
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2022
Journal Article
Determining the in vitro susceptibility of tebipenem, an oral carbapenem, against third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolated from bloodstream infections
Ranasinghe, Ama, Henderson, Andrew, Cottrell, Kyra, Tan, Cindy S. E., Burnard, Delaney, Kato, Hideo, Paterson, David L. and Harris, Patrick N. A. (2022). Determining the in vitro susceptibility of tebipenem, an oral carbapenem, against third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolated from bloodstream infections. JAC-Antimicrobial Resistance, 4 (5) dlac105, 1-6. doi: 10.1093/jacamr/dlac105
2022
Journal Article
Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens
Forde, Brian M., Bergh, Haakon, Cuddihy, Thom, Hajkowicz, Krispin, Hurst, Trish, Playford, E Geoffrey, Henderson, Belinda C., Runnegar, Naomi, Clark, Julia, Jennison, Amy V., Moss, Susan, Hume, Anna, Leroux, Hugo, Beatson, Scott A., Paterson, David L. and Harris, Patrick N. A. (2022). Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens. Clinical Infectious Diseases, 76 (3), e1277-e1284. doi: 10.1093/cid/ciac726
2022
Journal Article
Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates
Isler, Burcu, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Stewart, Adam, Simos, Peter, Falconer, Caitlin, Bauer, Michelle J., Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe ... Can, Füsun (2022). Comparison of ceftazidime-avibactam susceptibility testing methods against OXA-48-like carrying Klebsiella blood stream isolates. Diagnostic Microbiology and Infectious Disease, 104 (1) 115745, 1-4. doi: 10.1016/j.diagmicrobio.2022.115745
2022
Journal Article
Multiplex microsphere PCR (mmPCR) allows simultaneous gram typing, detection of fungal DNA, and antibiotic resistance genes
Browne, Daniel J., Liang, Fang, Gartlan, Kate H., Harris, Patrick N. A., Hill, Geoffrey R., Corrie, Simon R. and Markey, Kate A. (2022). Multiplex microsphere PCR (mmPCR) allows simultaneous gram typing, detection of fungal DNA, and antibiotic resistance genes. Laboratory Medicine, 53 (5), 459-464. doi: 10.1093/labmed/lmac023
2022
Journal Article
Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Escherichia coli clinical isolates
Sumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Escherichia coli clinical isolates. Journal of Antimicrobial Chemotherapy, 77 (11), 3026-3034. doi: 10.1093/jac/dkac273
2022
Journal Article
SARS-CoV-2 RT-PCR to screen for B.1.617.2 (Delta) Variant of Concern
Lowry, Kym, Wang, Claire, Bordin, Amanda, Buckley, Cameron, Badman, Steven, Harris, Patrick, Mackay, Ian and Whiley, David (2022). SARS-CoV-2 RT-PCR to screen for B.1.617.2 (Delta) Variant of Concern. Diagnostics, 12 (9) 2056, 1-7. doi: 10.3390/diagnostics12092056
2022
Journal Article
Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model
Islam, Kamrul, Sime, Fekade B., Wallis, Steven C., Bauer, Michelle J., Naicker, Saiyuri, Won, Hayoung, Zowawi, Hosam M., Choudhury, Md Abu, Shirin, Tahmina, Habib, Zakir H., Harris, Patrick N. A., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model. Antimicrobial Agents and Chemotherapy, 66 (9), e0016222. doi: 10.1128/aac.00162-22
2022
Journal Article
Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model
Islam, Kamrul, Sime, Fekade B., Bauer, Michelle J., Forde, Brian M., Wallis, Steven C., Harris, Patrick, Naicker, Saiyuri, Shirin, Tahmina, Habib, Zakir H., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model. International Journal of Antimicrobial Agents, 60 (2) 106623, 1-7. doi: 10.1016/j.ijantimicag.2022.106623
2022
Journal Article
Achromobacter species: an emerging cause of community-onset bloodstream infections
Isler, Burcu, Paterson, David L., Harris, Patrick N. A., Ling, Weiping, Edwards, Felicity, Rickard, Claire M., Kidd, Timothy J., Gassiep, Ian and Laupland, Kevin B. (2022). Achromobacter species: an emerging cause of community-onset bloodstream infections. Microorganisms, 10 (7) 1449, 1-9. doi: 10.3390/microorganisms10071449
2022
Journal Article
Performance of the BioFire Blood Culture Identification 2 Panel for the diagnosis of bloodstream infections
Peri, Anna Maria, Bauer, Michelle J., Bergh, Haakon, Butkiewicz, Dominika, Paterson, David L. and Harris, Patrick N. A. (2022). Performance of the BioFire Blood Culture Identification 2 Panel for the diagnosis of bloodstream infections. Heliyon, 8 (7) e09983, 1-6. doi: 10.1016/j.heliyon.2022.e09983
2022
Journal Article
Carriage duration and household transmission of Enterobacterales producing extended-spectrum beta-lactamase in the community: a systematic review and meta-analysis
Ling, Weiping, Peri, Anna Maria, Furuya-Kanamori, Luis, Harris, Patrick N.A. and Paterson, David L. (2022). Carriage duration and household transmission of Enterobacterales producing extended-spectrum beta-lactamase in the community: a systematic review and meta-analysis. Microbial Drug Resistance, 28 (7), 1-11. doi: 10.1089/mdr.2022.0035
2022
Journal Article
Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model
Islam, Kamrul, Sime, Fekade B., Wallis, Steven C., Bauer, Michelle J., Forde, Brian M., Harris, Patrick, Shirin, Tahmina, Habib, Zakir H., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli clinical isolates in a hollow-fibre infection model. Journal of Antimicrobial Chemotherapy, 77 (9), 2448-2455. doi: 10.1093/jac/dkac186
2022
Journal Article
Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strains
Burnard, Delaney, Bauer, Michelle J., Falconer, Caitlin, Gassiep, Ian, Norton, Robert E., Paterson, David L. and Harris, Patrick NA (2022). Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strains. PLoS Neglected Tropical Diseases, 16 (6) e0009482, 1-12. doi: 10.1371/journal.pntd.0009482
2022
Journal Article
Sphingomonas paucimobilis bloodstream infection is a predominantly community-onset disease with significant lethality
Laupland, Kevin B., Paterson, David L., Stewart, Adam G., Edwards, Felicity and Harris, Patrick N. A. (2022). Sphingomonas paucimobilis bloodstream infection is a predominantly community-onset disease with significant lethality. International Journal of Infectious Diseases, 119, 172-177. doi: 10.1016/j.ijid.2022.03.060
2022
Journal Article
Guideline of guidelines: management of recurrent urinary tract infections in women
Kwok, Michael, McGeorge, Stephen, Mayer‐Coverdale, Johanna, Graves, Bianca, Paterson, David L., Harris, Patrick N.A., Esler, Rachel, Dowling, Caroline, Britton, Sumudu and Roberts, Matthew J. (2022). Guideline of guidelines: management of recurrent urinary tract infections in women. BJU International, 11 (2), 104-107. doi: 10.1111/bju.15756
2022
Journal Article
Efficacy and safety of carbapenems versus new antibiotics for treatment of adult patients with complicated urinary tract infections: a systematic review and meta-analysis
Ezure, Yukiko, Rico, Veronica, Paterson, David L., Hall, Lisa, Harris, Patrick N. A., Soriano, Alex, Roberts, Jason A., Bassetti, Matteo, Roberts, Matthew J., Righi, Elda and Wright, Hugh (2022). Efficacy and safety of carbapenems versus new antibiotics for treatment of adult patients with complicated urinary tract infections: a systematic review and meta-analysis. Open Forum Infectious Diseases, 9 (5) ofaa480, ofaa480. doi: 10.1093/ofid/ofaa480
2022
Journal Article
Morganella morganii, an emerging cause of bloodstream infections
Laupland, Kevin B., Paterson, David L., Edwards, Felicity, Stewart, Adam G. and Harris, Patrick N. A. (2022). Morganella morganii, an emerging cause of bloodstream infections. Microbiology Spectrum, 10 (3), e0056922. doi: 10.1128/spectrum.00569-22
2022
Journal Article
Speed and safety of mass spectrometry for identification of Burkholderia pseudomallei directly from spiked blood cultures
Gassiep, Ian, Bauer, Michelle J., Harris, Patrick N. A. and Norton, Robert (2022). Speed and safety of mass spectrometry for identification of Burkholderia pseudomallei directly from spiked blood cultures. Journal of Medical Microbiology, 71 (4) 001521. doi: 10.1099/jmm.0.001521
2022
Journal Article
Standard rectal swabs as a surrogate sample for gut microbiome monitoring in intensive care
Schlebusch, Sanmarié, Graham, Rikki M. A., Jennison, Amy V., Lassig-Smith, Melissa M., Harris, Patrick N. A., Lipman, Jeffrey, Ó Cuív, Páraic and Paterson, David L. (2022). Standard rectal swabs as a surrogate sample for gut microbiome monitoring in intensive care. BMC Microbiology, 22 (1) 99, 1-14. doi: 10.1186/s12866-022-02487-0
2022
Journal Article
Shewanella spp. bloodstream infections in Queensland, Australia
Laupland, Kevin B, Stewart, Adam G, Edwards, Felicity, Paterson, David L, Coulter, Sonali, Heney, Claire, George, Narelle and Harris, Patrick (2022). Shewanella spp. bloodstream infections in Queensland, Australia. Emerging Infectious Diseases, 28 (4), 701-706. doi: 10.3201/eid2804.212193
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
Enquiries
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