Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

201 - 220 of 249 works

2005

Conference Publication

Behavioural outcomes of transient prenatal vitmain D deficiency in rats

Burne, T. H. J., Eyles, D. W., Kesby, J. P., Mackay-Sim, A. and McGrath, J. J. (2005). Behavioural outcomes of transient prenatal vitmain D deficiency in rats. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, 30 January - 2 February 2005. Australia: Australian Neuroscience Society Inc.

Behavioural outcomes of transient prenatal vitmain D deficiency in rats

2005

Conference Publication

Prenatal vitamin D3 deficiency produces selective locomotion abnormalities in adult offspring

Kesby, J. P., Burne, T, Ko,, McGrath, J and Eyles, D. W. (2005). Prenatal vitamin D3 deficiency produces selective locomotion abnormalities in adult offspring. Australian Neuroscience Society, Perth, Western Australia, 30 January - 2 February. Australia: Australian neuroscience society incorporated.

Prenatal vitamin D3 deficiency produces selective locomotion abnormalities in adult offspring

2005

Journal Article

Behavioural characterization of Vitamin D receptor knockout mice

Burne, T. H. J., McGrath, J. J., Eyles, D. W. and Mackay-Sim, A. (2005). Behavioural characterization of Vitamin D receptor knockout mice. Behavioural Brain Research, 157 (2), 299-308. doi: 10.1016/j.bbr.2004.07.008

Behavioural characterization of Vitamin D receptor knockout mice

2005

Conference Publication

Developmental vitamin D deficiency and brain development: An informative animal mode of schizophrenia

Burne, T, McGrath, J. J., Mackay-Sim, A. and Eyles, D. W. (2005). Developmental vitamin D deficiency and brain development: An informative animal mode of schizophrenia. Joint CINP/ASPR Scientific Meeting, Brisbane Convention Centre, Brisbane, 7-9 Dec.. Oxford: Blackwell Publishing.

Developmental vitamin D deficiency and brain development: An informative animal mode of schizophrenia

2005

Conference Publication

Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D

Burne, T., Kesby, J. P., Feron, F., Eyles, D. W., Mackay-Sim, A. and McGrath, J. (2005). Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, 3 January - 2 February. Australia: Australian Neuroscience Society Inc..

Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D

2005

Journal Article

Developmental Vitamin D-3 deficiency alters the adult rat brain

Feron, F, Burne, THJ, Brown, J, Smith, E, McGrath, JJ, Mackay-Sim, A and Eyles, DW (2005). Developmental Vitamin D-3 deficiency alters the adult rat brain. Brain Research Bulletin, 65 (2), 141-148. doi: 10.1016/j.brainresbull.2004.12.007

Developmental Vitamin D-3 deficiency alters the adult rat brain

2005

Journal Article

Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats

Becker, A., Eyles, D. W., McGrath, J. J. and Grecksch, G. (2005). Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behavioural Brain Research, 161 (2), 306-312. doi: 10.1016/j.bbr.2005.02.015

Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats

2005

Journal Article

Distribution of the Vitamin D receptor and 1 alpha-hydroxylase in human brain

Eyles, Darryl W., Smith, Steven, Kinobe, Robert, Hewison, Martin and McGrath, John J. (2005). Distribution of the Vitamin D receptor and 1 alpha-hydroxylase in human brain. Journal Of Chemical Neuroanatomy, 29 (1), 21-30. doi: 10.1016/j.jchemneu.2004.08.006

Distribution of the Vitamin D receptor and 1 alpha-hydroxylase in human brain

2005

Conference Publication

The Effects of vitmain D on NGF and GDNF production in primary glial cells

Harvey, L., McGrath, J. J. and Eyles, D. W. (2005). The Effects of vitmain D on NGF and GDNF production in primary glial cells. Perth, 30 Jan. - 2 Feb.. Australia: Australian Neuroscience Society Inc.

The Effects of vitmain D on NGF and GDNF production in primary glial cells

2004

Journal Article

Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development

Ko, Pauline, Burkert, Rachel, McGrath, John and Eyles, Darryl (2004). Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development. Developmental Brain Research, 153 (1), 61-68. doi: 10.1016/j.devbrainres.2004.07.013

Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development

2004

Conference Publication

The distribution of the vitamin D receptor and the enzyme responsible for it's synthesis in human brain

Eyles, D., Kinobe, R., Smith, S., Hewison, M. and McGrath, J. (2004). The distribution of the vitamin D receptor and the enzyme responsible for it's synthesis in human brain. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 Feb 2004. Amsterdam, Netherlands: Elsevier Science Bv. doi: 10.1016/j.schres.2003.10.001

The distribution of the vitamin D receptor and the enzyme responsible for it's synthesis in human brain

2004

Journal Article

Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats

Burne, T. H. J., Becker, A., Brown, J., Eyles, D. W., MacKay-Sim, A. and McGrath, J. J. (2004). Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats. Behavioural Brain Research, 154 (2), 549-555. doi: 10.1016/j.bbr.2004.03.023

Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats

2004

Conference Publication

Behavioural outcomes of prenatal vitamin D deficiency in rats

Burne, T. H. J., Eyles, D. W., Becker, A., Brown, J., Mackay-Sim, A. and McGrath, J. J. (2004). Behavioural outcomes of prenatal vitamin D deficiency in rats. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 Feb 2004. Amsterdam, Netherlands: Elseveir, Science BV. doi: 10.1016/j.schres.2003.10.001

Behavioural outcomes of prenatal vitamin D deficiency in rats

2004

Journal Article

Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle

Burne, T. H. J., Feron, F., Brown, J., Eyles, D. W., McGrath, J. J. and Mackay-Sim, A. (2004). Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle. Physiology & Behavior, 81 (4), 651-655. doi: 10.1016/j.physbeh.2004.03.004

Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle

2004

Conference Publication

Transient prenatal and early life hypovitaminosis D induce permanent alterations in brain morphology, cell density and gene expression consistent with alterations observed in schizophrenia

Eyles, D., Burne, T., Brown, J., Smith, E., Mackay-Sim, A., McGrath, J. and Feron, F. (2004). Transient prenatal and early life hypovitaminosis D induce permanent alterations in brain morphology, cell density and gene expression consistent with alterations observed in schizophrenia. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 Feb 2004. Amsterdam, Netherlands: Elsevier Science Bv. doi: 10.1016/j.schres.2003.10.001

Transient prenatal and early life hypovitaminosis D induce permanent alterations in brain morphology, cell density and gene expression consistent with alterations observed in schizophrenia

2004

Conference Publication

Prenatal vitamin D deficiency induces hyperlocomotion and impairs PPI in adult offspring - a role for dopamine?

Rogers, E., Burne, T., McGrath, J. and Eyles, D. W. (2004). Prenatal vitamin D deficiency induces hyperlocomotion and impairs PPI in adult offspring - a role for dopamine?. 24th CINP Congress, Paris, France, 20-24 June 2004. Oxford, United Kingdom: Oxford University Press. doi: 10.1017/S1461145704004547

Prenatal vitamin D deficiency induces hyperlocomotion and impairs PPI in adult offspring - a role for dopamine?

2004

Conference Publication

Low prenatal vitamin D alters morphology, cell density and gene expression in adult rat brain: Correlations with schizophrenia

Eyles, D. W., Burne, T., Mackay-Sim, A., McGrath, J. and Feron, F. (2004). Low prenatal vitamin D alters morphology, cell density and gene expression in adult rat brain: Correlations with schizophrenia. XXIVth CINP Congress, Paris, France, 20–24 June 2004. Cambridge, United Kingdom: Cambridge University Press.

Low prenatal vitamin D alters morphology, cell density and gene expression in adult rat brain: Correlations with schizophrenia

2004

Conference Publication

Vitamin D-3 - implications for brain development

McGrath, John J., Feron, François P., Burne, Thomas H. J., Mackay-Sim, Alan and Eyles, Darryl W. (2004). Vitamin D-3 - implications for brain development. 12th Workshop on Vitamin D, Maastricht, The Netherlands, 06-10 July 2003. Oxford, U.K.: Pergamon Press. doi: 10.1016/j.jsbmb.2004.03.070

Vitamin D-3 - implications for brain development

2004

Book Chapter

Schizophrenia, vitamin D, and brain development

Mackay-Sim, Alan, Feron, Francois, Eyles, Darryl, Burne, Thomas and McGrath, John (2004). Schizophrenia, vitamin D, and brain development. Disorders of Synaptic Plasticity And Schizophrenia. (pp. 351-380) edited by John Smythies. USA: Elsevier. doi: 10.1016/S0074-7742(04)59014-1

Schizophrenia, vitamin D, and brain development

2004

Conference Publication

Prenatal vitamin D deficiency causes behavioural changes in adult offspring: Evidence of dopaminergic dysregulation

Rogers, F., Burne, T.H.J., Eyles, D.W. and McGrath, J.J. (2004). Prenatal vitamin D deficiency causes behavioural changes in adult offspring: Evidence of dopaminergic dysregulation. XIIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004 . Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.schres.2003.10.001

Prenatal vitamin D deficiency causes behavioural changes in adult offspring: Evidence of dopaminergic dysregulation

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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