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2021 Journal Article Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysisWen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787 |
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2021 Journal Article The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized childrenChannon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187 |
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2017 Journal Article Predicting risk of serious bacterial infections in febrile children in the emergency departmentIrwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853 |
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2025 Journal Article Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 - December 2023Williams, Anita, Coombs, Geoffrey, Bell, Jan, Daley, Denise, Mowlaboccus, Shakeel, Bryant, Penelope, Campbell, Anita, Cooley, Louise, Howard-Jones, Annaleise, Iredell, Jon, Irwin, Adam, McMullan, Brendan, Warner, Morgyn, Williams, Phoebe and Blyth, Christopher (2025). Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs - bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 - December 2023. Communicable Diseases Intelligence, 49, 1-29. doi: 10.33321/cdi.2025.49.052 |
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2025 Journal Article A novel, standardised approach to balancing effectiveness, efficiency and utility of surveillance AI prediction models for hospitalised patients using sepsis prediction as an exemplarvan der Vegt, Anton H, Campbell, Victoria K, Webb, Robert, Venkatesh, Balasubramanian, Lane, Paul J, Wilks, Kathryn, McPhail, Steven, Rice, Michael, Isaacs, Tara, Abdel-Hafez, Ahmad, Whebell, Stephen, Irwin, Adam, Schnetler, Rudolf J, Shetty, Amith and Scott, Ian A (2025). A novel, standardised approach to balancing effectiveness, efficiency and utility of surveillance AI prediction models for hospitalised patients using sepsis prediction as an exemplar. Journal of the American Medical Informatics Association : JAMIA ocaf192. doi: 10.1093/jamia/ocaf192 |
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2025 Journal Article Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key evidence gapsYeoh, Daniel K., Boast, Alison, Wen, Sophie C. H., Williams, Phoebe C. M., Voss, Lesley, Ritchie, Brett, Mostaghim, Mona, Lutui, Flora, Lei, Alice, Lai, Tony, Irwin, Adam D., Harwood, Kiera, Ewin, Thomas, Cooper, Celia, Best, Emma, Bannister, Sarah, Gwee, Amanda, Beggs, Sean, Bowen, Asha, Carr, Jeremy, Hung, Te Yu, Lorenzen, Ulrik, McMullan, Brendan, Rockliff, Bradley, Snelling, Thomas, Walls, Tony, Weerdenburg, Heather and Wilkins, Amanda (2025). Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key evidence gaps. The Lancet Regional Health - Western Pacific, 64 101735, 101735. doi: 10.1016/j.lanwpc.2025.101735 |
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2025 Journal Article Identifying a therapeutic target for ganciclovir against cytomegalovirus in immunocompromised childrenYang, Wenyu, Irwin, Adam, Weerdenburg, Heather, McWhinney, Brett, Cole, Theresa, Lei, Alice, Zhu, Xiao and Gwee, Amanda (2025). Identifying a therapeutic target for ganciclovir against cytomegalovirus in immunocompromised children. British Journal of Clinical Pharmacology bcp.70315. doi: 10.1002/bcp.70315 |
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2025 Journal Article Probe-capture targeted next-generation sequencing: A novel approach for pathogen and antimicrobial resistance detection in sepsisRavi, Chitra, Irwin, Adam D. and Harris, Patrick N. A. (2025). Probe-capture targeted next-generation sequencing: A novel approach for pathogen and antimicrobial resistance detection in sepsis. Clinical and Translational Discovery, 5 (4) e70079, 4. doi: 10.1002/ctd2.70079 |
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2025 Journal Article Corrigendum to “The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions” [Aust Crit Care 35 (2022) 651–660]Schults, Jessica, Charles, Karina, Long, Debbie, Brown, Georgia, Copnell, Beverley, Dargaville, Peter, Davies, Kylie, Erikson, Simon, Forrest, Kate, Harnischfeger, Jane, Irwin, Adam, Kendrick, Tina, Lake, Anna, Ntoumenopoulos, George, Waak, Michaela, Woodard, Mark, Tume, Lyvonne, Cooke, Marie, Mitchell, Marion, Hall, Lisa and Ullman, Amanda (2025). Corrigendum to “The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions” [Aust Crit Care 35 (2022) 651–660]. Australian Critical Care, 38 (4) 101224, 1-1. doi: 10.1016/j.aucc.2025.101224 |
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2025 Journal Article Utilizing Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkersHe, Jingni, Ganesamoorthy, Devika, Chang, Jessie J.-Y., Zhang, Jianshu, Trevor, Sharon L., Gibbons, Kristen S., McPherson, Stephen J., Kling, Jessica C., Schlapbach, Luregn J., Blumenthal, Antje, Coin, Lachlan J. M., RAPIDS Study Group, Irwin, Adam and Bialasiewicz, Seweryn (RAPIDS Study Group member) (2025). Utilizing Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkers. BMC Infectious Diseases, 25 (1) 692, 1-19. doi: 10.1186/s12879-025-11078-z |
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2025 Journal Article Impact of a statewide sepsis pathway on quality of antibiotic use in children in the Emergency DepartmentIrwin, Adam D., Graham, Nicolette, Gartrell, Kyana, Fletchett, Emily, Cross, Jack, Doyle, Kayla, Owen, Kieran, Seaton, Robert, Rice, Michael, Lane, Paul, Ergetu, Endrias, Gilholm, Patricia, Gibbons, Kristen S., Raman, Sainath, Harley, Amanda, Lister, Paula, Grimwood, Keith, Schlapbach, Luregn J., on behalf of the Queensland Statewide Sepsis Collaborative, Redpath, Lyndell, Mason, Donna, Kalke, Vikrant, Mehta, Naitik, Taylor, Scott and Bell, Anna (2025). Impact of a statewide sepsis pathway on quality of antibiotic use in children in the Emergency Department. Intensive Care Medicine – Paediatric and Neonatal, 3 (1) 11, 1-10. doi: 10.1007/s44253-025-00060-x |
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2025 Journal Article A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisationRawlinson, Daniel, Zhou, Chenxi, Kaforou, Myrsini, Cao, Kim-Anh Lê, Coin, Lachlan J. M., RAPIDS Study Group, Irwin, Adam, Gibbons, Kristen and Bialasiewicz, Seweryn (RAPIDS Study Group member) (2025). A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation. PLoS Digital Health, 4 (3) e0000780, 1-24. doi: 10.1371/journal.pdig.0000780 |
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2025 Journal Article Impact of COVID-19 on antimicrobial stewardship activities in hospitalised children: a scoping reviewMohammed, Zabiuddin Ahad, Grant, Gary, Irwin, Adam D., Hattingh, Laetitia, Kalwaje Eshwara, Vandana, Okonkwo, Rose I. and Khan, Sohil (2025). Impact of COVID-19 on antimicrobial stewardship activities in hospitalised children: a scoping review. Journal of Paediatrics and Child Health, 61 (3), 333-343. doi: 10.1111/jpc.16786 |
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2025 Journal Article Identification of distinct clinical profiles of sepsis risk in paediatric emergency department patients using Bayesian profile regressionGilholm, Patricia, Raman, Sainath, Irwin, Adam, Lister, Paula, Harley, Amanda, Schlapbach, Luregn J. and Gibbons, Kristen S. (2025). Identification of distinct clinical profiles of sepsis risk in paediatric emergency department patients using Bayesian profile regression. BMJ Paediatrics Open, 9 (1) e003100, e003100-1. doi: 10.1136/bmjpo-2024-003100 |
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2025 Journal Article A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenesBrouwer, Stephan, Das, Swairindhree, Hayes, Andrew J., Bertolla, Olivia M., Davies, Mark R., Walker, Mark J., Whiley, David M., Irwin, Adam D. and Tickner, Jacob A. (2025). A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes. The Journal of Infectious Diseases, 231 (2), e375-e384. doi: 10.1093/infdis/jiae437 |
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2025 Journal Article Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021Williams, Anita, Coombs, Geoffrey W., Bell, Jan M., Daley, Denise A., Mowlaboccus, Shakeel, Bryant, Penelope, Campbell, Anita, Cooley, Louise, Iredell, Jon, Irwin, Adam D., Kesson, Alison, McMullan, Brendan, Warner, Morgyn S., Williams, Phoebe and Blyth, Christopher C. (2025). Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021. Journal of the Pediatric Infectious Diseases Society, 14 (2) piae110. doi: 10.1093/jpids/piae110 |
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2025 Journal Article Comparison of Random Forest and Stepwise Regression for Variable Selection Using Low Prevalence Predictors: A case Study in Paediatric SepsisGilholm, Patricia, Lister, Paula, Irwin, Adam, Harley, Amanda, Raman, Sainath, Schlapbach, Luregn J. and Gibbons, Kristen S. (2025). Comparison of Random Forest and Stepwise Regression for Variable Selection Using Low Prevalence Predictors: A case Study in Paediatric Sepsis. Maternal and Child Health Journal, 29 (5), 1-10. doi: 10.1007/s10995-025-04038-1 |
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2024 Journal Article Antimicrobial resistance in Enterobacterales, Acinetobacter spp. and Pseudomonas aeruginosa isolates from bloodstream infections in Australian children, 2013-2021Williams, Anita, Coombs, Geoffrey W., Bell, Jan M., Daley, Denise A., Mowlaboccus, Shakeel, Bryant, Penelope, Campbell, Anita, Cooley, Louise, Iredell, Jon, Irwin, Adam D., Kesson, Alison, McMullan, Brendan, Warner, Morgyn S., Williams, Phoebe and Blyth, Christopher C. (2024). Antimicrobial resistance in Enterobacterales, Acinetobacter spp. and Pseudomonas aeruginosa isolates from bloodstream infections in Australian children, 2013-2021. Journal of the Pediatric Infectious Diseases Society, 13 (12), 617-625. doi: 10.1093/jpids/piae111 |
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2024 Journal Article Trends in Enterobacterales Bloodstream Infections in ChildrenGibbs, Anna A.M., Laupland, Kevin B., Edwards, Felicity, Ling, Weiping, Channon-Wells, Samuel, Harley, David, Falster, Kathleen, Paterson, David L., Harris, Patrick N.A. and Irwin, Adam D. (2024). Trends in Enterobacterales Bloodstream Infections in Children. Pediatrics, 154 (4) e2023063532. doi: 10.1542/peds.2023-063532 |
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2024 Journal Article Serum ganciclovir drug exposure in children receiving standard ganciclovir dosingYang, Wenyu, Irwin, Adam, Weerdenburg, Heather, McWhinney, Brett, Cole, Theresa, Lei, Alice, Han, Bing, Zhu, Xiao and Gwee, Amanda (2024). Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing. Antimicrobial Agents and Chemotherapy, 68 (10) e0052524, e0052524. doi: 10.1128/aac.00525-24 |
