Professor Darryl Eyles
Professor

Darryl Eyles

Email: 

Background

Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. One of Darryl’s research directions is focused on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease including developmental vitamin D deficiency, prenatal hypoxia and maternal immune activation. Strikingly all these exposures affect the early development and later differentiation of early dopamine neurons. A second major focus is on understanding the effects of increased dopamine release in selective circuits and how this may be causal in schizophrenia. A third major interest is in factors such as the gut microbiome, and how increased testosterone contribute to altered brain function related to autism.

Availability

Professor Darryl Eyles is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Neurosciences

Qualifications

  • Postgraduate Diploma, Griffith University

Research impacts

The animal model produced to understand psychiatric neurobiology for Developmental Vitamin D deficiency is now in use in 8 international laboratories. The animal model of adolescent hyperdopaminergia is also being used by other laboratories in Australia and in the UK. Our work is a perfect example of reverse translation where we take clinical observations and build animal/cellular models to better understand neurobiology. The hope is that such findings can be forward translated back to the clinic to develop better treatments.

Search Professor Darryl Eyles’s works on UQ eSpace

249 works between 1989 and 2025
All (249) Journal Article (177) Book Chapter (8) Conference Publication (63) Other Outputs (1)

241 - 249 of 249 works

1994

Journal Article

Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia

Eyles, D. W., McLennan, H. R., Jones, A., McGrath, J. J., Stedman, T. J. and Pond, S. M. (1994). Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia. Clinical Pharmacology and Therapeutics, 56 (5), 512-520. doi: 10.1038/clpt.1994.172

Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia

1994

Journal Article

Nonlinear relationship between circulating concentrations of reduced haloperidol and haloperidol: evaluation of possible mechanisms

Eyles, Darryl W., Stedman, Terry J. and Pond, Susan M. (1994). Nonlinear relationship between circulating concentrations of reduced haloperidol and haloperidol: evaluation of possible mechanisms. Psychopharmacology, 116 (2), 161-166. doi: 10.1007/BF02245058

Nonlinear relationship between circulating concentrations of reduced haloperidol and haloperidol: evaluation of possible mechanisms

1992

Journal Article

Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody

Bowles, Mark R., Eyles, Darryl W., Hampson, Edith C. G. M. and Pond, Susan M. (1992). Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody. Toxicological Sciences, 19 (3), 375-379. doi: 10.1093/toxsci/19.3.375

Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody

1992

Journal Article

Quantitation of Paraquat in Biological Samples by Radioimmunoassay Using a Monoclonal-Antibody

Bowles, MR, Eyles, DW, Hampson, Ecgm and Pond, SM (1992). Quantitation of Paraquat in Biological Samples by Radioimmunoassay Using a Monoclonal-Antibody. Fundamental and Applied Toxicology, 19 (3), 375-379. doi: 10.1016/0272-0590(92)90176-I

Quantitation of Paraquat in Biological Samples by Radioimmunoassay Using a Monoclonal-Antibody

1992

Journal Article

Stereospecific reduction of haloperidol in human tissues

Eyles, Darryl W. and Pond, Susan M. (1992). Stereospecific reduction of haloperidol in human tissues. Biochemical Pharmacology, 44 (5), 867-871. doi: 10.1016/0006-2952(92)90117-2

Stereospecific reduction of haloperidol in human tissues

1992

Journal Article

Determination of Haloperidol and Reduced Haloperidol in the Plasma and Blood of Patients on Depot Haloperidol

Eyles, Darryl W., Whiteford, Harvey A., Stedman, Terry J. and Pond, Susan M. (1992). Determination of Haloperidol and Reduced Haloperidol in the Plasma and Blood of Patients on Depot Haloperidol. Psychopharmacology, 106 (2), 268-274. doi: 10.1007/BF02801983

Determination of Haloperidol and Reduced Haloperidol in the Plasma and Blood of Patients on Depot Haloperidol

1991

Journal Article

Identification of Potentially Neurotoxic Pyridinium Metabolite in the Urine of Schizophrenic Patients Treated with Haloperidol

Subramanyam, Babu, Pond, Susan M., Eyles, Darryl W., Whiteford, Harvey A., Fouda, Hassan G. and Castagnoli, Neal (1991). Identification of Potentially Neurotoxic Pyridinium Metabolite in the Urine of Schizophrenic Patients Treated with Haloperidol. Biochemical and Biophysical Research Communications, 181 (2), 574-578. doi: 10.1016/0006-291X(91)91228-5

Identification of Potentially Neurotoxic Pyridinium Metabolite in the Urine of Schizophrenic Patients Treated with Haloperidol

1991

Journal Article

Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients

Stedman, Terry, Whiteford, Harvey, Eyles, Darryl, Welham, Joy and Pond, Susan (1991). Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients. Journal of Clinical Psychopharmacology, 11 (1), 43-47.

Effects of nifedipine on psychosis and tardive dyskinesia in schizophrenic patients

1989

Journal Article

Effects of Paraquat On Canine Bronchoalveolar Lavage Fluid

Hampson, Ecgm, Eyles, DW and Pond, SM (1989). Effects of Paraquat On Canine Bronchoalveolar Lavage Fluid. Toxicology and Applied Pharmacology, 98 (2), 206-215. doi: 10.1016/0041-008X(89)90226-3

Effects of Paraquat On Canine Bronchoalveolar Lavage Fluid

Current funding

  • 2024 - 2026
    Intranasal delivery of clozapine to reduce side-effects: The preclinical evidence
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Assessment of the role of early life vitamin D on allergic disease outcomes in the Melbourne Atopy Cohort study (MACs)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2022
    A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention
    NHMRC Project Grant
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control study (NIH grant administered by the Sequoia Foundation)
    Sequoia Foundation
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways?
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Professor Francois Feron
    UQ Travel Grants Scheme
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    Vitamin D and risk of cancer and mortality in the Melbourne Collaborative Cohort Study (NHMRC Project administered by The Cancer Council Victoria)
    Cancer Council Victoria
    Open grant
  • 2010 - 2011
    Zebrafish behavioural suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2008
    HPLC to Support Behavioural Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    The impact of low maternal vitamin D on learning and memory in adult offspring: an animal model of schizophrenia
    Australian Brain Foundation
    Open grant
  • 1997
    Mitochondrial abnormalities in selective regions of post-mortem brains from schizophrenic patients treated with haloperidol: a link with tardive dyskinesia
    Brain Research Fund
    Open grant

Availability

Professor Darryl Eyles is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Investigating corticostriatal networks and cognitive flexibility to understand schizophrenia

    Associate Advisor

    Other advisors: Dr James Kesby

Completed supervision

Enquiries

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