Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

161 - 180 of 249 works

2009

Journal Article

Vitamin D and the Brain: A Neuropsychiatric Perspective

Harvey, Louise, Burne, Thomas, Cui, Xiaoying, Mackay-Sim, Alan, Eyles, Darryl and McGrath, John (2009). Vitamin D and the Brain: A Neuropsychiatric Perspective. Clinical Reviews in Bone and Mineral Metabolism, 7 (2), 199-205. doi: 10.1007/s12018-009-9031-0

Vitamin D and the Brain: A Neuropsychiatric Perspective

2009

Journal Article

Vitamin D and the brain: A neuropsychiatric perspective

Harvey, Louise, Burne, Thomas H. J., Cui, Xiaoying, Mackay-Sim, Alan, Eyles, Darryl and McGrath, John J. (2009). Vitamin D and the brain: A neuropsychiatric perspective. Clinical Reviews in Bone and Mineral Metabolism, 7 (2), 199-205. doi: 10.1007/s12018-009-9031-0

Vitamin D and the brain: A neuropsychiatric perspective

2009

Journal Article

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood

Saha, Sukanta, Barnett, Adrian G., Foldi, Claire, Burne, Thomas H., Eyles, Darryl W., Buka, Stephen L. and McGrath, John J. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood. PLoS Medicine, 6 (3), 0303-0311. doi: 10.1371/journal.pmed.1000040

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood

2009

Conference Publication

The Impact of Advanced Paternal Age On Intermediate Phenotypes Related to Neurodevelopmental Disorders

Burne, Tom, Foldi, C., Eyles, D. and McGrath, J. (2009). The Impact of Advanced Paternal Age On Intermediate Phenotypes Related to Neurodevelopmental Disorders. 12th International Congress on Schizophrenia Research, San Diego Ca, Mar 28-Apr 01, 2009. OXFORD: OXFORD UNIV PRESS.

The Impact of Advanced Paternal Age On Intermediate Phenotypes Related to Neurodevelopmental Disorders

2009

Conference Publication

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

Eyles, Darryl, Cui, X., Pelekanos, M., Kesby, J., Burne, T. and McGrath, J. (2009). Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny. 12th International Congress on Schizophrenia Research, San Diego, CA, United States, 28 March-1 April 2009. Oxford, United Kingdom: Oxford University Press.

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

2009

Journal Article

A sensitive LC/MS/MS assay of 25OH vitamin D₃ and 25OH vitamin D₂ in dried blood spots

Eyles, Darryl, Cameron Anderson, Ko, Pauline, Alun Jones, Andrew Thomas, Burne, Thomas H.J., Mortensen, Preban, Bo, Norgaard-Pedersen, Bent, Hougaard, David, Michael and McGrath, John J. (2009). A sensitive LC/MS/MS assay of 25OH vitamin D₃ and 25OH vitamin D₂ in dried blood spots. Clinica Chimica Acta, 403 (1-2), 145-151. doi: 10.1016/j.cca.2009.02.005

A sensitive LC/MS/MS assay of 25OH vitamin D₃ and 25OH vitamin D₂ in dried blood spots

2009

Conference Publication

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

Eyles, D., Cui, X., Pelekanos, M., Kesby, J., Burne, T. and McGrath, J. (2009). Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny. 17th EPA Congress, Lisbon, Portugal, January 2009. Paris, France: Elsevier Masson.

Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny

2009

Conference Publication

The utility of animal models to explore the neurodevelopmental features of schizophrenia

McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2009). The utility of animal models to explore the neurodevelopmental features of schizophrenia. 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, 28 March -1 April 2009. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbn173

The utility of animal models to explore the neurodevelopmental features of schizophrenia

2009

Conference Publication

Developmental Vitamin D Deficiency (DVD)and brain dopamine ontogeny

Eyles, D., Cui, X., Pelekanos, M., Kesby, J., Burne, T. and McGrath, J. (2009). Developmental Vitamin D Deficiency (DVD)and brain dopamine ontogeny. 12th International Congress on Schizophrenia Research, San Diego, CA, United States, 28 March - 01 April 2009. Oxford, United Kingdom: Oxford Universit Press.

Developmental Vitamin D Deficiency (DVD)and brain dopamine ontogeny

2009

Conference Publication

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort

McGrath, John Joseph, Barnett, A., Foldi, C., Burne, T. H., Eyles, D. W. and Buka, S. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort. 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, 28 March -1 April 2009. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbn173

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort

2008

Journal Article

Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency

McGrath, John, Iwazaki, Takeshi, Eyles, Darryl, Burne, Thomas, Cui, Xiaoying, Ko, Pauline and Matsumoto, Izuru (2008). Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency. PLoS One, 3 (6) e2383, e2383. doi: 10.1371/journal.pone.0002383

Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency

2008

Journal Article

Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice

Harms, Lauren R., Eyles, Darryl W., McGrath, John J., Mackay-Sim, Alan and Burne, Thomas H. J. (2008). Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice. Behavioural Brain Research, 187 (2), 343-350. doi: 10.1016/j.bbr.2007.09.032

Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice

2008

Conference Publication

Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice

Harms, L., Cowin, G., Eyles, D., Kurniawan, N., Mackay-Sim, A., McGrath, J. and Burne T. (2008). Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice. Australian Nueroscience Society Annual Meeting, Hobart; Australia, 27-30 Jan 2008. Kent Town, SA, Australia: Australian Neuroscience Society.

Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice

2008

Journal Article

Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary)

Burne, Thomas H. J., Eyles, Darryl and McGrath, John J. (2008). Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary). Behavioral And Brain Sciences, 31 (3), 264-265. doi: 10.1017/S0140525X08004251

Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary)

2008

Conference Publication

Advanced paternal age alters brain development and behaviour in C57BL/6J mice

Foldi, Claire Jennifer, Cowin G, Kurniawan, Nyoman D., McGrath, John J., Eyles, Darryl and Burne, Thomas H.J. (2008). Advanced paternal age alters brain development and behaviour in C57BL/6J mice. Australian Neuroscience Society, Hobart , Tasmania, 27-30 January, 2008. Bedford Park SA: Australian Neuroscience Society.

Advanced paternal age alters brain development and behaviour in C57BL/6J mice

2008

Conference Publication

Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801

Kesby, J., O'Loan, J. C., McGrath, J. J., Eyles, D. W. and Burne, T. H. J. (2008). Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801. 21st Congress of the European College of Neuropsychopharmacology, Barcelona, Spain, 30 August - 3rd September 2008. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0924-977X(08)70354-7

Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801

2007

Journal Article

Hyperserotonaemia and reduced brain serotonin in NaS1 sulfate transporter null mice

Lee, S., Kesby, J., Muslim, M. D., Steane, S. E., Eyles, D., Dawson, P. A. and Markovich, D. (2007). Hyperserotonaemia and reduced brain serotonin in NaS1 sulfate transporter null mice. NeuroReport, 18 (18), 1981-1985. doi: 10.1097/WNR.0b013e3282f22998

Hyperserotonaemia and reduced brain serotonin in NaS1 sulfate transporter null mice

2007

Journal Article

The impact of nonlinear exposure-risk relationships on seasonal time-series data: modelling Danish neonatal birth anthropometric data

McGrath, John, Barnett, Adrian, Eyles, Darryl, Burne, Thomas, Pedersen, Carsten B. and Mortensen, Preben Bo (2007). The impact of nonlinear exposure-risk relationships on seasonal time-series data: modelling Danish neonatal birth anthropometric data. BMC Medical Research Methodology, 7 (1) 45, Article Number: 45. doi: 10.1186/1471-2288-7-45

The impact of nonlinear exposure-risk relationships on seasonal time-series data: modelling Danish neonatal birth anthropometric data

2007

Journal Article

Maternal vitamin D depletion alters neurogenesis in the developing rat brain

Cui, X. Y., McGrath, J. J., Burne, T. H. J., Mackay-Sim, A. and Eyles, D. W. (2007). Maternal vitamin D depletion alters neurogenesis in the developing rat brain. International Journal of Developmental Neuroscience, 25 (4), 227-232. doi: 10.1016/j.ijdevneu.2007.03.006

Maternal vitamin D depletion alters neurogenesis in the developing rat brain

2007

Journal Article

The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude

van der Mei, I. A. F., Ponsonby, A., Engelsen, O., Pasco, J. A., McGrath, J. J., Eyles, D. W., Blizzard, L., Dwyer, T., Lucas, R. and Jones, G. (2007). The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. Environmental Health Perspectives, 115 (8), 1132-1139. doi: 10.1289/ehp.9937

The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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