Dr Patrick Harris
Dr

Patrick Harris

Email: 
Phone: 
+61 7 334 65476

Background

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria

Availability

Dr Patrick Harris is:
Available for supervision

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of London
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials

    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections

  • Antibiotic resistance

    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter

  • Clinical application of genomics

    Use of whole genome sequencing in clinical microbiology

Research impacts

He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics

Search Professor Patrick Harris’s works on UQ eSpace

237 works between 2009 and 2024
All (237) Journal Article (213) Book Chapter (2) Conference Publication (20) Other Outputs (2)

41 - 60 of 237 works

2023

Journal Article

Comparison of low‐level to high‐level disinfection in eliminating microorganisms from ultrasound transducers used on skin : a noninferiority randomized controlled trial

Peters, Nathan, Williamson, Frances, Bauer, Michelle J., Llewellyn, Stacey, Snelling, Peter J., Marsh, Nicole, Harris, Patrick N. A., Stewart, Adam G. and Rickard, Claire M. (2023). Comparison of low‐level to high‐level disinfection in eliminating microorganisms from ultrasound transducers used on skin : a noninferiority randomized controlled trial. Journal of Ultrasound in Medicine, 42 (11), 2525-2534. doi: 10.1002/jum.16286

Comparison of low‐level to high‐level disinfection in eliminating microorganisms from ultrasound transducers used on skin : a noninferiority randomized controlled trial

2023

Journal Article

Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland

Permana, Budi, Harris, Patrick N. A., Runnegar, Naomi, Lindsay, Margaret, Henderson, Belinda C., Playford, E. G., Paterson, David L., Beatson, Scott A. and Forde, Brian M. (2023). Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland. Microbiology Spectrum, 11 (3) e0420422, 1-10. doi: 10.1128/spectrum.04204-22

Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland

2023

Journal Article

Deconstructing the 2023 Clinical and Laboratory Standards revised piperacillin-tazobactam breakpoints against Pseudomonas aeruginosa

Tamma, Pranita D., Harris, Patrick N. A., Mathers, Amy J., Wenzler, Eric and Humphries, Romney M. (2023). Deconstructing the 2023 Clinical and Laboratory Standards revised piperacillin-tazobactam breakpoints against Pseudomonas aeruginosa. Clinical Infectious Diseases, 76 (10), 1868-1870. doi: 10.1093/cid/ciad012

Deconstructing the 2023 Clinical and Laboratory Standards revised piperacillin-tazobactam breakpoints against Pseudomonas aeruginosa

2023

Journal Article

Expanding the geographic boundaries of Melioidosis in Queensland, Australia

Gassiep, Ian, Grey, Victoria, Thean, Li Jun, Farquhar, Drew, Clark, Julia E., Ariotti, Lawrence, Graham, Rikki, Jennison, Amy V., Bergh, Haakon, Anuradha, Satyamurthy, Dyer, Wendy, James, Christian, Huang, Andrea, Putt, Elise, Pakeerathan, Veenaa, Griffin, Paul M. and Harris, Patrick N. A. (2023). Expanding the geographic boundaries of Melioidosis in Queensland, Australia. The American Journal of Tropical Medicine and Hygiene, 108 (6), 1215-1219. doi: 10.4269/ajtmh.23-0002

Expanding the geographic boundaries of Melioidosis in Queensland, Australia

2023

Journal Article

In vitro activity of oral third-generation cephalosporins plus clavulanate against ESBL-producing Enterobacterales isolates from the MERINO trial

Stewart, Adam G., Bauer, Michelle J., Butkiewicz, Dominika, Hinton, Alexandra, Henderson, Andrew, Harris, Patrick N.A. and Paterson, David L. (2023). In vitro activity of oral third-generation cephalosporins plus clavulanate against ESBL-producing Enterobacterales isolates from the MERINO trial. International Journal of Antimicrobial Agents, 62 (2) 106858, 1-4. doi: 10.1016/j.ijantimicag.2023.106858

In vitro activity of oral third-generation cephalosporins plus clavulanate against ESBL-producing Enterobacterales isolates from the MERINO trial

2023

Journal Article

Bloodstream infection and colorectal cancer risk in Queensland Australia, 2000-2019

Laupland, Kevin B., Edwards, Felicity, Furuya-Kanamori, Luis, Paterson, David L. and Harris, Patrick N. A. (2023). Bloodstream infection and colorectal cancer risk in Queensland Australia, 2000-2019. The American Journal of Medicine, 136 (9), 896-901. doi: 10.1016/j.amjmed.2023.05.003

Bloodstream infection and colorectal cancer risk in Queensland Australia, 2000-2019

2023

Journal Article

A simplified, amplicon-based method for whole genome sequencing of human respiratory syncytial viruses

Dong, Xiaomin, Deng, Yi-Mo, Aziz, Ammar, Whitney, Paul, Clark, Julia, Harris, Patrick, Bautista, Catherine, Costa, Anna-Maria, Waller, Gregory, Daley, Andrew J, Wieringa, Megan, Korman, Tony and Barr, Ian G. (2023). A simplified, amplicon-based method for whole genome sequencing of human respiratory syncytial viruses. Journal of Clinical Virology, 161 105423, 1-6. doi: 10.1016/j.jcv.2023.105423

A simplified, amplicon-based method for whole genome sequencing of human respiratory syncytial viruses

2023

Journal Article

Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification

Ertl, Nicole G., Irwin, Adam D., Macdonald, Joanne, Bauer, Michelle J., Wang, Claire Y. T., Harris, Patrick N. A., Heney, Claire, Zowawi, Hosam M. and Whiley, David M. (2023). Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification. JAC - Antimicrobial Resistance, 5 (2) dlad023, dlad023. doi: 10.1093/jacamr/dlad023

Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification

2023

Journal Article

Significant clinical differences but not outcomes between Klebsiella aerogenes and Enterobacter cloacae bloodstream infections: a comparative cohort study

Laupland, Kevin B., Edwards, Felicity, Harris, Patrick N. A. and Paterson, David L. (2023). Significant clinical differences but not outcomes between Klebsiella aerogenes and Enterobacter cloacae bloodstream infections: a comparative cohort study. Infection, 51 (5), 1445-1451. doi: 10.1007/s15010-023-02010-1

Significant clinical differences but not outcomes between Klebsiella aerogenes and Enterobacter cloacae bloodstream infections: a comparative cohort study

2023

Journal Article

Population-based incidence and characteristics of adult Escherichia coli bloodstream infection in Queensland, Australia from 2000 to 2019

Ling, Weiping, Paterson, David L., Harris, Patrick N. A., Furuya-Kanamori, Luis, Edwards, Felicity and Laupland, Kevin B. (2023). Population-based incidence and characteristics of adult Escherichia coli bloodstream infection in Queensland, Australia from 2000 to 2019. Open Forum Infectious Diseases, 10 (3) ofad071, ofad071. doi: 10.1093/ofid/ofad071

Population-based incidence and characteristics of adult Escherichia coli bloodstream infection in Queensland, Australia from 2000 to 2019

2023

Journal Article

Infection and inflammation of the genitourinary tract

Kwok, M., McGeorge, S., Mayer-Coverdale, J., Graves, B., Paterson, D. L., Harris, P. N. A., Esler, R., Dowling, C., Britton, S. and Roberts, M. J. (2023). Infection and inflammation of the genitourinary tract. Journal of Urology, 209 (3), 617-617. doi: 10.1097/JU.0000000000003090

Infection and inflammation of the genitourinary tract

2023

Journal Article

Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to

Stewart, Adam G., Roberts, Jason A., Forde, Brian M., Bergh, Haakon, Kidd, Timothy J., Wright, Hugh and Harris, Patrick N. A. (2023). Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to . Microbial Drug Resistance, 29 (4), 145-149. doi: 10.1089/mdr.2022.0179

Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to

2023

Conference Publication

Incidence and predictors of Escherichia coli–producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia, from 2010 to 2019: A population-based spatial analysis

Ling, Weiping, Cadavid-Restrepo, Angela, Furuya-Kanamori, Luis, Harris, Patrick N.A. and Paterson, David L. (2023). Incidence and predictors of Escherichia coli–producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia, from 2010 to 2019: A population-based spatial analysis. 10th International Congress of the Asia Pacific Society of Infection Control 2022 (APSIC 2022), Singapore, 28 - 31 July 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/ash.2023.71

Incidence and predictors of Escherichia coli–producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia, from 2010 to 2019: A population-based spatial analysis

2023

Conference Publication

Proof of concept: artificial intelligence clustering of Burkholderia species according to antibiograms

Jung, Jeeyong and Harris, Patrick N.A. (2023). Proof of concept: artificial intelligence clustering of Burkholderia species according to antibiograms. Pathology Update 2023, Melbourne, VIC Australia, 24-26 February 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2022.12.333

Proof of concept: artificial intelligence clustering of Burkholderia species according to antibiograms

2023

Journal Article

Assessing the performance of the Cepheid Xpert in identifying and differentiating methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from blood culture bottles

Parkes-Smith, Jill, Bergh, Haakon and Harris, Patrick N.A. (2023). Assessing the performance of the Cepheid Xpert in identifying and differentiating methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from blood culture bottles. Pathology, 55 (1), 113-116. doi: 10.1016/j.pathol.2022.07.006

Assessing the performance of the Cepheid Xpert in identifying and differentiating methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from blood culture bottles

2023

Journal Article

Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia

Schults, Jessica, Edwards, Felicity, Charles, Karina, Irwin, Adam D., Rickard, Claire M., Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin (2023). Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 42 (2), 209-216. doi: 10.1007/s10096-022-04540-2

Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia

2023

Journal Article

A pilot randomized controlled trial of securement bundles to reduce peripheral intravenous catheter failure

Corley, Amanda, Ullman, Amanda J., Marsh, Nicole, Genzel, Jodie, Larsen, Emily N., Young, Emily, Booker, Catriona, Harris, Patrick N. A. and Rickard, Claire M. (2023). A pilot randomized controlled trial of securement bundles to reduce peripheral intravenous catheter failure. Heart and Lung, 57, 45-53. doi: 10.1016/j.hrtlng.2022.07.015

A pilot randomized controlled trial of securement bundles to reduce peripheral intravenous catheter failure

2023

Journal Article

Epidemiology of Aeromonas species bloodstream infection in Queensland, Australia: association with regional and climate zones

Sinclair, Holly A., Edwards, Felicity, Harris, Patrick N. A., Heney, Claire and Laupland, Kevin B. (2023). Epidemiology of Aeromonas species bloodstream infection in Queensland, Australia: association with regional and climate zones. Microorganisms, 11 (1) 36, 36. doi: 10.3390/microorganisms11010036

Epidemiology of Aeromonas species bloodstream infection in Queensland, Australia: association with regional and climate zones

2022

Journal Article

High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates

Isler, Burcu, Falconer, Caitlin, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem, Akova, Murat ... Paterson, David L. (2022). High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates. Journal of Medical Microbiology, 71 (12) 001629, 1-8. doi: 10.1099/jmm.0.001629

High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates

2022

Journal Article

Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review

Walker, Mikaela M., Roberts, Jason A., Rogers, Benjamin A., Harris, Patrick N. A. and Sime, Fekade B. (2022). Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review. Antibiotics, 11 (12) 1821, 1-20. doi: 10.3390/antibiotics11121821

Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review

Current funding

  • 2025 - 2029
    New diagnostic strategies for antibiotic-resistant infections
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Reducing blood culture contamination with the use of a needle-less blood draw device (PIVO Pro): An adaptive group sequential randomized controlled trial (The PIVO Trial)
    Becton, Dickinson and Company
    Open grant
  • 2024 - 2028
    Unlocking the gut microbiome to track the spread of AMR genes and pathogens
    NHMRC MRFF - Global Health Initiative
    Open grant
  • 2023 - 2026
    New diagnostic strategies for antibiotic-resistant infections
    Queensland Health Clinical Research Fellowships
    Open grant
  • 2023 - 2026
    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis
    The Children's Hospital Foundation
    Open grant
  • 2023 - 2025
    Development of Wastewater-based epidemiology as a complementary approach for antimicrobial resistance surveillance
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2023 - 2024
    Improving management of fungal infections during blood cancer treatment
    Gilead Australia Fellowship
    Open grant
  • 2018 - 2025
    Investigator Driven Randomized Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare Associated and Hospital Acquired Gram-negative Blood Stream Infection (the GAME CHANGER trial)
    Shionogi & Company, Limited
    Open grant

Past funding

  • 2022 - 2024
    The 3,000 Genomes project: using machine learning and artificial intelligence for robust culture-independent susceptibility testing
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2022 - 2023
    Non-inferiority of low-level (LLD) versus high-level disinfection (HLD) for elimination of bacteria on contaminated ultrasound transducers: A randomised controlled trial (ASUM grant via MNHHS)
    Metro North Hospital and Health Service
    Open grant
  • 2022 - 2024
    Prediction of catheter associated bloodstream infection and hospital-onset sepsis events in critically ill adults
    Heidi-CSIRO IDR and AMR Projects
    Open grant
  • 2021 - 2022
    Improving Diagnosis, Management and Prevention of Invasive Meningococcal Disease
    Metro North Hospital and Health Service
    Open grant
  • 2021 - 2022
    Peripherally inserted central catheter Innovation to reduce Infections and Clots: the PICNIC trial
    NHMRC Project Grant
    Open grant
  • 2020 - 2021
    Assessing the epidemiology and variation of the variable virulence factor BimABM of Burkholderia pseudomallei in Queensland
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on gut microbiota of hospitalized patients
    Avant Mutual Group Limited
    Open grant
  • 2020
    Rapid detection of resistance genes from Gram-negative bacteria isolated from blood in ICU-admitted patients
    Pathology Queensland - Study, Education & Research Trust Fund
    Open grant
  • 2020 - 2021
    Assessing the effects of new and old antibiotics on the gut microbiome of hospitalized patients
    Metro North Hospital and Health Service
    Open grant
  • 2019 - 2022
    A Multicentre, Parallel Group Open-label Randomised Controlled Non-Inferiority Phase 3 Trial, of ceftolozane-tazobactam versus meropenem for definitive treatment [...] MERINO-3
    Merck Sharp & Dohme Australia
    Open grant
  • 2019 - 2021
    Virulence and detection of Escherichia coli that cause neonatal meningitis
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Rapid point-of-care tests for multidrug resistant bacteria tailored for QLD paediatrics
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    A multifaceted approach to the treatment and prevention of antibiotic-resistant bacterial infections
    NHMRC Early Career Fellowships
    Open grant
  • 2019 - 2023
    Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2019 - 2021
    Peripherally inserted central catheter Innovation to reduCe Infections and Clots: the PICNIC trial (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2019 - 2020
    Rapid detection of resistance genes from gram-negative bacteria isolated from blood in ICU-admitted patients to enable timely and effective treatment
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2023
    Cluster randomised trial of a multimodal intervention to reduce antimicrobial use in residential aged care facilities
    NHMRC MRFF - Antimicrobial Resistance Targeted Call for Research
    Open grant
  • 2018 - 2019
    Evaluation of cefiderocol (S-649266) against Burkholderia pseudomallei isolates from Queensland, Australia
    Shionogi & Company, Limited
    Open grant
  • 2018
    Rapid characterisation of pathogens for personalised antimicrobial selection in critically ill patients
    Metro North Hospital and Health Service
    Open grant
  • 2017 - 2018
    Pilot Randomised Controlled Trial of Penicillin versus Flucloxacillin for Definitive Treatment of Invasive Penicillin susceptible Staphylococcus aureas
    Metro North Hospital and Health Service
    Open grant
  • 2015
    Pilot randomised controlled trial of meropenem versus piperacillin-tazobactam for the definitive treatment of bloodstream infections caused by AmpC beta-lactamase producing Enterobacter spp, ...
    Royal Brisbane and Women's Hospital
    Open grant

Availability

Dr Patrick Harris is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis

    Principal Advisor

  • Doctor Philosophy

    Burkholderia pseudomallei: towards rapid diagnosis and management

    Principal Advisor

    Other advisors: Mr Mark Chatfield

  • Doctor Philosophy

    Novel trial design in evaluation of antibiotics.

    Associate Advisor

    Other advisors: Mr Mark Chatfield

  • Doctor Philosophy

    Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections

    Associate Advisor

    Other advisors: Dr Brian Forde, Mr Mark Chatfield

  • Doctor Philosophy

    Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.

    Associate Advisor

    Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin

  • Doctor Philosophy

    Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics

    Associate Advisor

  • Doctor Philosophy

    Clinical and laboratory applications of new and emerging methods of diagnosis of infection

    Associate Advisor

Completed supervision

Enquiries

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