
Overview
Background
Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Emerging Leader (EL2) Fellow at The University of Queensland Centre for Clinical Research (UQCCR).
Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, and now is a Group Leader at UQCCR, with a research focus on the diagnosis and clinical management of infections caused by multi-drug resistant bacteria
Availability
- Dr Patrick Harris is:
- Available for supervision
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of London
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials
Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
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Antibiotic resistance
Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
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Clinical application of genomics
Use of whole genome sequencing in clinical microbiology
Research impacts
He has published more than 190 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics
Works
Search Professor Patrick Harris’s works on UQ eSpace
2022
Journal Article
Comparative evaluation of Panther Fusion and real-time PCR for detection of Burkholderia pseudomallei in spiked human blood
Gassiep, Ian, Bauer, Michelle J., Page, Melissa, Harris, Patrick N. A. and Norton, Robert (2022). Comparative evaluation of Panther Fusion and real-time PCR for detection of Burkholderia pseudomallei in spiked human blood. Access Microbiology, 4 (3) 000333, 1-6. doi: 10.1099/acmi.0.000333
2022
Conference Publication
Burkholderia pseudomallei serology: Worth the hassle?
Gassiep, Ian, Ganeshalingam, Vibooshini, Chatfield, Mark D., Harris, Patrick N.A. and Norton, Robert (2022). Burkholderia pseudomallei serology: Worth the hassle?. RCPA Quality Assurance Programs Presentations, Unknown, Unknown. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2021.12.276
2022
Conference Publication
Can mass spectrometry be used to identify burkholderia pseudomallei directly from spiked blood cultures?
Gassiep, Ian, Bauer, Michelle J., Harris, Patrick N.A. and Norton, Robert (2022). Can mass spectrometry be used to identify burkholderia pseudomallei directly from spiked blood cultures?. Pathology Update 2022, Sydney, NSW Australia, 4-6 March 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2021.12.274
2022
Journal Article
Perioperative transjugular intrahepatic portosystemic shunt is associated with decreased postoperative complications in decompensated cirrhotics undergoing abdominal surgery
Aryan, Mahmoud, McPhail, James, Ravi, Sujan, Harris, Patrick, Allamneni, Chaitanya and Shoreibah, Mohamed (2022). Perioperative transjugular intrahepatic portosystemic shunt is associated with decreased postoperative complications in decompensated cirrhotics undergoing abdominal surgery. American Surgeon, 88 (7), 1613-1620. doi: 10.1177/00031348211069784
2022
Journal Article
Pasteurella species bloodstream infections in Queensland, Australia, 2000–2019
Laupland, Kevin B., Stewart, Adam G., Edwards, Felicity, Harris, Patrick, Heney, Claire, George, Narelle, Coulter, Sonali and Paterson, David L. (2022). Pasteurella species bloodstream infections in Queensland, Australia, 2000–2019. European Journal of Clinical Microbiology and Infectious Diseases, 41 (4), 609-614. doi: 10.1007/s10096-022-04411-w
2022
Journal Article
Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study
McNamara, John F, Harris, Patrick NA, Chatfield, Mark D and Paterson, David L (2022). Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study. International Journal of Infectious Diseases, 114, 34-44. doi: 10.1016/j.ijid.2021.10.047
2022
Journal Article
Melioidosis: laboratory investigations and association with patient outcomes
Gassiep, Ian, Ganeshalingam, Vibooshini, Chatfield, Mark D., Harris, Patrick N A and Norton, Robert E. (2022). Melioidosis: laboratory investigations and association with patient outcomes. The American Journal of Tropical Medicine and Hygiene, 106 (1), 54-59. doi: 10.4269/ajtmh.21-0548
2022
Journal Article
Determining risk factors for symptomatic urinary tract infection following trial of void: A retrospective analysis
Kwok, Michael, Yaxley, William, Ranasinghe, Sachinka, Morton, Leanne, Perera, Sachin, Ponen, Kreyen, Pelecanos, Anita, Britton, Sumudu, Harris, Patrick N. A., Paterson, David L., Esler, Rachel, Hussey, David, Yaxley, John W. and Roberts, Matthew J. (2022). Determining risk factors for symptomatic urinary tract infection following trial of void: A retrospective analysis. Journal of Clinical Urology, 17 (6), 205141582210998-587. doi: 10.1177/20514158221099856
2022
Journal Article
Performance of the BioFire Blood Culture Identification 2 Panel for the diagnosis of bloodstream infections on blood cultures from the intensive care unit and emergency department
Peri, Anna Maria, Bauer, Michelle J., Bergh, Haakon, Butkiewicz, Dominika, Paterson, David L. and Harris, Patrick N.A. (2022). Performance of the BioFire Blood Culture Identification 2 Panel for the diagnosis of bloodstream infections on blood cultures from the intensive care unit and emergency department. SSRN Electronic Journal. doi: 10.2139/ssrn.4003859
2022
Journal Article
CATHAI: cluster analysis tool for healthcare-associated infections
Cuddihy, Thom, Harris, Patrick N. A., Permana, Budi, Beatson, Scott A. and Forde, Brian M. (2022). CATHAI: cluster analysis tool for healthcare-associated infections. Bioinformatics Advances, 2 (1) vbac040, vbac040. doi: 10.1093/bioadv/vbac040
2022
Journal Article
Genomic analysis of Elizabethkingia species from aquatic environments: evidence for potential clinical transmission
Hem, Sopheak, Jarocki, Veronica M., Baker, Dave J., Charles, Ian G., Drigo, Barbara, Aucote, Sarah, Donner, Erica, Burnard, Delaney, Bauer, Michelle J., Harris, Patrick N.A., Wyrsch, Ethan R. and Djordjevic, Steven P. (2022). Genomic analysis of Elizabethkingia species from aquatic environments: evidence for potential clinical transmission. Current Research in Microbial Sciences, 3 100083, 100083. doi: 10.1016/j.crmicr.2021.100083
2022
Journal Article
Treatment strategies for OXA-48-like and NDM producing Klebsiella pneumoniae infections
Isler, Burcu, Aslan, Abdullah Tarık, Akova, Murat, Harris, Patrick and Paterson, David L. (2022). Treatment strategies for OXA-48-like and NDM producing Klebsiella pneumoniae infections. Expert Review of Anti-Infective Therapy, 20 (11), 1389-1400. doi: 10.1080/14787210.2022.2128764
2021
Journal Article
Activity of temocillin against third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae bloodstream isolates from a clinical trial
Stewart, Adam G, Henderson, Andrew, Bauer, Michelle J, Paterson, David L and Harris, Patrick N A (2021). Activity of temocillin against third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae bloodstream isolates from a clinical trial. JAC-Antimicrobial Resistance, 4 (1) dlab192, dlab192. doi: 10.1093/jacamr/dlab192
2021
Journal Article
Investigator-Driven Randomised Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare-Associated and Hospital-Acquired Gram-negative Bloodstream Infection: Study protocol (the GAME CHANGER trial): study protocol for an open-label, randomised controlled trial
Wright, Hugh, Harris, Patrick N. A., Chatfield, Mark D., Lye, David, Henderson, Andrew, Harris-Brown, Tiffany, Donaldson, Anna and Paterson, David L. (2021). Investigator-Driven Randomised Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare-Associated and Hospital-Acquired Gram-negative Bloodstream Infection: Study protocol (the GAME CHANGER trial): study protocol for an open-label, randomised controlled trial. Trials, 22 (1) 889. doi: 10.1186/s13063-021-05870-w
2021
Journal Article
A systematic review of antimicrobial susceptibility testing as a tool in clinical trials assessing antimicrobials against infections due to Gram negative pathogens. Intended category: systematic review
Henderson, Andrew, Bursle, Evan, Stewart, Adam, Harris, Patrick N. A., Paterson, David, Chatfield, Mark D., Paul, Mical, Dickstein, Yaakov, Rodriguez-Baño, Jesus, Turnidge, John D. and Kahlmeter, Gunnar (2021). A systematic review of antimicrobial susceptibility testing as a tool in clinical trials assessing antimicrobials against infections due to Gram negative pathogens. Intended category: systematic review. Clinical Microbiology and Infection, 27 (12), 1746-1753. doi: 10.1016/j.cmi.2021.03.019
2021
Journal Article
Ceftolozane-tazobactam versus meropenem for definitive treatment of bloodstream infection due to extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales (“MERINO-3”): study protocol for a multicentre, open-label randomised non-inferiority trial
Stewart, Adam G., Harris, Patrick N. A., Chatfield, Mark D., Littleford, Roberta and Paterson, David L. (2021). Ceftolozane-tazobactam versus meropenem for definitive treatment of bloodstream infection due to extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales (“MERINO-3”): study protocol for a multicentre, open-label randomised non-inferiority trial. Trials, 22 (1) 301, 301. doi: 10.1186/s13063-021-05206-8
2021
Journal Article
Culture-independent detection systems for bloodstream infection
Peri, Anna Maria, Harris, Patrick N. A. and Paterson, David L. (2021). Culture-independent detection systems for bloodstream infection. Clinical Microbiology and Infection, 28 (2), 195-201. doi: 10.1016/j.cmi.2021.09.039
2021
Journal Article
An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa–—authors’ response
Isler, Burcu, Harris, Patrick, Stewart, Adam G. and Paterson, David L. (2021). An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa–—authors’ response. Journal of Antimicrobial Chemotherapy, 76 (12), 3327-3328. doi: 10.1093/jac/dkab366
2021
Journal Article
Adverse clinical outcomes associated with carbapenem-resistant Acinetobacter (CRA) infections: a systematic review and meta-analysis
Ling, Weiping, Furuya-Kanamori, Luis, Ezure, Yukiko, Harris, Patrick N. A. and Paterson, David L. (2021). Adverse clinical outcomes associated with carbapenem-resistant Acinetobacter (CRA) infections: a systematic review and meta-analysis. JAC-Antimicrobial Resistance, 3 (4) dlab157, 1-12. doi: 10.1093/jacamr/dlab157
2021
Conference Publication
Con) Piperacillin-tazobactam for ESBL-producing Enterobacterales
Harris, Patrick N. A. (2021). Con) Piperacillin-tazobactam for ESBL-producing Enterobacterales. 13th International Symposium on Antimicrobial Agents and Resistance (ISAAR 2021), Online, 9-10 September 2021. Amsterdam, Netherlands: Elsevier . doi: 10.1016/j.ijantimicag.2021.106420.27
Funding
Current funding
Supervision
Availability
- Dr Patrick Harris is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Clinical impact of rapid molecular diagnostics in the diagnosis of bloodstream infections and sepsis
Principal Advisor
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Doctor Philosophy
Novel technologies for the diagnosis of bloodstream infection: performance and clinical application
Principal Advisor
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Doctor Philosophy
New diagnostic strategies for antibiotic-resistant infections
Principal Advisor
Other advisors: Associate Professor Adam Irwin
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Clinical and laboratory applications of new and emerging methods of diagnosis of infection
Associate Advisor
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Doctor Philosophy
Genomic approaches to the surveillance and control of multidrug resistant Enterobacterales.
Associate Advisor
Other advisors: Dr Brian Forde
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Novel trial design in evaluation of antibiotics.
Associate Advisor
Other advisors: Mr Mark Chatfield
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Doctor Philosophy
Randomised controlled trial of ceftolozane-tazobactam vs meropenem for bloodstream infections
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Clinical epidemiology and treatment of central nervous system infections in Asia
Associate Advisor
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Doctor Philosophy
Accelerating pathogen detection and antibiotic resistance prediction in children with suspected sepsis.
Associate Advisor
Other advisors: Associate Professor David Whiley, Associate Professor Adam Irwin
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Doctor Philosophy
Treatment Strategies for Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-producing Enterobacterales
Associate Advisor
Other advisors: Dr Brian Forde, Mr Mark Chatfield
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Doctor Philosophy
Early impact antibiotic therapy for carbapenem resistant organisms, guided by rapid diagnostics
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Burkholderia pseudomallei: towards rapid diagnosis and management
Principal Advisor
Other advisors: Mr Mark Chatfield
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2024
Doctor Philosophy
Epidemiology of Escherichia coli Producing Extended-Spectrum Beta-Lactamase (ESBL-Ec) in Queensland, Australia
Associate Advisor
Other advisors: Associate Professor Luis Furuya Kanamori
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2024
Doctor Philosophy
OXA-48 and NDM producing Klebsiella pneumoniae Infections: Trick to Treat
Associate Advisor
Media
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