Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

81 - 100 of 249 works

2015

Conference Publication

Developmental vitamin D deficient rat model of autism spectrum disorder

Ali, A., Eyles, D. and Cui, X. (2015). Developmental vitamin D deficient rat model of autism spectrum disorder. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Developmental vitamin D deficient rat model of autism spectrum disorder

2015

Conference Publication

Rapid modulation of neuronal voltage-gated calcium channels by vitamin D

Gooch, H., Cui, X., Burne, T., Eyles, D., Anggono, V., Sah, P. and McGrath, J. (2015). Rapid modulation of neuronal voltage-gated calcium channels by vitamin D. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, Aug 23-27, 2015. HOBOKEN: WILEY-BLACKWELL.

Rapid modulation of neuronal voltage-gated calcium channels by vitamin D

2015

Journal Article

Wolbachia influences the production of octopamine and affects Drosophila male aggression

Rohrscheib, Chelsie E., Bondy, Elizabeth, Josh, Peter, Riegler, Markus, Eyles, Darryl, van Swinderen, Bruno, Weible, Michael W. and Brownlie, Jeremy C. (2015). Wolbachia influences the production of octopamine and affects Drosophila male aggression. Applied and Environmental Microbiology, 81 (14), 4573-4580. doi: 10.1128/AEM.00573-15

Wolbachia influences the production of octopamine and affects Drosophila male aggression

2015

Journal Article

Vitamin D and the brain: key questions for future research

Cui, Xiaoying, Gooch, Helen, Groves, Natalie J., Sah, Pankaj, Burne, Thomas H., Eyles, Darryl W. and McGrath, John J. (2015). Vitamin D and the brain: key questions for future research. The Journal of Steroid Biochemistry and Molecular Biology, 148, 305-309. doi: 10.1016/j.jsbmb.2014.11.004

Vitamin D and the brain: key questions for future research

2015

Journal Article

Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

Tovey, Euan R., Stelzer-Braid, Sacha, Toelle, Brett G., Oliver, Brian G., Reddel, Helen K., Willenborg, Christiana M., Belessis, Yvonne, Garden, Frances L., Jaffe, Adam, Strachan, Roxanne, Eyles, Darryl, Rawlinson, William D. and Marks, Guy B. (2015). Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma. Journal of Allergy and Clinical Immunology, 135 (3), 663-669.e12. doi: 10.1016/j.jaci.2014.10.020

Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

2015

Journal Article

Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins

Mills, Natalie T., Wright, Margaret J., Henders, Anjali K., Eyles, Darryl W., Baune, Bernhard T., McGrath, John J., Byrne, Edna M., Hansell, Narelle K., Birosova, Eva, Scott, James G., Martin, Nicholas G., Montgomery, Grant W., Wray, Naomi R. and Vinkhuyzen, Anna A. E. (2015). Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins. Twin Research and Human Genetics, 18 (1), 28-35. doi: 10.1017/thg.2014.70

Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins

2015

Journal Article

Autism spectrum disorder and low vitamin D at birth: a sibling control study

Fernell, Elisabeth, Bejerot, Susanne, Westerlund, Joakim, Miniscalco, Carmela, Simila, Henry, Eyles, Darryl, Gillberg, Christopher and Humble, Mats B. (2015). Autism spectrum disorder and low vitamin D at birth: a sibling control study. Molecular Autism, 6 (1) 3, 3.1-3.9. doi: 10.1186/2040-2392-6-3

Autism spectrum disorder and low vitamin D at birth: a sibling control study

2015

Conference Publication

A proteomic study of the nucleus accumbens following sensitisation to MK-801 in the rat

Lefevre, E., Josh, P., Eyles, D. and Burne, T. (2015). A proteomic study of the nucleus accumbens following sensitisation to MK-801 in the rat. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

A proteomic study of the nucleus accumbens following sensitisation to MK-801 in the rat

2015

Conference Publication

The association of the vitamin D receptor and nuclear matrix in a neuroblastoma line

Cui, X., Pertile, R. and Eyles, D. (2015). The association of the vitamin D receptor and nuclear matrix in a neuroblastoma line. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189

The association of the vitamin D receptor and nuclear matrix in a neuroblastoma line

2015

Conference Publication

Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase

Luan, W., Alexander, S., Osborne, G., Nink, V., Cui, X. and Eyles, D. (2015). Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188

Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase

2015

Conference Publication

Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats

Moe, A. A. K., Cui, X., Kurniawan, N. D., Alexander, S., Burne, T. H. J. and Eyles, D. W. (2015). Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188

Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats

2015

Journal Article

Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study

Vinkhuyzen, Anna A.E., Eyles, Darryl W., Burne, Thomas H., Blanken, Laura M.E., Kruithof, Claudia J., Verhulst, Frank, Jaddoe, Vincent W., Tiemeier, Henning and McGrath, John J. (2015). Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study. Journal of Steroid Biochemistry And Molecular Biology, 164, 161-167. doi: 10.1016/j.jsbmb.2015.09.018

Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study

2015

Journal Article

Vitamin D status during fetal life and childhood kidney outcomes

Miliku, K., Voortman, T., Franco, O. H., McGrath, J. J., Eyles, D. W., Burne, T. H., Hofman, A., Tiemeier, H. and Jaddoe, V. W. V. (2015). Vitamin D status during fetal life and childhood kidney outcomes. European Journal of Clinical Nutrition, 70 (5), 629-634. doi: 10.1038/ejcn.2015.216

Vitamin D status during fetal life and childhood kidney outcomes

2014

Journal Article

Ontogeny of small RNA in the regulation of mammalian brain development

Hollins, Sharon L., Goldie, Belinda J., Carroll, Adam P., Mason, Elizabeth A., Walker, Frederick R., Eyles, Darryl W. and Cairns, Murray J. (2014). Ontogeny of small RNA in the regulation of mammalian brain development. BMC Genomics, 15 (777) 777, 1-13. doi: 10.1186/1471-2164-15-777

Ontogeny of small RNA in the regulation of mammalian brain development

2014

Journal Article

Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in Plasma

Heath, Alicia K., Williamson, Elizabeth J., Ebeling, Peter R., Kvaskoff, David, Eyles, Darryl W and English, Dallas R. (2014). Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in Plasma. Journal of Clinical Endocrinology and Metabolism, 99 (9), 3319-3324. doi: 10.1210/jc.2014-1269

Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in Plasma

2014

Journal Article

Neonatal vitamin D status and risk of multiple sclerosis

Ueda, Peter, Rafatnia, Farshid, Baarnhielm, Maria, Frobom, Robin, Korzunowicz, Greg, Lonnerbro, Ragnar, Hedstrom, Anna Karin, Eyles, Darryl, Olsson, Tomas and Alfredsson, Lars (2014). Neonatal vitamin D status and risk of multiple sclerosis. Annals of Neurology, 76 (3), 338-346. doi: 10.1002/ana.24210

Neonatal vitamin D status and risk of multiple sclerosis

2014

Journal Article

MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex

Cui, Xiaoying, Lefevre, Emilia, Turner, Karly M., Coelho, Carlos M., Alexander, Suzy, Burne, Thomas H. J. and Eyles, Darryl W. (2014). MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex. Psychopharmacology, 232 (3), 509-517. doi: 10.1007/s00213-014-3689-9

MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex

2014

Journal Article

Intracellular distribution of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with development

Eyles, D. W., Liu, P. Y., Josh, P. and Cui, X. (2014). Intracellular distribution of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with development. Neuroscience, 268, 1-9. doi: 10.1016/j.neuroscience.2014.02.042

Intracellular distribution of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with development

2014

Journal Article

Season of birth, neonatal vitamin D status, and cardiovascular disease risk at 35 y of age: A cohort study from Sweden

Tornhammar, Per, Ueda, Peter, Hult, Martin, Simila, Henry, Eyles, Darryl and Norman, Mikael (2014). Season of birth, neonatal vitamin D status, and cardiovascular disease risk at 35 y of age: A cohort study from Sweden. American Journal of Clinical Nutrition, 99 (3), 472-478. doi: 10.3945/ajcn.113.072520

Season of birth, neonatal vitamin D status, and cardiovascular disease risk at 35 y of age: A cohort study from Sweden

2014

Journal Article

Developmentally vitamin D-deficient rats show enhanced prepulse inhibition after acute δ9-tetrahydrocannabinol

Burne, T. H. J., Alexander, S., Turner, K. M., Eyles, D. W. and McGrath, J. J. (2014). Developmentally vitamin D-deficient rats show enhanced prepulse inhibition after acute δ9-tetrahydrocannabinol. Behavioural Pharmacology, 25 (3), 236-244. doi: 10.1097/FBP.0000000000000041

Developmentally vitamin D-deficient rats show enhanced prepulse inhibition after acute δ9-tetrahydrocannabinol

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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