Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2025
Journal Article
Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study
Roberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 105051. doi: 10.1016/j.cmicom.2024.105051
2025
Journal Article
Klebsiella pneumoniae species complex bloodstream infection in adult patients: changing epidemiology and determinants of poor outcomes
Stewart, Adam G., Harris, Patrick N. A., Edwards, Felicity, Kiani, Behzad, Paterson, David L. and Laupland, Kevin B. (2025). Klebsiella pneumoniae species complex bloodstream infection in adult patients: changing epidemiology and determinants of poor outcomes. Infection. doi: 10.1007/s15010-024-02457-w
2025
Journal Article
Differentiation of Providencia species bloodstream infections: A population-based analysis
Edwards, Felicity, Edwards, Kristin H., Tabah, Alexis, Harris, Patrick N.A. and Laupland, Kevin B. (2025). Differentiation of Providencia species bloodstream infections: A population-based analysis. Diagnostic Microbiology and Infectious Disease, 111 (1) 116602, 116602. doi: 10.1016/j.diagmicrobio.2024.116602
2024
Journal Article
Pathogen genomics in healthcare: overcoming barriers to proactive surveillance
Sundermann, Alexander J., Rosa, Rossana, Harris, Patrick N. A., Snitkin, Evan, Javaid, Waleed, Moore, Nicholas M., Hayden, Mary K., Allen, Krisandra, Rodino, Kyle, Peacock, Sharon J., Abbo, Lilian M. and Harrison, Lee H. (2024). Pathogen genomics in healthcare: overcoming barriers to proactive surveillance. Antimicrobial Agents and Chemotherapy. doi: 10.1128/aac.01479-24
2024
Journal Article
Integrating omics techniques and culture-independent systems may improve the detection of persistent candidemia: data from an observational study
Peri, Anna Maria, O’Callaghan, Kevin, Rafiei, Nastaran, Bergh, Haakon, Tabah, Alexis, Chatfield, Mark D, Harris, Patrick NA and Paterson, David L (2024). Integrating omics techniques and culture-independent systems may improve the detection of persistent candidemia: data from an observational study. Annals of Clinical Microbiology and Antimicrobials, 23 (1) 75. doi: 10.1186/s12941-024-00736-w
2024
Journal Article
Exploring desirability of outcome ranking and generalised pairwise comparisons as endpoints in serious infections: post hoc application with the MERINO trial
Hardy, Melissa J., Harris, Patrick N. A., Chatfield, Mark D., Mo, Yin and Paterson, David L. (2024). Exploring desirability of outcome ranking and generalised pairwise comparisons as endpoints in serious infections: post hoc application with the MERINO trial. CMI Communications, 1 (2) 105040, 1-7. doi: 10.1016/j.cmicom.2024.105040
2024
Journal Article
Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae
Aslan, Abdullah Tarik, Demir, Mervenur, Tanriverdi, Elif Seren, Permana, Budi, Izuagbe, Rhys, Ramsay, Kay A., Forde, Brian, Otlu, Baris, Paterson, David L., Harris, Patrick, Akova, Murat and Hazirolan, Gulsen (2024). Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae. Journal of Global Antimicrobial Resistance, 39, 7. doi: 10.1016/j.jgar.2024.10.019
2024
Journal Article
Trends in Enterobacterales Bloodstream Infections in Children
Gibbs, Anna A.M., Laupland, Kevin B., Edwards, Felicity, Ling, Weiping, Channon-Wells, Samuel, Harley, David, Falster, Kathleen, Paterson, David L., Harris, Patrick N.A. and Irwin, Adam D. (2024). Trends in Enterobacterales Bloodstream Infections in Children. Pediatrics, 154 (4) e2023063532. doi: 10.1542/peds.2023-063532
2024
Journal Article
Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes
Wen, Sophie C. H., Harris, Patrick N. A., Forde, Brian, Permana, Budi, Chatfield, Mark D., Lau, Colleen L., Spurling, Geoffrey, Bauer, Michelle J., Balch, Ross, Chambers, Henry, Schlapbach, Luregn J., Clark, Julia E., Dougherty, Sonia, Blyth, Christopher C., Britton, Philip N., Clifford, Vanessa, Haeusler, Gabrielle M., McMullan, Brendan, Wadia, Ushma, Paterson, David L., Irwin, Adam D., on behalf of the PAEDS network, Carr, Jeremy, Vasilunas, Nan, Francis, Joshua R., Macartney, Kristine, Crawford, Nigel W., Wood, Nicholas, Buttery, Jim ... Glover, Catherine (2024). Characterization of gram-negative bloodstream infections in hospitalised Australian children and their clinical outcomes. Clinical Infectious Diseases, 79 (3), 734-743. doi: 10.1093/cid/ciae341
2024
Journal Article
Getting up to speed: Rapid pathogen and antimicrobial resistance diagnostics in sepsis
Liborio, Mariana P., Harris, Patrick N. A., Ravi, Chitra and Irwin, Adam D. (2024). Getting up to speed: Rapid pathogen and antimicrobial resistance diagnostics in sepsis. Microorganisms, 12 (9) 1824, 1-29. doi: 10.3390/microorganisms12091824
2024
Journal Article
Performance characteristics of genus or species-specific Polymerase Chain Reaction (PCR) for the microbial diagnosis of joint infections: a systematic review and meta-analysis
Subedi, Shradha, Isler, Burcu, Ezure, Yukiko, Furuya-Kanamori, Luis, Eriksson, Lars, Paterson, David L and Harris, Patrick N. A. (2024). Performance characteristics of genus or species-specific Polymerase Chain Reaction (PCR) for the microbial diagnosis of joint infections: a systematic review and meta-analysis. Diagnostic Microbiology and Infectious Disease, 110 (1) 116422, 1-8. doi: 10.1016/j.diagmicrobio.2024.116422
2024
Journal Article
Rapid diagnostic tests and antimicrobial stewardship programs for the management of bloodstream infection: What is their relative contribution to improving clinical outcomes? A systematic review and network meta-analysis
Peri, Anna Maria, Chatfield, Mark D., Ling, Weiping, Furuya-Kanamori, Luis, Harris, Patrick N. A. and Paterson, David L. (2024). Rapid diagnostic tests and antimicrobial stewardship programs for the management of bloodstream infection: What is their relative contribution to improving clinical outcomes? A systematic review and network meta-analysis. Clinical Infectious Diseases, 79 (2), 502-515. doi: 10.1093/cid/ciae234
2024
Journal Article
The genomic epidemiology of clinical Burkholderia pseudomallei isolates in North Queensland, Australia
Gassiep, Ian, Chatfield, Mark D., Permana, Budi, Burnard, Delaney, Bauer, Michelle J., Cuddihy, Thom, Forde, Brian M., Mayer-Coverdale, Johanna, Norton, Robert E. and Harris, Patrick N. A. (2024). The genomic epidemiology of clinical Burkholderia pseudomallei isolates in North Queensland, Australia. Pathogens, 13 (7) 584, 584. doi: 10.3390/pathogens13070584
2024
Journal Article
Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia
Langham, Freya, Tsai, Danny, Forde, Brian M., Camilleri, Shayne, Harris, Patrick N.A., Roberts, Jason A. and Chiong, Fabian (2024). Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia. Pathology, 56 (7), 1012-1020. doi: 10.1016/j.pathol.2024.04.013
2024
Journal Article
Proteus species bloodstream infections: Comparative epidemiology of three species
Laupland, Kevin B., Edwards, Felicity and Harris, Patrick N.A. (2024). Proteus species bloodstream infections: Comparative epidemiology of three species. Diagnostic Microbiology and Infectious Disease, 109 (2) 116286, 116286. doi: 10.1016/j.diagmicrobio.2024.116286
2024
Journal Article
High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection
Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Hancock, Steven J., Peters, Kate M., Alvarez-Fraga, Laura, Forde, Brian M., Andersen, Stacey B., Miliya, Thyl, Harris, Patrick N. A., Beatson, Scott A., Schlebusch, Sanmarie, Bergh, Haakon, Turner, Paul, Brauner, Annelie, Westerlund-Wikström, Benita, Irwin, Adam D. and Schembri, Mark A (2024). High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection. eLife, 12 RP91853. doi: 10.7554/elife.91853.3
2024
Journal Article
Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9
2024
Journal Article
<i>Pseudomonas stutzeri</i> bloodstream infection is a prevailing community-onset disease with important mortality rates: results from a retrospective observational study in Australia
Horcajada, Juan P., Edwards, Felicity, Fonio, Silvia, Montero, Milagro, Harris, Patrick, Paterson, David L. and Laupland, Kevin B. (2024). Pseudomonas stutzeri bloodstream infection is a prevailing community-onset disease with important mortality rates: results from a retrospective observational study in Australia. Infectious Diseases, ahead-of-print (ahead-of-print), 1-10. doi: 10.1080/23744235.2024.2333979
2024
Journal Article
Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus
Nong, Yi, Steinig, Eike, Pollock, Georgina L., Taiaroa, George, Carter, Glen P., Monk, Ian R., Pang, Stanley, Daley, Denise A., Coombs, Geoffrey W., Forde, Brian M., Harris, Patrick N. A., Sherry, Norelle L., Howden, Benjamin P., Pasricha, Shivani, Baines, Sarah L. and Williamson, Deborah A. (2024). Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus. Communications Biology, 7 (1) 349, 349. doi: 10.1038/s42003-024-06012-z
2024
Journal Article
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 1-9. doi: 10.1007/s00134-024-07353-3
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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