harms, Lauren, Ko, Pauline, McGrath, John J. and Burne, Thomas H.J. (2009). Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology, 34 (Supplement 1), S247-S257. doi: 10.1016/j.psyneuen.2009.04.015

Developmental vitamin D deficiency causes abnormal brain development

2009

Journal Article

Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain

Kesby, James P., Cui, Xiaoying, Ko, Pauline, McGrath, John J., Burne, Thomas H. J. and Eyles, Darryl W. (2009). Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain. Neuroscience Letters, 461 (2), 155-158. doi: 10.1016/j.neulet.2009.05.070

Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain

2009

Journal Article

Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases

Fernandes de Abreu, D. A., Eyles, D. and Feron, F. (2009). Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology, 34 (1), S265-S277. doi: 10.1016/j.psyneuen.2009.05.023

Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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