
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2023
Journal Article
Significant clinical differences but not outcomes between Klebsiella aerogenes and Enterobacter cloacae bloodstream infections: a comparative cohort study
Laupland, Kevin B., Edwards, Felicity, Harris, Patrick N. A. and Paterson, David L. (2023). Significant clinical differences but not outcomes between Klebsiella aerogenes and Enterobacter cloacae bloodstream infections: a comparative cohort study. Infection, 51 (5), 1445-1451. doi: 10.1007/s15010-023-02010-1
2023
Journal Article
Population-based incidence and characteristics of adult Escherichia coli bloodstream infection in Queensland, Australia from 2000 to 2019
Ling, Weiping, Paterson, David L., Harris, Patrick N. A., Furuya-Kanamori, Luis, Edwards, Felicity and Laupland, Kevin B. (2023). Population-based incidence and characteristics of adult Escherichia coli bloodstream infection in Queensland, Australia from 2000 to 2019. Open Forum Infectious Diseases, 10 (3) ofad071, ofad071. doi: 10.1093/ofid/ofad071
2023
Journal Article
Infection and inflammation of the genitourinary tract
Kwok, M., McGeorge, S., Mayer-Coverdale, J., Graves, B., Paterson, D. L., Harris, P. N. A., Esler, R., Dowling, C., Britton, S. and Roberts, M. J. (2023). Infection and inflammation of the genitourinary tract. Journal of Urology, 209 (3), 617-617. doi: 10.1097/JU.0000000000003090
2023
Journal Article
Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to
Stewart, Adam G., Roberts, Jason A., Forde, Brian M., Bergh, Haakon, Kidd, Timothy J., Wright, Hugh and Harris, Patrick N. A. (2023). Treatment Failure Due to Adaptive Resistance Mechanisms in a Severe and Complicated Bloodstream Infection Due to . Microbial Drug Resistance, 29 (4), 145-149. doi: 10.1089/mdr.2022.0179
2023
Conference Publication
Proof of concept: artificial intelligence clustering of Burkholderia species according to antibiograms
Jung, Jeeyong and Harris, Patrick N.A. (2023). Proof of concept: artificial intelligence clustering of Burkholderia species according to antibiograms. Pathology Update 2023, Melbourne, VIC Australia, 24-26 February 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2022.12.333
2023
Journal Article
Assessing the performance of the Cepheid Xpert in identifying and differentiating methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from blood culture bottles
Parkes-Smith, Jill, Bergh, Haakon and Harris, Patrick N.A. (2023). Assessing the performance of the Cepheid Xpert in identifying and differentiating methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from blood culture bottles. Pathology, 55 (1), 113-116. doi: 10.1016/j.pathol.2022.07.006
2023
Conference Publication
Incidence and predictors of Escherichia coli–producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia, from 2010 to 2019: A population-based spatial analysis
Ling, Weiping, Cadavid-Restrepo, Angela, Furuya-Kanamori, Luis, Harris, Patrick N.A. and Paterson, David L. (2023). Incidence and predictors of Escherichia coli–producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia, from 2010 to 2019: A population-based spatial analysis. 10th International Congress of the Asia Pacific Society of Infection Control 2022 (APSIC 2022), Singapore, 28 - 31 July 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/ash.2023.71
2023
Journal Article
Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia
Schults, Jessica, Edwards, Felicity, Charles, Karina, Irwin, Adam D., Rickard, Claire M., Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin (2023). Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 42 (2), 209-216. doi: 10.1007/s10096-022-04540-2
2023
Journal Article
A pilot randomized controlled trial of securement bundles to reduce peripheral intravenous catheter failure
Corley, Amanda, Ullman, Amanda J., Marsh, Nicole, Genzel, Jodie, Larsen, Emily N., Young, Emily, Booker, Catriona, Harris, Patrick N. A. and Rickard, Claire M. (2023). A pilot randomized controlled trial of securement bundles to reduce peripheral intravenous catheter failure. Heart and Lung, 57, 45-53. doi: 10.1016/j.hrtlng.2022.07.015
2023
Journal Article
Epidemiology of Aeromonas species bloodstream infection in Queensland, Australia: association with regional and climate zones
Sinclair, Holly A., Edwards, Felicity, Harris, Patrick N. A., Heney, Claire and Laupland, Kevin B. (2023). Epidemiology of Aeromonas species bloodstream infection in Queensland, Australia: association with regional and climate zones. Microorganisms, 11 (1) 36, 36. doi: 10.3390/microorganisms11010036
2022
Journal Article
High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates
Isler, Burcu, Falconer, Caitlin, Vatansever, Cansel, Özer, Berna, Çınar, Güle, Aslan, Abdullah Tarık, Forde, Brian, Harris, Patrick, Şimşek, Funda, Tülek, Necla, Demirkaya, Hamiyet, Menekşe, Şirin, Akalin, Halis, Balkan, İlker İnanç, Aydın, Mehtap, Tigen, Elif Tükenmez, Demir, Safiye Koçulu, Kapmaz, Mahir, Keske, Şiran, Doğan, Özlem, Arabacı, Çiğdem, Yağcı, Serap, Hazırolan, Gülşen, Bakır, Veli Oğuzalp, Gönen, Mehmet, Saltoğlu, Neşe, Azap, Alpay, Azap, Özlem, Akova, Murat ... Paterson, David L. (2022). High prevalence of ArmA-16S rRNA methyltransferase among aminoglycoside-resistant Klebsiella pneumoniae bloodstream isolates. Journal of Medical Microbiology, 71 (12) 001629, 1-8. doi: 10.1099/jmm.0.001629
2022
Journal Article
Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review
Walker, Mikaela M., Roberts, Jason A., Rogers, Benjamin A., Harris, Patrick N. A. and Sime, Fekade B. (2022). Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review. Antibiotics, 11 (12) 1821, 1-20. doi: 10.3390/antibiotics11121821
2022
Conference Publication
Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bloodstream infections in Central Australia
Langham, Freya, Tsai, Danny, Camilleri, Shayne, Forde, Brian, Harris, Patrick, Roberts, Jason A. and Chiong, Fabian (2022). Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bloodstream infections in Central Australia. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, WA Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2213-7165(22)00286-7
2022
Journal Article
β-lactam-resistant Streptococcus pneumoniae dynamics following treatment: a dose-response meta-analysis
Griskaitis, Matas, Furuya-Kanamori, Luis, Allel, Kasim, Stabler, Richard, Harris, Patrick, Paterson, David L. and Yakob, Laith (2022). β-lactam-resistant Streptococcus pneumoniae dynamics following treatment: a dose-response meta-analysis. Clinical Infectious Diseases, 75 (11), 1962-1970. doi: 10.1093/cid/ciac293
2022
Journal Article
Case report: a fatal case of Aspergillus felis infection in an immunocompetent host
Parkes-Smith, Jill, Bauer, Michelle J., Bergh, Haakon, Eidan, Anthony, Forde, Brian M., Hilton, John, Kidd, Timothy J., Schmidt, Campbell, Stewart, Adam G. and Harris, Patrick N. A. (2022). Case report: a fatal case of Aspergillus felis infection in an immunocompetent host. Access Microbiology, 4 (11) acmi000453, 1-4. doi: 10.1099/acmi.0.000453
2022
Journal Article
Culture-based determinants and outcome of Staphylococcus aureus bloodstream infections
Laupland, Kevin B., Harris, Patrick N. A., Stewart, Adam G., Edwards, Felicity and Paterson, David L. (2022). Culture-based determinants and outcome of Staphylococcus aureus bloodstream infections. Diagnostic Microbiology and Infectious Disease, 104 (3) 115772, 1-5. doi: 10.1016/j.diagmicrobio.2022.115772
2022
Journal Article
Optimized method for bacterial nucleic acid extraction from positive blood culture broth for whole-genome sequencing, resistance phenotype prediction, and downstream molecular applications
Bauer, Michelle J., Peri, Anna Maria, Lüftinger, Lukas, Beisken, Stephan, Bergh, Haakon, Forde, Brian M., Buckley, Cameron, Cuddihy, Thom, Tan, Patrice, Paterson, David L., Whiley, David M. and Harris, Patrick N. A. (2022). Optimized method for bacterial nucleic acid extraction from positive blood culture broth for whole-genome sequencing, resistance phenotype prediction, and downstream molecular applications. Journal of Clinical Microbiology, 60 (11) e01012-22, 1-11. doi: 10.1128/jcm.01012-22
2022
Journal Article
Incidence and predictors of Escherichia coli producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia from 2010 to 2019: a population-based spatial analysis
Ling, Weiping, Cadavid-Restrepo, Angela, Furuya-Kanamori, Luis, Harris, Patrick N.A. and Paterson, David L. (2022). Incidence and predictors of Escherichia coli producing extended-spectrum beta-lactamase (ESBL-Ec) in Queensland, Australia from 2010 to 2019: a population-based spatial analysis. Epidemiology and Infection, 150 e178, 1-27. doi: 10.1017/s0950268822001637
2022
Journal Article
Performance of BioFire Blood Culture Identification 2 Panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies
Peri, Anna Maria, Ling, Weiping, Furuya-Kanamori, Luis, Harris, Patrick N. A. and Paterson, David L. (2022). Performance of BioFire Blood Culture Identification 2 Panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies. BMC Infectious Diseases, 22 (1) 794, 1-14. doi: 10.1186/s12879-022-07772-x
2022
Journal Article
Determinants and outcomes of bloodstream infections related to obesity
Edwards, Felicity, Glen, Kate, Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin B. (2022). Determinants and outcomes of bloodstream infections related to obesity. European Journal of Clinical Microbiology and Infectious Diseases, 41 (11), 1347-1353. doi: 10.1007/s10096-022-04501-9
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
Enquiries
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