
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 200 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2025
Journal Article
Clinical and cost implications of Biofire FilmArray® meningitis / encephalitis panel testing: a systematic review
Rafiei, Nastaran, Subedi, Shradha, Harris, Patrick NA and Paterson, David L (2025). Clinical and cost implications of Biofire FilmArray® meningitis / encephalitis panel testing: a systematic review. Diagnostic Microbiology and Infectious Disease, 112 (3) 116823, 116823. doi: 10.1016/j.diagmicrobio.2025.116823
2025
Journal Article
Differences in antimicrobial resistance gene abundance and microbial diversity of the gut microbiome in patients on antibiotics enrolled in a clinical trial
Stewart, Adam G., Harris, Patrick N. A., Graham, Rikki M. A., Jennison, Amy V., Schlebusch, Sanmarie, Kakkanat, Asha, Harris-Brown, Tiffany, Paterson, David L. and Forde, Brian M. (2025). Differences in antimicrobial resistance gene abundance and microbial diversity of the gut microbiome in patients on antibiotics enrolled in a clinical trial. Therapeutic Advances in Infectious Disease, 12 20499361251337597, 1-12. doi: 10.1177/20499361251337597
2025
Journal Article
Practical considerations for the Implementation of Syndromic Panels and Diagnostic stewardship in the era of syndromic panel testing
Subedi, Shradha, Harris, N. A. Patrick, Hall, Lisa and Paterson, L. David (2025). Practical considerations for the Implementation of Syndromic Panels and Diagnostic stewardship in the era of syndromic panel testing. Clinical Microbiology and Infection. doi: 10.1016/j.cmi.2025.06.013
2025
Journal Article
A Global Survey of Diagnostic Practices in Prosthetic Joint Infections
Subedi, Shradha, Harris, Patrick NA, Chapman, Paul, Chen, Antonia F, Davis, Joshua S, Liu, Po-Yu, Marais, Leonard C, Salles, Mauro J, Roberts, Jason A, Rodriguez-Bano, Jesus, Wouthuyzen-Bakker, Marjan, Paterson, David L and Benito, Natividad (2025). A Global Survey of Diagnostic Practices in Prosthetic Joint Infections. Diagnostic Microbiology and Infectious Disease, 113 (2) 116919, 116919-2. doi: 10.1016/j.diagmicrobio.2025.116919
2025
Journal Article
Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance
Stewart, Adam G, Laupland, Kevin B, Edwards, Felicity, Koo, Sophia, Hammond, Sarah P, Harris, Patrick NA, Paterson, David L, Slavin, Monica A and Chen, Sharon C-A (2025). Population-based longitudinal study over two decades of Candida and Candida-like species bloodstream infection reveals gender and species differences in mortality, recurrence and resistance. Journal of Infection, 91 (1) 106513, 106513. doi: 10.1016/j.jinf.2025.106513
2025
Journal Article
Speciation of coagulase-negative staphylococci: A cohort study on clinical relevance and outcomes
Keogh, Samantha, Larsen, Emily N., Edwards, Felicity, Totsika, Makrina, Marsh, Nicole, Harris, Patrick.N.A. and Laupland, Kevin B. (2025). Speciation of coagulase-negative staphylococci: A cohort study on clinical relevance and outcomes. Infection, Disease & Health. doi: 10.1016/j.idh.2025.04.001
2025
Journal Article
Community-onset bloodstream infection among people with opioid use disorders: a twenty-year population-based cohort study in Queensland, Australia
Laupland, Kevin B., Stewart, Adam G., Edwards, Felicity, Harris, Patrick N. A. and Coulter, Sonali (2025). Community-onset bloodstream infection among people with opioid use disorders: a twenty-year population-based cohort study in Queensland, Australia. Infectious Diseases, 57 (7), 669-675. doi: 10.1080/23744235.2025.2471823
2025
Journal Article
Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study
Roberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 105051. doi: 10.1016/j.cmicom.2024.105051
2025
Journal Article
Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial
Marsh, Nicole, O’Brien, Catherine, Larsen, Emily N., Alexandrou, Evan, Ware, Robert S., Pearse, India, Coyer, Fiona, Patel, Maharshi S., Royle, Ruth H., Rickard, Claire M., Sosnowski, Kellie, Harris, Patrick N. A., Laupland, Kevin B., Bauer, Michelle J., Fraser, John F., McManus, Craig, Byrnes, Joshua and Corley, Amanda (2025). Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial. Critical Care Medicine, 53 (2), e282-e293. doi: 10.1097/ccm.0000000000006533
2025
Conference Publication
A perplexing diagnosis: role of real-time PCR for diagnosis of Haycocknema perplexum
Davidson, Natalie, Lowry, Kym, Parmar, Bijendrasinh Vikramsinh, Robertson, Thomas, Gupta, Rita, Harris, Patrick and Whiley, David (2025). A perplexing diagnosis: role of real-time PCR for diagnosis of Haycocknema perplexum. Pathology Update 2025, Melbourne, VIC Australia, 21-23 February 2025. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2024.12.378
2025
Journal Article
A Comparison of Peripherally Inserted Central Catheter Materials
Ullman, Amanda J., August, Deanne, Kleidon, Tricia M., Walker, Rachel M., Marsh, Nicole, Bulmer, Andrew C., Pearch, Ben, Runnegar, Naomi, Leema, Joanne, Lee-Archer, Paul, Biles, Cathy, Gibson, Victoria, Royle, Ruth, Southam, Katrina, Byrnes, Joshua, Chopra, Vineet, Coulthard, Alan, Mollee, Peter, Rickard, Claire M., Harris, Patrick N. A. and Ware, Robert S. (2025). A Comparison of Peripherally Inserted Central Catheter Materials. New England Journal of Medicine, 392 (2), 161-172. doi: 10.1056/nejmoa2406815
2025
Journal Article
Klebsiella pneumoniae species complex bloodstream infection in adult patients: changing epidemiology and determinants of poor outcomes
Stewart, Adam G., Harris, Patrick N. A., Edwards, Felicity, Kiani, Behzad, Paterson, David L. and Laupland, Kevin B. (2025). Klebsiella pneumoniae species complex bloodstream infection in adult patients: changing epidemiology and determinants of poor outcomes. Infection, 53 (3), 1-9. doi: 10.1007/s15010-024-02457-w
2025
Journal Article
Comparison of Piperacillin-tazobactam and Vancomycin (TZP-VAN) with Piperacillin-tazobactam and Teicoplanin (TZP-TEI) for the risk of Acute Kidney Injury (CONCOMITANT): A prospective observational, multinational, multi-centre cohort study
Aslan, Abdullah Tarık, Kara, Emre, Köksal, Gamze, Bilir, Yeliz, Saraçoğlu, Kemal Tolga, Eser, Fatma, Güner, Rahmet, Alkan, Sevil, D'Avino, Alessandro, Escudero-Sanchez, Rosa, Kutluca, Kürşat, Kaya, Sibel Yıldız, Saltoğlu, Neşe, Loiacono, Laura, Coladonato, Simona, Giacomo, Paola Del, Cascio, Antonio, Pallotto, Carlo, Francisci, Daniela, Öztürk, Barçın, Pınar, Aslı, Dağ, Osman, Harris, Patrick N.A., Paterson, David L. and Akova, Murat (2025). Comparison of Piperacillin-tazobactam and Vancomycin (TZP-VAN) with Piperacillin-tazobactam and Teicoplanin (TZP-TEI) for the risk of Acute Kidney Injury (CONCOMITANT): A prospective observational, multinational, multi-centre cohort study. International Journal of Antimicrobial Agents, 65 (3) 107446, 107446. doi: 10.1016/j.ijantimicag.2025.107446
2025
Journal Article
Differentiation of Providencia species bloodstream infections: A population-based analysis
Edwards, Felicity, Edwards, Kristin H., Tabah, Alexis, Harris, Patrick N.A. and Laupland, Kevin B. (2025). Differentiation of Providencia species bloodstream infections: A population-based analysis. Diagnostic Microbiology and Infectious Disease, 111 (1) 116602, 1-5. doi: 10.1016/j.diagmicrobio.2024.116602
2024
Journal Article
Risk of mortality in Fusobacterium species bloodstream infection from a large Australian cohort
Stewart, Adam G., Edwards, Felicity, Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin B. (2024). Risk of mortality in Fusobacterium species bloodstream infection from a large Australian cohort. European Journal of Clinical Microbiology and Infectious Diseases, 44 (2), 427-436. doi: 10.1007/s10096-024-05012-5
2024
Journal Article
Pathogen genomics in healthcare: overcoming barriers to proactive surveillance
Sundermann, Alexander J., Rosa, Rossana, Harris, Patrick N. A., Snitkin, Evan, Javaid, Waleed, Moore, Nicholas M., Hayden, Mary K., Allen, Krisandra, Rodino, Kyle, Peacock, Sharon J., Abbo, Lilian M. and Harrison, Lee H. (2024). Pathogen genomics in healthcare: overcoming barriers to proactive surveillance. Antimicrobial Agents and Chemotherapy, 69 (1), e0147924. doi: 10.1128/aac.01479-24
2024
Conference Publication
Emulating a Target Trial of Early Compared to Late Initiation of Appropriate Antibiotic Therapy for Hospital-acquired Monobacterial Gram-negative Blood Stream Infections
Aslan, Abdullah Tarik, Ezure, Yukiko, Tanriverdi, Elif Seren, Dag, Osman, Cimen, Cansu, Otlu, Baris, Harris, Patrick, Akova, Murat and Paterson, David L. (2024). Emulating a Target Trial of Early Compared to Late Initiation of Appropriate Antibiotic Therapy for Hospital-acquired Monobacterial Gram-negative Blood Stream Infections. 33rd International Congress of Antimicrobial Chemotherapy (ICC), Istanbul, Turkey, 3-6 November 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jgar.2024.10.020
2024
Journal Article
Exploring desirability of outcome ranking and generalised pairwise comparisons as endpoints in serious infections: post hoc application with the MERINO trial
Hardy, Melissa J., Harris, Patrick N. A., Chatfield, Mark D., Mo, Yin and Paterson, David L. (2024). Exploring desirability of outcome ranking and generalised pairwise comparisons as endpoints in serious infections: post hoc application with the MERINO trial. CMI Communications, 1 (2) 105040, 1-7. doi: 10.1016/j.cmicom.2024.105040
2024
Conference Publication
Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae
Aslan, Abdullah Tarik, Demir, Mervenur, Tanriverdi, Elif Seren, Permana, Budi, Izuagbe, Rhys, Ramsay, Kay A., Forde, Brian, Otlu, Baris, Paterson, David L., Harris, Patrick, Akova, Murat and Hazirolan, Gulsen (2024). Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae. 33rd International Congress of Antimicrobial Chemotherapy (ICC), Istanbul, Turkey, 3-6 November 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jgar.2024.10.019
2024
Journal Article
Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia
Langham, Freya, Tsai, Danny, Forde, Brian M., Camilleri, Shayne, Harris, Patrick N.A., Roberts, Jason A. and Chiong, Fabian (2024). Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia. Pathology, 56 (7), 1012-1020. doi: 10.1016/j.pathol.2024.04.013
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin, Dr Brian Forde
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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