Overview
Background
Brian Forde is a fellow in microbial bioinformatics and Advance Queensland Industry Research Fellow at the University of Queensland (UQ) Centre for Clinical Research (CCR). Brian was awarded a PhD from University College Cork, Ireland, in 2013 and developed his interest in bacterial genomics as a postdoctoral fellow at the UQ School of Chemistry and Molecular Biosciences (SCMB). Currently, his work is primarily focused on clinical microbial genomics, including: the evolution of antibiotic resistance, genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice. Since 2017 he has been part of a multidisciplinary team, including researchers, infectious diseases clinicians and infection control professionals, leading the introduction of WGS to investigate hospital-acquired infection in Queensland (https://www.queenslandgenomics.org). In 2020, Brian was awarded Advance Queensland Industry Research Fellowship to explore the application of Artificial Intelligence to genomic surveillance and transmission dynamics.
Availability
- Dr Brian Forde is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Science (Advanced), unknown
- Doctor of Philosophy, National University of Ireland
Research impacts
Since 2010 Brian has co-authored 52 journal articles, with 13 as first, co-first or senior author. His has been cited 1430 times, resulting in a h-index of 19 and an i10-index of 25 (Google Scholar 28/10/2020). Brians work is regularly published in leading specialist microbiology or infectious disease journals including MBio, AAC and JAC and have also featured in high impact journals such as Nat Comm, Nat Micro, PNAS, CID and CMR. Recent work include a longitudinal study describing a unique comprehensive genomic analysis of a clonal lineage within a single individual over a 5-year period (Forde et al. Nat Comm, 2019). This work provided the framework for the utilization of genomics to help manage and treat patients suffering from debilitating chronic infections.
As part of Queensland Genomics Brian has led and assisted in projects that apply genomics to characterise and resolve infectious outbreaks in clinical settings (Chapman & Forde et al. JCM, 2020; Roberts et al. Nat Comm, 2020; Roberts et al. bioRxiv, 2018). In his current role as lead Bioinformatician for the Queensland Genomics (QG) infectious diseases (ID) project, Brian has developed pipelines for surveillance of priority bacterial pathogens. These tools, which included the development of an outbreak detection and visualisation tool, CATHAI (https:cathai.beatsonlab.com), are used by infection control professional in large Brisbane metropolitan hospitals.
Works
Search Professor Brian Forde’s works on UQ eSpace
2024
Journal Article
The Genomic Epidemiology of Clinical Burkholderia pseudomallei Isolates in North Queensland, Australia
Gassiep, Ian, Chatfield, Mark D., Permana, Budi, Burnard, Delaney, Bauer, Michelle J., Cuddihy, Thom, Forde, Brian M., Mayer-Coverdale, Johanna, Norton, Robert E. and Harris, Patrick N. A. (2024). The Genomic Epidemiology of Clinical Burkholderia pseudomallei Isolates in North Queensland, Australia. Pathogens, 13 (7) 584, 584. doi: 10.3390/pathogens13070584
2024
Journal Article
Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia
Langham, Freya, Tsai, Danny, Forde, Brian M., Camilleri, Shayne, Harris, Patrick N.A., Roberts, Jason A. and Chiong, Fabian (2024). Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia. Pathology. doi: 10.1016/j.pathol.2024.04.013
2024
Journal Article
Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes
Wen, Sophie C.H., Harris, Patrick N. A., Forde, Brian, Permana, Budi, Chatfield, Mark D., Lau, Colleen L., Spurling, Geoffrey, Bauer, Michelle J., Balch, Ross, Chambers, Henry, Schlapbach, Luregn J., Clark, Julia E., Dougherty, Sonia, Blyth, Christopher C., Britton, Philip N., Clifford, Vanessa, Haeusler, Gabrielle M., McMullan, Brendan, Wadia, Ushma, Paterson, David L., Irwin, Adam D., on behalf of the PAEDS network, Carr, Jeremy, Vasilunas, Nan, Francis, Joshua R., Macartney, Kristine, Crawford, Nigel W., Wood, Nicholas, Buttery, Jim ... Glover, Catherine (2024). Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes. Clinical Infectious Diseases. doi: 10.1093/cid/ciae341
2024
Journal Article
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Hancock, Steven J., Peters, Kate M., Alvarez-Fraga, Laura, Forde, Brian M., Andersen, Stacey B., Miliya, Thyl, Harris, Patrick N. A., Beatson, Scott A., Schlebusch, Sanmarie, Bergh, Haakon, Turner, Paul, Brauner, Annelie, Westerlund-Wikström, Benita, Irwin, Adam D. and Schembri, Mark A (2024). High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection. eLife, 12 ARTN RP91853. doi: 10.7554/elife.91853.3
2024
Journal Article
Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9
2024
Journal Article
Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus
Nong, Yi, Steinig, Eike, Pollock, Georgina L., Taiaroa, George, Carter, Glen P., Monk, Ian R., Pang, Stanley, Daley, Denise A., Coombs, Geoffrey W., Forde, Brian M., Harris, Patrick N. A., Sherry, Norelle L., Howden, Benjamin P., Pasricha, Shivani, Baines, Sarah L. and Williamson, Deborah A. (2024). Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus. Communications Biology, 7 (1) 349, 349. doi: 10.1038/s42003-024-06012-z
2024
Journal Article
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 1-9. doi: 10.1007/s00134-024-07353-3
2024
Journal Article
TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection
Stupar, Miljan, Tan, Lendl, Kerr, Edward D., De Voss, Christopher J., Forde, Brian M., Schulz, Benjamin L. and West, Nicholas P. (2024). TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection. Nature Communications, 15 (1) 1615, 1-14. doi: 10.1038/s41467-024-45343-7
2024
Journal Article
HAIviz: an interactive dashboard for visualising and integrating healthcare-associated genomic epidemiological data
Permana, Budi, Harris, Patrick N. A., Roberts, Leah W., Cuddihy, Thom, Paterson, David L., Beatson, Scott A. and Forde, Brian M. (2024). HAIviz: an interactive dashboard for visualising and integrating healthcare-associated genomic epidemiological data. Microbial Genomics, 10 (2) 001200. doi: 10.1099/mgen.0.001200
2024
Journal Article
Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales
White, Rhys T., Bull, Matthew J., Barker, Clare R., Arnott, Julie M., Wootton, Mandy, Jones, Lim S., Howe, Robin A., Morgan, Mari, Ashcroft, Melinda M., Forde, Brian M., Connor, Thomas R. and Beatson, Scott A. (2024). Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales. Nature Communications, 15 (1) 1371, 1-10. doi: 10.1038/s41467-024-45608-1
2024
Journal Article
Differences in antimicrobial resistance gene abundance and microbial diversity of the gut microbiome in patients on antibiotics enrolled in a clinical trial
Stewart, Adam G., Harris, Patrick N.A., Graham, Rikki M.A., Jennison, Amy V., Schlebusch, Sanmarie, Harris-Brown, Tiffany, Paterson, David L. and Forde, Brian M. (2024). Differences in antimicrobial resistance gene abundance and microbial diversity of the gut microbiome in patients on antibiotics enrolled in a clinical trial. Pathology, 56, S36-S37. doi: 10.1016/j.pathol.2023.12.137
2024
Conference Publication
The molecular epidemiology of Burkholderia pseudomallei in North Queensland
Gassiep, Ian, Burnard, Delaney, Permana, Budi, Bauer, Michelle J., Cuddihy, Thom, Forde, Brian M., Chatfield, Mark D., Ling, Weiping, Mayer-Coverdale, Johanna, Norton, Robert and Harris, Patrick N.A. (2024). The molecular epidemiology of Burkholderia pseudomallei in North Queensland. Pathology Update 2024, Adelaide, VIC, Australia, 1 - 3 March 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2023.12.133
2024
Journal Article
Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis
Harris, Patrick N. A., Bauer, Michelle J., Lüftinger, Lukas, Beisken, Stephan, Forde, Brian M., Balch, Ross, Cotta, Menino, Schlapbach, Luregn, Raman, Sainath, Shekar, Kiran, Kruger, Peter, Lipman, Jeff, Bialasiewicz, Seweryn, Coin, Lachlan, Roberts, Jason A., Paterson, David L. and Irwin, Adam D. (2024). Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis. Microbiology spectrum, 12 (2) e0306523, e0306523. doi: 10.1128/spectrum.03065-23
2024
Book Chapter
Microbiome-based approaches to food allergy treatment
Yao, Lu, Forde, Brian, Lunjani, Nonhlanhla, Cronin, Caoimhe and O'Mahony, Liam (2024). Microbiome-based approaches to food allergy treatment. Encyclopedia of Food Allergy. (pp. 610-623) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-323-96018-2.00109-7
2024
Journal Article
Association between gut microbiota development and allergy in infants born during pandemic-related social distancing restrictions
Korpela, Katri, Hurley, Sadhbh, Ford, Sinead Ahearn, Franklin, Ruth, Byrne, Susan, Lunjani, Nonhlanhla, Forde, Brian, Neogi, Ujjwal, Venter, Carina, Walter, Jens, Hourihane, Jonathan and O'Mahony, Liam (2024). Association between gut microbiota development and allergy in infants born during pandemic-related social distancing restrictions. Allergy: European Journal of Allergy and Clinical Immunology, 79 (7), 1938-1951. doi: 10.1111/all.16069
2023
Journal Article
Melioidosis Queensland: an analysis of clinical outcomes and genomic factors
Gassiep, Ian, Burnard, Delaney, Permana, Budi, Bauer, Michelle J., Cuddihy, Thom, Forde, Brian M., Chatfield, Mark D., Ling, Weiping, Norton, Robert and Harris, Patrick N. A. (2023). Melioidosis Queensland: an analysis of clinical outcomes and genomic factors. PLoS Neglected Tropical Diseases, 17 (10) e0011697, 1-13. doi: 10.1371/journal.pntd.0011697
2023
Journal Article
Higher rates of cefiderocol resistance among NDM producing Klebsiella bloodstream isolates applying EUCAST over CLSI breakpoints
Isler, Burcu, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Falconer, Caitlin, Bauer, Michelle J., Forde, Brian, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem, Akova, Murat ... Harris, Patrick N. A. (2023). Higher rates of cefiderocol resistance among NDM producing Klebsiella bloodstream isolates applying EUCAST over CLSI breakpoints. Infectious Diseases, 55 (9), 607-613. doi: 10.1080/23744235.2023.2226709
2023
Journal Article
GraphSNP: an interactive distance viewer for investigating outbreaks and transmission networks using a graph approach
Permana, Budi, Beatson, Scott A. and Forde, Brian M. (2023). GraphSNP: an interactive distance viewer for investigating outbreaks and transmission networks using a graph approach. BMC Bioinformatics, 24 (1) 209, 1-9. doi: 10.1186/s12859-023-05332-x
2023
Journal Article
Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland
Permana, Budi, Harris, Patrick N. A., Runnegar, Naomi, Lindsay, Margaret, Henderson, Belinda C., Playford, E. G., Paterson, David L., Beatson, Scott A. and Forde, Brian M. (2023). Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland. Microbiology Spectrum, 11 (3) e0420422, 1-10. doi: 10.1128/spectrum.04204-22
2023
Journal Article
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
Funding
Current funding
Past funding
Supervision
Availability
- Dr Brian Forde is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Malaria and Infections Diseases in military personnel in the Asia Pacific Region
Principal Advisor
-
Doctor Philosophy
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Associate Advisor
Other advisors: Associate Professor Nick West
-
Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Patrick Harris, Mr Mark Chatfield
Completed supervision
-
2022
Doctor Philosophy
Comparative Genomics of Extraintestinal Pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2022
Doctor Philosophy
New approaches in visualising genomic data for surveillance and control of drug-resistant bacteria in healthcare settings
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2019
Doctor Philosophy
Factors that influence Neisseria gonorrhoeae antimicrobial resistance and transmission in Australia
Associate Advisor
Other advisors: Associate Professor Scott Beatson, Associate Professor David Whiley
-
2019
Doctor Philosophy
Evolution and function of mobile genetic elements and DNA methyltransferases in extraintestinal pathogenic Escherichia coli
Associate Advisor
Other advisors: Associate Professor Scott Beatson
Media
Enquiries
For media enquiries about Dr Brian Forde's areas of expertise, story ideas and help finding experts, contact our Media team: