Associate Professor Adam Irwin
Associate Professor

Adam Irwin

Email: 
Phone: 
+61 7 334 66075

Background

Dr Adam Irwin is a Principal Research Fellow in Paediatric Infectious Diseases at The University of Queensland and Queensland Children’s Hospital in Brisbane, Australia. His research focuses on the early recognition of invasive infections and sepsis, and the optimal use of antimicrobials in children. He is the medical co-chair of the Queensland Paediatric Sepsis Program which was awarded a Global Sepsis Alliance award in 2020, and Queensland Health Excellence awards in 2022 for Healthcare Delivery and Consumer Engagement, and a member of the Australian Group on Antimicrobial Resistance-Kids Steering Committee. He is a recipient of a National Health and Medical Research Council Emerging Leadership Fellowship to investigate the management of multi-drug resistant gram-negative infections in children.

Adam studied at the University of Birmingham Medical School and completed training in Paediatric Infectious Disease and Immunology in London. He was awarded his PhD by the University of Liverpool Institute of Infection and Global Health in 2016. Prior to relocating to Queensland, he was secretary of the British Paediatric Allergy, Immunity and Infection Group.

Availability

Associate Professor Adam Irwin is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of Birmingham
  • Doctor of Philosophy, University of Liverpool

Search Professor Adam Irwin’s works on UQ eSpace

77 works between 2001 and 2024
All (77) Journal Article (72) Conference Publication (5)

1 - 20 of 77 works

Featured

2021

Journal Article

Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis

Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787

Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis

Featured

2021

Journal Article

The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children

Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187

The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children

Featured

2017

Journal Article

Predicting risk of serious bacterial infections in febrile children in the emergency department

Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853

Predicting risk of serious bacterial infections in febrile children in the emergency department

2024

Journal Article

Trends in Enterobacterales Bloodstream Infections in Children

Gibbs, Anna A.M., Laupland, Kevin B., Edwards, Felicity, Ling, Weiping, Channon-Wells, Samuel, Harley, David, Falster, Kathleen, Paterson, David L., Harris, Patrick N.A. and Irwin, Adam D. (2024). Trends in Enterobacterales Bloodstream Infections in Children. Pediatrics, 154 (4). doi: 10.1542/peds.2023-063532

Trends in Enterobacterales Bloodstream Infections in Children

2024

Journal Article

Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing

Yang, Wenyu, Irwin, Adam, Weerdenburg, Heather, McWhinney, Brett, Cole, Theresa, Lei, Alice, Han, Bing, Zhu, Xiao and Gwee, Amanda (2024). Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing. Antimicrobial Agents and Chemotherapy, 68 (10) e0052524. doi: 10.1128/aac.00525-24

Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing

2024

Journal Article

Getting up to speed: Rapid pathogen and antimicrobial resistance diagnostics in sepsis

Liborio, Mariana P., Harris, Patrick N. A., Ravi, Chitra and Irwin, Adam D. (2024). Getting up to speed: Rapid pathogen and antimicrobial resistance diagnostics in sepsis. Microorganisms, 12 (9) 1824, 1-29. doi: 10.3390/microorganisms12091824

Getting up to speed: Rapid pathogen and antimicrobial resistance diagnostics in sepsis

2024

Journal Article

A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes

Brouwer, Stephan, Das, Swairindhree, Hayes, Andrew J., Bertolla, Olivia M., Davies, Mark R., Walker, Mark J., Whiley, David M., Irwin, Adam D. and Tickner, Jacob A. (2024). A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes. The Journal of Infectious Diseases. doi: 10.1093/infdis/jiae437

A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes

2024

Journal Article

Australian Group on Antimicrobial Research surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 - December 2021

Williams, Anita, Coombs, Geoffrey W, Bell, Jan, Daley, Denise A, Mowlaboccus, Shakeel, Bryant, Penelope A, Campbell, Anita J, Cooley, Louise, Iredell, Jon, Irwin, Adam D, Kesson, Alison, McMullan, Brendan, Warner, Morgyn S, Williams, Phoebe and Blyth, Christoper C (2024). Australian Group on Antimicrobial Research surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 - December 2021. Communicable diseases intelligence (2018), 48 ARTN 32. doi: 10.33321/cdi.2024.48.32

Australian Group on Antimicrobial Research surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 - December 2021

2024

Journal Article

Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial)

Ullman, Amanda, Takashima, Mari, Gibson, Victoria, Comber, Elouise, Borello, Eloise, Bradford, Natalie, Byrnes, Joshua, Cole, Roni, Eisenstat, David, Henson, Nicole, Howard, Philippa, Irwin, Adam, Keogh, Samantha, Kleidon, Tricia, Martin, Michelle, McCleary, Karen, McLean, Jordana, Moloney, Susan, Monagle, Paul, Moore, Andrew, Newall, Fiona, Noyes, Michelle, Rowan, Gemma, St John, Amanda, Wood, Andrew, Wolf, Joshua and Ware, Robert (2024). Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial). BMJ Open, 14 (7) e085637, e085637-9. doi: 10.1136/bmjopen-2024-085637

Preventing adverse events during paediatric cancer treatment: protocol for a multi-site hybrid randomised controlled trial of catheter lock solutions (the CLOCK trial)

2024

Journal Article

Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes

Wen, Sophie C.H., Harris, Patrick N. A., Forde, Brian, Permana, Budi, Chatfield, Mark D., Lau, Colleen L., Spurling, Geoffrey, Bauer, Michelle J., Balch, Ross, Chambers, Henry, Schlapbach, Luregn J., Clark, Julia E., Dougherty, Sonia, Blyth, Christopher C., Britton, Philip N., Clifford, Vanessa, Haeusler, Gabrielle M., McMullan, Brendan, Wadia, Ushma, Paterson, David L., Irwin, Adam D., on behalf of the PAEDS network, Carr, Jeremy, Vasilunas, Nan, Francis, Joshua R., Macartney, Kristine, Crawford, Nigel W., Wood, Nicholas, Buttery, Jim ... Glover, Catherine (2024). Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes. Clinical Infectious Diseases, 79 (3), 734-743. doi: 10.1093/cid/ciae341

Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes

2024

Journal Article

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

2024

Journal Article

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

2024

Journal Article

High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Hancock, Steven J., Peters, Kate M., Alvarez-Fraga, Laura, Forde, Brian M., Andersen, Stacey B., Miliya, Thyl, Harris, Patrick N. A., Beatson, Scott A., Schlebusch, Sanmarie, Bergh, Haakon, Turner, Paul, Brauner, Annelie, Westerlund-Wikström, Benita, Irwin, Adam D. and Schembri, Mark A (2024). High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection. eLife, 12 ARTN RP91853. doi: 10.7554/elife.91853.3

High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

2024

Journal Article

Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9

Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

2024

Journal Article

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 1-9. doi: 10.1007/s00134-024-07353-3

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

2024

Journal Article

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

2024

Journal Article

Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study

McWhinney, Brett, Ungerer, Jacobus, LeMarsey, Renate, Phillips, Natalie, Raman, Sainath, Gibbons, Kristen, Schlapbach, Luregn J., on behalf of Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis (RAPIDS) Study Investigators and Irwin, Adam (RAPIDS member) (2024). Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study. Pediatric Critical Care Medicine, 25 (2), 171-176. doi: 10.1097/PCC.0000000000003349

Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study

2024

Journal Article

Prevalence of extra-pulmonary tuberculosis in Africa: a systematic review and meta-analysis

Hailu, Semira, Hurst, Cameron, Cyphers, Griffin, Thottunkal, Stefan, Harley, David, Viney, Kerri, Irwin, Adam, Dean, Judith and Nourse, Clare (2024). Prevalence of extra-pulmonary tuberculosis in Africa: a systematic review and meta-analysis. Tropical Medicine & International Health, 29 (4), 257-265. doi: 10.1111/tmi.13970

Prevalence of extra-pulmonary tuberculosis in Africa: a systematic review and meta-analysis

2024

Journal Article

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

Harris, Patrick N. A., Bauer, Michelle J., Lüftinger, Lukas, Beisken, Stephan, Forde, Brian M., Balch, Ross, Cotta, Menino, Schlapbach, Luregn, Raman, Sainath, Shekar, Kiran, Kruger, Peter, Lipman, Jeff, Bialasiewicz, Seweryn, Coin, Lachlan, Roberts, Jason A., Paterson, David L. and Irwin, Adam D. (2024). Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis. Microbiology spectrum, 12 (2) e0306523, e0306523. doi: 10.1128/spectrum.03065-23

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

2023

Journal Article

Implementing paediatric appropriate use criteria for endotracheal suction to reduce complications in mechanically ventilated children with respiratory infections

Schults, Jessica A., Charles, Karina R., Harnischfeger, Jane, Ware, Robert S., Royle, Ruth H., Byrnes, Joshua M., Long, Debbie A., Ullman, Amanda J., Raman, Sainath, Waak, Michaela, Lake, Anna, Cooke, Marie, Irwin, Adam, Tume, Lyvonne and Hall, Lisa (2023). Implementing paediatric appropriate use criteria for endotracheal suction to reduce complications in mechanically ventilated children with respiratory infections. Australian Critical Care, 37 (1), 1-9. doi: 10.1016/j.aucc.2023.09.008

Implementing paediatric appropriate use criteria for endotracheal suction to reduce complications in mechanically ventilated children with respiratory infections

Current funding

  • 2024 - 2026
    Genomics of paediatric inborn errors of immunity
    TRI Leading Innovations through New Collaborations Scheme
    Open grant
  • 2023 - 2026
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2023 - 2026
    Pharmacogenomics for better treatment of fungal infections in cancer
    MRFF Quality, Safety and Effectiveness of Medicine Use and Medicine Intervention by Pharmacists
    Open grant
  • 2023 - 2028
    Optimising the treatment of antibiotic resistant urinary tract infections in children: The FOSUTI Trial (MRFF CTA led by UNSYD)
    University of Sydney
    Open grant
  • 2021 - 2025
    Preventing adverse events during paediatric cancer treatment: A multi-site hybrid randomised controlled trial of innovative catheter lock solutions
    Cancer Council Queensland
    Open grant
  • 2021 - 2026
    ARC Training Centre for Information Resilience
    ARC Industrial Transformation Training Centres
    Open grant
  • 2021 - 2025
    Overcoming the barriers to treatment of multi-drug resistant Gram-negative bloodstream infections in Australian children
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2023
    The co-design and delivery of a state-wide paediatric sepsis pathway
    Children's Health Queensland Hospital and Health Service
    Open grant
  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2022
    Preventing healthcare acquired, ventilator- associated conditions in the PICU: Implementation of new airway clearance guidance
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2021
    Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2020 - 2023
    The development of an integrated molecular diagnostic pathway to optimise the treatment of cytomegalovirus in children undergoing haematopoietic stem cell transplant
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2021
    Understanding the clinical and molecular epidemiology of Gram-negative bloodstream infections to improve outcomes in Australian children
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Virulence and detection of Escherichia coli that cause neonatal meningitis
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Rapid point-of-care tests for multidrug resistant bacteria tailored for QLD paediatrics
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2020
    Optimising the treatment of invasive infection in critically ill neonates, through application of an innovative microsampling approach
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2020
    An innovative Antimicrobial Stewardship Program for children in remote and regional areas: optimising antibiotic use through early intravenous-to-oral conversion
    The Children's Hospital Foundation
    Open grant
  • 2018 - 2019
    Sakzewski Core Translational Research Group
    The Children's Hospital Foundation
    Open grant

Availability

Associate Professor Adam Irwin is:
Available for supervision

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Supervision history

Current supervision

Enquiries

Contact Associate Professor Adam Irwin directly for media enquiries about:

  • Antimicrobial resistance
  • Childhood infections
  • Sepsis

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