Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

101 - 120 of 249 works

2013

Journal Article

The impact of adult vitamin D deficiency on behaviour and brain function in male Sprague-Dawley rats

Byrne, Jacqueline H., Voogt, Meggie, Turner, Karly M., Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2013). The impact of adult vitamin D deficiency on behaviour and brain function in male Sprague-Dawley rats. PLoS ONE, 8 (8) e71593, e71593.1-e71593.14. doi: 10.1371/journal.pone.0071593

The impact of adult vitamin D deficiency on behaviour and brain function in male Sprague-Dawley rats

2013

Journal Article

Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia

Kesby, James P., Cui, Xiaoying, Burne, Thomas H. J. and Eyles, Darryl W. (2013). Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia. Frontiers in Cellular Neuroscience, 7 (111) 111, 1-13. doi: 10.3389/fncel.2013.00111

Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia

2013

Journal Article

Low vitamin D concentration exacerbates adult brain dysfunction

Cui, Xiaoying, Groves, Natalie J., Burne, Thomas H. J., Eyles, Darryl W. and McGrath, John J. (2013). Low vitamin D concentration exacerbates adult brain dysfunction. American Journal of Clinical Nutrition, 97 (5), 907-908. doi: 10.3945/ajcn.113.061176

Low vitamin D concentration exacerbates adult brain dysfunction

2013

Journal Article

The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain

Cui, X., Pelekanos, M., Liu, P-Y, Burne, T. H. J., McGrath, J. J. and Eyles, D. W. (2013). The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience, 236, 77-87. doi: 10.1016/j.neuroscience.2013.01.035

The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain

2013

Journal Article

Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats

Turner, Karly M., Young, Jared W., McGrath, John J., Eyles, Darryl W. and Burne, Thomas H. J. (2013). Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats. Behavioural Brain Research, 242 (1), 47-53. doi: 10.1016/j.bbr.2012.12.029

Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats

2013

Journal Article

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves, Natalie J., Kesby, James P., Eyles, Darryl W., McGrath, John J., Mackay-Sim, Alan and Burne, Thomas H. J. (2013). Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice. Behavioural Brain Research, 241 (1), 120-131. doi: 10.1016/j.bbr.2012.12.001

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

2013

Journal Article

Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life

Lanham, S. A., Roberts, C., Habgood, A. K., Alexander, S., Burne, T. H. J., Eyles, D. W., Trueman, C. N., Cooper, M., McGrath, J. J. and Oreffo, R. O. C. (2013). Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life. Journal of Developmental Origins of Health and Disease, 4 (1), 49-55. doi: 10.1017/S2040174412000542

Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life

2013

Journal Article

Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

Eyles, Darryl, Burne, Thomas H. J. and McGrath, John J. (2013). Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34 (1), 47-64. doi: 10.1016/j.yfrne.2012.07.001

Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

2013

Journal Article

Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia

Calcagno, B., Eyles, D., van Alphen, B. and van Swinderen, B. (2013). Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia. Translational Psychiatry, 3 (1), e206.1-e206.10. doi: 10.1038/tp.2012.139

Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia

2012

Journal Article

Neonatal vitamin D status and childhood peanut allergy: a pilot study

Mullins, Raymond James, Clark, Sunday, Wiley, Veronica, Eyles, Darryl and Camargo, Carlos A. (2012). Neonatal vitamin D status and childhood peanut allergy: a pilot study. Annals of Allergy, Asthma and Immunology, 109 (5), 324-328. doi: 10.1016/j.anai.2012.07.009

Neonatal vitamin D status and childhood peanut allergy: a pilot study

2012

Journal Article

The neurodevelopmental hypothesis of schizophrenia: Convergent clues from epidemiology and neuropathology

Piper, Michael, Beneyto, Monica, Burne, Thomas H. J., Eyles, Darryl W., Lewis, David A. and McGrath, John J. (2012). The neurodevelopmental hypothesis of schizophrenia: Convergent clues from epidemiology and neuropathology. Psychiatric Clinics of North America, 35 (3), 571-584. doi: 10.1016/j.psc.2012.06.002

The neurodevelopmental hypothesis of schizophrenia: Convergent clues from epidemiology and neuropathology

2012

Journal Article

Prenatal Vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation

Fernandes de Abreu, Diana Andrea, Landel, Verena, Barnett, Adrian G., McGrath, John, Eyles, Darryl and Feron, Francois (2012). Prenatal Vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation. International Journal of Molecular Sciences, 13 (9), 10911-10919. doi: 10.3390/ijms130910911

Prenatal Vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation

2012

Journal Article

Transient knockdown of tyrosine hydroxylase during development has persistent effects on behaviour in adult zebrafish (Danio rerio)

Formella, Isabel, Scott, Ethan, Burne, Thomas H.J., Lauren Harms, Liu, Pei-Yun, Karly Turner, Cui, Xiaoying and Eyles, Darryl (2012). Transient knockdown of tyrosine hydroxylase during development has persistent effects on behaviour in adult zebrafish (Danio rerio). PLoS ONE, 7 (8) e42482, e42482.1-e42482.8. doi: 10.1371/journal.pone.0042482

Transient knockdown of tyrosine hydroxylase during development has persistent effects on behaviour in adult zebrafish (Danio rerio)

2012

Journal Article

Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS

Stewart, Niall, Simpson, Steve Jr., van der Mei, Ingrid, Ponsonby, Anne-Louise, Blizzard, Leigh, Dwyer, Terrence, Pittas, Fotini, Eyles, Darryl, Ko, Pauline and Taylor, Bruce V. (2012). Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS. Neurology, 79 (3), 254-260. doi: 10.1212/WNL.0b013e31825fded9

Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS

2012

Journal Article

Distribution of 25-hydroxyvitamin D3 in dried blood spots and implications for its quantitation by tandem mass spectrometry

Kvaskoff, David, Ko, Pauline, Simila Henry and Eyles, Darryl (2012). Distribution of 25-hydroxyvitamin D3 in dried blood spots and implications for its quantitation by tandem mass spectrometry. Journal of Chromatography B, 901 (6), 47-52. doi: 10.1016/j.jchromb.2012.05.040

Distribution of 25-hydroxyvitamin D3 in dried blood spots and implications for its quantitation by tandem mass spectrometry

2012

Journal Article

Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency

Harms, Lauren R., Cowin, Gary, Eyles, Darryl W., Kurniawan, Nyoman D., McGrath, John J. and Burne, Thomas H. J. (2012). Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency. Behavioural Brain Research, 230 (1), 125-131. doi: 10.1016/j.bbr.2012.02.007

Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency

2012

Journal Article

Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring

Kesby, James P., O'Loan, Jonathan C., Alexander, Suzanne, Deng, Chao, Huang, Xu-Feng, McGrath, John J., Eyles, Darryl W. and Burne, Thomas H. J. (2012). Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring. Psychopharmacology, 220 (3), 455-463. doi: 10.1007/s00213-011-2492-0

Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring

2012

Journal Article

Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency

Harms, Lauren R., Turner, Karly M., Eyles, Darryl W., Young, Jared W., McGrath, John J. and Burne, Thomas H. J. (2012). Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency. PLoS One, 7 (4 Article No. ee35896) e35896, e35896. doi: 10.1371/journal.pone.0035896

Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency

2012

Journal Article

Schizophrenia: Do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models

Eyles, D., Feldon, J. and Meyer, U. (2012). Schizophrenia: Do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models. Translational Psychiatry, 2 (2) e81, e81.1-e81.10. doi: 10.1038/tp.2012.6

Schizophrenia: Do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models

2012

Book Chapter

Developmental vitamin D deficiency as a risk factor for schizophrenia

Cui, Xiaoying, Eyles, Darryl W., Burne, Thomas H. J. and McGrath, John J. (2012). Developmental vitamin D deficiency as a risk factor for schizophrenia. The origins of schizophrenia. (pp. 282-299) edited by Alan S. Brown and Paul H. Patterson. New York, United States: Columbia University Press.

Developmental vitamin D deficiency as a risk factor for schizophrenia

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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