Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

221 - 240 of 249 works

2003

Journal Article

Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera

McGrath, J. J., Eyles, Darryl Walter, Mowry, Bryan, Yolken, R. and Buka, S. (2003). Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophrenia Research, 63 (1 - 2), 73-78. doi: 10.1016/S0920-9964(02)00435-8

Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera

2003

Journal Article

Vitamin D receptor expression in the embryonic rat brain

Burket, Rachel, McGrath, John and Eyles, Darryl (2003). Vitamin D receptor expression in the embryonic rat brain. Neuroscience Research Communications, 33 (1), 63-71. doi: 10.1002/nrc.10081

Vitamin D receptor expression in the embryonic rat brain

2003

Journal Article

1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons

Brown, Jillanne, Bianco, John I., McGrath, John J. and Eyles, Darryl W. (2003). 1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neuroscience Letters, 343 (2), 139-143. doi: 10.1016/S0304-3940(03)00303-3

1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons

2003

Journal Article

Vitamin D3 and brain development

Eyles, D., Brown, J., Mackay-Sim, A., McGrath, J. and Feron, F. (2003). Vitamin D3 and brain development. Neuroscience, 118 (3), 641-653. doi: 10.1016/S0306-4522(03)00040-X

Vitamin D3 and brain development

2003

Journal Article

The neurodevelopmental hypothesis of schizophrenia: a review of recent developments

McGrath, J. J., Feron, F. P., Burne, T. H. J., Mackay-Sim, A. and Eyles, D. W. (2003). The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Annals of Medicine, 35 (2), 86-93. doi: 10.1080/07853890310010005

The neurodevelopmental hypothesis of schizophrenia: a review of recent developments

2002

Conference Publication

Disruption of pro-differentiating signals may underlie both loss of cerebral asymmetry and craniofacial features in schizophrenia

McGrath, J., Eyles, D., Feron, F., Mackay-Sim, A. and Lieberman, D. (2002). Disruption of pro-differentiating signals may underlie both loss of cerebral asymmetry and craniofacial features in schizophrenia. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, February 24–March 1, 2002. Amsterdam: Elsevier. doi: 10.1016/S0920-9964(01)00381-4

Disruption of pro-differentiating signals may underlie both loss of cerebral asymmetry and craniofacial features in schizophrenia

2002

Journal Article

Neuronal calcium-binding proteins and schizophrenia

Eyles, DW, McGrath, JJ and Reynolds, GP (2002). Neuronal calcium-binding proteins and schizophrenia. Schizophrenia Research, 57 (1), 27-34. doi: 10.1016/S0920-9964(01)00299-7

Neuronal calcium-binding proteins and schizophrenia

2002

Conference Publication

Low vitamin D disrupts pre-pulse inhibition in adult but not young rats: A new animal model of schizophrenia

Mackay-Sim, A., Brown, J., Feron, F., Eyles, D. and McGrath, J. (2002). Low vitamin D disrupts pre-pulse inhibition in adult but not young rats: A new animal model of schizophrenia. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February - 1 March, 2002. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0920-9964(01)00381-4

Low vitamin D disrupts pre-pulse inhibition in adult but not young rats: A new animal model of schizophrenia

2002

Journal Article

Vitamin D-3 regulates the low affinity neurotrophin receptor P75 in the developing rat brain

Eyles, DW, Burkert, R and McGrath, J (2002). Vitamin D-3 regulates the low affinity neurotrophin receptor P75 in the developing rat brain. Schizophrenia Research, 53 (3), 228-228.

Vitamin D-3 regulates the low affinity neurotrophin receptor P75 in the developing rat brain

2002

Conference Publication

Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera

McGrath, J., Eyles, D., Mowry, B., Yolken, R. and Buka, S. (2002). Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February 2002. Amsterdam, Netherlands: Elsevier.

Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera

2002

Conference Publication

Vitamin D depletion during development markedly alters gene expression in the adult rat brain: Gene array assessment of a novel risk factor for schizophrenia

Feron, F., Mackay-Sim, A., Eyles, D., Brown, J. and McGrath, J. (2002). Vitamin D depletion during development markedly alters gene expression in the adult rat brain: Gene array assessment of a novel risk factor for schizophrenia. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February - 1 March 2002. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0920-9964(01)00381-4

Vitamin D depletion during development markedly alters gene expression in the adult rat brain: Gene array assessment of a novel risk factor for schizophrenia

2002

Conference Publication

Low maternal vitamin D-3 disrupts foetal brain maturation

Eyles, D. W., Feron, F., Brown, J., Mackay-Sim, A. and McGrath, J. (2002). Low maternal vitamin D-3 disrupts foetal brain maturation. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February 2002. Amsterdam, Netherlands: Elsevier.

Low maternal vitamin D-3 disrupts foetal brain maturation

2001

Journal Article

Vitamin D insufficiency in south-east Queensland

McGrath, J.J., Kimlin, M.G., Saha, S., Eyles, D.W. and Parisi, A.V. (2001). Vitamin D insufficiency in south-east Queensland. Medical Journal of Australia, 174 (3), 150-151. doi: 10.5694/j.1326-5377.2001.tb143195.x

Vitamin D insufficiency in south-east Queensland

2001

Conference Publication

The impact of low prenatal vitamin D on brain development: using an animal model to examine the vitamin D hypothesis of schizophrenia

McGrath, J. J., Feron, F., Eyles, D. W., Brown, J. and Mackay-Sim, A . (2001). The impact of low prenatal vitamin D on brain development: using an animal model to examine the vitamin D hypothesis of schizophrenia. VIIIth International Congress on Schizophrenia Research, British Columbia, Canada, 28 April-2 May 2001. Amsterdam, Netherlands: Elsevier.

The impact of low prenatal vitamin D on brain development: using an animal model to examine the vitamin D hypothesis of schizophrenia

2001

Journal Article

Vitamin D: the neglected neurosteroid?

McGrath, J., Feron, F., Eyles, D. and Mackay-Sim, A. (2001). Vitamin D: the neglected neurosteroid?. Trends In Neurosciences, 24 (10), 570-571. doi: 10.1016/S0166-2236(00)01949-4

Vitamin D: the neglected neurosteroid?

2000

Journal Article

Mitochondrial ultrastructure and density in a primate model of persistent tardive dyskinesia

Eyles, Darryl W., Pond, Susan M., Van Der Schyf, Cornelis J. and Halliday, Glenda M. (2000). Mitochondrial ultrastructure and density in a primate model of persistent tardive dyskinesia. Life Sciences, 66 (14), 1345-1350. doi: 10.1016/S0024-3205(00)00442-2

Mitochondrial ultrastructure and density in a primate model of persistent tardive dyskinesia

1998

Journal Article

Chirality of reduced haloperidol in humans

Eyles, D.W., McGrath, J.J., Stedman, T.J. and Pond, S.M. (1998). Chirality of reduced haloperidol in humans. European Neuropsychopharmacology, 8 (2), 127-129. doi: 10.1016/S0924-977X(97)00049-7

Chirality of reduced haloperidol in humans

1997

Journal Article

Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem

Eyles, Darryl W., Avent, Kathryn M., Stedman, Terry J. and Pond, Susan M. (1997). Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem. Life Sciences, 60 (8), 529-534. doi: 10.1016/S0024-3205(96)00656-X

Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem

1996

Journal Article

Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon

Avent, Kathryn M., Usuki, Etsuko, Eyles, Darryl W., Keeve, Ronel, Van Der Schyf, Cornelis J., Castagnoli Jr., Neal and Pond, Susan M. (1996). Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon. Life Sciences, 59 (17), 1473-1482. doi: 10.1016/0024-3205(96)00475-4

Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon

1996

Journal Article

Formation of pyridinium species of haloperidol in human liver and brain

Eyles, D. W., McGrath, J. J. and Pond, S. M. (1996). Formation of pyridinium species of haloperidol in human liver and brain. Psychopharmacology, 125 (3), 214-219. doi: 10.1007/BF02247331

Formation of pyridinium species of haloperidol in human liver and brain

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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